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Category: biotech/medical

Quantum sensors use atoms, electrons and light as ultra‑steady rulers

Quantum computers get a lot of attention, even though they are not ready for prime time, but quantum sensors are already doing useful work. These sensors measure fields, forces and motion so small that ordinary background noise can drown them out. Some sensors are already in daily use, while others are moving from research labs into flight tests, hospitals and field instruments.

For example, a human brain produces magnetic signals in the femtotesla-to-picotesla range—billions of times weaker than a refrigerator magnet—far weaker than the magnetic noise in an ordinary room. That is why brain scanners that measure these signals need ultrasensitive detectors and strong magnetic shielding. In some hospitals, these detectors use quantum technology to help map brain activity before epilepsy surgery, without touching the brain.

Quantum sensors are showing up in other fields as well, including in navigation when GPS signals are jammed or spoofed, mapping gravity to reveal what’s underground, and boosting astronomers’ ability to measure gravitational waves. I am a photonics and quantum technologies researcher. My lab applies physics to develop a range of devices, including quantum sensors.

A unifying model of stem cell dynamics explains age-related methylation patterns across mammals

A parsimonious model of stem cell dynamics describes how DNA methylation changes arise and propagate with age, unifying diverse epigenetic aging patterns and suggesting that stem cell dynamics are a key driver of aging across mammals.

AI atlas reveals hidden whole-body-damage caused by obesity

Obesity affects far more than metabolism and fat storage. It alters immune activity, nerve structure, and tissue organization across multiple organ systems, increasing the risk of diseases including type 2 diabetes, cardiovascular disease, stroke, neuropathy and cancer. Yet despite these systemic effects, researchers have lacked tools capable of studying disease-associated changes across the entire body in intact organisms and at high resolution.

A team led by Prof. Ali Ertürk, Director of the Institute for Biological Intelligence (iBIO) at Helmholtz Munich and Professor at the LMU, has now developed MouseMapper, a suite of foundation-model-based deep-learning algorithms designed to analyze whole-body biological imaging data. The framework automatically segments 31 organs and tissue types while quantitatively mapping nerves and immune cells throughout the body, enabling comprehensive multi-system analysis in intact mice.

“MouseMapper is built on a foundation model, which means it generalizes far beyond the data it was originally trained on,” says Ying Chen, co-first author of the study published in Nature.

Chickens Hatch From World’s First Artificial Eggs

On May 19, Dallas-based Colossal Biosciences, which last year made headlines when it effectively de-extincted the dire wolf, announced that it had hatched a flock of 26 live chicks from fully artificial eggs. The technology behind the breakthrough can be later applied to bring back the dodo and New Zealand’s giant, flightless moa—both on Colossal’s de-extinction ‘to do’ list…

…Designing an artificial shell is not easy because a natural shell is deceptively complex. Made principally of calcium carbonate arranged in a crystalline structure, a typical egg shell is no more than 0.4 mm thick, and covered with up to 17,000 tiny pores to allow for gas exchange with the ambient atmosphere—carbon dioxide out, and oxygen in. There are, too, a pair of slick inner membranes in the egg that perform another critical function, protecting the growing chick from invading bacteria. But those membranes have to be exceedingly thin…

…The egg Colossal invented was very different. The inner membranes were made of vanishingly thin silicon using a proprietary technology that Colossal is planning to patent. The shell itself was only about two-thirds of a shell—a titanium structure that resembles nothing so much as a soft-boiled-egg cup with its top missing, albeit with hundreds of hexagonal pores to allow for gas exchange. Once a few dozen of the titanium eggs were manufactured, Colossal gathered fertilized chicken eggs from an avian farm the company owns and operates and transported them to the lab. There, the scientists gently opened the top of the egg and transferred the yolk and the white and the tiny embryo onto the titanium egg cup and covered the cup with a transparent lid. The embryos were about three days past fertilization when they were transferred, meaning that they had 18 days remaining in their three-week incubation cycle.

‘We place the egg into an incubator that controls the environment,’ says Lambert. ‘We then collect visual images at periodic milestones to understand how development is progressing.’ When the incubation period was done, the chicks began ‘pipping,’ using their beaks to break through the membrane just the way an ordinary chick breaks through its shell. Eventually, the 26 chicks were moved to the same Texas farm from which their eggs were collected, where they can live out their five to 10 year lifespan.

The breakthrough could help bring giant birds back from extinction.

Treating age‐related loss of muscle mass and function: Where should we be focusing?

Aging human breast atlas reveals cancer susceptibility

The team used advanced imagining techniques to analyse breast tissue from more than 500 women aged 15 to 86 years old. The tissue included biopsies taken from women for non-cancer-related reasons.

Combining these images with details of the hormone receptors and immune cells present, as well as the tissue architecture, the researchers were able to map how breast tissue changes over time in unprecedented detail. Their findings point to reasons why breast cancer risk increases with age and why tumors in younger women differ biologically.

The author added: “Our map revealed that as women age, their breast tissue goes through major changes, with the most dramatic changes occurring at menopause. There are changes, too, during their twenties, possibly linked to pregnancy and childbirth, but these are far less pronounced.”

The map revealed that all types of cells become fewer in number and divide far less often. Milk-producing structures known as lobules shrink or disappear, while the ducts that that carry milk become relatively more common, with the supporting layer around them becoming thicker. Fat cells increase while blood vessels decrease.

Meanwhile, changes occur in the immune environment. Younger breasts have more B cells and active T cells, which helps them identify and kill cancer cells. As tissue ages, these types of cells decline in number, replaced by other types of immune cell that indicate a more inflammatory and potentially less protective immune environment. ScienceMission sciencenewshighlights.

Continue reading “Treating age‐related loss of muscle mass and function: Where should we be focusing?” | >

Cracking the code of p53 fragility: Why the genome guardian is prone to failure

The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it is also one of the most frequently mutated and dysfunctional proteins in human tumors.

A longstanding mystery has been why p53—unlike its closely related paralogs p63 and p73—is so prone to misfolding and forming toxic aggregates. A new study published in Communication Chemistry now provides a detailed molecular explanation for this vulnerability.

Led by researchers at the Federal University of Rio de Janeiro (UFRJ), the D’Or Institute for Research and Education (IDOR), the University of Campinas (Unicamp), and the Federal University of Tri ngulo Mineiro (UFTM), the team mapped the protein’s internal landscape at residue-level resolution using high-pressure NMR spectroscopy, fluorescence spectroscopy, and molecular dynamics simulations.

Cytokine-armored CAR-T cell therapy helps eliminate aggressive brain tumors in preclinical study

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have developed a new cytokine-armored CAR-T cell therapy that helps the immune system better attack aggressive brain tumors in mice while reducing dangerous side effects that have long limited immune-based treatments for glioblastoma, one of the deadliest and most treatment-resistant brain cancers.

The therapy works by reprogramming CAR-T cells to release immune-stimulating proteins, called IL-12 and DR-18, that activate the body’s own immune system, strengthening the overall anti-cancer response. In mouse models, the approach improved tumor control, including against cancers made up of mixed cell populations that often escape therapies.

Researchers also found that pairing the treatment with a second CAR-T strategy targeting VEGF, a protein that drives abnormal blood vessel growth and contributes to swelling in glioblastoma, helped reduce side effects while preserving strong anti-tumor activity.

Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

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