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Biomaterials and cell-based therapy post spinal cord injury

Spinal cord injury (SCI) imposes a significant physical, social, and economic burden on millions of patients and their families worldwide. Although medical and surgical care improvements have decreased mortality rates, sustained recovery remains constrained. Cell-based therapies offer a promising strategy for neuroprotection and neuro-regeneration post-SCI. This article reviews the most promising preclinical approaches, encompassing the transplantation of embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), oligodendrocyte progenitor cells (OPCs), Schwann cells (SCs), and olfactory ensheathing cells (OECs), along with the activation of endogenous pluripotency cell banking strategies. We also outline key ancillary strategies to enhance graft cell viability and differentiation, such as trophic factor assistance, engineered biomaterials for supportive scaffolds, and innovative methods for a synergistic effect in treatment, including promoting neuronal regeneration and reducing glial scars. We highlight the key aspects of SCI pathophysiology, the fundamental biology of cell treatments, and the advantages and limitations of each approach.

There are several approaches to treating spinal cord injuries that show great promise: Cellular therapies, which utilize a range of cells such as embryonic, neural, and mesenchymal stem cells, along with astrocytes, Schwann cells, olfactory ensheathing cells, and reprogrammed cells; The use of innovative biomaterials, including hydrogels, collagen, polycaprolactone fibers, and advanced 3D-printing technologies, provides valuable support for tissue repair.

GitHub notifications abused to impersonate Y Combinator for crypto theft

A massive phishing campaign targeted GitHub users with cryptocurrency drainers, delivered via fake invitations to the Y Combinator (YC) W2026 program.

Y Combinator is a startup accelerator that funds and mentors projects in their early stages, and connects founders with a network of alumni and venture capital firms.

The attacker abused GitHub’s notification system to deliver the fraudulent messages, by creating issues across multiple repositories and tagging targeted users.

Physicists demonstrate 3,000 quantum-bit system capable of continuous operation

One often-repeated example illustrates the mind-boggling potential of quantum computing: A machine with 300 quantum bits could simultaneously store more information than the number of particles in the known universe.

Now process this: Harvard scientists just unveiled a system that was 10 times bigger and the first quantum machine able to operate continuously without restarting.

In a paper published in the journal Nature, the team demonstrated a system of more than 3,000 (or qubits) that could run for more than two hours, surmounting a series of technical challenges and representing a significant step toward building the super computers, which could revolutionize science, medicine, finance, and other fields.

AI can now pass the hardest level of the CFA exam in a matter of minutes

Several artificial intelligence models are now advanced enough to pass the three-part chartered financial analyst exam, even the most difficult Level III test.

Previous research, particularly from two years ago, had found AI could clear Levels I and II of the exam, but it struggled with Level III, due to the essay questions.

The new study was developed by researchers from New York University Stern School of Business and Goodfin, an AI-powered wealth-management platform.

For humans to pass the prestigious, three-part chartered financial analyst exam, it typically takes around 1,000 hours of studying over the course of several years. New research found that the technology underpinning a slew of artificial intelligence models is now advanced enough to pass even the most difficult – Level III – mock exams in a matter of minutes.

The new study – developed by researchers from New York University Stern School of Business and GoodFin, an AI-powered wealth management platform – evaluated 23 large language models on their ability to answer multiple choice and essay questions on mock CFA Level III exams. They found frontier reasoning models, including o4-mini, Gemini 2.5 Pro and Claude Opus, were able to use “chain-of-thought prompting” to successfully pass.

Previous research, particularly from two years ago, had found artificial intelligence could clear Levels I and II of the exam, but it struggled with Level III, due to the essay questions. However, the technology has evolved so rapidly that the researchers wanted to know whether the models could handle, “specialized, high-stakes analytical reasoning required for professional financial decision-making.” The third CFA exam is primarily focused on portfolio management and wealth planning.

Continue reading “AI can now pass the hardest level of the CFA exam in a matter of minutes” | >

The CRITICAL RoboTaxi Milestone Tesla Stock Investors CAN’T Ignore

Tesla’s upcoming robo-taxi milestone of deploying 2,000 vehicles is expected to significantly boost its margins and potentially double or triple its free cash flow, marking a critical point in the company’s expansion and growth ##

## Questions to inspire discussion.

Tesla’s Robo Taxi Strategy.

🚕 Q: What is Tesla’s approach to deploying robo taxis across the US? A: Tesla plans to seed robo taxis across multiple cities nationwide, rather than focusing on a single market, to demonstrate benefits to regional regulators, define drop-off and pickup zones, and establish presence before scaling up.

🏙️ Q: Which cities are part of Tesla’s initial robo taxi expansion plans? A: Tesla’s robo taxi expansion includes Austin, Bay Area, Nevada, Arizona, Florida, and other states, with Austin and Bay Area currently offering invite-only services.

Financial Impact and Pricing.

Continue reading “The CRITICAL RoboTaxi Milestone Tesla Stock Investors CAN’T Ignore” | >

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Hi everybody. I’m writing to you because we are reaching an important moment in our reproduction of Harold Katcher’s seminal study of rats rejuvenation, in which we are only 9 months from starting the injections but we raised 71% of the total cost of the experiment. We already published the article of our 2024 experiment in a peer-reviewed journal (https://journals.tmkarpinski.com/index.php/ejbr/article/view/772), in which we injected the Pig Plasma Extracellular Particles (PPEPs) in young rats to assess a potential acute immunogenicity or toxicity — without any negative effect observed. Nina Torres Zanvettor (cofounder of ICR together with me) and I were interviewed some weeks ago by Eleanor Sheekey in her YouTube channel (https://youtu.be/Q-lS1UMHG1o?si=ImDWycjM8r8-KpyF), as we are trying to spread the word about the experiment and the crowdfunding. We are making the experiment in collaboration with Unicamp university and Dr. Marcelo Mori, a world-class aging scientist. The rats are already aging in the university facility and we are preparing the epigenetic age measurements with Horvath’s foundation (Clock Foundation), but we still have to raise 29% (US$21,000) of the total cost (US$75,000).

(https://youtu.be/Q-lS1UMHG1o

We will publish everything (methods, materials and results) immediately, but we need the help of the community too, as we will give back all the information for the community. Could you help us to fund the study? Any amount is important. The link to make a donation is https://www.rejuvenescimento.org/donation. I don’t even consider it precisely a “donation”, but a financial collaboration, as the “donor” would be able to use the information, and maybe they can also use the rejuvenation technology that some day would arise from this research. By the way, if we manage to rejuvenate the rats, we will then try to keep them young as long as we can, in a longevity experiment. Also, if we rejuvenate the rats, we will carry out a safety experiment in a Good Laboratory Practices facility here in Brazil that would allow regulatory approval to try the therapy in human patients who don’t have any other alternative to be kept alive — we expect to be able to carry out those human trials in 2028. So we intend to go all the way to the clinic, if we confirm Katcher’s results.

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Scattered Spider Resurfaces With Financial Sector Attacks Despite Retirement Claims

Cybersecurity researchers have tied a fresh round of cyber attacks targeting financial services to the notorious cybercrime group known as Scattered Spider, casting doubt on their claims of going “dark.”

Threat intelligence firm ReliaQuest said it has observed indications that the threat actor has shifted their focus to the financial sector. This is supported by an increase in lookalike domains potentially linked to the group that are geared towards the industry vertical, as well as a recently identified targeted intrusion against an unnamed U.S. banking organization.

“Scattered Spider gained initial access by socially engineering an executive’s account and resetting their password via Azure Active Directory Self-Service Password Management,” the company said.

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