Transiently reprogramming human fibroblasts up to the maturation phase rejuvenates cells according to several aging markers whilst enabling them to return to their original identity.
Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen lifespan; how there is a subset of youthful stem cells in older animals which can increase lifespan; the most comprehensive study of life extending molescules in the roundworm; and, in the Canadian content study, how disrupting antioxidant defences in a single organ can extend longevity. https://youtu.be/uiEcPFH0EDk
Kicking off the new year with a lifespan special, we will take a look at reversing the senescence of senescent cells to increase mouse lifespan; the discovery and beneficial effects of a subset of youthful stem cells which can also increase mouse longevity; the most comprehensive study of life-extending molecules in the roundworm c.elegans ; and in the Canadian Content study, how disrupting the antioxidant defences in a specific organ in c.elegans can increase its lifespan.
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
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Longevity Snapshot #5 — Reviewing a trial which shows that a combination of Omega 3, Vitamin D and Exercise slows down biological aging in older adults according to 4 epigenetic clocks.
Superlongevity via epigenetic reprogramming. 🏆
Life Biosciences:
“If the FDA approves its application, the company will repeat the methods from the mouse and monkey experiments, Rosenzweig-Lipson said. Scientists will inject volunteers’ eyes with Yamanaka factors that can be turned off or on with the antibiotic doxycycline, Rosenzweig-Lipson said. The hope is that the cells in people’s damaged optic nerves will grow more youthful at an epigenetic level, and their vision will improve.”
Can reprogramming our genes make us young again? A breakthrough in longevity research may be nearing its first human trials.
Researchers from Osaka University have discovered that the protein subunit AP2A1 may play a role in the unique structural organization of senescent cells.
There are countless products on the market that claim to restore a youthful appearance by reducing wrinkles or tightening the jawline. But what if aging could be reversed at the cellular level? Researchers in Japan may have uncovered a way to do just that.
A recent study published in Cellular Signaling by scientists at Osaka University identifies a key protein that regulates the transition between “young” and “old” cell states.
The eye protein rhodopsin of the Greenland shark was found to have amino acid variations that made them more adept at processing blue-light wavelengths – a feature that is advantageous when living in the dim deep ocean waters.
“These genomic analyses offer new insights into the molecular basis of the exceptional longevity of the Greenland shark and highlight potential genetic mechanisms that could inform future research into longevity,” scientists wrote in the study.