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Category: life extension

Perovskite solar cells need decades-long durability. New work shows which fast-aging tests come closest

Perovskite solar cells (PSCs) could conquer the mass market within a few years, perhaps even being produced in Europe. Their large-scale production is highly cost-effective, and unlike silicon solar cells, their production is less energy-intensive. However, perovskite solar cells ideally need to achieve decades-long warranties, which remains a challenge.

To assess their long-term stability, various test methods are used to accelerate aging. But how accurately do these methods reflect the actual degradation processes? A new study in Joule by a team led by Dr. Carolin Ulbrich (HZB) and Andreas Bartelt (HTW Berlin) now answers this question.

Inducing cell death in pancreatic cancer cells

Researchers have discovered a previously unknown mechanism that makes most pancreatic cancer cells susceptible to a form of programmed cell death. The team showed that cancer cells with mutations in the KRAS gene develop a vulnerability which can be used to eliminate tumor cells in preclinical models. The findings open up new perspectives for treating pancreatic cancer. The study was published in the journal Nature Communications.

Pancreatic cancer is one of the most aggressive forms of cancer and has so far shown only limited response to available treatments. In approximately 90 percent of cases, these tumors carry mutations in the KRAS gene that drive cancer growth. Due to the ageing population and the lack of effective therapies, physicians, clinicians, and researchers expect pancreatic carcinoma to become one of the leading causes of cancer-related deaths worldwide in the coming years. With the discovery of this newly identified vulnerability, a therapeutically promising approach has now been identified for treating this disease following future clinical trials.

The researchers discovered that KRAS-mutated tumor cells continuously activate signals from the innate immune system. This primes the cancer cells for an inflammatory form of cell death known as necroptosis. In order to survive, tumor cells rely heavily on the protein caspase-8, which usually inhibits necroptosis. If caspase-8 is blocked, the tumor cells die. “KRAS-mutated tumors have a previously unknown Achilles heel,” says the senior author of the study. “By switching off the tumor cells’ defence mechanisms, we can significantly kill these tumors.”

Vascular Control Of Aging And Regeneration (Featuring Anjali Kusumbe, PhD)

Join us on Patreon! / michaellustgartenphd.

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs, for those who blood test with Quest): https://www.ultalabtests.com/partners… those who blood test with LabCorp: https://www.anrdoezrs.net/click-10161… At-Home Metabolomics: https://www.iollo.com?ref=michael-lus… Use Code: CONQUERAGING At Checkout Clearly Filtered Water Filter: https://get.aspr.app/SHoPY Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=… Use Code: CONQUERAGING NAD+ Quantification: https://www.jinfiniti.com/intracellul… Use Code: ConquerAging At Checkout Oral Microbiome: https://www.bristlehealth.com/?ref=mi… Enter Code: ConquerAging SiphoxHealth Blood Testing (ApoB, GrimAge): https://siphoxhealth.com/mlustgarten Green Tea: https://www.ochaandco.com/?ref=fqbtflod Use Code: ML10OFF Diet Tracking: https://shareasale.com/r.cfm?b=139013… If you’d like to support the channel, you can do that with the website, Buy Me A Coffee: https://www.buymeacoffee.com/mlhnrca Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-sprin…

Blood Testing Essentials (Biological Age, CVD-Risk, Kidney Health and Function):
PhenoAge (Biological Age): https://www.ultalabtests.com/partners…

Measure the Bortz biological clock biomarkers: https://www.ultalabtests.com/partners…

Calculate your biological age using the Bortz clock: https://www.longevity-tools.com/human…

Faster aging, chronic disease linked to WTC responders with PTSD

Post-traumatic stress disorder (PTSD) remains a common condition affecting World Trade Center (WTC) responders 25 years after the attack on the Twin Towers. While the condition is considered mainly psychological, a new study sheds light on changes in the biological processes of WTC patients with PTSD that may explain why PTSD is associated with a variety of chronic diseases that ultimately contribute to aging.

Completed by a team of researchers affiliated with the Stony Brook World Trade Center Health and Wellness Program, which monitors the health of and provides patient care to some 10,000 WTC responders, and scientists at Duke University, the study is published in Nature Communications.

The work represents more than a decade of research led by Benjamin J. Luft, MD, senior author, the Edmund D. Pellegrino Professor of Medicine in the Renaissance School of Medicine (RSOM) at Stony Brook University and director of the WTC Health and Wellness Program; and Pei-Fen Kuan, Ph.D., first author and professor in the Department of Applied Mathematics and Statistics in the College of Engineering and Applied Sciences at Stony Brook University.

Faster aging in younger generations linked to rise in early-onset cancer

A new study led by researchers at Washington University School of Medicine in St. Louis provides evidence that younger generations are indeed aging faster biologically than their older counterparts. The causes remain under investigation around the world, including global efforts led by research members of Siteman Cancer Center, based at Barnes-Jewish Hospital and WashU Medicine, and Cancer Grand Challenges, a global initiative co-founded by the National Cancer Institute and Cancer Research U.K.; but importantly, the new research links this accelerated aging to an increased risk of early-onset cancers in younger generations. In general, early-onset cancers are those diagnosed at age 55 or younger.

The larger the gap between biological age — that is, how old our bodies appear to be — and chronological age — which is how many years we have actually lived — the higher the cancer risk, according to the researchers. They found that people in more recent birth cohorts had larger age gaps than those in older birth cohorts, which may help explain the rise in early-onset cancer in recent generations.

Their study also identified links between faster aging in particular organ systems and increased risks for certain cancers. For instance, an immune system that appears older than its actual age was associated with early-onset lung cancer. Similarly, fat tissue that appears older than its chronological age was associated with early-onset colorectal cancer.

Humans Were Injected: BREAKTHROUGH Age Reversal For Every Tissue

Life Biosciences just dosed the first human patient with ER-100 — an OSK gene therapy built from three Yamanaka factors, designed to reprogram old cells back toward a younger state. The first target is the eye. But the real implication is much bigger: this method appears to work on every tissue type it has been tried on.

If this first eye trial comes back safe, it could be the first domino in a much larger age-reversal wave: eye, liver, brain, skin, muscle, heart, kidney, blood vessels — potentially every tissue in the body.

This episode reveals the tidal wave of companies racing toward human trials using the same basic strategy: epigenetically reprogramming old cells so they behave young again. Billions of dollars are pouring into this from Jeff Bezos, Sam Altman, Brian Armstrong, Peter Thiel, and the biggest names in longevity biotech.

We walk through who they are, what they are trying to cure, why the eye came first, what worked in mice and monkeys, why NewLimit is going after liver rejuvenation, and whether the cheap pill version could be right behind the expensive gene therapy.

Bottom line: real age reversal is now in a human trial.

LONGEVITY LATTE PRE-ORDER:

Continue reading “Humans Were Injected: BREAKTHROUGH Age Reversal For Every Tissue” | >

“Aging, goal-directedness, and bioelectricity” by Michael Levin

This is ~23 minute talk overviewing our recent results and the way we think about aging and longevity. It was for a conference with quite short speaking slots so I had to talk fast… Longer talk coming with more data but this outlines some ideas and overviews our published recent work on aging.

The Role of NAD+ in Regenerative Medicine

The understanding of the molecular and cellular basis of aging has grown exponentially over recent years, and it is now accepted within the scientific community that aging is a malleable process; just as it can be accelerated, it can also be slowed and even reversed. This has far-reaching implications for our attitude and approach toward aging, presenting the opportunity to enter a new era of cellular regenerative medicine to not only manage the external signs of aging but also to develop therapies that support the body to repair and restore itself back to a state of internal well-being. A wealth of evidence now demonstrates that a decline in cellular nicotinamide adenine dinucleotide (NAD+) is a feature of aging and may play a role in the process. NAD+ plays a pivotal role in cellular metabolism and is a co-substrate for enzymes that play key roles in pathways that modify aging.

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