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Category: neuroscience

New genetic toolkit enables genome-wide analysis

Researchers at Cornell University have developed a powerful new genetic toolkit that allows scientists to study how genes function at the level of individual cells, an advance that could accelerate discoveries in development, neuroscience and disease.

The system builds on MAGIC (Mosaic Analysis by gRNA-Induced Crossing-over), a method originally created by the labs of Chun Han, associate professor in the Department of Molecular Biology and Genetics in the College of Agriculture and Life Sciences (CALS) and the Weill Institute for Cell and Molecular Biology. MAGIC uses CRISPR gene editing to generate individual mutant cells within otherwise normal tissue, enabling precise comparisons within a living organism.

In the new study, graduate researcher Yifan Shen expanded the approach into a genome-wide toolkit for Drosophila melanogaster, creating resources that work across all chromosomes and allow researchers to study genes that were previously difficult, or impossible, to analyze at single-cell resolution.

Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

Cellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, senescent cell-based phenotypic screen of a small panel of natural products, we identified tomatidine, an aglycone of tomatine found in tomatoes, as a previously unrecognized senotherapeutic agent. In senescent human brain microvascular endothelial cells and fibroblasts, tomatidine selectively suppressed SASP expression without affecting p16Ink4a or p21Cip1 levels consistent with a senomorphic effect. In aged mice, tomatidine reduced frailty and improved motor coordination and cognitive performance. These functional benefits were accompanied by reduced senescence markers (p16 Ink4a, p21 Cip1, and telomere-associated DNA damage foci) in liver, skin, and hippocampal neurons, along with decreased neuroinflammation and microglial activation. Tomatidine also diminished brain endothelial cell senescence while enhancing tight junction protein expression, suggesting preserved blood–brain barrier integrity. Together, these findings identify tomatidine as a promising senescence-targeting compound with beneficial effects in aged mice and support its further evaluation in mechanistic and translational studies.

Brain scans reveal how a woman voluntarily enters a psychedelic-like trance without drugs

A groundbreaking fMRI study has mapped the exact neural shifts of a self-induced visionary state. Researchers discovered that a woman capable of voluntary trance actively disconnects her sensory networks while boosting internal cognitive control.

New ‘Unifying Theory’ May Explain How Alzheimer’s Emerges in The Brain

The origins of Alzheimer’s remain contentious, but a new study suggests the disease may emerge as two key proteins compete inside brain cells.

Alzheimer’s disease, the most common form of dementia, has long been associated with the build-up of two proteins in the brain: amyloid-beta and tau.

This new study ties those two together, offering a “unifying theory” that, according to the team of chemists proposing it, resolves some conflicting ideas about Alzheimer’s.

How the human brain builds our sense of time

How does Jannik Sinner manage to hit the ball at exactly the right moment, with remarkable precision? And how do we, in everyday life, perceive the duration of events around us? The answer lies in how the brain constructs the perception of time, as shown by research published in PLOS Biology by Valeria Centanino, Gianfranco Fortunato, and Domenica Bueti. Starting from what we see—such as an approaching ball—temporal information is processed by the brain through progressively more complex stages: from the occipital visual cortex, to parietal and premotor areas, and finally to frontal regions.

Using high-field functional magnetic resonance imaging (fMRI) and measuring time perception in healthy volunteers, the researchers shed light on what happens in the brain when we estimate the duration of a visual stimulus. “Our results show that time perception is not a unitary process, but the outcome of multiple processing stages distributed across the cerebral cortex,” the authors explain. “Each stage contributes differently, from encoding physical duration to constructing the subjective experience of time.”

In an initial stage, occipital visual areas encode duration through gradual (monotonic) neural responses: the longer the stimulus, the stronger the neural response. This information is then transformed in parietal and premotor regions into selective (unimodal) representations, where distinct neural populations respond preferentially to specific durations, enabling the “readout” of time. Finally, higher-order regions, including the frontal cortex and anterior insula, are involved in the subjective categorization of duration, shaping how time is perceived.

Abstract: Genetic analysis of neurodegenerative diseases:

As part of the JCI’s Review Series on Neurodegeneration, Sonja W. Scholz and colleagues highlight key genomic technologies advancing diagnosis and research in neurodegeneration.

1Neurodegenerative Diseases Research Section, National Institute of Neurological Disorders and Stroke;

2Neurogenetics Branch, National Institute of Neurological Disorders and Stroke; and.

3Neuromuscular Diseases Research Section, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland, USA.

How beliefs about demons shape the experience of mental illness

For some evangelical Christians, attributing mental illness to demonic forces can offer a sense of meaning, while for others, it creates harmful barriers to medical care. A recent qualitative study published in Spirituality in Clinical Practice outlines how these widespread spiritual explanations act as a double-edged sword for individuals experiencing psychological distress. The research indicates that integrating religious beliefs with standard psychiatric care may be a safer path forward for many faith communities.

Religion frequently shapes how people interpret their physical and mental health. Psychologists recognize that religious frameworks offer a primary system for individuals to make sense of the world around them. By relying on theological teachings, people construct meaning around their personal suffering. This process of religious meaning construction can influence health outcomes in both positive and negative directions.

Within evangelical Christianity, foundational teachings often emphasize the active existence of spiritual forces. This includes the belief that angels, demons, and other supernatural entities directly influence the physical world. This worldview can lead to the belief that spiritual forces cause human ailments, including severe psychological distress.

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