This lifeform’s extraordinary biology could hold the key to anti-aging breakthroughs.
Category: life extension
CLN3 mediates chloride efflux from lysosomes
Lysosomes degrade damaged organelles and macromolecules to recycle nutrient components. Lysosomal storage diseases (LSDs) are linked to mutations of genes encoding lysosomal proteins and may lead to age-related disorders, including neurodegenerative diseases. But, how lysosomal dysfunction contributes to neurodegenerative diseases is not clear yet…
The researchers identify CLN3 (ceroid lipofuscinosis, neuronal 3), linked to Batten disease as a conserved lysosomal protein that regulates lysosomal chloride homeostasis, pH, and protein degradation.
Curcumin analog C1 is a natural compound with anti-inflammatory properties could enhance CLN3 activity and improve lysosomal function by activating TFEB. sciencenewshighlights ScienceMission https://sciencemission.com/CLN3-n-chloride-efflux-n-lysosomes
Wang et al. identify CLN3 as a conserved lysosomal protein that regulates lysosomal chloride homeostasis, pH, and protein degradation. Transcription factor EB (TFEB) activation enhances CLN3 function, revealing the TFEB-CLN3 signaling axis as a promising therapeutic target for lysosomal storage disorders.
The first human test of a rejuvenation method will begin “shortly”
In a bid to treat blindness, Life Biosciences will try out potent cellular reprogramming technology on volunteers.
Physicists eye emerging technology for solar cells in outer space
Solar cells face significant challenges when deployed in outer space, where extremes in the environment decrease the efficiency and longevity they enjoy back on Earth. University of Toledo physicists are taking on these challenges at the Wright Center for Photovoltaics Innovation and Commercialization, in line with a large-scale research project supported by the Air Force Research Laboratory.
One recent advancement pertains to an emerging technology that utilizes antimony compounds as light-absorbing semiconductors. A group of UToledo faculty and students recently published a first-of-its-kind assessment exploring the promising characteristics of these antimony chalcogenide-based solar cells for space applications in the journal Solar RRL, which highlighted the work on its front cover.
“Antimony chalcogenide solar cells exhibit superior radiation robustness compared to the conventional technologies we’re deploying in space,” said Alisha Adhikari, a doctoral student in physics who co-led the team of undergraduate, graduate and faculty researchers at UToledo. “But they’ll need to become much more efficient before they become a competitive alternative for future space missions.”
New MRI technique lights up ‘zombie cells’ that contribute to arthritis
By Rachel Tompa
Research led by Stanford Medicine points to the first non-invasive imaging method to visualize senescent cells, which are alive but dormant and play a key role in many diseases.
For decades, memory-like responses in immune cells have remained unexplained
Katherine Y. King & team now identify epigenetic changes in hematopoietic stem and progenitor cells in a mycobacterial infection model that are retained in downstream macrophages, providing mechanistic mediators of innate immune memory and explaining persistence of central trained immunity.
1Graduate Program in Cancer and Cell Biology.
2Department of Pediatrics, Division of Infectious Disease, Texas Children’s Hospital and Baylor College of Medicine.
3Stem Cells and Regenerative Medicine Center.
4Department of Molecular and Human Genetics.
Brain Scans Reveal Hidden Changes After Menopause
New research suggests menopause is associated with brain volume loss in key regions tied to memory and emotions, along with higher rates of anxiety, depression, and sleep issues.
Hormone therapy didn’t prevent these changes, though it may slow age-related declines in reaction speed.
Menopause linked to brain changes and mental health challenges.
Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia — Harnessing The Therapeutic Power Of Mitochondria
Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia Therapeutics — Harnessing The Therapeutic Power Of Mitochondria
Is Co-Founder and CEO of Minovia Therapeutics (https://minoviatx.com/), a biotech company dedicated to rapidly advance life-changing therapies that address the unmet need of serious and complex mitochondrial diseases, and are the first clinical-stage company to develop a mitochondrial transplantation approach to treat a broad range of indications generated by a mitochondrial dysfunction which lead to rare-genetic or age-related diseases.
Dr. Yivgi-Ohana has twenty years of experience in mitochondrial research and received her Ph.D. in Biochemistry at The Hebrew University, after which she completed her postdoctoral fellowship at the Weizmann Institute of Science.
Dr. Yivgi-Ohana also has her B.Sc., Medical Sciences Ben-Gurion University of the Negev and her Master’s Degree, Human Reproduction Bar-Ilan University.
Dr. Yivgi-Ohana founded Minovia with a passion to help children and adults with mitochondrial diseases worldwide.
Stress-reduction molecule has potential to treat aging and metabolic disorders
University of Queensland researchers say the discovery of a new stress reduction role for a naturally occurring molecule in the body could lead to new drugs and treatment for metabolic disorders and aging.
Professor Steven Zuryn, a molecular geneticist from UQ’s Queensland Brain Institute, was part of a team that found that very small RNA molecules, called microRNAs, bind to genes and prevent them from being over-activated.
MicroRNAs were discovered in C. elegans about 30 years ago and have since been shown to be important in human health and disease. This initial discovery led to the 2024 Nobel Prize in Physiology or Medicine.