Lifeboat Foundation

In a new work, a team from the University of Pennsylvania tracked the impact of alcohol consumption from the age of 20 on brain health and came to disappointing conclusions.

UNIVERSITY PARK, Pa. — Binge drinking in early adults can lead to long-lasting and potentially permanent dysregulation in the brain, according to a new study in mice, led by researchers at Penn State. They found that neurons, cells that transmit information in the brain via electrical and chemical signals, showed changes following binge drinking were similar in many ways to those seen with cognitive decline.

These findings, published in the journal Neurobiology of Aging, reveal that binge drinking early in life may have lasting impacts that are predictive of future health issues, like Alzheimer’s disease and related dementias, the researchers said. The work could inform the development of therapeutics to help combat these changes — particularly in aging populations who may have given up alcohol decades earlier, according to Nikki Crowley, director of the Penn State Neuroscience Institute at University Park, Huck Early Career Chair in Neurobiology and Neural Engineering, assistant professor of biology in the Eberly College of Science, and the leader of the research team.

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Summary: Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier. The innovative blood-brain barrier-crossing conjugate (BCC) platform utilizes a biological process called γ-secretase-mediated transcytosis to safely transport drugs like oligonucleotides and proteins into the central nervous system via intravenous injection.

In mouse models and human brain tissue, the system effectively silenced harmful genes linked to diseases such as ALS and Alzheimer’s without causing significant side effects. This advancement could revolutionize treatments for neurological and psychiatric disorders, solving a critical challenge in brain research.

The Public Utilities Commission of Texas (PUCT) on Thursday adopted a rule requiring virtual currency mining facilities in the region maintained by the Energy Reliability Council of Texas (ERCOT) to register with the commission. In these registrations, the PUCT seeks each facility to share its location, ownership information and demand for electricity.

Cryptocurrency mining, in which computers crack codes in order to verify crypto transactions, has been on the rise in Texas for the past few years, specifically after China banned the practice in May 2021. The state itself was luring miners to set up shop here, offering relative regulatory freedom at first. But in the last year, Texans have been speaking out against the mines, which operate scores of their large computers at all hours of the day. The computer usage, coupled with the fans required to cool down the hard-working machines, can use up a lot of power and make the kind of noise that residents say make them sick.

When you think of nuclear devastation, you imagine shockwaves, fireballs, and destruction. But the true nightmare lies in what comes after—the fallout. Now, imagine a weapon so lethal it could render Earth uninhabitable for centuries. Meet the cobalt bomb, a terrifying \.

Longevity is becoming mainstream. A central player has become hormones who hold the power to radically transform our well-being.

Elon Musk says that Starlink’s new system enables internet connectivity for your mobile phone with ‘no extra equipment or special app’ required.

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Advanced Navigation and MBDA are creating a GPS-free drone navigation system using NILEQ’s neuromorphic sensors for terrain positioning.

It’ll certainly take some work.