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Archive for the ‘DNA’ category

Jun 17, 2018

Harvard Rewinds the Biological Clock of Time

Posted by in categories: bioengineering, biological, DNA, health, life extension, science, transhumanism

Investigators at Harvard Medical School have identified the key cellular mechanisms behind vascular aging and its effects on muscle health, and they have successfully reversed the process in animals.

The scientists used a chemical compound that’s an NAD+ booster called NMN which plays a critical role in repairing cellular DNA as well as maintaining cell vitality to test what would happen.

Could reversing the aging of blood vessels hold the key to restoring youthful vitality? If the old adage “you are as old as your arteries” reigns true then the answer is yes, at least in mice.

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Jun 11, 2018

Bioquark Inc. — “Living Forever” — Future Sandwich Podcast — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, cryonics, DNA, futurism, genetics, health, life extension, Peter Diamandis

Jun 9, 2018

Human Skeletal Muscle Aging and Mutagenesis

Posted by in categories: aging, DNA, genetics, health, life extension

Study based upon human skeletal muscle aging, mutagenesis, and the role of #satellite cells.

“A more comprehensive understanding of the interplay of stem cell–intrinsic and extrinsic factors will set the stage for improving cell therapies capable of restoring tissue homeostasis and enhancing muscle repair in the aged.”

Human aging has multiple effects on the human body. One of the effects of human aging is the reduction in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident stem cells. The whole genome of single SC clones of the leg muscle vastus lateralis from healthy individuals of different ages (21–78 years) was analyzed, to study the specific connection between SC aging and muscle impairment. In healthy adult muscle rapid increase of SCs is consistent with the accumulation rate of 13 somatic mutations per genome per year. Mutations typically do not happen in SkM-expressed genes because they are protected. However, as mutations in exons and promoters increase, genes involved in SC activity and muscle function are targeted which results in aging. Exons are coding sections of an RNA transcript, or the DNA encoding it, that are translated into protein. Proteins are the synthesis of molecules. A change in of a single base pair that caused the substitution of a different amino acid in the resulting protein (missense mutation) that was propagated to the muscle and detected in association with SC mutations affecting the whole tissue. #Somatic mutagenesis in SCs as a result is the driving force in the age related decline of SkM function.

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Jun 5, 2018

Can You Actually Hack Your DNA to Slow Down Aging? — Bioquark Inc. — Ira Pastor

Posted by in categories: aging, biotech/medical, DNA, genetics, health, innovation, life extension, neuroscience, science, transhumanism

http://www.thepathmag.com/can-you-actually-hack-your-dna-to-slow-down-aging/

Many technologies / interventions progressing down the development pathways in the coming years — but there are a lot of free, common sense adjustments you can make today:

Jun 5, 2018

Bioquark Inc. — Healthy Relationship Talk Radio — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, cryonics, disruptive technology, DNA, futurism, genetics, health, life extension

https://player.fm/series/healthy-relationship-talk-radio/cel…1-2018

Jun 5, 2018

Bioquark Inc. — Free Your Mind Podcast — Ira Pastor

Posted by in categories: aging, biotech/medical, business, DNA, education, finance, futurism, health, life extension, neuroscience

http://www.blogtalkradio.com/entrepreneursempower/2018/06/03…ira-pastor

May 22, 2018

Bioquark Inc. — Enterprise NOW! Podcast — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, business, disruptive technology, DNA, economics, finance, futurism, genetics

https://enterprise-now.biz/podcast/blog/ep-96-mother-nature-…ira-pastor

May 17, 2018

Selfish Ledger: Google’s mass sociology experiment

Posted by in categories: big data, complex systems, DNA, ethics, evolution, genetics, information science, internet, surveillance

Check out the internal Google film, “The Selfish Ledger”. This probably wasn’t meant to slip onto a public web server, and so I have embedded a backup copy below. Ping me if it disappears. I will locate a permanent URL.

This 8½ minute video is a lot deeper—and possibly more insipid—than it appears. Nick Foster may be the Anti-Christ, or perhaps the most brilliant sociologist of modern times. It depends on your vantage point, and your belief in the potential of user controls and cat-in-bag containment.

He talks of a species propelling itself toward “desirable goals” by cataloging, data mining, and analyzing the past behavior of peers and ancestors—and then using that data to improve the experience of each user’s future and perhaps even their future generations. But, is he referring to shared goals across cultures, sexes and incomes? Who controls the algorithms and the goal filters?! Is Google the judge, arbiter and God?

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May 15, 2018

Bioquark Inc. — HumanOS Podcast — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, cryonics, disruptive technology, DNA, genetics, health, life extension, science

https://www.youtube.com/watch?v=qNSxkxyVptw

May 8, 2018

Bioquark Inc. — Parents Are Hard To Raise Podcast — Ira Pastor

Posted by in categories: aging, bioengineering, biological, biotech/medical, DNA, futurism, health, life extension, neuroscience, science
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