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Misinformation exploits outrage to spread online

We tested a hypothesis that misinformation exploits outrage to spread online, examining generalizability across multiple platforms, time periods, and classifications of misinformation. Outrage is highly engaging and need not be accurate to achieve its communicative goals, making it an attractive signal to embed in misinformation. In eight studies that used US data from Facebook (1,063,298 links) and Twitter (44,529 tweets, 24,007 users) and two behavioral experiments (1475 participants), we show that (i) misinformation sources evoke more outrage than do trustworthy sources; (ii) outrage facilitates the sharing of misinformation at least as strongly as sharing of trustworthy news; and (iii) users are more willing to share outrage-evoking misinformation without reading it first.

AARS1 promotes tumor progression and immune evasion via ATF6 lactylation-mediated tryptophan metabolism in hepatocellular carcinoma

Wang et al. identify a metabolic-immune feedback circuit in hepatocellular carcinoma, in which tumor cell-intrinsic AARS1-mediated ATF6 lactylation activates the TDO2-kynurenine axis to promote Treg differentiation and immunosuppression, while Treg-derived eNAMPT enhances tumor glycolysis and lactate production, revealing a therapeutic vulnerability to AARS1 inhibition combined with PD-1/PD-L1 blockade.

Nearby super-Earth emerges as a top target in the search for life

Researchers have pinpointed a super-Earth in the habitable zone of a nearby M-dwarf star only 18 light-years away. Sophisticated instruments detected the planet’s gentle tug on its star, hinting at a rocky world that could hold liquid water. Future mega-telescopes may be able to directly image it—something impossible today.

Kinesin ARK2 coordinates PIN2 trafficking and nanoclustering to mediate root gravitropism in Arabidopsis

Liu et al. identifies ARK2 as a dual-function kinesin that controls PIN2 microtubule-dependent trafficking and direct interaction-mediated nanodomain assembly to sustain auxin asymmetry in Arabidopsis root gravitropism.

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