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Category: biotech/medical

Blood protein clocks flag higher risks of death and chronic disease

Organ-specific age gaps showed strong associations with cancers affecting the corresponding organ. The strongest association was observed between kidney biological age and renal cancer (HR, 1.6). Organ-specific aging in lungs and intestines also increased the risk of lung cancer and stomach cancer, respectively (HR, 1.4 for both). The sensitivity analysis yielded largely similar results, except for attenuations in kidney and lung cancer, indicating the robustness of the primary findings.

The Global Proteomic Aging Clock predicted mortality from any cause as accurately as conventional risk factors. Combining the findings with established risk factors further improved mortality prediction compared with using risk factors alone.

Single Injection Reverses Osteoarthritis in Animals in Just 4 Weeks

The chronic loss of joint cartilage known as osteoarthritis causes pain and bone decay for hundreds of millions of people every day.

But a new treatment option just got a step closer to human trials – in the form of a simple, single shot.

Based on ongoing animal experiments, researchers have shown that injecting a carefully engineered, slow-release drug-delivery system into the damaged joint can coax the body’s own cartilage and bone cells to carry out an effective repair job in just a few weeks.

Addressing Barriers to Transitioning Pediatric Patients With Epilepsy to Adult Health Care in the United StatesA Narrative Review

Purpose of ReviewAdolescents with childhood-onset epilepsy, along with their families, must navigate a complex constellation of uncertainties related to physical, psychological, and social changes as well as medical and possibly legal ramifications as…

Routine eye exams reveal stage 2 hypertension in half of diabetes patients

Diabetes opens people to other noncommunicable diseases like obesity, retinopathy and cardiovascular diseases like heart attacks and hypertension. A recent study by researchers at the University of Virginia School of Medicine sought to understand how common high blood pressure (BP) was among people with diabetes. They measured the BP of 172 adults with type 1 or type 2 diabetes and asked for their opinions on being screened during their eye exams.

Uncontrolled blood pressure was a common finding among the patients. Of the entire cohort, only about one in 12 had a normal blood pressure reading. Roughly half of the patients had stage 2 hypertension. They also found that about 10.5% had BP levels in the hypertensive crisis range—a level at which BP becomes a medical emergency because, if left untreated, it can lead to serious events such as a heart attack or stroke.

Having their blood pressure checked at the eye doctor was considered reasonable and acceptable by 93% of patients, as many were unaware they had a medical condition that needed attention, and some were under the impression that their BP was under control.

Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells

Human trisomy 21, responsible for Down syndrome, is the most prevalent genetic cause of cognitive impairment and remains a key focus for prenatal and preimplantation diagnosis. However, research directed toward eliminating supernumerary chromosomes from trisomic cells is limited. The present study demonstrates that allele-specific multiple chromosome cleavage by clustered regularly interspaced palindromic repeats Cas9 can achieve trisomy rescue by eliminating the target chromosome from human trisomy 21 induced pluripotent stem cells and fibroblasts. Unlike previously reported allele-nonspecific strategies, we have developed a comprehensive allele-specific (AS) Cas9 target sequence extraction method that efficiently removes the target chromosome. The temporary knockdown of DNA damage response genes increases the chromosome loss rate, while chromosomal rescue reversibly restores gene signatures and ameliorates cellular phenotypes. Additionally, this strategy proves effective in differentiated, nondividing cells. We anticipate that an AS approach will lay the groundwork for more sophisticated medical interventions targeting trisomy 21.

Keywords: CRISPR/Cas; Down syndrome; allele specificity; chromosome cut; chromosome loss; human trisomy 21.

© The Author(s) 2025. Published by Oxford University Press on behalf of National Academy of Sciences.

DNA-based nanoswitch can flip in milliseconds and stay in one state for days without continuous forcing

Scientists have engineered a nanoscale switch using DNA “origami.” Inspired by macroscale mechanical switches, the device achieves long-term functionality without the continuous forcing mechanism that past versions required while remaining capable of fast switching. The paper is published in the journal Science Robotics.

This is not the first time scientists have used DNA as a building material. DNA origami—a technique that folds a single-stranded DNA scaffold into precise 2D or 3D shapes using short DNA strands—offers a way to build custom nanomachines. It has been used in everything from drug delivery to electrically actuated devices. However, in electrically actuated devices, many prior designs faced a trade-off between speed, stability and durability.

In particular, researchers have been interested in creating nanoscale switches that act like their macroscopic counterparts. So far, attempts at DNA-based nanoswitches have lacked either long-term stability without continuous forcing, millisecond switching or high cycle endurance. Many earlier devices relied on DNA “latches,” but these were slow or prone to spontaneous dissociation from natural nanoscale thermal movements.

RNA Folding Energy of Long-Range Genomic Interactions Regulates Discontinuous Transcription in SARS-CoV-2

Coronaviruses use discontinuous transcription to generate subgenomic RNAs (sgRNAs) that encode structural and accessory proteins. However, the factors regulating sgRNA abundance in SARS-CoV-2 remain unclear. Here, we combined strand-specific RNA sequencing, RNA–RNA interaction mapping, prediction of RNA folding energies, and targeted mutagenesis to define the regulation of (–) sgRNA synthesis in SARS-CoV-2 infection. We demonstrated that the relative (–) sgRNA abundance across viral genes is stable throughout infection and largely correlates with corresponding (+) sgmRNA levels. Through meta-analysis of published SPLASH data, we found that the frequency of long-range interactions between the 5′ genomic transcription regulatory sequence TRS-Leader and downstream TRS-Body sequences correlates with sgRNA abundance.

Custom prosthetic hand adapts to each user, decoding 19 gestures in real time

Most prosthetic hands today still struggle with a fundamental problem: No two amputees are the same, yet most devices are designed as if they are. That mismatch makes natural, intuitive control difficult, often turning what should feel like a seamless extension of the body into something that requires constant learning and adjustment.

Even with advanced technology, users are frequently left to interpret faint muscle signals that can shift with sweat, skin changes or everyday movement—creating a gap between intention and control that can be frustrating and, in some cases, lead people to abandon the device altogether.

Researchers have made progress by improving how muscle signals are interpreted, but the core challenge remains: The signals are often unstable and hard to translate into natural movement.

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