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AI Finds Life Shortening Hormone Disorder Using Only Hand Photos

A privacy-first AI can diagnose a life-shortening hormone disorder—just from a photo of your hand.

Researchers at Kobe University have developed an artificial intelligence system that can identify a rare endocrine disorder by examining photos of the back of a person’s hand and their clenched fist. By avoiding facial images, the approach was designed with privacy in mind. The team believes this tool could help doctors refer patients to specialists more efficiently and help narrow gaps in access to care.

Acromegaly and Delayed Diagnosis.

Trojanized Gaming Tools Spread Java-Based RAT via Browser and Chat Platforms

Threat actors are luring unsuspecting users into running trojanized gaming utilities that are distributed via browsers and chat platforms to distribute a remote access trojan (RAT).

“A malicious downloader staged a portable Java runtime and executed a malicious Java archive (JAR) file named jd-gui.jar,” the Microsoft Threat Intelligence team said in a post on X. “This downloader used PowerShell and living-off-the-land binaries (LOLBins) like cmstp.exe for stealthy execution.”

The attack chain is also designed to evade detection by deleting the initial downloader and by configuring Microsoft Defender exclusions for the RAT components.

Microsoft testing Windows 11 batch file security improvements

Microsoft is rolling out new Windows 11 Insider Preview builds that improve security and performance during batch file or CMD script execution.

As Microsoft explained today, IT administrators can now enable a more secure processing mode that prevents batch files from being modified while they run by adding the LockBatchFilesInUse registry value under HKEY_LOCAL_MACHINE\Software\Microsoft\Command Processor.

Policy authors can also enable this mode using the LockBatchFilesWhenInUse application manifest control.

NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation

Nishada Ramphal, Ari Waisman et al. (Johannes Gutenberg-Universität Mainz) reveal that NIK drives neuroantigen-specific T cell priming by regulating antigen presentation and IL-23 production, identifying NIK as a key orchestrator of myeloid-driven CNS autoimmunity.

Neuroinflammation.

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Teaching NeuroImage: Honeycomb Appearance of the Basal Ganglia Suggests Biallelic Nitrilase-1 Variants

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Spinal Cord Leptomeningeal Enhancement as a Marker of Extensive Spinal Cord Involvement in Children With MOGAD

This study characterizes the clinical, imaging, and biological features of myelitis associated with spinal cord leptomeningeal enhancement in children with MOGAD and seronegative myelitis.

Background and Objectives.

Micro- and nanoplastics facilitate the propagation of antimicrobial resistance in mixed microbial consortia

Zhen et al. show that micro-/nanoplastics increase antimicrobial resistance gene abundance and mobilization in mixed microbial consortia. Nanoplastics intensify oxidative stress and SOS responses and strengthen ARG-MGE co-localization, promoting dense horizontal gene transfer networks and turning plastisphere biofilms into resistance hotspots.

Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi

Amin et al. present telomere-to-telomere assemblies of nine Borrelia burgdorferi strains from Canada, uncovering the diversity at chromosome ends and plasmid profiles. They identify an lp28-1a plasmid subtype and detect plasmid-chromosome recombination, offering insights into genomic plasticity and potential mechanisms of adaptation in Borrelia.

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