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Molecular difference in autistic brains may explain signaling imbalance

Yale School of Medicine (YSM) scientists have discovered a molecular difference in the brains of autistic people compared to their neurotypical counterparts.

Autism is a neurodevelopmental condition associated with behavioral differences including difficulties with social interaction, restrictive or intense interests, and repetitive movements or speech. But it’s not clear what makes autistic brains different.

Now, a study in the American Journal of Psychiatry has found that the brains of autistic people have fewer of a specific kind of receptor for glutamate, the most common excitatory neurotransmitter in the brain. The reduced availability of these receptors may be associated with various characteristics linked to autism.

AI-powered knowledge graph links heart images to genes and drug predictions

Knowledge graphs are a powerful tool for bringing together information from biological databases and linking what is already known about genes, diseases, treatments, molecular pathways and symptoms in a structured network. Until now, they have lacked detailed, individual-level information about how the affected organ actually looks and functions.

The latest research, led by postdoctoral researcher Dr. Khaled Rjoob and group leader Professor Declan O’Regan from the Computational Cardiac Imaging Group at the MRC Laboratory of Medical Sciences, has advanced this technology by adding imaging data to a knowledge graph for the first time. CardioKG provides a detailed view of the heart’s structure and function which dramatically improves the accuracy of predicting which genes are linked to disease and whether existing drugs could treat them.

The work is published in the journal Nature Cardiovascular Research.

Stiffer colon could signal risk of early-onset colorectal cancer

Increased stiffness of the colon, spurred by chronic inflammation, may encourage the development and progression of early-onset colorectal cancer (CRC), a study co-led by UT Southwestern Medical Center researchers suggests. The findings, published in Advanced Science, could lead to new ways to prevent and treat this deadly subset of CRC.

“We consider this study a significant advancement toward identifying those at risk of early-onset CRC and finding new ways to treat them,” said Emina Huang, M.D., M.B.A., Professor of Surgery in the Division of Colon and Rectal Surgery and Executive Vice Chair of Research for Surgery at UT Southwestern. She is also Professor of Biomedical Engineering and in the Harold C. Simmons Comprehensive Cancer Center.

UT Southwestern partnered with researchers from The University of Texas at Dallas on the study.

Physicists & Philosophers debunk The Fine Tuning Argument

The Fine-Tuning Argument is often seen as the best argument for the existence of God. Here we have assembled some of the world’s top physicists and philosophers to offer a reply. Not every critic of the argument comes from the same perspective. Some doubt there is a problem to be solved whilst others agree it is a genuine problem but think there are better solutions than the God hypothesis. Some like the multiverse and anthropics other don’t. We have tried to represent these different approaches and so it should be taken as given, that not all of the talking heads agree with each other. Nevertheless, they all share the view that the fine-tuning argument for God does not work. Nor are all the objectors atheist, Hans Halvorson offers what we think is a strong theological objection to the argument. This film does not try to argue that God doesn’t exist only that the fine-tuning argument is not a good reason to believe in God. Most of the footage was filmed exclusively for this film with some clips being re-used from our Before the Big Bang series, which can be viewed here: • Before the Big Bang 5: The No Boundary Pro… All of the critics of the fine tuning argument that appear were sent a draft of the film more than a month before release and asked for any objections either to their appearance, the narration or any other aspect of the film. No objections were raised, and many replies were extremely positive and encouraging. A timeline of the subjects covered is below:
(We define God as a perfect Omni immaterial mind as for example modern Christians and Muslims advocate, there are other conceptions of God which our video does not address).
Just to be clear, this is a polemical film arguing against the fine tuning argument.

Timecodes.

0:00 Introduction.
4:11 The universe as a roll of the dice.
6:15 what is probability?
7:28 probability problems.
9:25 measure problem.
15:45 deceptive probabilities.
20:23 the flatness problem.
22:14 counterfactuals versus probabilities.
23:59 fine tuning versus God.
37:02 necessity.
38:53 multiverse and anthropics.
47:34 Boltzmann brains.
49:45 Entropy.
52:45 Cosmological Natural Selection.
59:10 conclusion.

Variations of Severely Reduced Myocardial Flow Reserve in PET Myocardial Perfusion Imaging

Severely reduced myocardial flow reserve in cardiac positron emission tomography is a diagnostic challenge. 🫀☢️ This JACCIMG iPIX lays out the full differential—from 3-vessel coronary artery disease to artifacts—to spot the patterns, avoid the pitfalls, and not miss the diagnosis.

The Journal of the American College of Cardiology (JACC) stands as a leading global resource for impactful cardiovascular research, delivering essential peer-reviewed articles and crucial clinical practice guidelines. Gain access to authoritative medical content and vital CME resources designed to advance cardiovascular medicine and improve heart patient outcomes.

Brain immune cells may drive more damage in females than males with Alzheimer’s

More than 7 million Americans have Alzheimer’s disease, and two-thirds of them are women, according to the Alzheimer’s Association. The O’Banion Lab at the Del Monte Institute for Neuroscience at the University of Rochester has long been studying this disease and is looking more closely at the differences between male and female brains.

“It is well documented that males and females are diagnosed with Alzheimer’s disease at different rates,” said M. Kerry O’Banion, MD, Ph.D., professor of Neuroscience and Neurology. “But we still do not have a great understanding of why this is the case. We can only improve any possible treatment or prevention of this disease if we know the why, when, and where these differences are occurring.”

Bird feeders have caused a dramatic evolution of California hummingbirds

Evolution doesn’t always take thousands or millions of years. Sometimes it happens right before our eyes.

Such is the case with the Anna’s hummingbird, a species that has undergone a dramatic transformation in just a few generations, all thanks to the advent of hummingbird feeders.

Beaks have grown longer and larger, and ranges have expanded to follow the feeders.

Antibiotic resistance forecast to kill 39 million people by 2050

According to the most comprehensive study to date, the global death toll from antibiotic resistance is expected to reach 1.9 million people annually by 2050.

Read this great article at.

The number of people worldwide directly killed by antibiotic resistance will rise to 1.9 million a year by 2050, according to the most comprehensive study so far.

By Michael Le Page

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