Protein–protein interactions (PPIs) underpin biological function, yet proteome-scale interaction prediction remains bottlenecked by the quadratic computational complexity of all-vs.-all pairwise comparisons. Here, we present FlashPPI, a contrastive learning framework, grounded in residue-level interactions, that enables linear-time prediction of physical protein interfaces across a microbial proteome. By leveraging a genomic language model that captures cross-protein coevolutionary signals from metagenomic sequences, FlashPPI aligns interacting partners in a shared latent space. We demonstrate a four-fold performance increase over existing sequence-based methods, while reducing proteome-wide screening time from days to minutes. Crucially, FlashPPI achieves comparable screening performance to state-of-the-art structure-folding models at a fraction of the computational cost. Finally, we integrate FlashPPI into an interactive web platform that combines predicted networks with functional annotations and genomic context, making proteome-wide network analysis rapid and accessible for microbial discovery.
From cosmic rays to solar storms, space travel is a radiation gauntlet… but water may be the simplest, smartest solution. Discover how future starships might turn their life-support systems into life-saving armor.
Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthur. Watch my exclusive video Nearby Supernovae: https://nebula.tv/videos/isaacarthur–… out Gods & Monsters: https://nebula.tv/curiousarchive/gods… 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Fishbowl Starships Water As Shielding Episode 721; June 1, 2025; Nebula Exclusive Written, Produced, & Narrated by: Isaac Arthur Graphics: Bryan Versteeg, Jeremy Jozwik, Udo Schroeter Select imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creator Taras Harkavyi, “Alpha and…” Chris Zabriskie, “Unfoldment, Revealment”, “A New Day in a New Sector” “Oxygen Garden”, “Wonder Cycle” Stellardrone, “Red Giant”, “Billions and Billions” Chapters: 0:00 Intro 1:45 The Threat — Radiation In Space 2:36 Galactic Cosmic Rays (GCRs) 3:44 Solar Particle Events (SPEs) 4:16 Van Allen Belt Radiation 5:19 Radiation’s Impact on Humans and Equipment 8:18 Radiation Shielding Basics 9:18 Water as a Radiation Shield 11:19 Effectiveness of Water 15:42 Difficulties Using Water 17:29 Beyond Water: Alternative Radiation Shielding Methods 17:59 Metallic Shielding 18:58 Regolith & Asteroid-Based Shielding 20:27 Hydrogen-Rich Polymers 21:22 Graphene, CNTs, and BNNTs 23:54 Active Shielding: Magnetic & Plasma Barriers 24:49 Fusion Fuel Shielding 25:27 Hybrid Shielding Approaches 28:16 God & Monsters 29:26 The Future of Radiation Shielding 30:00 Smart & Self-Healing Shielding 31:29 Artificial Magnetospheres 33:22 Biological Adaptation 35:35 Radiation-Resistant AI & Robotics 37:45 The Future of Space Radiation Protection 38:55 The Future of Water-Based Shielding. Check out Gods \& Monsters: https://nebula.tv/curiousarchive/gods…
🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net. ❤️ Support us on Patreon: / isaacarthur. ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1583992725237264 📣 Reddit Community: / isaacarthur. 🐦 Follow on Twitter / X: / isaac_a_arthur. 💬 SFIA Discord Server: / discord. Credits: Fishbowl Starships Water As Shielding. Episode 721; June 1, 2025; Nebula Exclusive. Written, Produced, \& Narrated by: Isaac Arthur. Graphics: Bryan Versteeg, Jeremy Jozwik, Udo Schroeter. Select imagery/video supplied by Getty Images. Music Courtesy of Epidemic Sound http://epidemicsound.com/creator. Taras Harkavyi, \
Fourteen years ago, Cory Doctorow told me the #Singularity is a progressive apocalypse.
I have not stopped thinking about that phrase since.
We like to imagine the future as one clean break. A line crossed. A god booted up in a server farm. Cory saw something stranger. The end of the world, sold to us as the perfection of the world. Rapture for the people who swapped faith for code.
His sharpest point was about stories. Good #ScienceFiction does not predict the future. It predicts the present. The genre is not a telescope. It is a mirror.
Re-listening in 2026, the reflection is uncomfortable.
The surveillance he warned about is now infrastructure. The platforms he distrusted now mediate almost everything we do. We still treat the internet as a glorified video-on-demand service, and we still pour everything we are onto it anyway.
To build a Proxima Centauri b generational ship; designed to protect the life aboard during the 100 year journey from Earth; designed to build the first structures of the settlement on the surface of the new planet.
✧ Find me on Substack where I write sci-fi story essays: J.Barry / Between Worlds. https://jbarrybetweenworlds.substack… The fourth volume of ‘The Encyclopedia of the Future’ is now available on my Patreon. / shop ✧ The Garden Telescope (and Other Short Stories) Ebook is also available to Patreon members, or as a single purchase download Visit my Patreon here: / venturecity Created by: J. Barry — Book recommendations on artificial intelligence, future technology and innovations, and sci-fi stories (affiliate links): • Superintelligence: Paths, Dangers, Strategies https://amzn.to/3j28WkP • Life 3.0: Being Human in the Age of Artificial Intelligence https://amzn.to/3790bU1 • The Expanse: https://amzn.to/3Q0mG61 • The Hitchhikers Guide to the Galaxy: https://amzn.to/3kNFSyW — Other videos to watch: 1. The 100 Year Journey to Proxima Centauri b • The 100 Year Journey to Proxima Centauri B… 2. The First 10,000 Days on Proxima Centauri b • The First 10,000 Days on Proxima Centauri… 3. TIMELAPSE of Future Space Stations • TIMELAPSE of Future Space Stations. ✧ The fourth volume of ‘The Encyclopedia of the Future’ is now available on my Patreon. / shop. ✧ The Garden Telescope (and Other Short Stories) Ebook is also available to Patreon members, or as a single purchase download.
Visit my Patreon here: / venturecity.
Created by: J. Barry.
Book recommendations on artificial intelligence, future technology and innovations, and sci-fi stories (affiliate links): • Superintelligence: Paths, Dangers, Strategies https://amzn.to/3j28WkP • Life 3.0: Being Human in the Age of Artificial Intelligence https://amzn.to/3790bU1 • The Expanse: https://amzn.to/3Q0mG61 • The Hitchhikers Guide to the Galaxy: https://amzn.to/3kNFSyW
A solar storm hitting Earth appears to have reduced the amount of incoming high-energy cosmic rays, suggesting a new way of measuring solar activity.
Solar activity has a well-known impact on the flux of low-energy cosmic rays that strike Earth. Now researchers have detected a solar-storm-induced change in the flux of higher-energy cosmic rays [1]. Using data from a large detector array in China, the team measured a decrease—over several hours—in cosmic-ray showers coming from a particular direction in the sky. The timing of this anisotropy suggests that cosmic rays heading into the outward-moving storm were preferentially scattered by the storm’s magnetic fields. The results could lead to a new way to study the magnetic structures in solar storms.
The solar wind—the spray of charged particles continually emitted by the Sun—partially shields Earth and other planets from cosmic rays that stream into the Solar System from all directions. The wind contains magnetic fields that help deflect the high-energy protons and other particles that make up the cosmic rays. In 2024, when the wind was at the peak in its 11-year cycle, the flux of cosmic rays was down by about 0.5% compared to the average.
Astronomers from Germany and Turkey have analyzed available data from various space telescopes to investigate an ultraluminous X-ray source designated X-4, which is located in the nearby galaxy NGC 4631. Results of the new study, published June 22 on the preprint server arXiv, yield important insights into the spectral and timing variability of this source.
Ultraluminous X-ray sources (ULXs) are point sources in the sky that are so bright in X-rays that each emits more radiation than a million suns emit at all wavelengths. They are less luminous than active galactic nuclei but more consistently luminous than any known stellar process. Although numerous studies of ULXs have been conducted, the basic nature of these sources remains unknown.
Transhumanism promises a better humanity—or perhaps something no longer human at all. Join us as we explore the moral dilemmas and future paths of human augmentation.
Watch my exclusive video Mass Drivers on the Moon: https://nebula.tv/videos/isaacarthur–… Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa… Use the link https://gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $36. Visit our Website: http://www.isaacarthur.net Join Nebula: https://go.nebula.tv/isaacarthur Support us on Patreon: / isaacarthur Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Facebook Group: / 1,583,992,725,237,264 Reddit: / isaacarthur Twitter: / isaac_a_arthur on Twitter and RT our future content. SFIA Discord Server: / discord Credits: The Ethics of Transhumanism July 17, 2025; Episode 740 Written, Produced & Narrated by: Isaac Arthur Editor: Donagh Broderick Select imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creator Stellardrone, “Red Giant”, “Billions and Billions” Taras Harkavyi, “Alpha and…” Chapters 0:00 Intro 1:36 The Promise and Peril of Transhumanism 3:56 Origins of Transhumanism 9:07 Subjective vs. Objective Improvements – Where Do We Draw the Line? 10:58 Nature and Morality – Three Views of Natural Law 13:03 The Road Ahead – What Does It Mean to Be Human? 14:35 The Moral Case for Transhumanism 18:01 The Risks & Dangers of Transhumanism 27:07 Navigating the Ethical Landscape — How Do We Proceed? 32:47 The Transhuman Future: Utopia, Dystopia, or Something Else? 33:57 Final Reflections: What Does It Mean to Be Human? Get Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur. Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa… Use the link https://gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $36.
Visit our Website: http://www.isaacarthur.net. Join Nebula: https://go.nebula.tv/isaacarthur. Support us on Patreon: / isaacarthur. Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Facebook Group: / 1583992725237264 Reddit: / isaacarthur. Twitter: / isaac_a_arthur on Twitter and RT our future content. SFIA Discord Server: / discord. Credits: The Ethics of Transhumanism. July 17, 2025; Episode 740 Written, Produced \& Narrated by: Isaac Arthur. Editor: Donagh Broderick. Select imagery/video supplied by Getty Images. Music Courtesy of Epidemic Sound http://epidemicsound.com/creator. Stellardrone, \
Trions form when three particles, like quarks or electrons, come together. This formation occurs in quantum particles in nuclear physics, semiconductors and magnets, and understanding its behavior can be challenging. Rice University’s Kaden Hazzard and his team recently developed a theory on how these formations occur and behave, which was published in Physical Review Letters.
“Our theory sheds light on how trions form and interact with each other,” said Hazzard, associate professor of physics and astronomy and corresponding author on the paper. “It predicts the strength of the interactions needed to form the trions, and that, after formation, they arrange themselves in a checkerboard pattern.”
If you imagine a space full of equal amounts of red, blue and yellow balls, a trion would form when a red, blue and yellow ball all stuck to each other, Hazzard explained. Once all the balls, or particles, are bound together, he was curious about how these trions would arrange themselves in space.
The Gaia mission has allowed researchers to understand the motions of stars like never before, even revealing possible interactions between our solar system and nearby stars. Planetary Science Institute Senior Scientist Nathan Kaib and collaborator Sean Raymond (Universite de Bordeaux) have found that a recent stellar passage likely triggered a huge increase in comet formation as the star’s gravity altered Oort cloud objects’ orbits, sending them cascading into the inner solar system. We may even still be feeling the effects of this passage today. This work is being presented at the American Astronomical Society Division on Dynamical Astronomy.
HD 7,977 is a nearby sun-like star in the constellation Cassiopeia whose close passage was discovered by the Gaia mission. Approximately 2.5 million years ago, the orbits of the sun and HD 7,977 brought the two stars close together, but exactly how close is still an open question. Gaia data suggest they passed within 4,000–25,000 astronomical units of one another. Now, Kaib and Raymond have shown that the orbits of long-period comets suggest HD 7,977 came within 6,000–10,000 AU of our sun, setting off a major shower of new comets into the inner solar system.
