Getting older might seem like a slow, gradual process – but research suggests that this is not always the case.
In fact, if you wake up one morning, look in the mirror, and wonder if your aging somehow accelerated, you might not be imagining things.
According to a 2024 study into the molecular changes associated with aging, humans experience two abrupt lurches forward, one at the average age of 44 and the other at around age 60.
A new spin on robotics, thanks to a novel 3D printing method
At the entrance to Starbase in south Texas, a glowing sign now welcomes visitors with the words “Gateway to Mars.” The display sits in front of SpaceX facilities where giant Starship rockets are being assembled with one bold purpose in mind: Elon Musk wants to build a self-sustaining city on Mars.
In recent years he has begun to put numbers on that dream. Musk has repeatedly said that building the first sustainable city on Mars would require around 1,000 Starship rockets and roughly 20 years of launch campaigns, moving up to 100,000 people per favorable Earth-Mars alignment and eventually reaching about one million settlers plus millions of tons of cargo.
It sounds like science fiction with a project plan. Yet the language he uses, “sustainable city,” is very familiar to climate and energy experts here on Earth. So what does sustainability really mean on a frozen, air-thin world and how does that huge effort interact with the environmental crisis on our own planet?
Neuromorphic computers modeled after the human brain can now solve the complex equations behind physics simulations — something once thought possible only with energy-hungry supercomputers. The breakthrough could lead to powerful, low-energy supercomputers while revealing new secrets about how our brains process information.
Meta-analysis of 115 studies evaluating cognitive function in people with Schizophrenia confirms that processing speed, especially as measured by symbol coding tasks, remains among the most impaired cognitive domains compared to controls.
This impairment was reliably more severe than that observed in most other tested cognitive domains, suggesting processing speed may be central to broader cognitive deficits in this population and may relate to altered brain connectivity.
This meta-analysis provides an updated review of the evidence for a central processing speed impairment in people with schizophrenia.
It’s mucus season—the time of year this sticky goo makes an appearance in the form of runny noses and phlegmy coughs. While most people are only aware of mucus when they are sick, their organs are blanketed with the stuff year-round. And, when it comes to the microbes living in our bodies, mucus is incredibly important. It provides a spatial and nutritional niche for diverse organisms to thrive, while also preventing them from getting too close to host tissues. Mucus also regulates microbial growth, metabolism and virulence, ultimately controlling the composition of microbial communities throughout the body. As such, scientists are looking at how to exploit mucus-microbe interactions to foster human health.
Mucus is found in creatures spanning the tree of life, from corals to people. In humans and other mammals, the slick goop coats epithelial tissues, including those in the mouth, lungs, gut and urogenital tract. In these regions, mucus protects cells from physical and enzymatic stress, heals wounds and selectively filters particles that can pass through to underlying tissues.
CGAS forms condensates on cytosolic double-stranded (ds)DNA and initiates inflammatory responses. Lueck et al. find that, although cGAS forms condensates on various nucleic acids, it enters a hydrogel-like state only with dsDNA via dimerization. The gel-like cGAS condensate not only protects bound dsDNA from exonucleases but also facilitates catalysis.
Weight loss is a well-recognized but poorly understood non-motor feature of Parkinson’s disease (PD). Many patients progressively lose weight as the disease advances, often alongside worsening motor symptoms and quality of life. Until now, it was unclear whether this reflected muscle loss, poor nutrition, or deeper metabolic changes. New research shows that PD-related weight loss is driven mainly by a selective loss of body fat, while muscle mass is largely preserved, and is accompanied by a fundamental shift in how the body produces energy.
Although PD is classically viewed as a neurological disorder, increasing evidence points to widespread metabolic dysfunction. Patients often experience fatigue and nutritional decline, yet dietary advice has largely focused on boosting calories. The new findings challenge this conventional view, showing that weight loss in PD reflects a failure of the body’s standard energy-producing pathways rather than reduced food intake alone. The findings are published in the Journal of Neurology, Neurosurgery & Psychiatry.
The study was led by Professor Hirohisa Watanabe from the Department of Neurology at Fujita Health University, School of Medicine, Japan, along with Dr. Atsuhiro Higashi and Dr. Yasuaki Mizutani from Fujita Health University. The team aimed to clarify what exactly is lost when patients with PD lose weight and why the body is forced to change its energy strategy.