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Glutathione is critical for mediated immunity

Glutathione is critical for NK cell-mediated immunity.


Guerra et al. show that glutathione (GSH) sustains IL-15-driven NK cell metabolism and effector functions. Loss of GSH unleashes T cell immunity and improves viral clearance. In contrast, NK cell-mediated control of metastases, but not solid tumors, critically depends on GSH.

Peripheral Immune Remodeling After Spinal Cord InjuryMarked by Expansion of CD38+, CTLA-4+, and PD-1+ T and NK Cells

Study findings reveal noteworthy changes in immune cell activation and exhaustion markers that may contribute to immune vulnerability after spinal cord injury, offering novel insights into potential therapeutic targets, such as NAD+ metabolism and immune checkpoint modulation.


Background and Objectives.

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