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Immune cells regulate eye pressure linked to glaucoma

In the study, researchers tracked fluorescently tagged resident macrophages in mouse eyes. Long-lived resident tissue macrophages were concentrated in the trabecular meshwork and Schlemm’s canal, whereas steady-state monocyte-derived macrophages were abundant around distal vessels.

When they selectively removed these cells, the eye’s drain became clogged, fluid built up, and eye pressure increased and was linked to aberrant extracellular matrix turnover in the resistance-generating tissues of the trabecular meshwork.

“Our findings show that resident macrophages are essential for maintaining healthy eye pressure,” said the author. “Disruption of this system may contribute directly to the development of glaucoma.”

This discovery could lead to the development of future glaucoma treatments. The next step is to do research that identifies these resident macrophages in human eye tissue. ScienceMission sciencenewshighlights.


When the eye’s drainage system clogs, pressure builds up and causes damage. The pressure can lead to glaucoma and vision loss.

New research published in the journal Immunity, reveals that a specialized set of immune cells act as the cleanup crew, pointing to a promising new target for therapies to prevent a major cause of blindness.

Joscha Bach: Galactic Game Theory

Joscha Bach on the possibility that advanced / mature civs converge on strategy and value, and join the cosmic collective. https://www.scifuture.org/transparency-of-history-in-galactic-game-theory/ Many thanks for tuning in! Please support SciFuture by subscribing and sharing! Buy me a coffee? https://buymeacoffee.com/tech101z Have any ideas about people to interview? Want to be notified about future events? Any comments about the STF series? Please fill out this form: https://docs.google.com/forms/d/1mr9PIfq2ZYlQsXRIn5BcLH2onbiSI7g79mOH_AFCdIk/ Kind regards, Adam Ford — Science, Technology & the Future — #SciFuture — http://scifuture.org

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A single injection of mRNA-like treatment could help heart muscle heal after a heart attack in mice and pigs. Could it work in humans too?

Link:- https://www.livescience.com/health/a-single-injection-of-mrn…tUEC70CfRQ


Link:-?utm_source=facebook&utm_medium=social&utm_campaign=dhfacebook&utm_content=app.dashsocial.com/live-science/library/media/652167657

Adobe Will Pay $75 Million to Settle Lawsuit over Its Subscriptions

“Adobe fails to adequately disclose to consumers that by signing up for the ‘Annual, Paid Monthly’ subscription plan, they are agreeing to a year-long commitment and a hefty early termination fee that can amount to hundreds of dollars,” the complaint read.

This lawsuit is finally closed, with Adobe agreeing to pay $75 million worth of services for free to the affected customers and an extra $75 million to the Department of Justice.

However, the company doesn’t agree with the accusations made against it.

Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement

Astrocyte-microglia crosstalk in thalamocortical synapse refinement.

Both microglia and astrocytes play crucial role in synapse refinement during development but it is not clear how they communicate to balance synapse formation and elimination.

The researchers show that astrocytes instruct this process through the secreted synaptogenic protein Hevin/Sparcl1.

The proteolytically generated C-terminal of Hevin signals to microglia via TLR4, triggering a pro-phagocytic state that promotes refinement of thalamocortical synapses in the developing visual cortex. sciencenewshighlights ScienceMission https://sciencemission.com/Hevin-and-Toll-like-receptor


Microglia are key drivers of synapse refinement during development. Ramirez et al. show that astrocytes instruct this process through the secreted synaptogenic protein Hevin/Sparcl1. The proteolytically generated C-terminal of Hevin signals to microglia via TLR4, triggering a pro-phagocytic state that promotes refinement of thalamocortical synapses in the developing visual cortex.

Evolutionary causes and consequences of gene duplication

Gene duplication is a key evolutionary mechanism, as initially redundant paralogues diverge over time. The authors review how adaptive and non-adaptive forces influence the evolutionary fates of gene duplicates, highlighting the importance of function–fitness relationships and gene expression dynamics.

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