Year 2024
Caption :
MIT researchers have 3D printed a miniature ionizer, which is a key component of a mass spectrometer. The new miniature ionizer could someday enable an affordable, in-home mass spectrometer for health monitoring. Pictured are parts of the new device, including a green printed circuit board (PCB) with orange casing on top. Under the casing is a black rectangle where the electrospray emitter is located.
Alzheimer’s disease is a neurodegenerative disease characterized by a progressive decline in mental functions and memory loss. Along with frontotemporal dementia and some other neurodegenerative disorders, Alzheimer’s disease has been associated with an accumulation inside neurons of abnormal clumps of a protein called “tau.”
The tau protein is important for brain health, stabilizing structures called microtubules inside neurons. In Alzheimer’s disease and other tauopathies (i.e., diseases linked with the abnormal accumulation of tau), tau proteins aggregate into toxic and insoluble clumps that are harmful to brain cells, gradually leading to their death.
Researchers at Zhejiang University, Xiamen University and other institutes in China recently carried out a study aimed at better understanding the processes via which tau aggregation contributes to the death of neurons in patients with Alzheimer’s disease. Their findings, published in Nature Neuroscience, suggest that these tau clumps prompt the reactivation of transposable DNA elements in neurons, which can in turn lead to their death.
A supplement widely promoted for athletic performance may interfere with some of the heart’s beneficial adaptations to exercise, according to new Dalhousie University research published in Scientific Reports.
While these supplements are often promoted to support exercise performance and cardiovascular function, researchers found the combination of sodium nitrate and running prevented several beneficial cardiac improvements normally associated with exercise in females.
Those benefits included changes linked to heart structure, ventricular function and calcium handling in heart cells, which helps regulate contraction and relaxation. The effects were much less pronounced in males, pointing to important sex differences that researchers say are too often overlooked in supplement research.
A study by researchers at The University of Manchester, carried out alongside the Universities of Melbourne and Copenhagen, could hold the key to understanding the causes of long-term health problems, such as infertility and ovarian cancer.
The study, published in PRX Life, used a combination of high-resolution imaging, flow measurements, and mathematical modeling to examine fluid flows around corals that are driven by cilia—densely packed tiny hairs on the coral’s surface. The collective beating of the cilia contributes to the movement of fluid around the surface of the coral, regulating the animal’s immediate environment through the transport of particles such as oxygen.
The researchers found that heterogeneity in ciliary orientation —small variations in the direction individual cilia beat—can significantly boost transport efficiency. For substances that diffuse slowly through the fluid, this natural variability increased particle transport by more than 50% compared to perfectly aligned cilia. This contrasts with other biological systems, highlighting how coral cilia are uniquely adapted to their environment.
A health scare prompted the first ever early return from the International Space Station for a medical reason. Does it change the plan for deep space missions?
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Just a few hours before the Orion spacecraft crossed the sky en route to the moon on April 1, mechatronics engineer Rodrigo Trevisan Okamoto received confirmation he had been waiting for since the Artemis 2 mission was announced in 2023. The email from NASA stated that the crew of the first crewed mission to orbit the moon in half a century would carry a device developed by Okamoto and his team at Condor Instruments, a São Paulo-based startup.
“The NASA announcement was sudden and caught us by surprise. And it was only after the mission concluded that we learned the astronauts had been using the equipment in tests for the past two years,” Okamoto told Agência FAPESP.
The device, called an actigraph, is shaped like a wristwatch and incorporates accelerometers, as well as light and temperature sensors, to precisely map the user’s sleep and wake patterns over the course of days or weeks.