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Brad Younggren | Therapeutic Plasma Exchange (TPE): A Tool Against Aging and Disease

Offering TPE. I do not see a cost though.


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*Foresights Personal Longevity Group* Exploring anti-aging methods, monthly virtual meetings, expert discussions, private group for Foresight Patrons. https://foresight.org/personal-longevity-group/

*Brad Younggren | Therapeutic Plasma Exchange (TPE): A Tool Against Aging and Disease*
Bio: Brad Younggren, MD, is CEO and co-founder of Circulate Health, a company dedicated to extending human healthspan. A former U.S. Army physician, Dr. Younggren served as a combat physician in Iraq and was awarded a Bronze Star and Combat Medical Badge. An emergency medicine specialist and seasoned healthcare executive, Younggren has led teams at the cutting edge of medicine for decades. Most recently, he was President and Chief Medical Officer at 98point6, where he led the development and launch of AI-powered primary care solutions. He previously served as CMO at Cue Health, Shift Labs, and Mobisante. At Circulate, Younggren leads an expert team of clinicians and scientists working to harness the potential of therapeutic plasma exchange to advance health and longevity.
https://www.circulate.health/

Abstract: Aging is the primary risk factor for most chronic diseases, driving over 90% of U.S. healthcare expenditures. However, emerging science suggests that aging itself can be targeted as a modifiable process. Therapeutic Plasma Exchange (TPE) is a promising intervention that removes harmful substances from the bloodstream, reducing inflammation, disease burden, and potentially reversing aspects of biological aging. Circulate Health is pioneering this space, with clinical trial data demonstrating measurable reductions in biological age and improvements in key biomarkers. Beyond its longevity benefits, recent findings suggest TPE may help reduce microplastics and other environmental toxins—offering a practical, scalable approach to mitigating modern health threats. In this talk, we’ll explore the science behind TPE, its clinical applications, and why Circulate Health’s model makes this groundbreaking treatment accessible to more patients and clinics.

Quantum simulation of chemical dynamics achieved for the first time

Researchers at the University of Sydney have successfully performed a quantum simulation of chemical dynamics with real molecules for the first time, marking a significant milestone in the application of quantum computing to chemistry and medicine.

Understanding in real time how atoms interact to form new compounds or interact with light has long been expected as a potential application of quantum technology. Now, quantum chemist Professor Ivan Kassal and Physics Horizon Fellow Dr Tingrei Tan, have shown it is possible using a quantum machine at the University of Sydney.

The innovative work leverages a novel, highly resource-efficient encoding scheme implemented on a trapped-ion quantum computer in the University of Sydney Nanoscience Hub, with implications that could help transform medicine, energy and materials science.


University of Sydney scientists have made a big step towards future design of treatments for skin cancer or improved sunscreen by modelling photoactive chemical dynamics with a quantum computer.

New hybrid quantum–classical computing approach used to study chemical systems

Caltech professor of chemistry Sandeep Sharma and colleagues from IBM and the RIKEN Center for Computational Science in Japan are giving us a glimpse of the future of computing. The team has used quantum computing in combination with classical distributed computing to attack a notably challenging problem in quantum chemistry: determining the electronic energy levels of a relatively complex molecule.

The work demonstrates the promise of such a quantum–classical hybrid approach for advancing not only , but also fields such as , nanotechnology, and drug discovery, where insight into the electronic fingerprint of materials can reveal how they will behave.

“We have shown that you can take classical algorithms that run on high-performance classical computers and combine them with quantum algorithms that run on quantum computers to get useful chemical results,” says Sharma, a new member of the Caltech faculty whose work focuses on developing algorithms to study quantum . “We call this quantum-centric supercomputing.”

Surprising versatility of boron nitride nanotubes displayed in fusion of art and science

In an elegant fusion of art and science, researchers at Rice University have achieved a major milestone in nanomaterials engineering by uncovering how boron nitride nanotubes (BNNTs)—touted for their strength, thermal stability and insulating properties—can be coaxed into forming ordered liquid crystalline phases in water. Their work, published in Langmuir, was so visually striking it graced the journal’s cover.

That vibrant image, however, represents more than just the beauty of science at the nanoscale. It captures the essence of a new, scalable method to align BNNTs in using a common bile-salt surfactant—sodium deoxycholate (SDC)—opening the door to next-generation materials for aerospace, electronics and beyond.

“This work is very interesting from the fundamental point of view because it shows that BNNTs can be used as model systems to study novel nanorod liquid crystals,” said Matteo Pasquali, the A.J. Hartsook Professor of Chemical and Biomolecular Engineering, professor of chemistry, materials science and nanoengineering and corresponding author on the study.

Engineering biology applications for environmental solutions: potential and challenges

Engineering biology applies synthetic biology to address global environmental challenges like bioremediation, biosequestration, pollutant monitoring, and resource recovery. This perspective outlines innovations in engineering biology, its integration with other technologies (e.g., nanotechnology, IoT, AI), and commercial ventures leveraging these advancements. We also discuss commercialisation and scaling challenges, biosafety and biosecurity considerations including biocontainment strategies, social and political dimensions, and governance issues that must be addressed for successful real-world implementation. Finally, we highlight future perspectives and propose strategies to overcome existing hurdles, aiming to accelerate the adoption of engineering biology for environmental solutions.


The scale of global environmental challenges requires a multi-pronged approach, which utilises all the technologies at our disposal. Here, authors provide their perspective on the potential of engineering biology for environmental biotechnology, summarizing their thoughts on the key challenges and future possibilities for the field.

Breakthrough in Solar-Blind Tech: Diamond Nanowires Set a New Benchmark

A new photodetector design using platinum-infused diamond nanowires achieves record-breaking UV sensitivity and heat resistance. Diamond nanowires embedded with platinum nanoparticles could transform high-temperature solar-blind photodetection thanks to their impressive performance and stability.

Photo-switchable DNA condensates enable remote-controlled microflow systems

Remote-controlled microflow using light-controlled state transitions within DNA condensates has been reported by scientists from the Institute of Science Tokyo, Japan. By switching between ultraviolet light (UV) and visible light irradiation, the researchers demonstrated that the novel DNA motifs containing azobenzene can dissociate or reassemble. Furthermore, localized photo-switching within a DNA liquid condensate generated two distinct directional motions. This study can fuel the development of innovative fluid-based diagnostic chips and molecular computers.

Advancements in micro-and nano-scale fabrication technologies have given rise to diverse micrometer-sized entities such as microgels and liposomes, which are widely utilized in therapeutic formulations and microfluidic sensors. The precise control of the structure and function permits the adoption of micro-scale objects in various applications. However, the remote controllability of miniaturized fluidic objects has not yet been realized.

A recent study by scientists from the Institute of Science Tokyo (Science Tokyo), Japan, represents a significant step toward the development of remotely controllable microfluidic objects that are capable of performing mechanical actions. The research team comprised Professor Masahiro Takinoue and Specially Appointed Assistant Professor Hirotake Udono, both from the Department of Computer Science, along with Associate Professor Shin-ichiro M. Nomura from the Department of Robotics, Graduate School of Engineering, Tohoku University. Their research findings were published online in Nature Communications on May 14, 2025.

Glass nanostructures reflect nearly all visible light, challenging photonics assumptions

A research team led by SUTD has created nanoscale glass structures with near-perfect reflectance, overturning long-held assumptions about what low-index materials can do in photonics.

For decades, glass has been a reliable workhorse of optical systems, valued for its transparency and stability. But when it comes to manipulating light at the nanoscale, especially for high-performance optical devices, glass has traditionally taken a backseat to higher refractive index materials. Now, a research team led by Professor Joel Yang from the Singapore University of Technology and Design (SUTD) is reshaping this narrative.

With findings published in Science Advances, the team has developed a new method to 3D-print glass structures with nanoscale precision and achieve nearly 100% reflectance in the . This level of performance is rare for low-refractive-index materials like silica, and it opens up a broader role for glass in nanophotonics, including in wearable optics, integrated displays, and sensors.

Light-as-a-feather nanomaterial extracts drinking water from air

An international scientific collaboration has developed a novel nanomaterial to efficiently harvest clean drinking water from water vapor in the air. The nanomaterial can hold more than three times its weight in water and can achieve this far quicker than existing commercial technologies, features that enable its potential in direct applications for producing potable water from the air.

The collaboration is led by the Australian Research Council Center of Excellence for Carbon Science and Innovation (ARC COE-CSI) UNSW Associate Professor Rakesh Joshi and Nobel Laureate Professor Sir Kostya Novoselov. Prof Joshi is based at the School of Materials Science and Engineering, University of New South Wales (UNSW). Prof Novoselov is based at the National University of Singapore.

A United Nations report estimates that 2.2 billion people lack safely managed drinking water.

Phonon-mediated heat transport across materials visualized at the atomic level

Gao Peng’s research group at the International Center for Quantum Materials, School of Physics, Peking University, has developed a breakthrough method for visualizing interfacial phonon transport with sub-nanometer resolution. Leveraging fast electron inelastic scattering in electron microscopy, the team directly measured temperature fields and thermal resistance across interfaces, unveiling the microscopic mechanism of phonon-mediated heat transport at the nanoscale.

The study is published in Nature under the title “Probing transport dynamics across an interface by .”

Phonons are central to heat conduction, electrical transport, and light interactions. In modern semiconductor devices, phonon mismatches at material interfaces create significant thermal resistance, limiting performance. Yet, existing methods lack the spatial resolution needed for today’s sub-10 nm technologies.