Background and ObjectivesPathogenic variants in the SCN2A gene, encoding the α-subunit type 2 of the voltage-gated sodium channel NaV1.2, cause a phenotypic spectrum including 4 major disorders as benign familial infantile seizures, developmental and…

Arad Soffer, Aishwarya Bhosale, Carien M. Niessen, Chen Luxenburg, Matthias Rübsam (Universität zu Köln) and colleagues identify spectrin as a central component of epithelial cortical actomyosin networks to control cortex mechanics and signaling.

Cell shape and fate are tightly linked, yet how the cortical cytoskeleton integrates regulation of shape and fate remains unclear. Using the multilayered epidermis as a paradigm for cell shape–guided changes in differentiation, we identify spectrin as an essential organizer of the actomyosin cortex to integrate transitions in cell shape with spatial organization of signaling. Loss of αII-spectrin (Sptan1) in mouse epidermis altered cell shape in all layers and impaired differentiation and barrier formation. High-resolution imaging and laser ablation revealed that E-cadherin organizes gradients of cortical actin and spectrin into layer-specific submembranous networks with discrete structural and mechanical properties that coordinate cell shape and fate. This layer-specific organization dissipates tension and, in upper layers, retains activated growth factor receptor EGFR and the calcium channel TRPV3 at the membrane to induce terminal differentiation. Together, these findings reveal how polarized organization of the cortical cytoskeleton directs transitions in cell shape and cell fate at the tissue scale necessary to establish epithelial barriers.

Danish nuclear technology company Copenhagen Atomics has completed two years of continuous operation of a molten salt pump and test loop at its facilities in Copenhagen. The system has been running without issues under high-temperature molten salt conditions, marking one of the longest continuous durability tests of its kind worldwide, it said. ;

Dashiell Hammett mentioned Sam Spade’s jutting chin in the opening sentence of his novel, “The Maltese Falcon.” Spade’s chin was among the facial features Hammett used to describe his fictional detective’s appearance, but starting with that distinctive chin was—at least from an evolutionary perspective—an unintentional redundancy, since every chin is distinctive in the sense that humans are the only primates to possess that physical characteristic.

Chimpanzees, humans’ closest living relatives, do not have a chin. Neither did Neanderthals, Denisovans, or any other extinct human species. Humans, it turns out, have a unique capacity to “take it on the chin” because we’re uniquely in possession of that physical feature. That exclusive nature makes the chin well suited for identifying Homo sapiens in the fossil record.

In simplest terms, a chin is a bony projection of the lower jaw. So why is it there? How and why did it evolve?

Microsoft patches 59 vulnerabilities, including six actively exploited zero-days, with CISA mandating urgent federal remediation.

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New research shows that a fragile clay layer beneath the Japan Trench played a key role in the extreme seafloor movement during the 2011 earthquake.

Researchers have identified a bone-driven signaling pathway that may explain how spinal degeneration leads to chronic pain.