Liu et al. identifies ARK2 as a dual-function kinesin that controls PIN2 microtubule-dependent trafficking and direct interaction-mediated nanodomain assembly to sustain auxin asymmetry in Arabidopsis root gravitropism.
Category: futurism
Could We Reach Alpha Centauri in 20 Years?
Alpha Centauri is 4.37 light years away—so could we reach it in 20 years? Only by leaving ordinary rockets behind for beamed sails, antimatter, or stranger drives. 🚀 Join this channel to get access to perks: https://www.youtube.com/channel/UCZFipeZtQM5CKUjx6grh54g/join 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall.com/ 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: https://www.patreon.com/IsaacArthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-arthur 👥 Facebook Group: https://www.facebook.com/groups/1583992725237264/ 📣 Reddit Community: https://www.reddit.com/r/IsaacArthur/ 🐦 Follow on Twitter / X: https://twitter.com/Isaac_A_Arthur 💬 SFIA Discord Server: https://discord.gg/53GAShE
Time is a Processing Delay
I show how the time dilation derived in special relativity by assuming an abstract concept of malleable time, can be derived in a more mechanistic manner by assuming that the cosmos is like a simulation \& time is a processing delay.
I had this idea while playing minecraft with my son — every time I approached a large villager-town the PC slowed down and I thought \.
Self-Amplifying RNA: Advantages and Challenges of a Versatile Platform for Vaccine Development
Self-amplifying RNA is synthetic nucleic acid engineered to replicate within cells without generating viral particles. Derived from alphavirus genomes, saRNA retains the non-structural elements essential for replication while replacing the structural elements with an antigen of interest. By enabling efficient intracellular amplification, saRNA offers a promising alternative to conventional mRNA vaccines, enhancing antigen expression while requiring lower doses. However, this advantage comes with challenges. In this review, we highlight the key limitations of saRNA technology and explore potential strategies to overcome them. By identifying these challenges, we aim to provide insights that can guide the future design of saRNA-based therapeutics, extending their potential beyond vaccine applications.
Cachexia-induced alterations of miR-27a-3p drive cell-type specific effects in FAPs and tumor cells that coincide with muscle wasting
Self-amplifying RNA is synthetic nucleic acid engineered to replicate within cells without generating viral particles. Derived from alphavirus genomes, saRNA retains the non-structural elements essential for replication while replacing the structural elements with an antigen of interest. By enabling efficient intracellular amplification, saRNA offers a promising alternative to conventional mRNA vaccines, enhancing antigen expression while requiring lower doses. However, this advantage comes with challenges. In this review, we highlight the key limitations of saRNA technology and explore potential strategies to overcome them. By identifying these challenges, we aim to provide insights that can guide the future design of saRNA-based therapeutics, extending their potential beyond vaccine applications.
This Will Replace Silicon Chips
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Timestamps:
00:00 — New Semiconductor.
08:44 — Computers of The Future.
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Watch this spider crawl like an ant to avoid being eaten
Unlike some other spiders that camouflage themselves with drab colors and sticklike appendages, the jumping spider Siler collingwoodi disguises itself by the way it moves. The bright blue and orange arachnid—a pea-size animal native to China and Japan—crawls like an ant, according to a new study.
In a side-by-side comparison, researchers found that S. collingwoodi spiders copied the movements of multiple spikey, aggressive species of ants. The spiders walked at a similar pace, bobbed their abdomens like the ants did, and elevated their first pair of legs when they walked, imitating antennae.
