In the past decade, there has been significant interest in studying the expression of our genetic code down to the level of single cells, to identify the functions and activities of any cell through the course of health or disease.
The identity of a cell, and the way that identity can go awry, is critical to its role in many of the biggest health challenges we face, including cancer, neurodegeneration, or genetic and developmental disorders. Zooming in on single cells allows us to tell the difference between variants which would otherwise be lost in the average of a region. This is essential for finding new medical solutions to diseases.
Most single-cell gene expression experiments make use of a technology called single-cell RNA sequencing (scRNA-seq), which produces a map of exactly which genes are being copied out into short “transcripts” inside the nucleus. However, scRNA-seq only gives us a window into the intermediate step between the genetic code and the proteins which take care of (almost) all the tasks inside our bodies.
The widespread prevalence of plastics and in particular, microplastics (MPs) raises concerns about their potential toxic effects. MPs, defined as particles smaller than 5 mm, are distributed throughout ecosystem and can enter the human body through the food chain. There is a lack of knowledge regarding MP potential harmful effects on the mammal’s body, especially the brain. This study aimed to examine the impact of low-density polyethylene (LDPE) MPs (< 30 μm) on blood–brain barrier (BBB) integrity, oxidative stress, and neuronal health. Male rats were exposed to LDPE MPs via oral administration for 3 and 6 weeks. The results revealed no significant changes in brain water content across groups. However, BBB integrity was significantly compromised after both 3 and 6 weeks of exposure. Oxidative stress increased in MP-treated groups, evidenced by decreased superoxide dismutase (SOD) levels and elevated malondialdehyde (MDA). Additionally, brain-derived neurotrophic factor (BDNF) levels significantly declined in the 6-week group. Histological analysis indicated neuronal damage and death in both treatment durations. These findings demonstrate that chronic exposure to LDPE MPs impairs BBB integrity, increases oxidative stress, and induces neuronal damage in rats. The results highlight the neurotoxic potential of MPs and emphasize the need for further research to address their possible health risks.
A new study finds that a high-salt diet triggers brain inflammation that drives up blood pressure. The research, led by McGill University scientist Masha Prager-Khoutorsky in collaboration with an interdisciplinary team at McGill and the Research Institute of the McGill University Health Center, suggests the brain may be a missing link in certain forms of high blood pressure—or hypertension—traditionally attributed to the kidneys.
“This is new evidence that high blood pressure can originate in the brain, opening the door for developing treatments that act on the brain,” said Prager-Khoutorsky, associate professor in McGill’s Department of Physiology.
Hypertension affects two-thirds of people over 60 and contributes to 10 million deaths worldwide each year. Often symptomless, the condition increases the risk of heart disease, stroke and other serious health problems.
Fresh grapes contain a potent mix of over 1,600 compounds that benefit heart, brain, skin, and gut health. New evidence suggests they deserve official superfood recognition, with benefits even at the genetic level.
A new article appearing in the current issue of the peer-reviewed Journal of Agriculture and Food Chemistry explores the concept of “superfoods” and makes a case that fresh grapes have earned what should be a prominent position in the superfood family. The author, leading resveratrol and cancer researcher John M. Pezzuto, Ph.D., D.Sc., Dean of the College of Pharmacy and Health Sciences at Western New England University, brings forth an array of evidence to support his perspective on this issue.
As noted in the article, the term “superfood” is a common word without an official definition or established criteria. Mainstream superfoods are typically part of the Mediterranean Diet and generally rich in natural plant compounds that are beneficial to a person’s health. Pezzuto addresses the broader topic of superfoods in detail, then makes the scientific case for grapes, noting that fresh grapes are underplayed in this arena and often not included with mention of other similar foods, such as berries.
