Toggle light / dark theme

Immune ‘energy signature’ linked to tuberculosis may explain why some individuals control infection

Researchers at Trinity College Dublin have identified key differences in how immune cells generate and use energy, a process known as cellular metabolism, in people with latent versus active tuberculosis (TB). The findings offer new insights into why some individuals control infection while others develop disease.

The study, published in the Journal of Infection, focused on circulating monocytes, key immune cells involved in the defense against TB infection. The researchers found that cells from people with latent TB remain metabolically flexible, allowing them to mount strong antibacterial responses, whereas cells from people with active TB disease show impaired metabolism and weaker responses to infection.

TB remains the world’s leading infectious killer, with 10.8 million cases and 1.25 million deaths recorded globally in 2023. While many people infected with Mycobacterium tuberculosis never become ill, researchers still do not fully understand why some individuals progress to active disease while others successfully control the infection. The findings could help pave the way for improved TB monitoring tools and future therapies or vaccines that target how immune cells generate energy.

Earth’s oxygen-rich atmosphere may owe its existence to cold subduction

Earth was mostly devoid of oxygen for much of its 4.5 billion year lifetime. That is, until certain processes started to allow for the eventual buildup of oxygen up to the levels we have now (around 21% of the atmosphere). While scientists have found evidence of the approximate timescales of rises in oxygen over time and are aware of some of the mechanisms behind it, the main driver behind Earth’s long-term oxygenation is still unclear.

A new study explores whether changes in subduction style—how tectonic plates sink—influenced oxygen levels over time. The study, published in Proceedings of the National Academy of Sciences, points to a process called cold subduction as the main driving factor behind Earth’s rise in oxygen levels, which ultimately led to a more habitable Earth.

Analysis of more than 10,000 cities reveals hidden details governments can use to better support their people

The world’s urban population increased by 785 million people between 2000 and 2020, but that tells only part of the story. Now, a research team including an expert from the University of Michigan has dug into the demographics of more than 10,000 individual cities to obtain insights that can be lost in the aggregate. The findings are published in the journal Nature Cities.

Can you enforce strong Active Directory password rules without frustrating users?

If you’re rethinking your password strategy, we can help you build an approach that improves protection while maintaining the user experience.

Contact us today or book a demo to see our solutions in action.

Sponsored and written by Specops Software.

/* */