Toggle light / dark theme

A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology

This multicenter study demonstrates use of dried and capillary blood as a minimally invasive, scalable approach for Alzheimer’s biomarker testing in research, with potential as a widely scalable population-based research approach, especially in resource-limited settings.

Kidney Stone Link to Cancer Risk Increased in Recent Studies

A systematic review and meta-analysis found that people with kidney stones have about twice the risk of developing kidney cancer compared with those without stones, across patient subgroups. The findings support closer cancer surveillance in patients with a history of kidney stones and further research into shared disease mechanisms, given the prevalence of kidney stones and the aggressive nature of kidney cancer.


A new meta-analysis further supports the previously reported link between kidney stones and an increased risk for kidney cancer, with a stronger relationship observed in newer studies.

TMAO Is Bad For Health, But Can Be Reduced (21-Test Analysis)

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Sulfate and carbon in fine air pollution tied to higher depression risk

Long-term exposure to fine particulate matter like PM2.5 components in polluted air can not only cause respiratory diseases, but also increase the risk of depression in older people, especially in those living with preexisting heart, metabolic and neurological conditions.

Depression has caused more loss of healthy life worldwide than any other mental health condition. This disorder has snatched away people’s will to perform the basics of daily activities. An analysis of global health data in 2021 showed that all the years people lived with disability or reduced quality of life because of depression added up to about 56.3 million years.

A recent population-based cohort study collected data from nearly 23.7 million U.S. Medicare beneficiaries aged 65 years and older between 2000 and 2018 to examine specific components of PM2.5 exposure, both individually and in combination, and its associations with the risk of developing depression. Among those tracked, more than 5.5 million developed depression during the follow-up period. These findings are published in JAMA Network Open.

CRISPR Supercharges a Meatlike Fungus Into a Sustainable Protein Powerhouse

The modified strain grows faster, uses far fewer resources, and lowers greenhouse gas emissions by up to 60%. It also dramatically outperforms chicken farming in land and water use. The findings highlight a promising path for eco-friendly protein…

…’There is a popular demand for better and more sustainable protein for food,’ says corresponding author Xiao Liu of Jiangnan University in Wuxi, China. ‘We successfully made a fungus not only more nutritious but also more environmentally friendly by tweaking its genes.’

Animal agriculture contributes roughly 14% of global greenhouse gas emissions. It also requires large areas of land and significant amounts of fresh water, which are already under pressure from climate change and human activity. Because of these drawbacks, microbial proteins found in organisms such as yeast and fungi are gaining attention as a more sustainable alternative to traditional meat.


CRISPR has turned a simple fungus into a fast-growing, meat-like protein source with impressively low environmental impact.

3D-printable concrete alternative hardens in three days, not four weeks

Although we’ve heard a lot about how 3D-printing concrete homes speeds up the construction process, you still have to wait up to 28 days for the concrete to sufficiently cure. A new printable substitute, however, is ready to go in just three days.

Concrete consists of three parts: water, an aggregate such as sand or gravel, and a cement which binds everything together. The cement is the part that typically takes about a month to cure after being poured. And a slow curing time isn’t cement’s only problem.

Traditional Portland-style cement is made by grinding up limestone and other raw materials, then heating the resulting powder to temperatures of up to 1,450 ºC (2,642 ºF). Unfortunately, the processes by which that heat is generated produce a lot of carbon dioxide.

Shrinking materials hold big potential for smart devices, researchers say

Wearable electronics could be more wearable, according to a research team at Penn State. The researchers have developed a scalable, versatile approach to designing and fabricating wireless, internet-enabled electronic systems that can better adapt to 3D surfaces, like the human body or common household items, paving the path for more precise health monitoring or household automation, such as a smart recliner that can monitor and correct poor sitting habits to improve circulation and prevent long-term problems.

The method, detailed in Science Advances, involves printing liquid metal patterns onto heat-shrinkable polymer substrates—otherwise known as the common childhood craft “Shrinky Dinks.” According to team lead Huanyu “Larry” Cheng, James L. Henderson, Jr. Memorial Associate Professor of Engineering Science and Mechanics in the College of Engineering, the potentially low-cost way to create customizable, shape-conforming electronics that can connect to the internet could make the broad applications of such devices more accessible.

“We see significant potential for this approach in biomedical uses or wearable technologies,” Cheng said, noting that the field is projected to reach $186.14 billion by 2030. “However, one significant barrier for the sector is finding a way to manufacture an easy-to-customize device that can be applied to freestanding, freeform surfaces and communicate wirelessly. Our method solves that.”

/* */