The idea of self-amplifying gene editing is to get cells to pass on packages of CRISPR machinery to their neighbours, boosting the effect
Category: bioengineering
Using synthetic biology and AI to address global antimicrobial resistance threat
James J. Collins, the Termeer Professor of Medical Engineering and Science at MIT and faculty co-lead of the Abdul Latif Jameel Clinic for Machine Learning in Health, is embarking on a multidisciplinary research project that applies synthetic biology and generative artificial intelligence to the growing global threat of antimicrobial resistance (AMR).
The research project is sponsored by Jameel Research, part of the Abdul Latif Jameel International network. The initial three-year, $3 million research project in MIT’s Department of Biological Engineering and Institute of Medical Engineering and Science focuses on developing and validating programmable antibacterials against key pathogens.
AMR — driven by the overuse and misuse of antibiotics — has accelerated the rise of drug-resistant infections, while the development of new antibacterial tools has slowed. The impact is felt worldwide, especially in low-and middle-income countries, where limited diagnostic infrastructure causes delays or ineffective treatment.
Rocket science? 3D printing soft matter in zero gravity
What happens to soft matter when gravity disappears? To answer this, UvA physicists launched a fluid dynamics experiment on a sounding rocket. The suborbital rocket reached an altitude of 267 km before falling back to Earth, providing six minutes of weightlessness.
In these six minutes, the researchers 3D-printed large droplets of a soft material similar to the inks used for bioprinting —a developing technology that shows huge potential for regenerative and personalized medicine, tissue engineering and cosmetics. Bioprinting involves 3D-printing a mix of cells and bio-inks or bio-materials in a desired shape, often to construct living tissues.
The experiment was called COLORS (COmplex fluids in LOw gravity: directly observing Residual Stresses). Using a special optical set-up, the researchers could see where the printed material experienced internal stresses (forces) as the droplets spread and merged. Stressed regions stand out as bright colors in the experiment. Investigating how and where these stresses emerge is important because they can get frozen in a material as it solidifies, creating weak points where 3D-printed objects are most likely to break.
Why the Future of Intelligence Is Already Here | Alex Wissner-Gross | TEDxBoston
The future of intelligence is rapidly evolving with AI advancements, poised to transform numerous aspects of life, work, and existence, with exponential growth and sweeping changes expected in the near future.
## Questions to inspire discussion.
Strategic Investment & Career Focus.
🎯 Q: Which companies should I prioritize for investment or career opportunities in the AI era?
A: Focus on companies with the strongest AI models and those advancing energy abundance, as these will have the largest marginal impact on enabling the innermost loop of robots building fabs, chips, and AI data centers to accelerate exponentially.
Understanding Market Dynamics.
Future Humans: The Coming Diversity of Engineered Bodies and Synthetic Minds
For the first time in Earth’s history, one species can rewrite its own genome, rebuild its own brain, and design entirely new forms of intelligence. That combination makes Homo sapiens look less like evolution’s end point and more like a transitional form: an ancestral species whose descendants may be biological, mechanical, or something in between. The way future humans remember us may depend on how seriously our generation takes its role as the first conscious ancestor.
Imagine a descendant civilization, thousands or millions of years from now, trying to reconstruct its origins. Its members might not have bones or blood. They might be born in free-fall habitats orbiting other stars, or instantiated as software in computational substrates that current engineers can barely imagine. Their analysts would comb through archives from a small blue planet called Earth and conclude that the strange, warlike primates who built the first rockets and the first neural networks were not the culmination of evolution, but an ancestral phase.
That premise — the idea that present-day humans are an ancestral species for future humans and other intelligent beings — is beginning to migrate from science fiction into serious scientific and philosophical discussion. Advances in gene editing, synthetic biology, space medicine, brain–computer interfaces and artificial intelligence all point toward a future in which “intelligent beings” no longer form a single species, or even share a single kind of body. The more that picture comes into focus, the more it forces a rethinking of what “being human” means.
Why the next 25 years could surpass anything in modern memory | Peter Leyden: Full Interview
Become a Big Think member to unlock expert classes, premium print issues, exclusive events and more: https://bigthink.com/membership/?utm_…
“Old systems of the past are collapsing, and new systems of the future are still to be born. I call this moment the great progression.”
Up next, We are living through a slowdown in human progress | Jason Crawford ► • We are living through a slowdown in human…
We are at a tipping point. In the next 25 years, technologies like AI, clean energy, and bioengineering are poised to reshape society on a scale few can imagine.
Peter Leyden draws on decades of observing technological revolutions and historical patterns to show how old systems collapse, new ones rise, and humanity faces both extraordinary risk and unprecedented opportunity.
0:00 We’re on the cusp of an era of progress.
Brave New Biology: Intelligence Trumps DNA — with Dr. Michael Levin and Dr. John Vervaeke
Dr. Michael Levin is a professor in the Department of Biology at Tufts University and an associate faculty member at the Wyss Institute at Harvard. He directs the Allen Discovery Center at Tufts, where his team integrates biophysics, computational modeling, and behavioral science to study how cellular collectives make decisions during embryogenesis, regeneration, and cancer.
Levin’s research centers on diverse forms of intelligence and unconventional embodied minds, bridging conceptual theory, experimental biology, and translational work aimed at regenerative medicine. His lab also pioneers efforts in artificial intelligence and the bioengineering of novel living machines.
Read more about Dr. Michael Levin’s work: https://drmichaellevin.org/
X: https://twitter.com/drmichaellevin.
YouTube: @drmichaellevin
John Vervaeke’s YouTube channel: @johnvervaeke
📖 Let’s take our stories back. Check out our latest book in the Tales for Now and Ever series, Rapunzel and the Evil Witch: https://rapunzelbook.com/
Join Fr. Stephen De Young in his Jubilees and the Nephilim course, now streaming live on The Symbolic World: https://www.thesymbolicworld.com/cour… 00:00 — Coming up 01:14 — Intro music 01:40 — Introduction 02:23 — What Michael does 06:19 — Example experiments 07:51 — Memories outside the brain 12:46 — Terminology: memory 13:59 — Communicate to biological cells 15:54 — Limitations? 17:39 — Platonic patterns 34:06 — Incarnation and constraints 39:26 — Causes 49:28 — New beings in new spaces 52:25 — What the Enlightenment dismissed 55:32 — Molecular medicine 57:36 — Subtle bodies 01:00:45 — Ethics 01:03:37 — Medical and meaning applications 01:11:42 — Frightening 01:14:31 — Against the status quo 01:19:03 — Should we dabble in this technology? 💻 Website and blog: http://www.thesymbolicworld.com 🔗 Linktree: https://linktr.ee/jonathanpageau 🔒 BECOME A PATRON: https://thesymbolicworld.com/subscribe Our website designers: https://www.resonancehq.io/ My intro was arranged and recorded by Matthew Wilkinson: https://matthewwilkinson.net/
Michael Levin: Novel Embodiments of Mind: Natural, Bioengineered, and Hybrid Interfaces
This is an invited talk in BAMΞ’s Mathematical Phenomenology Sprint.
Cf. https://bamxi.org/research-activities/mathematical-phenomenology-sprint/
Organizing Institutions:
Bamberg Mathematical Consciousness Science Initiative (BAMΞ) https://bamxi.org.
& Association for Mathematical Consciousness Science (AMCS) https://amcs-community.org
Bioengineers build branched, perfusable kidney collecting ducts using 3D bioprinting
The human kidney filters about a cup of blood every minute, removing waste, excess fluid, and toxins from it, while also regulating blood pressure, balancing important electrolytes, activating Vitamin D, and helping the body produce red blood cells. This broad range of functions is achieved in part via the kidney’s complex organization. In its outer region, more than a million microscopic units, known as nephrons, filter blood, reabsorb necessary nutrients, and secrete waste in the form of urine.
To direct urine produced by this enormous number of blood-filtering units to a single ureter, the kidney establishes a highly branched three-dimensional, tree-like system of “collecting ducts” during its development. In addition to directing urine flow to the ureter and ultimately out of the kidney, collecting ducts reabsorb water that the body needs to retain, and maintain, the body’s balance of salts and acidity at healthy levels.
Finding ways to recreate this system of collecting ducts is the focus of researchers and bioengineers who are interested in understanding how duct defects cause certain kidney diseases, underdeveloped kidneys, or even the complete absence of a kidney. Being able to fabricate the kidney’s plumbing system from the bottom up would be a giant step toward tissue replacement therapies for many patients waiting for a kidney donation: In the U.S. alone, 90,000 patients are on the kidney transplant waiting list. However, rebuilding this highly branched fluid-transporting ductal system is a formidable challenge and not possible yet.
