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Caudal Granular Insular Cortex to Somatosensory Cortex I: A Critical Pathway for the Transition of Acute to Chronic Pain

Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.


METTL3 undergoes S-palmitoylation, which promotes cytoplasmic phase separation to facilitate mRNA translation and maintain its stability. We identify a small molecule that enhances this modification, providing a mechanistic basis for a potential osteoarthritis therapy.

Double the doublet, shake well, break one, and keep the other intact: welcome, dark scalars!

The search isn’t over—future runs of the High-Luminosity LHC and the proposed Future Circular Collider (FCC) will continue to hunt for these “inert” twins to see if they are hiding at even higher energy levels.


For the first time ever, the CMS experiment has designed a dedicated analysis using parametrised machine learning to look for new dark particles that don’t socialize with Standard Model fermions, one of them being a favourite candidate in the search for dark matter.

Using proton-proton collisions delivered by the LHC in 2016–2018 and 2022, CMS collaborators have been looking for new scalar particles in a theoretical framework that had never before been tested with a dedicated analysis, leading to the widest excluded mass range to date for this model.

Are there more Higgs-boson-like particles?

Having found a Higgs boson (a scalar particle), theorists naturally ask themselves: could there be more than one? In fact, rather than a single Higgs boson, which is the only observable particle, the Standard Model predicts a so-called Higgs doublet. While we’re at it, let’s add a second electroweak doublet; why not? The effect is the conception of 4 new scalar particles: two neutral ones, labeled H and A (with H the lightest of the two), and two charged ones, H+ and H-. The search for such extra scalar particles has already spanned several decades, but only when they actually interact with our Standard Model particles. With an extra ingredient, called the ℤ2 symmetry, the new scalars become allergic to our matter particles, the fermions, and only prefer to talk to bosons like themselves: the Higgs boson, but also the W and Z bosons. They become so-called inert, or dark, scalars and the model inherits this name — the Inert Doublet Model.

Fossil X-ray reveals new species of baby dino named for iconic Korean cartoon

Cute, green, and sporting two sprigs of hair on his head, a mischievous baby dinosaur named Dooly is one of the most beloved cartoon characters in South Korea. So, when researchers from The University of Texas at Austin and the Korean Dinosaur Research Center discovered a new species of baby dinosaur from Korea’s Aphae Island, they knew exactly what to call it: Doolysaurus.

“Dooly is one of the very famous, iconic dinosaur characters in Korea. Every generation in Korea knows this character,” said Jongyun Jung, a visiting postdoctoral researcher at UT’s Jackson School of Geosciences who led the research. “And our specimen is also a juvenile or ‘baby,’ so it’s perfect for our dinosaur species name to honor Dooly.”

The baby dinosaur is the first new dinosaur species discovered in Korea in 15 years and the first Korean dinosaur fossil found with portions of its skull. The skull bones were revealed when the fossil underwent a scientific micro-CT scan at the University of Texas High-Resolution X-ray Computed Tomography (UTCT) facility.

The way you walk can reveal your true feelings

Whether you’re striding with purpose, swaggering with confidence, or trudging slowly along the street, the way you walk can reveal how you’re feeling, according to new research published in the journal Royal Society Open Science. We already know that some features of our gait can reflect our emotional state, such as heavy steps conveying anger and slumped shoulders indicating sadness. However, researchers led by Mina Wakabayashi at the Advanced Telecommunications Research Institute International in Japan and her colleagues sought to determine whether there is a specific, coordinated movement pattern that reliably signals these emotional states.

The team conducted two experiments. In the first, they asked actors to recall life events that evoked anger, happiness, fear, and sadness, and to then walk a short distance while contemplating each memory. The actors also walked with a neutral expression to give the researchers a baseline for comparison.

The recordings were then converted into point-light videos of 17 white dots representing the body’s main joints, which were shown to adult volunteers who had to click a button to identify the emotion they perceived. They correctly identified emotions at a level significantly above chance.

USP10 Deubiquitinates MTX2 to Suppress cGAS-STING Signaling in MI

Zhao & colleagues found how a protective protein, USP10, helps limit excessive inflammation after a heart attack, which may open new avenues for treating cardiac injury. Learn more at.


BACKGROUND: Myocardial infarction (MI) results in 3 distinct regions within the left ventricle:

The infarct zone, the border zone (BZ), and the remote zone. A major focus of MI research.

Is investigating the intrinsic mechanisms in the BZ to alleviate myocardial injury.

USP10 (ubiquitin-specific peptidase 10) expression is reduced in BZ cardiomyocytes.

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