Real-time MRI-guided ventricular ablation was demonstrated as a technically feasible and safe approach, providing precise cardiac visualization without radiation.
This case report demonstrates the technical feasibility and safety of the first-in-human real-time magnetic resonance (MR)–guided radiofrequency ventricular ablation procedure for outflow tract premature ventricular complexes.
Long-known as the ‘workhorses of the cell,’ proteins are responsible for powering nearly every function in the body. Often critical to this is their interactions with other small molecules known as ligands. In a new study published in Nature Structural and Molecular Biology, the researchers introduce HT-PELSA, a high-throughput adaptation of an earlier tool that detects these interactions. This new tool can process samples at an unprecedented scale, a breakthrough that promises to accelerate drug discovery and our understanding of fundamental biological processes.
Still a fairly new tool itself, the original PELSA (peptide-centric local stability assay) method, launched last year by researchers identifies protein-ligand interactions by tracking how ligand binding affects protein stability. When a ligand binds to a protein, that part of the protein becomes more stable and less prone to the effects of enzymes like trypsin, which cuts proteins into smaller peptide fragments.
What made PELSA especially noteworthy was its ability to detect peptide-level changes in stability across the entire proteome – that is, across all of the proteins in an organism. Although effective, nearly every step in the PELSA workflow is done by hand, meaning scientists can only process a few samples at a time. This not only requires a lot of time and effort but also increases the risk of contamination and accidental error.
HT-PELSA streamlines this process significantly by shifting from full-size tubes to micro-wells. Such a change enables automation of PELSA’s steps and allows researchers to analyse hundreds of samples in parallel while maintaining the same sensitivity and reproducibility.
“Before, I could only do at most, maybe 30 samples per day,” said the first author of the study. “Now, with HT-PELSA, we can scan 400 samples per day – it has highly simplified the workflow”
While in PELSA, trypsin-cleaved peptides are separated from whole proteins based on their mass, HT-PELSA leverages the water-repellant nature of proteins. It utilises a surface that proteins stick to more readily than peptides, thus allowing the scientists to separate the two. This not only further automates the process, but also enables the detection of membrane proteins that, up until now, were hard or even impossible to study.
“The most striking thing was the high dust levels,” said Dr. Eva Dock.
What risks can metal recycling pose to workers? This is what a recent study published in the International Journal of Hygiene and Environmental Health hopes to address as a collaborative team of researchers from Sweden investigated metal and dust exposure to recycling workers. This study holds the potential to help scientists, legislators, and the public better understand the risks of metal recycling as a means for enhancing green technologies.
For the study, the researchers analyzed observation and questionnaire data obtained from 139 recycling workers across 13 Swedish metal recycling companies. Additionally, the team obtained dust and metal samples to ascertain employee exposure and biological samples, including blood and urine, to ascertain individual metal and dust exposure. The goal of the study was to ascertain the efficacy of safety protocols and the severity of exposure to employees.
In the end, the researchers discovered alarming results, including 19 percent of the employees discovered to have heightened levels of more than 10 metals within their body and 94 having heightened levels of six metals. Of the 139 employees, 32 percent were involved in e-waste recycling, while safety protocols to mitigate dust exposure were discovered to be less than satisfactory, specifically regarding the use of respiratory equipment or hygiene protocols.
Leiden researchers can now visualize the connections between brain cells. Their microscopy technique could significantly advance the human quest to understand brain functions. The study is published in the Proceedings of the National Academy of Sciences.
How does information flow through the brain? To understand this, researchers map the brain at every scale, from small networks of cells to the entire nervous system. This provides insight into how our brains work and how connections between cells may become disrupted in disease.
The research group led by Professor Sense Jan van der Molen uses a microscope that reveals how a brain structure is built. It can do so down to the level of a synapse, the tiny junction through which one neuron communicates with another cell.
A new study shows that children born preterm who are later diagnosed with autism often present with more extensive support needs and a higher number of co-occurring conditions than autistic children born at full term. Surprisingly, however, the researchers found no differences in genetic variants across the genome, nor in specific genes already linked to autism, between the groups—a result that contradicted their initial hypothesis.
The study was conducted at KIND (Center of Neurodevelopmental Disorders at Karolinska Institutet) and published in October 2025 in the journal Genome Medicine.
“We did not observe any genetic differences between preterm and full-term autistic children, which was unexpected. We initially thought that preterm children might show fewer of the genetic factors associated with autism, as their early birth can be viewed as an environmental factor,” says Yali Zhang, doctoral student at Tammimies research group at KIND and first author of the study.
Scientists have found that human hair growth does not grow by being pushed out of the root; it’s actually pulled upward by a force associated with a hidden network of moving cells. The findings challenge decades of textbook biology and could reshape how researchers think about hair loss and regeneration.
The team, from L’Oréal Research & Innovation and Queen Mary University of London, used advanced 3D live imaging to track individual cells within living human hair follicles kept alive in culture. The study, published in Nature Communications, shows that cells in the outer root sheath—a layer encasing the hair shaft—move in a spiral downward path within the same region from where the upward pulling force originates.
Dr. Inês Sequeira, Reader in Oral and Skin Biology at Queen Mary and one of the lead authors, said, “Our results reveal a fascinating choreography inside the hair follicle. For decades, it was assumed that hair was pushed out by the dividing cells in the hair bulb. We found that instead that it’s actively being pulled upwards by surrounding tissue acting almost like a tiny motor.”
University of Pittsburgh researchers have made an important step toward providing hospitals and water treatment facilities with a safer, greener alternative to chlorine-based disinfection.
The team, which includes scientists from Drexel University and Brookhaven National Laboratory, uncovered key design principles for catalysts that can generate ozone, a disinfecting agent, on demand. The research is published in the journal ACS Catalysis.
This breakthrough addresses a critical challenge in water sanitation. Chlorine, commonly used to kill bacteria on surfaces and in water—including most municipal drinking water—is hazardous to transport and store, and its byproducts can be carcinogenic. These risks limit its use and motivate the search for safer disinfectants.
Researchers studying Yellowstone’s depths discovered that small earthquakes can recharge underground microbial life.
The quakes exposed new rock and fluids, creating bursts of chemical energy that microbes can use. Both the water chemistry and the microbial communities shifted dramatically in response. This dynamic may help explain how life survives in deep, dark environments.
A large portion of earth’s life lives underground.