Globally, metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease, affecting up to one in three people in the general population, with an estimated increase in prevalence of more than 50% in the last three decades. The rise in prevalence of MASLD will result in substantial increases in the number patients with decompensated cirrhosis and those developing liver cancer by 2030. Despite the complex pathobiology of MASLD, two major breakthroughs in phase 3 clinical trials now herald an era of licensed therapies for MASLD.

New research suggests the mysterious Roman-era “Beachy Head Woman” was likely from Britain, not the Mediterranean or sub-Saharan Africa. Advances in DNA sequencing are helping researchers resolve a mystery that has surrounded the Beachy Head Woman for more than ten years. The remains of a youn

This study provides the first direct evidence of cardiomyocyte mitosis in the adult human heart following myocardial infarction, challenging the long-standing paradigm that cardiac muscle cells are incapable of regeneration. Utilizing live human heart tissue models, researchers from the University of Sydney demonstrated that while fibrotic scarring occurs post-ischemia, the heart simultaneously initiates a natural regenerative program characterized by active cell division. The investigation further identified specific regulatory proteins that drive this mitotic process, offering a molecular blueprint for endogenous tissue repair. These findings suggest that the human heart possesses a latent regenerative capacity that could be therapeutically harnessed to prevent heart failure and reverse post-infarct tissue damage, representing a significant shift in regenerative cardiovascular medicine.

A world‑first University of Sydney study reveals that the human heart can regrow muscle cells after a heart attack, paving the way for breakthrough regenerative therapies to reverse heart failure.

Researchers have developed a novel noninvasive coronary artery bypass approach that may offer an alternative to traditional open-heart surgery for select patients with coronary disease. Early experience suggests this technique could reduce surgical trauma and change how some coronary conditions are treated, although broader clinical validation will be needed to define its role in future practice.

Researchers have created a new noninvasive technique for performing a type of artery bypass that may change the future of some coronary surgeries.

Deng et al. constructed a comprehensive bacterial and archaeal genome catalog from groundwater and uncovered extensive previously unknown microbial diversity. This study reveals genome size as an axis underlying allocation of microbial defense and redox regulation and identifies groundwater as a hotspot of selenium metabolism and functional innovation.