Multicellularity is one of the most profound phenomena in biology, and relies on the ability of a single cell to reorganize itself into a complex organism. It underpins the diversity in the animal kingdom, from insects to frogs, to humans. But how do cells establish and maintain their individuality with such precision? A team led by Jan Brugués at the Cluster of Excellence Physics of Life (PoL) at TUD Dresden University of Technology has uncovered fundamental mechanisms that shed light on this question.
The findings, published in Nature, reveal how cells establish physical boundaries through an inherently unstable process, and how different species have evolved distinct strategies to circumvent this process.
During early development, embryos divide rapidly and with remarkable precision, while reorganizing into many individual units. This requires the cell material (known as cytoplasm) to be partitioned into compartments in a highly orchestrated manner.








