This study reveals how temporally restricted enhancers control gene expression over time, highlighting their role in transcription dynamics and enhancer–promoter interactions during mouse limb development.
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LANL: Los Alamos To Play Key Role In Renewed Quantum Science Center
PRESS RELEASE — The Department of Energy has renewed funding for the Quantum Science Center, with Los Alamos National Laboratory continuing to play a vital role along with Oak Ridge National Laboratory in the center’s mission to advance quantum science and technology. The center will be funded for $125 million over five years to focus on quantum-accelerated high-performance computing.
“The Quantum Science Center is establishing the scientific and technical foundation for quantum computing,” said Mark Chadwick, associate Laboratory director for Simulation, Computing and Theory. “In this new, critical evolution for the center, the integration of quantum and high-performance computing stands to accelerate advancements in crucial scientific areas related to technological progress and even national security applications.”
The Quantum Science Center combines the efforts of three national laboratories, with ORNL hosting the center and Los Alamos a principal partner alongside various universities, industry partners and other laboratories. Created as one of five National Quantum Information Science Research Centers supported by the DOE’s Office of Science, the Quantum Science Center seeks to create a scientific ecosystem for the advancement of fault-tolerant, quantum-accelerated high-performance computing.
Cribriform Plate
The cribriform plate represents a transition from the base of the skull to the face at the upper aspect of the nose. The cribriform plate plays a role in the passage of olfactory nerves and disruption of this can lead to partial or total anosmia. A review of the incidence and factors involved in this sensory loss caused by trauma has been summarized.10 It is therefore intuitive to understand that disruption of the sensory fibers passing through this region can lead to permanent smell alteration. Fig. 5 demonstrates a Lefort II fracture whereby the nasal bone separated from the cranial base and was displaced 1-cm posteriorly as the maxilla-nasal complex rotated up and back as a single unit. This patient had resultant permanent anosmia.
ScienceDirect.
Genetic resistance to leukemia
A newly identified and rare genetic variant slows the growth of mutated blood stem cells, researchers report in Science, and it reduces the risk of leukemia.
The findings offer insight into why some people are naturally more resistant to clonal expansion and age-related blood cancers despite acquiring risky mutations.
Learn more in a new Science Perspective.
A genome-wide association study identifies a genetic variant that reduces the risk of leukemia.
Francisco Caiado and Markus G. Manz Authors Info & Affiliations
Science
What Are Cancer Vaccines?
Using mRNA is a promising new way to make [vaccines to help treat cancer](https://www.cancer.org/cancer/managing-cancer/treatment-type…nes.html).
Vaccines are substances that help your immune system learn to fight off something that doesn’t belong there. We’re most familiar with vaccines that help prevent some types of infections, such as the flu vaccine. But vaccines might also be helpful in treating cancer, if the vaccine can get the immune system to see and attack cancer cells. It’s been hard to make effective cancer vaccines for several reasons, but mRNA might provide a way to make cancer vaccines that are more effective and easier to create.
https://www.cancer.org/cancer/managing-cancer/treatment-type…cines.html
Some vaccines help protect against viruses that cause cancer, while others are used to treat cancer. Learn more about cancer vaccines here.
This years biggest breakthroughs in longevity!
Wrap up for 2025.
Every year I compile what I think were some important contributions to longevity research. Here is my list for 2025!!
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through PayPal — https://paypal.me/sheekeyscience?coun… through Patreon — / thesheekeyscienceshow TIMESTAMPS: 00:00 – Intro & “What is aging?” / Hallmarks 2025 02:07 – Cellular reprogramming 05:47 – Senescent cells 11:45 – GLP‑1 agonists & ITP 13:43 – Elastin fragments & ECM aging 15:22 – Cardiac ‘age‑switch’ experiment 16:18 – Systemic environment: FOXO3 cells, antler EVs, plasma exchange 19:26 – Things you wouldn’t have thought of: AI-predicted antibodies REFERENCES: What is aging / hallmarks Hallmarks of aging update 2025 (14 hallmarks, ECM + psychosocial isolation) https://www.sciencedirect.com/science… reprogramming Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming – Cell 2025 https://doi.org/10.1016/j.cell.2025.0… A single factor for safer cellular rejuvenation (SB000) – bioRxiv 2025 https://doi.org/10.1101/2025.06.05.65… https://www.biorxiv.org/content/10.11… OpenAI x Retro Biosciences: AI‑designed reprogramming factors https://openai.com/index/accelerating… Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche – Nature Aging 2024 (YouthBio’s scientific basis) https://doi.org/10.1038/s43587-024-00… Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan in Caenorhabditis elegans – EMBO Molecular Medicine 2025 https://doi.org/10.1038/s44321-025-00… https://pmc.ncbi.nlm.nih.gov/articles… Senescent cells An unbiased cell‑culture selection yields DNA aptamers as senescence‑specific reagents – Aging Cell 2025 https://doi.org/10.1111/acel.70245 Senolytic CAR T cells reverse senescence‑associated pathologies – Amor et al., Nature 2020 https://doi.org/10.1038/s41586-020-24… Anti‑uPAR CAR T cells reverse and prevent aging‑associated defects in intestinal regeneration and fitness – Nature Aging 2025 https://doi.org/10.1038/s43587-025-01… Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low‑Frequency Ultrasound – Aging Cell 2025 https://pmc.ncbi.nlm.nih.gov/articles… Supplements, ITP & GLP‑1s Are GLP‑1s the first longevity drugs? – Nature Biotechnology 2025 https://doi.org/10.1038/s41587-025-02… GLP‑1 receptor agonists at the crossroads of metabolism and longevity – Nature Aging https://www.nature.com/articles/s4151… Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female UM‑HET3 mice – GeroScience 2025 https://doi.org/10.1007/s11357-025-01… https://pubmed.ncbi.nlm.nih.gov/40973… ECM, elastin & cardiac environment Elastin‑derived extracellular matrix fragments drive aging through innate immune activation – Nature Aging 2025 https://doi.org/10.1038/s43587-025-00… Sun, A.R., Ramli, M.F.H., Shen, X. et al. Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing. Nat. Mater. 24, 1489–1501 (2025). https://doi.org/10.1038/s41563-025-02… Systemic environment: stem cells, EVs, plasma Senescence‑resistant human mesenchymal progenitor cells counter aging in primates – Cell 2025 https://doi.org/10.1016/j.cell.2025.0… Attenuation of primate aging via systemic infusion of senescence‑resistant cells – https://pmc.ncbi.nlm.nih.gov/articles… Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging‑related phenotypes – Nature Aging 2025 https://pmc.ncbi.nlm.nih.gov/articles… Human clinical trial of plasmapheresis effects on biomarkers of aging – Aging Cell 2025 https://pmc.ncbi.nlm.nih.gov/articles… “Things you wouldn’t think of” – AI antibodies Atomically accurate de novo design of antibodies with atomic precision – Baker Lab, Nature 2025 https://doi.org/10.1038/s41586-025-09… Computational design of human antibodies targeting any antigen – https://doi.org/10.1016/j.cell.2025.1… Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; “https://www.freepik.com/free-photos-v…“Background vector created by freepik — www.freepik.com.
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TIMESTAMPS:
Scientists use new technology to track individual monarch butterfly migrations
Monarch butterflies make one of the most extraordinary migrations in the natural world, often traveling thousands of miles across North America. Now, scientists are using new tracking technology to get a greater understanding of those journeys. Ali Rogin speaks with Dan Fagin, a Pulitzer Prize-winning journalist who teaches science journalism at New York University, to learn more.
Trends and Insights on Cybersecurity, Artificial Intelligence, and Quantum Computing
2026 — Trends and Insights on Cybersecurity, Artificial Intelligence, and Quantum Computing
By Chuck Brooks
Dear readers, Happy New Year! Please see the latest Security & Tech Insights newsletter that explores evolving tech and security trends for 2026. It is going to be an exciting year for AI, Quantum, Cybersecurity, Space and Robotics! Thanks, and best Chuck Brooks
What Every Company Needs To Know About Cybersecurity In 2026
THC Blood Limits Don’t Reliably Show Driving Impairment
After 48 hours of abstinence, 43% of 190 cannabis users still exceeded zero-tolerance THC limits, with 24% above 2 ng/mL and 5.3% above 5 ng/mL.
How does cannabis THC impact driver impairment and DUI laws? This is what a recent study published in Clinical Chemistry hopes to address as a team of researchers investigated current cannabis DUI laws and whether they are effective in identifying impaired drivers from cannabis use. This study has the potential to help researchers, law enforcement, medical professionals, and the public better understand cannabis DUI laws and whether they should be adjusted to accurately depict and identify impaired drivers.
For the study, the researchers analyzed data obtained from 190 cannabis users to evaluate baseline THC concentrations after 48 hours and whether they exceeded the current legal limits of THC concentrations. These limits include 2 or 5 ng/mL of THC in several states while some states have zero-tolerance policies. The participants were instructed to abstain from cannabis use for 48 hours to be evaluated for their THC levels. In the end, the researchers found that 43 percent of the participants exceeded zero-tolerance levels after 48 hours of abstaining from cannabis while 24 percent had baseline THC levels more that 2 ng/mL and 5.3 percent has greater than 5 ng/mL.
The study concluded, “More work needs to be done to address how to best identify drivers who are under the influence of cannabis and are unsafe to drive. A brief editorial highlights many of the challenges faced when developing a reliable test of cannabis impairment. At present, the best protocol is a combination of observations in the field and toxicology testing. We recognize that the current state of the art is lacking and have made recommendations on pathways for improvement. We feel that an essential component of improving highway safety is collaborations between law enforcement and the scientific community to develop standards that are unbiased and potentially lifesaving.”