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Low-frequency wireless sensor tracks artery stiffening in real time with less interference

Wireless sensors used in wearable smart devices and medical equipment must be capable of detecting minute changes while maintaining high operational stability. However, existing technologies often utilize excessively high frequencies, leading to electromagnetic interference (EMI) or potential health risks to the human body. To address these fundamental issues, a Korean research team has developed a low-frequency-based wireless sensor technology.

A joint research team, led by Professor Seungyoung Ahn from the KAIST Cho Chun Shik Graduate School of Mobility and Professor Do Hwan Kim from the Department of Chemical Engineering at Hanyang University, has developed the “WiLECS” (Wireless Ionic-Electronic Coupling System), a low-frequency wireless electrochemical sensing platform that combines ion-based materials with wireless power transfer technology. The research is published in the journal Nature Communications.

Conventional wireless sensors suffer from low capacitance (the ability to store electrical charge), requiring high frequencies in the megahertz (MHz) range to compensate. However, these high-frequency methods can cause tissue heating or signal instability, limiting their practical application in clinical medical settings.

NIH-funded breakthrough shrinks CRISPR for precision delivery in the body

Smaller gene-editing system could expand treatment options for cancer, ALS and other diseases.

A National Institutes of Health (NIH)-funded research team has discovered an enhanced CRISPR gene-editing system that could enable targeted delivery inside the human body — a key step toward broader clinical use. Researchers identified a naturally occurring enzyme, Al3Cas12f, that is small enough to fit into adeno-associated virus vectors, a leading targeted delivery method for gene therapies. They then engineered an enhanced version that dramatically improved gene-editing performance in human cells.

The advance addresses a major limitation in CRISPR technology. Commonly used gene-editing proteins are too large for targeted delivery systems, restricting clinical applications to cells modified outside the body, such as blood and bone marrow.

The Fight For Slow And Boring Research

Great article. I should note that it actually has nothing to do with slow and boring research — it’s about the importance of scientists practicing good communication and public engagement to facilitate fundraising from non-governmental sources.


As federal research funding shrinks, scientists are looking to other sources of support. Can they learn to sell their work without selling out?

Since the middle of the twentieth century, the National Institutes of Health and the National Science Foundation have embodied an imperfect social contract: Federal agencies would fund basic research at scale, and in return, that research would serve the public good through medical advances, technological progress, and economic growth.

For scientists, this system created a reliable pathway: Do good work, write strong grants, and federal agencies would keep your lab running. It was never a perfectly fair system, but it was predictable enough that you could build a life around it. If your work was solid and your grants were strong, the system would fund you.

Mitochondria-Derived Vesicles and Mitochondrial Extracellular Vesicles in Health and Cardiovascular Disease

@CircRes Compendium on Migration of Mitochondria Beyond Cell Boundary.

Authored by Drs. Rapushi & colleagues.


Mitochondria-derived vesicles (MDVs) and mitochondrial extracellular vesicles (mitoEVs) represent 2 related extensions of mitochondrial dynamics that link organelle maintenance to communication within and between cells. MDVs are small vesicles that bud directly from mitochondria, selectively packaging components of the outer membrane, inner membrane, or matrix. They serve as a localized quality control mechanism that removes oxidized or damaged material without engaging the entire mitophagic machinery. After budding, MDVs typically enter the endolysosomal pathway, where they can fuse with late endosomes or lysosomes for cargo degradation. A subset of MDVs also targets other organelles, particularly peroxisomes, contributing to organelle crosstalk, lipid metabolism, and redox balance.

Exercise induces sex-specific assembly of mitochondrial supercomplexes

Mitochondrial supercomplexes assembly in exercise.

The function of supercomplexes (SCs) formed from mitochondrial electron transport chain (ETC) is not well understood.

The researchers demonstrate that exercise dynamically modulates the assembly of mitochondrial respiratory complexes into supercomplexes (SCs) in human skeletal muscle, with this remodeling being sex dependent.

The authors found that males increased the assembly of complex III (CIII) into SCs, particularly high molecular weight SCs (HMWSCs), in an intensity-dependent manner within skeletal muscle. Females showed a stable content of both HMWSCs and I+III2 SCs during exercise.

This highlights the importance of accounting for biological sex when studying mitochondrial adaptations to exercise. sciencenewshighlights ScienceMission https://sciencemission.com/mitochondrial-supercomplexes-and-exercise


Huertas et al. demonstrate that exercise dynamically modulates the assembly of mitochondrial respiratory complexes into supercomplexes in human skeletal muscle, with this remodeling being sex dependent. This highlights the importance of accounting for biological sex when studying mitochondrial adaptations to exercise.

CPUID hacked to deliver malware via CPU-Z, HWMonitor downloads

Hackers gained access to an API for the CPUID project and changed the download links on the official website to serve malicious executables for the popular CPU-Z and HWMonitor tools.

The two utilities have millions of users who rely on them for tracking the physical health of internal computer hardware and for comprehensive specifications of a system.

Users who downloaded either tool reported on Reddit recently that the official download portal points to the Cloudflare R2 storage service and fetches a trojanized version of HWiNFO, another diagnostic and monitoring tool from a different developer.

Could a gut microbe influence muscle strength?

The trillions of microbes living in the human gut are increasingly recognized as important partners in human health. Scientists have linked the gut microbiome to several aspects of health, from metabolism and immunity to mental health.

A recent study suggests that these microbes may also influence an important aspect of fitness—muscle strength.

Muscle strength is a crucial feature of health for many reasons. It supports our joints and keeps our bones healthy, boosts athletic performance and even plays a role in metabolic health.

Street green space can help cool cities, but it will not be enough on its own

A new IIASA-led study finds that expanding street green space can reduce urban heat stress in cities worldwide, but even ambitious greening efforts are unlikely to offset a significant share of the additional heat expected under climate change. Instead, the research shows that street greenery should be part of a broader portfolio of urban adaptation measures.

Cities are on the front line of climate change, with rising temperatures and heat stress posing growing risks to health, productivity, and livability. Street green space, such as trees and vegetation along streets, is often promoted as a practical nature-based solution because it can provide shade, cooling, and other positive benefits, for example, improving the mental health of citizens. Yet, evidence on how much cooling street greenery can deliver, to which extent the amount of vegetation can be increased, and how much cooling can be expected in future climates has remained limited, particularly when taking a global view across very different urban forms and climate zones.

In the new study published in Environmental Research Letters, a team of researchers from IIASA and VITO Belgium combined high-resolution street greenery data with 100-meter urban microclimate model outputs for 133 cities worldwide, providing a neighborhood-scale assessment with global coverage. Rather than relying on satellite-based surface temperature alone, the team assessed how street green space relates to air temperature and wet-bulb globe temperature —a measure that captures heat stress more appropriately than temperature alone because it accounts for humidity, wind, and radiation.

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