The observation of ultrahigh-energy radiation from a binary star system suggests that such “gamma-ray binaries” could be significant contributors to the cosmic-ray spectrum.
Category: futurism
New Cisco DoS flaw requires manual reboot to revive devices
The company advised customers at the time to contact its Technical Assistance Center (TAC) to have them brought back online, as this required manual intervention.
Last year, Cisco patched another DoS vulnerability (CVE-2025–20115) that allowed attackers to crash the Border Gateway Protocol (BGP) process on IOS XR routers with a single BGP update message.
Citraconate preserves T cell stemness and antitumor immunity
The metabolite citraconate can preserve T cell stemness and suppress exhaustion, promoting antitumor immunity and responses to immunotherapies in mice.
Learn more in Science Immunology.
Sci. Immunol. 11, eadz0348 (2026). DOI:10.1126/sciimmunol.adz0348
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Cell proteins that drive severe viral infections identified
In two recently published studies, the nucleoporins NUP98 and NUP153 have been identified as key host factors in orthoflavivirus infection.
NUP98 and NUP153 are normally part of the nuclear pore complex, which regulates the transport of proteins and RNA between the cell nucleus and the cytosol, the fluid in which the cell’s internal components are suspended. Since orthoflaviviruses copy their RNA in the cytosol, these proteins had not previously been linked to the viral life cycle.
The researchers now show that during infection, both nucleoporins are recruited to viral replication sites in the cytosol, where they bind directly to viral RNA. In addition, NUP153 also interacts with viral proteins.
“It was surprising to see how proteins that normally act as ‘gatekeepers’ to the nucleus instead become active participants in the virus’s replication machinery,” says the first author.
The studies show that NUP98 and NUP153 have distinct roles during infection. NUP98 is required for efficient replication of viral RNA, while NUP153 influences how much of the different viral proteins are produced.
NUP153 binds to a specific region of the viral RNA located between the sequences encoding structural and non-structural proteins. Through this interaction, the balance between different viral proteins is regulated, which is critical at an early stage of infection. sciencenewshighlights ScienceMission.