Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al. have shown how intrinsically disordered regions of CBP temper each other to shape acetyltransferase activity.

Animators used data from the original sources.

A newly uncovered property of light suggests it may be far more self-sufficient than previously believed.

A method for lifting low-level world models to higher-level action spaces using waypoints, enabling efficient search-based planning for human-like embodiments.

Several sources told the ABJ that it’s well-known within the market – and nationwide – that the British semiconductor giant would be part of the research and development initiative.

A new study links fatty acid metabolism to rheumatoid arthritis treatment, revealing a natural compound that disrupts inflammation by targeting a previously overlooked enzyme.

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Jaklub shows some interesting navigation.

Locarno, Nava, Barsotti et al. define a fronto-coerulear anatomical-functional loop under endocannabinoid (eCB) negative feedback that regulates contextual discrimination. Prefrontal cortex (PFC) inputs drive locus coeruleus (LC) norepinephrine (NE) release to enhance cortical firing, while locally mobilized eCBs weaken PFC to LC synapses, constraining NE-dependent entrainment of PFC neuronal assemblies.