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Category: chemistry

Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have identified new inhibitors of the enzyme human 15-lipoxygenase-2 (h15-LOX-2). This protein plays an important role in inflammatory and metabolic processes and contributes to cellular homeostasis.

The discovery, described in the Journal of Medicinal Chemistry, could open up new avenues for investigating the biological and pathological functions of the enzyme and provide promising candidates for the development of new drugs.

“Although h15-LOX-2 is a potential biological target, it’s scarcely been explored for this purpose. Our work contributes to new inhibitors that have structural diversity among themselves and with respect to inhibitors already described in the literature. What’s more, they have similar drug properties according to predictions based on computational models,” says Lucas Gasparello Viviani, first author of the article.

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Scientists used advanced cryo-EM imaging to reveal how glutamate activates brain receptors, paving the way for new neurological treatments. To better understand how brain cells communicate using chemical signals, scientists have used a highly specialized microscope to capture detailed images of h

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Skoltech scientists discovered over 200 carbon-oxygen compounds with high energy potential, some rivaling TNT, offering new insights into non-nitrogen-based explosives and applications in energy, space, and chemical research. Skoltech researchers have conducted a theoretical study exploring a wid

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A new method to recycle wind turbine blades without using harsh chemicals resulted in the recovery of high-strength glass fibers and resins that allowed Washington State University researchers to repurpose the materials to create stronger plastics.

The innovation provides a simple and environmentally friendly way to recycle wind turbine blades to create useful products.

Reporting in the journal, Resource, Conservation, and Recycling, the team of researchers cut the that is commonly used in , called glass fiber-reinforced polymer (GFRP), into approximately two inch-sized blocks. They then soaked the flakes in a bath of low-toxicity organic salt in pressurized, superheated water for about two hours to break down the material. They then repurposed its components to make stronger plastics.

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A team of materials scientists, chemical engineers, and environmental scientists affiliated with a host of institutions in China has developed a redox flow battery (RFB) with 87.9% energy efficiency, which can also last for 850 cycles. In their project, published in the journal Nature Communications, the group developed a new kind of catalytic electrode to improve the efficiency of the battery.

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A chemical reaction that’s vital to a range of commercial and industrial goods may soon be initiated more effectively and less expensively thanks to a collaboration that included Oregon State University College of Engineering researchers.

The study, published in Nature, involves —adding the diatomic hydrogen molecule, H2, to other compounds.

“Hydrogenation is a critical and diverse reaction used to create food products, fuels, commodity chemicals and pharmaceuticals,” said Zhenxing Feng, associate professor of chemical engineering. “However, for the reaction to be economically viable, a catalyst such as palladium or platinum is invariably required to increase its reaction rate and thus lower cost.”

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New research suggests that Earth’s first crust, formed over 4.5 billion years ago, already carried the chemical traits we associate with modern continents. This means the telltale fingerprints of continental crust didn’t need plate tectonics to form, turning a long-standing theory on its head.

Using simulations of early Earth conditions, scientists found that the intense heat and molten environment of the planet’s infancy created these signatures naturally. The finding shakes up how we understand Earth’s evolution and could even influence how we think about crust formation on other planets.

A surprising shift in earth’s history.

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Although the heart has its own nervous system, its organization and functionality remain largely unknown. Here, the authors reveal the molecular, chemical, and functional diversity of neurons within the intracardiac nervous system and their role in controlling the heart’s rhythm in the zebrafish.

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The James Webb Space Telescope has captured its first direct images of carbon dioxide in a planet outside the solar system in HR8799, a multiplanet system 130 light-years away that has long been a key target for planet formation studies.

The observations provide strong evidence that the system’s four giant planets formed in much the same way as Jupiter and Saturn, by slowly building solid cores. They also confirm Webb can do more than infer atmospheric composition from starlight measurements—it can directly analyze the chemistry of exoplanet atmospheres.

“By spotting these strong carbon dioxide features, we have shown there is a sizable fraction of heavier elements, such as carbon, oxygen, and iron, in these planets’ atmospheres. Given what we know about the star they orbit, that likely indicates they formed via core accretion, which for planets that we can directly see is an exciting conclusion,” said William Balmer, a Johns Hopkins University astrophysicist who led the work.

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Carbon–carbon triple bonds exhibit a distinct Raman response in the region of 1,800–2,800 cm−1, known as the cellularly silent region. This unique chemical signature, coupled with the small size of alkyne moieties, presents these tags as useful imaging alternatives to bulky fluorescent probes. This Primer discusses the various Raman scattering processes used to image alkyne tags in cells, including the optical set-up required, how to choose an alkyne tag and imaging results from different cellular environments.

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