Toggle light / dark theme

Get the latest international news and world events from around the world.

Log in for authorized contributors

Creating CAR-T Cells Using Current Alzheimer’s Antibodies

A team of researchers has biologically engineered T cells with currently available Alzheimer’s drugs in order to directly attack the characteristic amyloid plaques of Alzheimer’s disease.

Building on the current paradigm

Most Alzheimer’s treatments used in the clinic are-mabs, monoclonal antibodies that are designed to attack the amyloid beta plaques that accumulate in the brains of people with Alzheimer’s. However, while they have been found to have enough meaningful benefits in clinical trials to be approved by the FDA, they are not a cure, and some analyses question their effectiveness [1].

Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior

Lee and Hikosaka show how animals overcome challenges and ultimately achieve goals. They find that LHb and PAG neurons encode prediction errors and the continuity of reward expectancy, with tonic PAG activity sustaining reward expectancy despite prediction errors.

Organic molecule stores solar energy for years, then releases it as heat on demand

When the sun goes down, solar panels stop working. This is the fundamental hurdle of renewable energy: how to save the sun’s power for a rainy day—or a cold night. Chemists at UC Santa Barbara have developed a solution that doesn’t require bulky batteries or electrical grids. In a paper published in the journal Science, Associate Professor Grace Han and her team detail a new material that captures sunlight, stores it within chemical bonds and releases it as heat on demand.

The material, a modified organic molecule called pyrimidone, is the latest advancement in molecular solar thermal (MOST) energy storage.

“The concept is reusable and recyclable,” said Han Nguyen, a doctoral student in the Han Group and the paper’s lead author.

Graham Priest: Dialetheism & the Limits of Classical Logic

For 2,500 years, Western thought has treated contradiction as catastrophic.

From Aristotle’s law of non-contradiction to modern formal systems, logic has operated under one sacred assumption: a statement cannot be both true and false.

But what if that assumption is wrong?

In my latest Singularity. FM conversation, I sit down with Graham Priest — one of the world’s leading philosophers of logic and the foremost defender of *dialetheism* — the view that some contradictions are true.

We explore:

• Why the liar paradox still unsettles logicians • How paraconsistent logic blocks “explosion” • Whether classical logic is incomplete rather than universal • What Buddhist philosophy understood about contradiction centuries ago • And whether AI systems may require non-classical logics to model human reasoning.

Single gene found to influence gut bacteria balance and IBD susceptibility

Two recent studies from the University of California, Riverside, published in the same issue of Gut Microbes highlight the role of a gene called PTPN2 in protecting the gut from harmful bacteria linked to inflammatory bowel disease (IBD).

Led by Declan McCole, a professor of biomedical sciences in the School of Medicine, the studies show that when PTPN2 does not function properly, the gut becomes more vulnerable to infection and inflammation.

People with IBD often have higher levels of AIEC, a harmful type of E. coli bacteria. AIEC can attach to the gut lining, invade gut cells, damage the gut’s protective barrier, and worsen inflammation.

Origami-inspired ring lets users ‘feel’ virtual worlds

Virtual reality (VR) and augmented reality (AR) are technologies that allow users to immerse themselves in digital worlds or enhance their surroundings with computer-generated filters or images, respectively. Both these technologies are now widely used worldwide, whether to experience video games and media content in more engaging ways or improve specific training and assist professionals in their daily tasks.

To date, VR and AR have primarily focused on what users see and hear, primarily improving the quality of digital experiences from a visual and auditory standpoint. The sense of touch, on the other hand, has been in great part overlooked.

Researchers at Sungkyunkwan University, École Polytechnique Fédérale de Lausanne and Istanbul Technical University recently developed a new wearable device that could allow users to also realistically “feel” tactile sensations aligned with what they are experiencing in a virtual world. This device, introduced in a paper published in Nature Electronics, is an origami-inspired ring that measures forces on a user’s skin, pushing back onto the finger to produce specific sensations.

Why Time Doesn’t Exist | Leonard Susskind

We experience time as something that flows. Seconds pass. Moments disappear. The future becomes the present and then turns into the past.

But modern physics does not describe time this way.

In this video, we explore why time — as we intuitively understand it — may not exist at the fundamental level of reality.

Drawing on ideas associated with Leonard Susskind, this documentary examines how relativity and quantum physics challenge the idea of a flowing temporal river. Einstein’s theory removes the notion of a universal present. There is no global “now” that sweeps across the universe.

Without a universal present, the idea of time flowing becomes difficult to define physically.

In the relativistic picture, spacetime is a four-dimensional structure. Events are not created moment by moment. They are embedded in geometry. The equations of physics do not contain a moving present. They describe relations between events.

The Role of Lipids and Lipoproteins in Atherosclerosis

Activation of endothelial cells causes a monocyte recruitment cascade involving rolling, adhesion, activation and transendothelial migration (Figure 1). Selectins, especially P-selectin, mediate the initial rolling interaction of monocytes with the endothelium (32). Monocyte adherence is then promoted by endothelial cell immunoglobulin-G proteins including VCAM-1 and ICAM-1 (32). Potent chemoattractant factors such as MCP-1 and IL-8 then induce migration of monocytes into the subendothelial space (33-35). Ly6hi monocytes, versus Ly6lo, preferentially migrate into the subendothelial space to convert to proinflammatory macrophages in mice (36-38). The enhanced migration of Ly6hi versus Ly6lo monocytes likely results from increased expression of functional P-selectin glycoprotein ligand-1 (39). In addition, the number of blood monocytes originating from the bone marrow and spleen, especially Ly6hi cells, increases in response to hypercholesterolemia (36). Furthermore, hypercholesterolemia and atherosclerosis increase monocytosis in humans (40,41). Importantly, increased numbers of inflammatory CD14++ CD16+ monocytes independently predicted cardiovascular death, myocardial infarction, and stroke in patients undergoing elective coronary angiography (42). Intimal macrophages also result from proliferation of monocyte/macrophages, especially in more advanced lesions (43). During the initial fatty streak phase of atherosclerosis (Figure 1), the monocyte-derived macrophages internalize the retained apoB-containing lipoproteins, which are degraded in lysosomes, where excess free cholesterol is trafficked to the endoplasmic reticulum (ER) to be esterified by acyl CoA: cholesterol acyltransferase (ACAT), and the resulting cholesteryl ester (CE) is packaged into cytoplasmic lipid droplets, which are characteristic of foam cells (42) (Figure 2) (44,45). Modification of apoB lipoproteins via oxidation and glycation enhances their uptake through a number of receptors not down-regulated by cholesterol including CD36, scavenger receptor A, and lectin-like receptor family (see details below) (Figure 2) (46,47). Enzyme-mediated aggregation of apoB lipoproteins enhances uptake via phagocytosis (Figure 2) (48,49). In addition, native remnant lipoproteins can induce foam cell formation via a number of apoE receptors (LRP1 and VLDLR) (Figure 2) (50,51). Uptake of native LDL by fluid phase pinocytosis may also contribute to foam cell formation (Figure 2) (52,53).

Macrophage Cholesterol Metabolism. Native LDL is recognized by the LDL receptor (LDLR). The LDL is endocytosed and trafficked to lysosomes, where the cholesteryl ester (CE) is hydrolyzed to free cholesterol (FC) by the acid lipase. The FC is transported to the endoplasmic reticulum (ER) to be esterified by acyl CoA: cholesterol acyltransferase (ACAT). Increased FC in an ER regulatory pool initiates a signaling cascade resulting in down-regulation of the LDL receptor. Cholesterol regulation of the LDLR prevents foam cell formation via this receptor in the setting of hypercholesterolemia. ApoB containing lipoproteins that also contain apoE (apoE remnants, VLDL) can cause cholesterol accumulation via interaction of apoE with apoE receptors including the LRP1 and the VLDL receptor, which are not regulated by cellular cholesterol. Uptake of native LDL by fluid phase pinocytosis may also contribute to foam cell formation.

A double helix twist in HIV vaccine design

In a new Science study, researchers demonstrate that DNA origami can be used to display HIV protein antigens. When given to mice, these nanoparticles elicited antibody responses that may pave the way for broadly protective immunity against infection.

This approach could lead to more effective HIV vaccines. Learn more in a new Science Perspective.


DNA origami scaffolds displaying HIV antigens stimulate focused antibody responses in mice.

Oliver Bannard and Mark R. Howarth Authors Info & Affiliations

Science

Vol 391, Issue 6785

/* */