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Category: life extension

The Scientist Who Plans To End Aging Forever — Aubrey de Grey

Aubrey de Grey believes aging isn’t inevitable — it’s a solvable engineering problem. In this conversation, we explore why society treats aging as untouchable, how “longevity escape velocity” could allow us to live indefinitely, and why reversing damage—not slowing it—is the future of medicine. He breaks down how our medical system profits from sickness, and how progress is slowed by fear and outdated norms. The end of aging as we know it is coming and it’s happening faster than you think. #preventativehealth #preventativecare #aging #health #medicine.

Connect With Me: / tim.doy1e.

Timestamps:
00:00 How We Understand Aging.
06:01 How Aubrey Found His Work.
10:42 Longevity Escape Velocity.
12:45 Not Being Controlled.
15:11 Investor-Humanitarian Structure.
16:51 Balancing Work With Publicity.
17:26 Aubrey’s Current Work.
27:36 Getting Pushback & The Medical System.
33:11 Shifting To Preventative Care.
36:14 What Has & Hasn’t Changed.
41:52 Consciousness & Aging.
46:00 How To Popularize Ideas.
48:10 The Future Of Aubrey’s Work.
50:58 Connect With Aubrey de Grey.

From whole-body to organ-specific biological age clocks

Zalesky and colleagues discuss the evolution of aging clocks into organ-specific aging readouts that harness omics and imaging data. They review the insights that this additional resolution provides on differential aging across organs within interconnected systems, as well as the methods, priorities and future directions.

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging

Mitochondrial decline impairs late-life metabolic plasticity. Using nematodes and human data, this study identifies reduced phosphatidylcholine synthesis as a natural trigger of mitochondrial dysfunction during aging.

Dr. Gregory Fahy on major evidence for human cryopreservation

Dr. Fahy is the Vice President and Chief Scientific Officer at 21st Century Medicine, Inc, and has co-founded Intervene Immune, a company developing clinical methods to reverse immune system aging. He was the 2022–2023 president of the Society for Cryobiology. Dr. Fahy is the lead author of a recent paper, “Ultrastructural and Histological Cryopreservation of Mammalian Brains by Vitrification” – the main topic of our conversation.

In December of 2014, I worked with Dr. Fahy to cryopreserve Dr. Stephen Coles under special conditions, with his permission to extract brain samples and test them for preservation quality. We did not know what the results would be. If bad, that would be discouraging for cryonics. In fact, the results were excellent, as Dr. Fahy details.

We discuss the Coles case and the results of the cerebral cortical biopsy. The paper includes results from rabbit brains. We also discuss the relative resilience of the brain compared to other organs when it comes to fracturing; how cryoprotectants prevent ice formation even when the blood-brain barrier remains closed; whether biostasis organizations should be using blood-brain barrier opening agents; Dr. Fahy’s thoughts about chemical preservation and the role of a combination of cryo an chemo, known as aldehyde-stabilized cryopreservation (ASC), and more.

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Build your post-human character from real genes — tardigrade radiation shields, naked-mole-rat cancer resistance, Greenland shark longevity — backed by scientific evidence tiers and real citations. Spend enhancement credits and 3D-print the result.

Reversing Humanity’s #1 Killer

Heart disease still kills nearly 20 MILLION people every year worldwide — roughly 1 person every 1.5 seconds. — But what if medicine could move beyond simply slowing plaque buildup…and actually REMOVE toxic oxidized cholesterol from arteries? — Dr. Matthew “Oki” O’Connor, CEO and Co-Founder, Cyclarity Therapeutics.

In the time it will take you watch this episode, over 2,000 people around the world will die from diseases driven by arterial plaque. But what if we could actually remove the toxic cholesterol already trapped inside arteries?

Today we’re diving into one of the biggest unsolved problems in medicine and aging: how do you actually remove arterial plaque instead of merely slowing its progression?

Cardiovascular disease remains the world’s leading killer, despite decades of statins, anti-inflammatory drugs, and newer RNA-based therapies. Most existing treatments help manage cholesterol and reduce risk, but very few directly target the toxic debris already embedded inside plaques.

But what if we could literally extract some of the most dangerous oxidized cholesterol molecules from the body?

Continue reading “Reversing Humanity’s #1 Killer” | >

Better helium reporting to improve fission and fusion materials modeling

Standardizing calculations of the helium byproducts generated in advanced fission and fusion energy system materials can increase reactor safety and longevity, according to a study led by University of Michigan Engineering with collaborators at Oak Ridge National Laboratory and its management contractor UT-Battelle.

Through a series of simulations, the researchers found that modeling assumptions and key alloy elements—like carbon, nitrogen and nickel—significantly influence helium generation predictions. If left unaddressed, excess helium in real-world reactors could lead to faster component failure as materials swell and become brittle.

“If used, our reporting methods will improve the experimental and modeling fidelity of the nuclear materials databases being generated both domestically and internationally, driving the rapid deployment of advanced nuclear,” said Kevin Field, a professor of nuclear engineering and radiological sciences at U-M and corresponding author of the study published in the Journal of Physics: Energy.

A unifying model of stem cell dynamics explains age-related methylation patterns across mammals

A parsimonious model of stem cell dynamics describes how DNA methylation changes arise and propagate with age, unifying diverse epigenetic aging patterns and suggesting that stem cell dynamics are a key driver of aging across mammals.

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