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The Singularity: Everyone’s Certain. Everyone’s Guessing

The Technological Singularity is the most overconfident idea in modern futurism: a prediction about the point where prediction breaks. It’s pitched like a destination, argued like a religion, funded like an arms race, and narrated like a movie trailer — yet the closer the conversation gets to specifics, the more it reveals something awkward and human. Almost nobody is actually arguing about “the Singularity.” They’re arguing about which future deserves fear, which future deserves faith, and who gets to steer the curve when it stops looking like a curve and starts looking like a cliff.

The Singularity begins as a definitional hack: a word borrowed from physics to describe a future boundary condition — an “event horizon” where ordinary forecasting fails. I. J. Good — British mathematician and early AI theorist — framed the mechanism as an “intelligence explosion,” where smarter systems build smarter systems and the loop feeds on itself. Vernor Vinge — computer scientist and science-fiction author — popularized the metaphor that, after superhuman intelligence, the world becomes as unreadable to humans as the post-ice age would have been to a trilobite.

In my podcast interviews, the key move is that “Singularity” isn’t one claim — it’s a bundle. Gennady Stolyarov II — transhumanist writer and philosopher — rejects the cartoon version: “It’s not going to be this sharp delineation between humans and AI that leads to this intelligence explosion.” In his framing, it’s less “humans versus machines” than a long, messy braid of tools, augmentation, and institutions catching up to their own inventions.

Genflow reports positive interim data from SIRT6 gene therapy trial in aged dogs

First dogs, then …


Biotechnology group says treated animals showed improved survival and functional measures in early-stage study

Genflow Biosciences Ltd (LSE: GENF, OTCQB: GENFF, FRA: WQ5) said positive preliminary interim results from its SLAB clinical trial showed improved survival and functional outcomes in aged dogs treated with its proprietary SIRT6 centenarian gene therapy.

The biotechnology company, which focuses on developing gene therapies for age-related diseases, said the randomised, blinded study enrolled 24 beagle dogs aged over 10 years and was conducted by an independent contract research organisation.

Cannabis Access Tied to Big Drop in Daily Opioid Use

Greater access to legal cannabis is associated with a significant drop in daily opioid use, suggesting that cannabis availability may reduce reliance on opioids for pain or other use.


How can cannabis legalization influence opioid use? This is what a recent study published in Drug and Alcohol Dependence hopes to address as a team of researchers investigated behavior connections between cannabis use and opioid use. This study has the potential to help scientists, medical professionals, legislators, and the public better understand the benefits of cannabis, including how it can help the opioid epidemic.

For the study, the researchers analyzed survey data collected from 28,069 individuals designated as people who inject drugs (PWID) during 2012, 2015, 2018, and 2022 across 13 states. The goal of the study was to compare medical cannabis and medical plus recreational cannabis use to opioid use. The respondents were asked to report their past 30-day use for both cannabis and opioids. In the end, the researchers found that users who subscribed to both medical plus recreational cannabis use compared to just medical cannabis use experienced a 9–11 percent decline in opioid use.

The study notes in its conclusions, “Cannabis legalization may shape daily opioid consumption among PWID, potentially reducing drug-related harms. Differences in cannabis use following legalization may reflect disparate impact by race, due to structural racism or other factors. Future research examining whether policy attributable changes in substance use manifest health benefits among PWID is critical to developing evidence-based cannabis reform.”

Scientists Discover a Brain Circuit That Enhances Physical Endurance In Mice

The effects of exercise would not be nearly as powerful without the input of the brain, according to new research.

A study on mice has found a critical signal in the central nervous system that helps build physical endurance in the wider body after repeated exercise.

Traditionally, scientists thought that our body’s extensive response to frequent exercise occurred mainly in the periphery, such as the bones and muscles, and the heart.

Brett Adcock: Humanoids Run on Neural Net, Autonomous Manufacturing, and $50 Trillion Market #229

Humanoid robots with full-body autonomy are rapidly advancing and are expected to create a $50 trillion market, transforming industries, economy, and daily life ## ## Questions to inspire discussion.

Neural Network Architecture & Control.

🤖 Q: How does Figure 3’s neural network control differ from traditional robotics? A: Figure 3 uses end-to-end neural networks for full-body control, manipulation, and room-scale planning, replacing the previous C++-based control stack entirely, with System Zero being a fully learned reinforcement learning controller running with no code on the robot.

🎯 Q: What enables Figure 3’s high-frequency motor control for complex tasks? A: Palm cameras and onboard inference enable high-frequency torque control of 40+ motors for complex bimanual tasks, replanning, and error recovery in dynamic environments, representing a significant improvement over previous models.

🔄 Q: How does Figure’s data-driven approach create competitive advantage? A: Data accumulation and neural net retraining provides competitive advantage over traditional C++ code, allowing rapid iteration and improvement, with positive transfer observed as diverse knowledge enables emergent generalization with larger pre-training datasets.

🧠 Q: Where is the robot’s compute located and why? A: The brain-like compute unit is in the head for sensors and heat dissipation, while the torso contains the majority of onboard computation, with potential for latex or silicone face for human-like interaction.

Scientific Notation Explained | Large & Small Numbers + Practice Questions

Scientific notation is a system developed to represent extremely large and extremely small numbers in a way that is easy to read, write, and understand. In chemistry and physics, many values such as the mass of an electron are too large or too small to be written conveniently in standard notation.

In this video, you will learn:

What scientific notation is and why it is used.
How to write numbers in the form a × 10ⁿ, where a is between 1 and 10
How to convert large numbers into scientific notation.
How to convert small numbers into scientific notation.

The LARS rule:
Left → Add to the exponent.
Right → Subtract from the exponent.

We also discuss how the direction of decimal movement affects the exponent and why the same rules apply to both very large and very small numbers.

📌 At the end of the video, you’ll find practice multiple-choice questions (MCQs) to test your understanding, including a real-life chemistry example involving the mass of an electron.

The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity

What are the genetic origins of early-onset obesity?

Studying a cohort of young adults in China, researchers in Science TranslationalMedicine performed deep sequencing and identified a loss-of-function variant in the gene TUB that impairs sensitivity to leptin.


Rare human TUB variants impair leptin sensitivity through disruption of STAT3 activation, leading to hyperphagic obesity.

Why Gentry Lee Became the Most Important Figure in Space Exploration You’ve Never Heard Of: STARMAN

There are documentaries about history, and then there are documentaries about the people who were quietly in the room when history happened.

STARMAN, the new film from Academy Award–nominated director Robert Stone, belongs firmly in the latter category. It chronicles the life of Gentry Lee—NASA scientist, mission architect, science communicator, and one of those rare figures whose career seems to map directly onto the modern Space Age.

If the Space Age began in 1957 with the launch of Sputnik, then Gentry Lee—born in 1942—has lived his entire adult life shaped by humanity’s reach beyond Earth. More than a witness to that history, Lee has been in the room for many of its defining moments.

As a senior scientist at NASA’s Jet Propulsion Laboratory, Lee served as Director of Science Analysis and Mission Planning for the Viking mission to Mars and the Galileo probe to Jupiter, missions that transformed our understanding of the solar system. Alongside this work, he collaborated with Carl Sagan on PBS’s landmark series COSMOS, narrated Discovery Channel’s ARE WE ALONE?, and co-authored four novels with legendary science fiction writer Arthur C. Clarke.

A Zelig-like figure at the crossroads of interplanetary science and science fiction, Gentry Lee has been everywhere—and worked with everyone—who helped define how we imagine space.

Now the subject of STARMAN, Lee guides us through a lifetime of curiosity, wonder, and exploration. The film is both entertaining and illuminating—and our conversation with him reflects that same spirit.

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