Laszlo Nagy & team define unique regulatory programs of placental Hofbauer cells, advancing understanding of their role in pregnancy health and potential disease:
The image shows enrichment of Hofbauer cells by CD163-based cell sorting Placenta Fetal Development.
1Department of Biochemistry and Molecular Biology, Faculty of Medicine, and.
2Doctoral School of Molecular Cell and Immune Biology, University of Debrecen, Debrecen, Hungary.
3Institute for Fundamental Biomedical Research, Johns Hopkins All Children’s Hospital, St. Petersburg, Florida, USA.
Researchers at DTU have developed a nanolaser that could be the key to much faster and much more energy-efficient computers, phones, and data centers. The technology offers the prospect of thousands of the new lasers being placed on a single microchip, thus opening a digital future where data is no longer transmitted using electrical signals, but using light particles, photons. The invention has been published in the journal Science Advances.
“The nanolaser opens up the possibility of creating a new generation of components that combine high performance with minimal size. This could be in information technology, for example, where ultra-small and energy-efficient lasers can reduce energy consumption in computers, or in the development of sensors for the health care sector, where the nanolaser’s extreme light concentration can deliver high-resolution images and ultrasensitive biosensors,” says DTU professor Jesper Mørk, who co-authored the paper together with, among others, Drs. Meng Xiong and Yi Yu from DTU Electro.
An existing drug currently used to treat glaucoma, altitude sickness, and seizures may also have the potential to prevent relapse in opioid use disorder, according to a study by researchers at University of Iowa Health Care. The work is published in the journal Neuropsychopharmacology.
The UI researchers led by John Wemmie, MD, Ph.D., focused on the drug known as acetazolamide (AZD) because it blocks the activity of a brain enzyme called carbonic anhydrase 4 (CA4). Wemmie’s team had previously discovered that inhibiting CA4 in the whole brain, or just in its reward center (the nucleus accumbens), of mice, significantly reduced the brain changes that occurred after cocaine withdrawal. In addition, blocking the CA4 enzyme reduced drug-seeking behavior and relapse in the mice.
“What makes this approach promising is that it works in a completely different way from current treatments,” says Wemmie, a professor of psychiatry in the UI Carver College of Medicine. “Instead of targeting opioid receptors, AZD targets a different pathway involved in drug-induced synaptic changes and drug-seeking behavior. This could open the door to new therapies that help people stay in recovery by addressing the brain’s long-term response to drug use.”
Greater access to legal cannabis is associated with a significant drop in daily opioid use, suggesting that cannabis availability may reduce reliance on opioids for pain or other use.
How can cannabis legalization influence opioid use? This is what a recent study published in Drug and Alcohol Dependence hopes to address as a team of researchers investigated behavior connections between cannabis use and opioid use. This study has the potential to help scientists, medical professionals, legislators, and the public better understand the benefits of cannabis, including how it can help the opioid epidemic.
For the study, the researchers analyzed survey data collected from 28,069 individuals designated as people who inject drugs (PWID) during 2012, 2015, 2018, and 2022 across 13 states. The goal of the study was to compare medical cannabis and medical plus recreational cannabis use to opioid use. The respondents were asked to report their past 30-day use for both cannabis and opioids. In the end, the researchers found that users who subscribed to both medical plus recreational cannabis use compared to just medical cannabis use experienced a 9–11 percent decline in opioid use.
The study notes in its conclusions, “Cannabis legalization may shape daily opioid consumption among PWID, potentially reducing drug-related harms. Differences in cannabis use following legalization may reflect disparate impact by race, due to structural racism or other factors. Future research examining whether policy attributable changes in substance use manifest health benefits among PWID is critical to developing evidence-based cannabis reform.”
The effects of exercise would not be nearly as powerful without the input of the brain, according to new research.
A study on mice has found a critical signal in the central nervous system that helps build physical endurance in the wider body after repeated exercise.
Traditionally, scientists thought that our body’s extensive response to frequent exercise occurred mainly in the periphery, such as the bones and muscles, and the heart.
Humanoid robots with full-body autonomy are rapidly advancing and are expected to create a $50 trillion market, transforming industries, economy, and daily life ## ## Questions to inspire discussion.
Neural Network Architecture & Control.
🤖 Q: How does Figure 3’s neural network control differ from traditional robotics? A: Figure 3 uses end-to-end neural networks for full-body control, manipulation, and room-scale planning, replacing the previous C++-based control stack entirely, with System Zero being a fully learned reinforcement learning controller running with no code on the robot.
🎯 Q: What enables Figure 3’s high-frequency motor control for complex tasks? A: Palm cameras and onboard inference enable high-frequency torque control of 40+ motors for complex bimanual tasks, replanning, and error recovery in dynamic environments, representing a significant improvement over previous models.
🔄 Q: How does Figure’s data-driven approach create competitive advantage? A: Data accumulation and neural net retraining provides competitive advantage over traditional C++ code, allowing rapid iteration and improvement, with positive transfer observed as diverse knowledge enables emergent generalization with larger pre-training datasets.
🧠 Q: Where is the robot’s compute located and why? A: The brain-like compute unit is in the head for sensors and heat dissipation, while the torso contains the majority of onboard computation, with potential for latex or silicone face for human-like interaction.
Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction.
1Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.
2Division of Clinical and Translational Research, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.
3Cardiovascular Research Institute, UCSF, San Francisco, California, USA.
James J. Collins, the Termeer Professor of Medical Engineering and Science at MIT and faculty co-lead of the Abdul Latif Jameel Clinic for Machine Learning in Health, is embarking on a multidisciplinary research project that applies synthetic biology and generative artificial intelligence to the growing global threat of antimicrobial resistance (AMR).
The research project is sponsored by Jameel Research, part of the Abdul Latif Jameel International network. The initial three-year, $3 million research project in MIT’s Department of Biological Engineering and Institute of Medical Engineering and Science focuses on developing and validating programmable antibacterials against key pathogens.
AMR — driven by the overuse and misuse of antibiotics — has accelerated the rise of drug-resistant infections, while the development of new antibacterial tools has slowed. The impact is felt worldwide, especially in low-and middle-income countries, where limited diagnostic infrastructure causes delays or ineffective treatment.
MILAN — The French-German aerospace company The Exploration Company completed mock splashdown tests for its Nyx space capsule, a modular, reusable spacecraft designed to transport cargo and eventually crew to low Earth orbit and beyond. The company conducted water-impact tests on a mock capsule from Jan. 13 through 28.
The testing campaign was not a full splashdown test, but a model-validation exercise carried out at the “Umberto Pugliese” towing tank facility in Italy. The company used a 135-kilogram, 1:4-scale mock-up in a 13.5-meter by 6.5-meter tank to characterize Nyx’s water-impact behavior and validate its numerical models. The testing is intended as a step toward future certification activities and subsequent splashdown activities.
“The primary objective was validation of the numerical splashdown model,” a company spokesperson told SpaceNews. “To do that, we varied release heights and velocities in a controlled way to reproduce multiple impact conditions with high repeatability.”
Found in everything from protein bars to energy drinks, erythritol has long been considered a safe alternative to sugar.
But research suggests this widely used sweetener may be quietly undermining one of the body’s most crucial protective barriers – with potentially serious consequences for heart health and stroke risk.
A study from the University of Colorado suggests erythritol may damage cells in the blood-brain barrier, the brain’s security system that keeps out harmful substances while letting in nutrients.
