Meichsner et al. review recent insights into mitochondria as dynamic signaling hubs. The authors describe how structural plasticity and interorganellar communication enable mitochondria to serve as both sources and targets of signaling, coordinating stress responses, metabolic adaptation, and innate immune pathways to safeguard cellular homeostasis.
Aubrey de Grey believes aging isn’t inevitable — it’s a solvable engineering problem. In this conversation, we explore why society treats aging as untouchable, how “longevity escape velocity” could allow us to live indefinitely, and why reversing damage—not slowing it—is the future of medicine. He breaks down how our medical system profits from sickness, and how progress is slowed by fear and outdated norms. The end of aging as we know it is coming and it’s happening faster than you think. #preventativehealth #preventativecare #aging #health #medicine.
Connect With Me: / tim.doy1e.
Timestamps:
00:00 How We Understand Aging.
06:01 How Aubrey Found His Work.
10:42 Longevity Escape Velocity.
12:45 Not Being Controlled.
15:11 Investor-Humanitarian Structure.
16:51 Balancing Work With Publicity.
17:26 Aubrey’s Current Work.
27:36 Getting Pushback & The Medical System.
33:11 Shifting To Preventative Care.
36:14 What Has & Hasn’t Changed.
41:52 Consciousness & Aging.
46:00 How To Popularize Ideas.
48:10 The Future Of Aubrey’s Work.
50:58 Connect With Aubrey de Grey.
Zalesky and colleagues discuss the evolution of aging clocks into organ-specific aging readouts that harness omics and imaging data. They review the insights that this additional resolution provides on differential aging across organs within interconnected systems, as well as the methods, priorities and future directions.
Dr. Fahy is the Vice President and Chief Scientific Officer at 21st Century Medicine, Inc, and has co-founded Intervene Immune, a company developing clinical methods to reverse immune system aging. He was the 2022–2023 president of the Society for Cryobiology. Dr. Fahy is the lead author of a recent paper, “Ultrastructural and Histological Cryopreservation of Mammalian Brains by Vitrification” – the main topic of our conversation.
In December of 2014, I worked with Dr. Fahy to cryopreserve Dr. Stephen Coles under special conditions, with his permission to extract brain samples and test them for preservation quality. We did not know what the results would be. If bad, that would be discouraging for cryonics. In fact, the results were excellent, as Dr. Fahy details.
We discuss the Coles case and the results of the cerebral cortical biopsy. The paper includes results from rabbit brains. We also discuss the relative resilience of the brain compared to other organs when it comes to fracturing; how cryoprotectants prevent ice formation even when the blood-brain barrier remains closed; whether biostasis organizations should be using blood-brain barrier opening agents; Dr. Fahy’s thoughts about chemical preservation and the role of a combination of cryo an chemo, known as aldehyde-stabilized cryopreservation (ASC), and more.
Hi all, you should check out this human enhancement game created by Anton Kulaga and his team! You’ll learn about various genetic factors with potential for increasing human capabilities. The content is all rooted in scientific literature! Once you design a character, you can also get a 3D printed shape sent to you which is influenced by your choices.
Build your post-human character from real genes — tardigrade radiation shields, naked-mole-rat cancer resistance, Greenland shark longevity — backed by scientific evidence tiers and real citations. Spend enhancement credits and 3D-print the result.
What if aging isn’t just “getting older” but the gradual breakdown of the biological systems protecting our DNA? Scientists are now exploring therapies designed to directly lengthen telomeres, the protective caps linked to cellular aging itself. The future of longevity may be far more programmable than we thought.
C Decaf even improved learning and memory, while caffeine boosted focus and reduced anxiety. Together, they show coffee works through multiple pathways beyond just caffeine.
Researchers at APC Microbiome Ireland, a leading research center at University College Cork, have taken a major step toward understanding how coffee benefits the body. For the first time, scientists have closely examined how coffee interacts with the gut-brain axis, the communication network that links the digestive system and the brain.
The findings, published in Nature Communications and supported by the Institute for Scientific Information on Coffee (ISIC), show that regularly drinking both caffeinated and decaffeinated coffee can shape the gut microbiome and influence mood and stress.
Heart disease still kills nearly 20 MILLION people every year worldwide — roughly 1 person every 1.5 seconds. — But what if medicine could move beyond simply slowing plaque buildup…and actually REMOVE toxic oxidized cholesterol from arteries? — Dr. Matthew “Oki” O’Connor, CEO and Co-Founder, Cyclarity Therapeutics.
In the time it will take you watch this episode, over 2,000 people around the world will die from diseases driven by arterial plaque. But what if we could actually remove the toxic cholesterol already trapped inside arteries?
Today we’re diving into one of the biggest unsolved problems in medicine and aging: how do you actually remove arterial plaque instead of merely slowing its progression?
Cardiovascular disease remains the world’s leading killer, despite decades of statins, anti-inflammatory drugs, and newer RNA-based therapies. Most existing treatments help manage cholesterol and reduce risk, but very few directly target the toxic debris already embedded inside plaques.
But what if we could literally extract some of the most dangerous oxidized cholesterol molecules from the body?