NIH scientists and collaborators reveal the brain preserves its representation of lost limb in clinical study.
Category: biotech/medical
Reproducing Rejuvenation: Inside the Pig Plasma Longevity Experiments
Could pig plasma fractions really rejuvenate aging rats? Join me as I interview Nicolás and Nina from the Rejuvenation Science Institute (Brazil), who are working to reproduce the headline-creating “pig plasma rejuvenation” results. We explore the origins, science, controversies, challenges, and hopes surrounding this research—plus their plans for the next breakthrough longevity experiment and open science collaboration.
https://www.rejuvenescimento.org/english.
https://www.rejuvenescimento.org/news… https://journals.tmkarpinski.com/inde… Timestamps 00:00 – Introduction: The Pig Plasma Rat Rejuvenation Debate 02:00 – Origins: Why try to reproduce these results? 08:30 – What is being injected? Fraction preparation explained 15:40 – Acute toxicity and safety results: did the rats survive? 26:00 – The next experiment: timelines, scale-up, and open science goals Find me on Twitter — / eleanorsheekey Support the channel through PayPal — https://paypal.me/sheekeyscience?coun… through Patreon —
/ thesheekeyscienceshow Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; “https://www.freepik.com/free-photos-v…Background“Background vector created by freepik — www.freepik.com.
https://journals.tmkarpinski.com/inde…
Timestamps.
00:00 – Introduction: The Pig Plasma Rat Rejuvenation Debate.
02:00 – Origins: Why try to reproduce these results?
08:30 – What is being injected? Fraction preparation explained.
15:40 – Acute toxicity and safety results: did the rats survive?
26:00 – The next experiment: timelines, scale-up, and open science goals.
Find me on Twitter — / eleanorsheekey.
Support the channel.
through PayPal — https://paypal.me/sheekeyscience?coun…
through Patreon — / thesheekeyscienceshow.
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; \.
Immunotherapy drug eliminates aggressive cancers in clinical trial
Over the past 20 years, a class of cancer drugs called CD40 agonist antibodies have shown great promise—and induced great disappointment. While effective at activating the immune system to kill cancer cells in animal models, the drugs had limited impact on patients in clinical trials and caused dangerously systemic inflammatory responses, low platelet counts, and liver toxicity, among other adverse reactions—even at a low dose.
But in 2018, the lab of Rockefeller University’s Jeffrey V. Ravetch demonstrated it could engineer an enhanced CD40 agonist antibody so that it improved its efficacy and could be administered in a manner to limit serious side effects. The findings came from research on mice, genetically engineered to mimic the pathways relevant in humans. The next step was to have a clinical trial to see the drug’s impact on cancer patients.
Now the results from the phase 1 clinical trial of the drug, dubbed 2141-V11, have been published in Cancer Cell. Of 12 patients, six patients saw their tumors shrink, including two who saw them disappear completely.
The researchers demonstrate that an engineered antibody improves a class of drugs that has struggled to make good on its early promise.
Fat-trapping microbeads provide drug-free weight loss in rats, study finds
Researchers developed edible microbeads made from green tea polyphenols, vitamin E and seaweed that, when consumed, bind to fats in the gastrointestinal tract.
AI can find cancer pathologists miss
Men assessed as healthy after a pathologist analyses their tissue sample may still have an early form of prostate cancer. Using AI, researchers at Uppsala University have been able to find subtle tissue changes that allow the cancer to be detected long before it becomes visible to the human eye.
Previous research has demonstrated that AI is able to detect tissue changes indicative of cancer. In the current study, published in Scientific Reports, the researchers show that AI can also find cancers missed by pathologists.
“The study has been nicknamed the ‘missed study’, as the goal of finding the cancer was ‘missed’ by the pathologists. We have now shown that with the help of AI, it is possible to find signs of prostate cancer that were not observed by pathologists in more than 80 per cent of samples from men who later developed cancer,” says Carolina Wählby, who led the AI development in the study.
“When we looked at the patterns that the AI ranked as informative, we saw changes in the tissue surrounding the glands in the prostate”, says Carolina Wählby. Photo: Mikael Wallerstedt.
Chan Zuckerberg Initiative’s rBio uses virtual cells to train AI, bypassing lab work
The Chan Zuckerberg Initiative announced Thursday the launch of rBio, the first artificial intelligence model trained to reason about cellular biology using virtual simulations rather than requiring expensive laboratory experiments — a breakthrough that could dramatically accelerate biomedical research and drug discovery.
The reasoning model, detailed in a research paper published on bioRxiv, demonstrates a novel approach called “soft verification” that uses predictions from virtual cell models as training signals instead of relying solely on experimental data. This paradigm shift could help researchers test biological hypotheses computationally before committing time and resources to costly laboratory work.
Groundbreaking new cancer detection replaces toxic compounds with diamonds
Scientists have developed a diamond-based sensor that could make it easier for doctors to detect the spread of cancer.
Researchers at the University of Warwick have created a handheld device that is designed to trace tiny magnetic particles injected into the body.
The scientists said this offers a non-toxic alternative to radioactive tracers and dyes currently used in hospitals.