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Identifying High-Risk Smoldering Multiple Myeloma for Early Intervention

In a cohort study comparing high-risk definitions for smoldering multiple myeloma (#SMM), the AQUILA trial criteria was assessed against the 2/20/20 risk model.

The AQUILA criteria classified approximately 3 times more individuals as high-risk versus the 2/20/20 model, but included a substantial group with lower progression risk.

The 2/20/20 model more precisely identified a smaller group of individuals with higher risk of progression, supporting its use to target early intervention for those most likely to benefit.


This cohort study compares the AQUILA trial inclusion criteria and the 2/20/20 risk stratification model definitions for identifying individuals with smoldering multiple myeloma at high risk of progression.

Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis

The current model of necroptosis assumes that MLKL’s N-terminal cytotoxic domain is unleashed from autoinhibition concurrent with phosphorylation by RIPK3. Here, Pan and Abbott show that inhibition of MLKL’s N terminus abolishes phosphorylation by RIPK3 whereas removal or relieving autoinhibition between the N-terminal and intermediate domains promotes its phosphorylation.

Your brain may be as blind to reality as a grasshopper is to calculus | Michelle Thaller

In the distant future could we redesign the brain for more understanding of the universe.


Become a Big Think member to unlock expert classes, premium print issues, exclusive events and more: https://bigthink.com/membership/?utm_… What if the universe was never designed to be understood? Astronomer Michelle Thaller makes a case that the human brain, despite its complexity, may be as poorly equipped to grasp ultimate reality as a grasshopper is to.

What if the universe was never designed to be understood? Astronomer Michelle Thaller makes a case that the human brain, despite its complexity, may be as poorly equipped to grasp ultimate reality as a grasshopper is to grasp calculus.

About Michelle Thaller:

Michelle Thaller is an astronomer and Assistant Director for Science Communication at NASA’s Goddard Space Flight Center.

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