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Earth’s energy imbalance has doubled—here’s why that matters

Heatwaves across Europe and South Asia have dominated the news recently. But these events are really a surface expression of more fundamental changes affecting our planet: Earth itself is accumulating heat faster than ever before.

We lead a large international team of scientists who come together every year to provide an update on the state of the climate system. This year, we find that Earth’s energy imbalance—the difference between the amount of energy entering and leaving the planet—has doubled in recent decades and is now at record levels.

This extra heat is a key indicator of the pace and scale of human-caused climate change. In a climate unaffected by human greenhouse gas emissions, Earth’s energy imbalance would be zero. But since the 1970s, Earth has become increasingly out of balance. This rate of increase is faster than expected, and work is underway to understand exactly why this is happening.

When the Virus Knows the Answer Before We’ve Asked the Question : How Scientists Are Learning to Forecast Pandemics Before They Happen

Climate change as the macro engine for viral emergence The BA.3.2 “Cicada” variant’s hidden evolution Yeast-display technology and viral forecasting Pan-coronavirus vaccine development at La Jolla Institute How conserved viral regions unlock universal defenses.


Scientists can now force a virus to evolve in a test tube — and predict a pandemic before it starts. Heliox explores the 2026 yeast-display breakthrough that reproduced Omicron’s exact mutations in just two generations, connects it to the climate-driven migration of bat populations worldwide, and asks: are we approaching the day when we vaccinate against a pandemic that hasn’t happened yet?

Blocking a female-only GABA signal that helps glioblastoma evade immunity may boost survival

Researchers have identified a critical biological difference in how glioblastoma develops in male and female laboratory models, pinpointing an immune pathway that fuels tumor growth only in females. The study shows that the neurotransmitter GABA boosts the cancer-protecting activity of immune cells in female models—but not male models—and that blocking that signal improved outcomes. The findings could one day lead to new drug targets and therapeutics specifically for women. The paper is published in the journal Nature Cancer.

Men and women experience many diseases very differently. Certain diseases present more commonly in one sex than in the other, some conditions may cause different symptoms in men and women, and some treatments work better—or not at all—for one sex over the other.

Cancer is no exception. There are major differences in male and female immune systems, and this system is critical both for cancer growth and for successfully becoming cancer-free. For example, some immunotherapies work better in men than in women, and vice versa.

Thirty years of proof: celebrating Sir Andrew Wiles and Fermat’s Last Theorem

The 23rd of June 2023 marks 30 years since Andrew Wiles delivered his first proof of Fermat’s Last Theorem, right here at INI. In this article, podcast and video interview, we celebrate this tremendous milestone for one of mathematics’ most compelling stories.

An AAV variant selected through NHP screens robustly transduces the brain and drives secreted protein expression in NHPs and mice

Tecedor et al. used directed evolution to engineer AAVs with enhanced ependymal and brain delivery after injection into the cerebrospinal fluid. I think it would be interesting to try lumbar puncture delivery of these AAVs as well to see if they maintain decent biodistribution. (See my other post about Hinderer et al.’s paper: https://doi.org/10.1016/j.omtm.2020.04.012).


AAV capsid variants enriched for transduction of ventricular lining cells and brain parenchyma reduce the dose required for gene therapy to the CNS.

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