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Category: life extension

Physicists eye emerging technology for solar cells in outer space

Solar cells face significant challenges when deployed in outer space, where extremes in the environment decrease the efficiency and longevity they enjoy back on Earth. University of Toledo physicists are taking on these challenges at the Wright Center for Photovoltaics Innovation and Commercialization, in line with a large-scale research project supported by the Air Force Research Laboratory.

One recent advancement pertains to an emerging technology that utilizes antimony compounds as light-absorbing semiconductors. A group of UToledo faculty and students recently published a first-of-its-kind assessment exploring the promising characteristics of these antimony chalcogenide-based solar cells for space applications in the journal Solar RRL, which highlighted the work on its front cover.

“Antimony chalcogenide solar cells exhibit superior radiation robustness compared to the conventional technologies we’re deploying in space,” said Alisha Adhikari, a doctoral student in physics who co-led the team of undergraduate, graduate and faculty researchers at UToledo. “But they’ll need to become much more efficient before they become a competitive alternative for future space missions.”

For decades, memory-like responses in immune cells have remained unexplained

Katherine Y. King & team now identify epigenetic changes in hematopoietic stem and progenitor cells in a mycobacterial infection model that are retained in downstream macrophages, providing mechanistic mediators of innate immune memory and explaining persistence of central trained immunity.

1Graduate Program in Cancer and Cell Biology.

2Department of Pediatrics, Division of Infectious Disease, Texas Children’s Hospital and Baylor College of Medicine.

3Stem Cells and Regenerative Medicine Center.

4Department of Molecular and Human Genetics.

Brain Scans Reveal Hidden Changes After Menopause

New research suggests menopause is associated with brain volume loss in key regions tied to memory and emotions, along with higher rates of anxiety, depression, and sleep issues.

Hormone therapy didn’t prevent these changes, though it may slow age-related declines in reaction speed.

Menopause linked to brain changes and mental health challenges.

Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia — Harnessing The Therapeutic Power Of Mitochondria

Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia Therapeutics — Harnessing The Therapeutic Power Of Mitochondria

Is Co-Founder and CEO of Minovia Therapeutics (https://minoviatx.com/), a biotech company dedicated to rapidly advance life-changing therapies that address the unmet need of serious and complex mitochondrial diseases, and are the first clinical-stage company to develop a mitochondrial transplantation approach to treat a broad range of indications generated by a mitochondrial dysfunction which lead to rare-genetic or age-related diseases.

Dr. Yivgi-Ohana has twenty years of experience in mitochondrial research and received her Ph.D. in Biochemistry at The Hebrew University, after which she completed her postdoctoral fellowship at the Weizmann Institute of Science.

Dr. Yivgi-Ohana also has her B.Sc., Medical Sciences Ben-Gurion University of the Negev and her Master’s Degree, Human Reproduction Bar-Ilan University.

Dr. Yivgi-Ohana founded Minovia with a passion to help children and adults with mitochondrial diseases worldwide.

Continue reading “Dr. Natalie Yivgi-Ohana, Ph.D. — CEO, Minovia — Harnessing The Therapeutic Power Of Mitochondria” | >

Stress-reduction molecule has potential to treat aging and metabolic disorders

University of Queensland researchers say the discovery of a new stress reduction role for a naturally occurring molecule in the body could lead to new drugs and treatment for metabolic disorders and aging.

Professor Steven Zuryn, a molecular geneticist from UQ’s Queensland Brain Institute, was part of a team that found that very small RNA molecules, called microRNAs, bind to genes and prevent them from being over-activated.

MicroRNAs were discovered in C. elegans about 30 years ago and have since been shown to be important in human health and disease. This initial discovery led to the 2024 Nobel Prize in Physiology or Medicine.

Visceral Fat Removal Extends Lifespan: Who Has The Lowest?

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Continue reading “Visceral Fat Removal Extends Lifespan: Who Has The Lowest?” | >

Cognition all the way down 2.0: neuroscience beyond neurons in the diverse intelligence era

This paper formalizes biological intelligence as search efficiency in multi-scale problem spaces, aiming to resolve epistemic deadlocks in the basal “cognition wars” unfolding in the Diverse Intelligence research program. It extends classical work on symbolic problem-solving to define a novel problem space lexicon and search efficiency metric. Construed as an operationalization of intelligence, this metric is the decimal logarithm of the ratio between the cost of a random walk and that of a biological agent. Thus, the search efficiency measures how many orders of magnitude of dissipative work an agentic policy saves relative to a maximal-entropy search strategy. Empirical models for amoeboid chemotaxis and barium-induced planarian head regeneration show that, under conservative (i.e.

Cancer tumors may protect against Alzheimer’s by cleaning out protein clumps

Cancer and Alzheimer’s are two of the most common chronic diseases associated with aging. For years, doctors have known about a curious aspect of these two conditions: people who survive cancers are significantly less likely to develop Alzheimer’s. While this link has been observed in the data for some time, the biological reasons for it have remained a mystery. Now, a new study published in the journal Cell has discovered a possible explanation.

In the Alzheimer’s brain, abnormal levels of a naturally occurring protein called amyloid-beta clump together to form plaques. The plaques disrupt communication between brain cells, eventually leading to cognitive decline and memory loss. Current medicines struggle to remove these clumps, but this new research suggests that cancer might be sending in a biological cleanup crew.

To see whether and how cancer provides this protection, researchers at the Huazhong University of Science and Technology in China used advanced mouse models of Alzheimer’s disease. They transplanted three types of tumors (lung, colon and prostate cancer) into the mice and found that the amyloid plaques in their brains shrank significantly.

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