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Category: chemistry

Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks

Normative modeling of morphometric similarity networks in ADHD identified three distinct biotypes with unique clinical-neural profiles, supporting more neurobiologically informed stratification for ADHD management.

Question Can normative modeling of topological properties derived from brain morphometric similarity networks yield robust stratification biomarkers for pediatric populations with attention-deficit/hyperactivity disorder (ADHD)?

Findings This multisite case-control study included 1,154 participants, characterizing ADHD heterogeneity through hub-centric topological deviations derived from morphometric similarity networks. Three distinct biotypes emerged, each exhibiting unique clinical-neural profiles with characteristic neurochemical and functional correlates, validated in an independent transdiagnostic cohort of 554 ADHD cases.

Meaning The integration of normative modeling with heterogeneity through discriminative analysis (HYDRA) clustering yielded both dimensional and categorical insights into ADHD heterogeneity, thereby enhancing our understanding of the ADHD’s neurobiological complexity.

A new eco-friendly water battery could theoretically last for centuries

The problem with many types of modern batteries is that they rely on harsh chemicals to work. Not only can these corrosive liquids damage internal parts over time, but they can also leach into soil and water when disposed of, contaminating it. But researchers from the City University of Hong Kong and Southern University of Science and Technology have developed an alternative, a new kind of eco-friendly battery that runs on a solution similar to the minerals used in tofu brine.

The team describes their work in a paper published in the journal Nature Communications.

The scientists replaced traditional acids and alkalis with neutral salts of magnesium and calcium to create the electrolyte. These are the same minerals used as brine in tofu production. Keeping this liquid at a neutral pH of 7.0 prevents the type of corrosive reactions that can destroy a battery from the inside out.

Chemists thought phosphorus had shown all its cards—until it surprised them with a new move

A discovery by UCLA organic chemists may one day put catalytic converter thieves out of business. In new research, they’ve used abundant, inexpensive phosphorus as a catalyst in chemical reactions that usually require precious metals like platinum, one of the metals targeted in theft of the automotive components that convert chemicals in vehicle exhaust into less harmful forms.

This advance, however, will likely be more useful in the pharmaceutical industry and could one day help bring down the price of some drugs.

Jupiter’s Moons May Have Held Life’s Ingredients at Birth

Dr. Olivier Mousis: “Our findings suggest that Jupiter’s moons did not form as chemically pristine worlds. Instead, they may have accreted, or accumulated, a significant inventory of COMs at birth, providing a chemical foundation that could later interact with the liquid water in their interiors.” [ https://www.labroots.com/trending/space/30236/jupiter-s-moon…ts-birth-2](https://www.labroots.com/trending/space/30236/jupiter-s-moon…ts-birth-2)

When did Jupiter’s Galilean moons first contain the ingredients for life? This is what complementary studies published in The Planetary Science Journal and Monthly Notices of the Royal Astronomical Society hopes to address as an international team of scientists investigated potential timescales for when three of Jupiter’s Galilean moons, Io, Europa, Ganymede, and Callisto, could have first formed the ingredients for life. This study has the potential to help scientists better understand the formation and evolution of the Galilean moons and what this could mean in the search for life beyond Earth.

For the studies, the researchers explored the formation of complex organic molecules (COMs) within Jupiter’s original disk of gas, dust, and ice, also called the circumplanetary disk, along with modeling how COMs could be delivered to the Jupiter system from the protoplanetary disk that formed the Sun and planets. They examined how interaction with ultraviolet radiation from the Sun could influence COM formation. The overarching goal of both studies was to ascertain both how and when Jupiter’s Galilean moons received the ingredients for life, specifically focusing on icy grains that currently comprise Europa, Ganymede, and Callisto.

In the end, the researchers found that icy grains could have obtained COMs and delivered them to Jupiter’s moons both within Jupiter’s circumplanetary disk and from the solar system’s protoplanetary disk. Additionally, the models showed that approximately half of the simulated icy grains could have formed within the solar system’s protoplanetary disk and were delivered to Jupiter’s moons. Finally, the researchers estimated these processes occurred billions of years ago during the early formation of the solar system.

New lab technique can reverse chemical process linked with Alzheimer’s disease

An Oregon State University scientist and a team of undergraduate students have uncovered real-time insights into a chemical process linked with Alzheimer’s disease, paving the way toward better drug designs. The researchers used a molecule measuring technique to observe in a laboratory setting how certain metals can promote the protein clumping that leads to the blocked neural pathways associated with Alzheimer’s. Led by Marilyn Rampersad Mackiewicz, associate professor of chemistry in the OSU College of Science, the research team also watched molecules known as chelators disrupt or reverse the clumping. The findings are published in ACS Omega.

Alzheimer’s disease is the most common form of dementia, a chronic condition of impaired cognitive function that affects large numbers of older adults and their loved ones. According to the Centers for Disease Control and Prevention, Alzheimer’s is the sixth-leading cause of death for people age 65 and older.

In Alzheimer’s patients, aggregations of amyloid-beta proteins interrupt brain cells’ ability to communicate with each other. The brain needs certain metals to work properly, but problems arise when the metals are present in unbalanced quantities.

FDA Greenlights Life Biosciences’ Human Study, Setting Up Pivotal Test for Aging Theory from Harvard’s David Sinclair

…Life Biosciences, a biotech company co-founded by Sinclair, received the FDA’s approval to begin a human trial testing its gene therapy based on the Information Theory of Aging. The gene therapy is designed to rewind the clock and restore the function of dying cells…

…Life Biosciences’ gene therapy has been under development for quite a while. In the 1990s, David Sinclair first contended that the deterioration and loss of epigenetic information—chemical tagging patterns on DNA that regulate which genes are turned on and off—plays an important role in driving aging. Sinclair subsequently dubbed this contention the Information Theory of Aging. Fast forward to the present day, and Life Biosciences has produced a gene therapy that delivers three proteins, which Sinclair’s laboratory helped establish, to reset epigenetic information to a more youthful state.

‘It’s extremely exciting,’ Sinclair told Endpoints News. ‘It’s been over 30 years to get to this point, and we’re about to learn if all of that work is going to come to fruition this year.’

The FDA has greenlighted Life Biosciences’ first human trial testing whether their gene therapy can confer a near-total rejuvenating reset of cells.

A new form of aluminum unlocks sustainable and cheaper catalysts

A research team at King’s College London has isolated a new form of aluminum—a highly abundant metal, that could provide a far cheaper and more sustainable alternative to commonly used rare earth metals. Dr. Clare Bakewell, Senior Lecturer in the Department of Chemistry, and her lab developed highly reactive aluminum molecules able to break apart tough chemical bonds. Published in Nature Communications, their work has also unlocked molecular structures that have never been observed before, which creates the potential for new kinds of reactive behavior.

The team reported the first example of a cyclotrialumane, a compound comprising three aluminum atoms arranged in a trimeric—triangular—structure. The trimeric molecule carries unprecedented reactivity as the structure is retained when dissolved into different solutions, making it robust enough for use in a range of chemical reactions. These include splitting dihydrogen and the stepwise insertion and chain growth of the 2-carbon hydrocarbon, ethene.

Metals are vital for making a whole range of commodity and fine chemicals produced in industry. However, many processes, especially catalytic ones, use expensive precious materials like platinum, which are environmentally damaging to extract.

Ultra-efficient optical sensors can keep light circulating longer inside a microscopic chip

CU Boulder researchers have built high-performing optical microresonators, opening the door for new sensor technologies. At its simplest form, a microresonator is a tiny device that can trap light and build up its intensity. Once the intensity is high enough, researchers can perform unique light operations.

“Our work is about using less optical power with these resonators for future uses,” said Bright Lu, a fourth-year doctoral student in electrical and computer engineering and a lead author on the study. “One day these microresonators can be adapted for a wide range of sensors from navigation to identifying chemicals.”

For this endeavor, published in Applied Physics Letters, the team focused on “racetrack” resonators, named for their elongated shape that resembles a running track.

Sunray-like ripples emerge on a frozen reaction front

Researchers in Belgium have unveiled a striking chemical reaction in which ripples along a frozen reaction front resemble the rays of a shining star. Publishing their results in Physical Review Letters, Anne De Wit and colleagues at the Université Libre de Bruxelles have shed new light on the patterns that emerge in reaction–diffusion systems, offering fresh insight into how similar structures arise in the natural world.

From forest fires to the spread of infectious diseases, many natural processes involve a “front” forming between two distinct states: be they burned and unburned forest, infected and healthy individuals, or any number of other examples in which one state spreads by consuming another.

Such behavior is often described using reaction–diffusion systems, where local reactions are coupled to transport processes such as diffusion. In the lab, this mechanism can be recreated by injecting a chemical compound into the center of a circular chamber filled with another reactant. If the chemistry is autocatalytic —where one of the reaction products catalyzes its own formation—a circular reaction front will form around the injection point.

Core–Shell Engineering of One-Dimensional Cadmium Sulfide for Solar Energy Conversion

Fabricating efficient photocatalysts that can be used in solar-to-fuel conversion and to enhance the photochemical reaction rate is essential to the current energy crisis and climate changes due to the excessive usage of nonrenewable fossil fuels.

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