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Category: biotech/medical

Study examines oligodendrocyte dynamics throughout the progression of multiple sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the disruption of nerve signals and various associated neurological symptoms, ranging from vision problems to numbness, weakness, fatigue and cognitive impairments. These symptoms emerge when the immune system starts to attack mature oligodendrocytes (MOLs), specialized cells that produce the protective sheath surrounding nerve fibers (i.e., myelin).

There are several subtypes of MOLs, which might exhibit different immune cell-like genetic responses in patients diagnosed with MS. While various studies have investigated the neural and molecular underpinnings of MS, how these different cell subtypes respond as the disease progresses has not yet been elucidated.

Researchers at Karolinska Institute in Sweden recently carried out a mouse study aimed at mapping how different MOL subtypes might differ in their sensitivity to neuroinflammation across different stages of MS.

Improved tracer labeling expands PET imaging possibilities

Imagine being able to watch organs and tissues work in real time. That’s the power of Positron Emission Tomography (PET) imaging, a technology that gives physicians and researchers a window into cellular processes.

In research recently published in Science, Virginia Tech chemist Wei Liu and his graduate student Chao Wang have found a new way to tag molecules to aid in PET scans—leading to improved processes, better imaging, and possibly more effective treatments.

Elegant solution for measuring ultrashort laser pulses discovered

Ultrashort laser pulses—that are shorter than a millionth of a millionth of a second—have transformed fundamental science, engineering and medicine. Despite this, their ultrashort duration has made them elusive and difficult to measure.

About 10 years ago, researchers from Lund University and Porto University introduced a tool for measuring pulse duration of ultrafast lasers. The same team has now achieved a breakthrough that enables the measurement of individual laser pulses across a wider parameter range in a more compact setup.

“The current standard measurements for femtosecond lasers, typically used in industry and medicine, give just an estimate of the pulse duration. Our approach gives a more complete measurement and can contribute to unleashing the whole potential of ultrafast laser technology,” says Daniel Díaz Rivas, doctoral student in Atomic Physics at Lund University.

New Pill Could Finally Treat Sleep Apnea Without a Mask

Sulthiame reduced breathing interruptions in sleep apnea patients, pointing toward a viable drug treatment. A European clinical trial has found that the drug sulthiame can reduce breathing pauses and improve sleep quality in people with obstructive sleep apnea, with researchers from the Universit

Hidden cellular layers in the brain’s memory center

Using a powerful RNA labeling method called RNAscope with high-resolution microscopy imaging, the team captured clear snapshots of single-molecule gene expression to identify CA1 cell types inside mouse brain tissue. Within 58.065 CA1 pyramidal cells, they visualized more than 330,000 RNA molecules—the genetic messages that show when and where genes are turned on. By tracing these activity patterns, the researchers created a detailed map showing the borders between different types of nerve cells across the CA1 region of the hippocampus.

The results showed that the CA1 region consists of four continuous layers of nerve cells, each marked by a distinct set of active genes. In 3D, these layers form sheets that vary slightly in thickness and structure along the length of the hippocampus. This clear, layered pattern helps make sense of earlier studies that saw the region as a more gradual mix or mosaic of cell types.

“When we visualized gene RNA patterns at single-cell resolution, we could see clear stripes, like geological layers in rock, each representing a distinct neuron type,” said a co–first author of the paper. “It’s like lifting a veil on the brain’s internal architecture. These hidden layers may explain differences in how hippocampal circuits support learning and memory.”

The hippocampus is among the first regions affected in Alzheimer’s disease and is also implicated in epilepsy, depression, and other neurological conditions. By revealing the CA1’s layered structure, the study provides a roadmap to investigate which specific neuron types are most vulnerable in these disorders.

The new CA1 cell-type atlas, built using data from the Hippocampus Gene Expression Atlas (HGEA), is freely available to the global research community. The dataset includes interactive 3D visualizations accessible through the Schol-AR augmented-reality app, which allows scientists to explore hippocampal layers in unprecedented detail.

Researchers have identified a previously unknown pattern of organization in one of the brain’s most important areas for learning and memory. The study, published in Nature Communications, reveals that the CA1 region of a mouse’s hippocampus, a structure vital for memory formation, spatial navigation, and emotions, has four distinct layers of specialized cell types. This discovery changes our understanding of how information is processed in the brain and could explain why certain cells are more vulnerable in diseases like Alzheimer’s and epilepsy.

Continue reading “Hidden cellular layers in the brain’s memory center” | >

Anil Seth — What is Consciousness: Data or Information?

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To study consciousness comprehensively and rigorously, what kinds of data or information are relevant? Data/information for Materialism theories, which are subject to the scientific method, can be well defined. But what about non-Materialism theories?

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Anil Seth is Professor of Cognitive and Computational Neuroscience at the University of Sussex, where he is also Director of the Sussex Centre for Consciousness Science. Seth is also Co-Director of the Canadian Institute for Advanced Research (CIFAR) Program on Brain, Mind, and Consciousness. Seth’s mission is to advance the science of consciousness, and to use its insights for the benefit of society, technology, and medicine.

Closer To Truth, hosted by Robert Lawrence Kuhn and directed by Peter Getzels, presents the world’s greatest thinkers exploring humanity’s deepest questions. Discover fundamental issues of existence. Engage new and diverse ways of thinking. Appreciate intense debates. Share your own opinions. Seek your own answers.

Light-printed electrodes turn skin and clothing into sensors

Researchers in Sweden have unveiled a way to create high-performance electronic electrodes using nothing more than visible light and specially designed water-soluble monomers. This gentle, chemical-free approach lets conductive plastics form directly on surfaces ranging from glass to textiles to living skin, enabling surprisingly versatile electronic and medical applications.

Cancer Cells Light Up With a Breakthrough Imaging System

A new ultra-sensitive imaging system can make cancer cells light up, paving the way for faster and earlier detection.

Researchers have created a compact Raman imaging system that can reliably tell tumor tissue apart from normal tissue. The goal is to support earlier cancer detection and make molecular imaging easier to use beyond specialized research labs.

How SERS nanoparticles help tumors stand out.

Wooden Neurons: An Artistic Vision of the Brain

For Louis-Jan Pilaz, days spent with tools and wood began as simple home improvement projects. He soon found himself learning how to whittle scraps of wood. Then, as a neurobiologist, Pilaz noticed a striking parallel. “It made so much sense to use wood to render neurons…They look like trees, and they have this flow of energy that is just like in neurons.” Inspired, he began to shape wood into intricate neural forms, transforming casual whittling into science-inspired woodworking art.

When he first shared his artwork on X (then Twitter), the response was positive, and people expressed their interest in his work. Encouraged by his graduate student, Pilaz opened an Etsy shop in 2021 to sell his wood sculptures, and NeuroWoodworks was born.

Pilaz’s group at Sanford Research studies the development and dysfunction of the cerebral cortex and makes extensive use of microscopy, which fuels his research and serves as a source of inspiration for his wood art. “I’ve been obsessed with cell morphology since my PhD,” Pilaz said. “I experimented, just like I do in the lab, with the tools I have and tried to make [different cell] shapes.” He uses different types of wood, such as walnut and padauk, to create a variety of cell types and structures from Purkinje cells and radial glia to mitochondria.

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