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Archive for the ‘life extension’ category

Feb 17, 2019

Stem Cells, Genome Editing, and the Path to Translational Medicine

Posted by in categories: biotech/medical, engineering, life extension

The derivation of human embryonic stem cells (hESCs) and the stunning discovery that somatic cells can be reprogrammed into human induced pluripotent stem cells (hiPSCs) holds the promise to revolutionize biomedical research and regenerative medicine. In this Review, we focus on disorders of the central nervous system and explore how advances in human pluripotent stem cells (hPSCs) coincide with evolutions in genome engineering and genomic technologies to provide realistic opportunities to tackle some of the most devastating complex disorders.


Advances in stem cell biology are paving new paths toward their use in the clinic, especially toward understanding and treating neurological and neurodegenerative disease.

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Feb 15, 2019

Researchers discover a weakness in a rare cancer that could be exploited with drugs

Posted by in categories: biotech/medical, life extension

Cancer cells are, in some respects, impressive: They can grow relentlessly, sidestep the aging process by becoming immortal, and evade the immune system’s persistent attacks. But in the process of acquiring such superpowers, the cells must occasionally relinquish other, more mundane skills—including the ability to produce certain nutrients.

Researchers at The Rockefeller University now announce the discovery of a rare tumor type that is unable to synthesize cholesterol, a molecule without which can’t survive.

“These cells become dependent on taking up cholesterol from their environment, and we can use this dependency to design therapies that block cholesterol uptake,” says Kivanç Birsoy, the Chapman Perelman Assistant Professor, who reports the findings in Nature.

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Feb 15, 2019

Anti-Aging Drug That Kills Old Cells Passes First Human Trial

Posted by in categories: biotech/medical, life extension

Over the course of three weeks, the patients took nine doses of a leukemia drug called dasatinib and quercetin, a supplement. By the end of the trial, the patients were reportedly able to walk farther than they could previously in the same amount of time and other signs of improved well being — all without any serious side effects.

“Though small, this pilot study marks a major breakthrough in how we treat age-related diseases such as IPF,” researcher Jamie Justice said in a press release. “Here, we’ve therapeutically targeted a fundamental biological hallmark of aging that is implicated in IPF, and we show early but promising results for the first time in human patients.”

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Feb 15, 2019

Ending Aging. Be Excited!

Posted by in categories: biotech/medical, life extension

Be excited! Technology is rapidly advancing to eliminate age related sickness and death.

Imagine a world where aging will be reversed and people can remain young and in good health. Dr. Aubrey de Gray and others are working on therapies in making this a reality.

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Feb 15, 2019

New experimental drug rapidly repairs age-related memory loss and improves mood

Posted by in categories: biotech/medical, life extension

A team of Canadian scientists has developed a fascinating new experimental drug that is purported to result in rapid improvements to both mood and memory following extensive animal testing. It’s hoped the drug will move to human trials within the next two years.

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Feb 15, 2019

New Aging Clock Accurately Predicts Biological Age

Posted by in categories: biological, life extension

Researchers at the Harvard T.H. Chan School of Public Health have discovered a new aging clock that can accurately determine both chronological and biological age in a wide variety of species.

Aging and the nucleolus

There are two kinds of age: chronological age, which is strictly the number of years that something has lived, and biological age, which is influenced by diet, exercise, environment, and similar factors. Biological age is the superior measure of true age and is an accurate predictor of all-cause mortality.

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Feb 14, 2019

New molecules reverse memory loss linked to depression, aging

Posted by in categories: biotech/medical, life extension, neuroscience

These molecules not only rapidly improve symptoms, but remarkably, also appear to renew the underlying brain impairments causing memory loss in preclinical models.

“Currently there are no medications to treat cognitive symptoms such as memory loss that occur in depression, other mental illnesses and aging,” says Dr. Etienne Sibille, Deputy Director of the Campbell Family Mental Health Research Institute at CAMH and lead scientist on the study.

What’s unique and promising about these findings, in the face of many failures in drug development for mental illness, is that the compounds are highly targeted to activate the impaired brain receptors that are causing memory loss, he says.

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Feb 14, 2019

Insects Are Dying Off at an Alarming Rate

Posted by in category: life extension

Forty percent of insect populations have seen declines in recent years and will drop even more without immediate action.

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Feb 14, 2019

Tardigrade: The micro-animal scientists can’t kill

Posted by in categories: existential risks, life extension

They’re little battlers, the greatest survivors on the planet and you may have them in your garden, writes Lana Hart.

They’ve been boiled, frozen, put in vacuums, starved, and exposed to unbearable pressures and radiation — but scientists can’t kill this creature.

They are the only animal to have survived all five of earth’s mass extinctions. This incredible feat is due to their development of unique survival mechanisms not seen in other parts of the animal kingdom.

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Feb 14, 2019

Immortal Jellyfish Rejuvenates Itself Like Benjamin Button

Posted by in categories: genetics, life extension

Multilateral efforts to decipher the rejuvenation phenomenon of Turritopsis jellyfish at the genetic level also have been initiated by several collaborating research scientists.

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