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Category: biotech/medical

Artificial ‘leaf’ powers wireless biomedical device

Plants convert light into energy efficiently through photosynthesis—an ability that scientists and engineers still struggle to match with electronic devices. Recently, researchers have looked beyond traditional semiconductor materials to create devices using a promising class of materials called nanoplasmonics. These tiny metal structures can absorb and concentrate optical energy and generate energetic charge carriers.

In a new study, researchers from the University of Chicago Pritzker School of Molecular Engineering (UChicago PME) and Department of Chemistry developed a nanoplasmonic “leaf,” a wireless bioelectronic device they used to stimulate nerves and pace heartbeats in an animal model.

The team also showed that their material could be used as a computer-like sensing platform, where users can interact with the screen using invisible light—a potentially secure way to transmit information.

Some patient groups are far more vulnerable to near-perfect privacy attacks from medical AI

From detecting pneumonia on a chest X-ray to assessing whether a dark spot on the skin is benign or malignant, medical AI systems are playing an increasingly important role in clinical diagnosis. Unfortunately, the models used to train these AI systems are often victims of cyberattacks, specifically membership inference attacks (MIAs), which can lead to people’s personal information being stolen or revealed.

In a recent study, researchers conducted a first-ever patient-level privacy audit to see how easily individual patients could be identified from the underlying data used to train medical AI models.

At first glance, an AI model may appear to protect everyone’s privacy equally well, but a closer look reveals a different story. Researchers found that attackers can identify certain individual patients with near-perfect accuracy, exposing a hidden unfairness in privacy.

Detect Dangerous Gases in Seconds With New Technology

A groundbreaking method known as coherently controlled quartz-enhanced photoacoustic spectroscopy has been developed to detect and identify gases at very low concentrations rapidly.

This new technique, with promising applications in environmental monitoring, early cancer detection, and chemical process safety, allows for comprehensive gas analysis in mere seconds, a process that traditionally took much longer.

Enhanced sensitivity in trace gas detection.

Combination of Neuronavigation-Guided Focused Ultrasound… : Neurosurgery

This was a prospective, single-arm, open-label pilot trial. The primary end point was 6-month progression-free survival (PFS). Disease progression was assessed according to the Response Assessment in Neuro-Oncology criteria by independent radiological review. Radiological response was evaluated using fluid-attenuated inversion-recovery sequences to compare FUS-exposed vs nonexposed regions. Plasma cell–free DNA (cfDNA) concentrations were measured before and after FUS treatment.

RESULTS:

Between July 2020 and August 2023, 6 patients received a median of 14.5 sessions of biweekly FUS-BEV (10 mg/kg). The median PFS was 11 months, with a 6-month PFS rate of 66.7%. The only FUS-related adverse event was transient scalp heating (grade 1; 1.9%). A fluid-attenuated inversion recovery normalization effect emerged within 1 month after treatment. Plasma cfDNA increased significantly post-FUS, with total cfDNA rising 2.03 ± 0.76-fold, EGFR cfDNA 1.77 ± 0.76-fold, and HMBS cfDNA 1.68 ± 0.66-fold.

Role for NANOG in human embryogenesis

New research has shown that a genome editing technique can be used to alter a single gene in human embryonic cells, enabling the study of very early human development in unparalleled detail.

The technique, called base editing, is a more precise version of the genome editing technique CRISPR/Cas9. It can change a single nucleotide base pair — the basic building block of DNA — within a human genome of approximately 3 billion base pairs.

Using base editing, the researchers blocked a gene called NANOG in very early-stage human embryos, and found that the cells of the early embryo could not develop into more specialised pluripotent cells called the epiblast — which later form the body.

Glass cells of atoms offer a new path to smarter, cheaper sensors

More accurate navigation systems and improved wireless communications may not come from traditional electronics, but rather from atoms. Researchers at Penn State and the National Institute of Standards and Technology (NIST) have developed a new way to build tinier, smarter glass sensors filled with highly precise and stable atoms.

The team’s work, published this week (June 18) in Microsystems and Nanoengineering, centers on a manufacturable, silicon-free version of traditional bulky “vapor cells”—sealed chambers that contain cesium and rubidium atoms—that are commonly used in precision measurement systems, in a gas state. These atoms can act as highly precise sensors because, unlike manufactured components, atoms are fundamentally identical.

“Using atoms for sensing is advantageous because the physics of individual atoms is very well understood, and all the atoms are equal,” said Daniel Lopez, co-lead author of the paper, Liang Professor of Electrical Engineering and Computer Science at Penn State and director of the Nanofabrication Lab at the Materials Research Institute (MRI). “That gives you a level of precision that’s very hard to achieve with traditional microfabricated devices.”

Epidemiology of cardiovascular–kidney–metabolic syndrome

The cardiovascular–kidney–metabolic (CKM) syndrome paradigm is aimed at reflecting the complex interactions between chronic kidney disease, cardiovascular disease and metabolic dysfunction. Here, the authors discuss current CKM syndrome epidemiological data, examine key determinants of CKM health and consider the potential clinical implications and limitations of the CKM syndrome framework.

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