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Category: life extension
Restoring youth: Scientists use engineered cells to restore vitality in primates
Researchers from the Chinese Academy of Sciences and Capital Medical University utilized gene editing to create senescence-resistant human mesenchymal progenitor cells (SRCs). In a 44-week trial on aged macaques, biweekly intravenous SRC injections induced no adverse effects and spurred multi-system rejuvenation in 10 major physiological systems and 61 tissue types. Treated macaques displayed enhanced cognitive function and diminished age-related degeneration. The SRCs work by releasing exosomes that curb cellular senescence and inflammation. This study presents the first primate-level proof of cell therapy’s safety and efficacy in reversing aging, presenting a potential multi-system approach for human anti-aging research.
Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast
Caffeine has long been associated with health benefits, including a reduced risk of age-related diseases. However, the specifics of how caffeine interacts with cellular mechanisms and nutrient and stress-responsive gene networks have remained elusive — until now.
In this pioneering research, published in the journal Microbial Cell, scientists used fission yeast, a single-celled organism with surprising similarities to human cells, to delve deeper into caffeine’s impact.
The researchers discovered that caffeine influences aging by engaging an ancient cellular energy system.
A few years ago, the same team found that caffeine prolongs cell life by acting on a growth regulator known as TOR (Target of Rapamycin). TOR is a molecular switch that regulates cell growth based on available food and energy and has been part of the evolutionary landscape for over 500 million years.
However, their latest study unveiled a surprising new finding: caffeine does not directly act on the TOR switch. Instead, it activates AMPK, a cellular fuel gauge that is conserved through evolution in both yeast and humans.
“When your cells are low on energy, AMPK kicks in to help them cope,” senior author Charalampos (Babis) Rallis, a reader in genetics, genomics and fundamental cell biology at Queen Mary University of London, said in a news release. “And our results show that caffeine helps flip that switch.”
Intriguingly, AMPK is also the target of metformin, a common diabetes medication currently under scrutiny for its potential to extend human lifespan when used alongside rapamycin.
Diglycerides Are Associated With An Older Biological Age
And an increased all-cause mortality risk…
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Scientists use gene editing to correct harmful mitochondrial mutations in human cells
In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The results, published in the open-access journal PLOS Biology, offer new hope for people with rare genetic conditions.
Mitochondria have their own small set of DNA. Mutations in this mitochondrial DNA can lead to a wide range of maternally inherited diseases, cancer, and aging-related conditions. While the development of CRISPR technology has given scientists new ways to correct mutations in nuclear DNA, this system cannot effectively cross the mitochondrial membrane and reach mitochondrial DNA.
In the new study, the researchers used a tool called a base editor—specifically, a DdCBE (double-stranded DNA deaminase toxin A-derived cytosine base editor). This tool allows scientists to change a single letter in the DNA code without cutting it, and it works on mitochondrial DNA.
Tesla Robotaxi Changes Everything!
Tesla’s Robotaxi has the potential to revolutionize transportation and disrupt various industries, including car ownership, urban planning, and traditional car dealerships, with its autonomous driving technology and low-cost, hassle-free ride experience ## ## Questions to inspire discussion.
Transportation Revolution.
🚕 Q: How will Tesla’s Robotaxi network change urban transportation?
A: Tesla’s Robotaxi will make personal vehicle ownership obsolete in dense cities, offering rides at 25 cents per mile that are both cost-effective and convenient, eliminating the need for parking spaces.
🚗 Q: What makes Tesla’s Cybercab unique?
A: Cybercab is designed to be the most utilitarian vehicle ever built, featuring 50% fewer parts than the Model 3, making it highly scalable for millions of rides with wireless charging and autonomous capabilities.
