Perioperative morbidity and mortality were reduced with off-pump vs on-pump coronary artery bypass grafting, though survival evened out over the long term.
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Proton therapy for colorectal cancer
SA-CME credits are available for this article here.
Ever since the first proton beam therapy (PBT) treatment in 1954 at University of California, Berkley, the use of PBT worldwide has rapidly increased.1 Due to the depth-dose characteristics of protons that allow for steep fall-off just distal to the tumor target, PBT can reduce unnecessary radiation dose to nearby normal tissues and allow for safer dose escalation in select clinical scenarios. Superior normal tissue avoidance can lead to reductions in acute and late toxicities, safe dose escalation can lead to improved local control, and the combination of both factors has the potential to impact overall survival (OS).
Early data have suggested that PBT led to improved clinical outcomes in the treatment of various pediatric cancers, ocular melanomas, sarcomas of the paravertebral region, and brain tumors when compared with traditional photon-based radiation.2 Historically, fewer studies evaluated the utility of PBT in the treatment of gastrointestinal (GI) malignancies; however, retrospective studies in the setting of gastroesophageal cancer and pancreatic cancer show that preoperative PBT may reduce postoperative complications and definitive PBT may improve outcomes for those with unresectable disease.3–6 Even fewer studies have evaluated the role of PBT in the primary or neoadjuvant treatment of colorectal cancer (CRC), but there have been published clinical outcomes in the treatment of recurrent disease as well as liver metastases. The aim of this review is to discuss the existing dosimetric and clinical data for PBT in the treatment of patients with CRC.
Injectable ‘satellite livers’ could offer an alternative to liver transplantation
More than 10,000 Americans who suffer from chronic liver disease are on a waitlist for a liver transplant, but there are not enough donated organs for all of those patients. Additionally, many people with liver failure aren’t eligible for a transplant if they are not healthy enough to tolerate the surgery.
To help those patients, MIT engineers have developed “mini livers” that could be injected into the body and take over the functions of the failing liver.
In a new study in mice, the researchers showed that these injected liver cells could remain viable in the body for at least two months, and they were able to generate many of the enzymes and other proteins that the liver produces.
Reduce rust by dumping your wok twice, and other kitchen tips
When you reach the bottom of a container of milk or honey, you might be tempted to tip the container over to get that last pesky little bit out. After all, you only need another teaspoon for that recipe, and you’re sure it’s in there. From emptying jars to drying dishes, research about thin film flows in the kitchen highlights everyday connections to physics.
In Physics of Fluids, researchers from Brown University present two related studies about thin film fluid flows in the kitchen: one about the relationship between how long it takes to tip the remaining liquid out of a container and its viscosity, and the other about the ideal time to wait before dumping water out of a wok to minimize rusting—it’s more effective to wait a few minutes to let the water accumulate so there’s more to pour out. “The kitchen is sort of the prime laboratory,” said author Jay Tang. “It deals with a lot of chemistry, materials science, and physics.”
Most people have an intuitive sense of what viscosity is, often described as how thick a fluid feels. It is measured scientifically by applying a certain amount of force to a fluid and measuring its flow rate.
BaSi₂-supported nickel catalyst boosts low-temperature hydrogen production
A new catalyst strategy developed at Institute of Science Tokyo uses BaSi2 as a support for nickel and cobalt to decompose ammonia at lower temperatures. By forming unique ternary transition metal–nitrogen–barium intermediates that facilitate nitrogen coupling, the system lowers the energy barrier for ammonia decomposition. This enables nickel-and cobalt-based catalysts to achieve high hydrogen-production activity at reduced temperatures, matching the performance of ruthenium while relying on Earth-abundant metals for cleaner hydrogen generation.
As the world turns toward cleaner energy sources, hydrogen has emerged as a promising alternative to fossil fuels. Hydrogen can be obtained from various sources such as natural gas, water, biomass, and hydrogen-rich carriers. Ammonia is one such source attracting growing attention as an efficient hydrogen carrier because it stores large amounts of hydrogen and is easier to transport. However, releasing hydrogen from ammonia is typically challenging, as it either requires precious metal catalysts such as ruthenium or non-precious metal catalysts operating at very high temperatures.
Addressing this challenge, a team of researchers led by Dr. Qing Guo and Dr. Shiyao Wang, together with Professor Masaaki Kitano and Specially Appointed Professor Hideo Hosono from the MDX Research Center for Element Strategy, Institute of Integrated Research, Institute of Science Tokyo, Japan, developed a new catalyst design strategy for ammonia decomposition. Instead of solely relying on the catalyst metal, this strategy focuses on using barium silicide (BaSi2) as an active support that directly participates in the catalytic process. The study was published in the Journal of the American Chemical Society on February 19, 2026.
Chemically ‘stapled’ peptides used to target difficult-to-treat cancers
Researchers at the University of Bath have developed a new technology that uses bacteria to build, chemically stabilize, and test millions of potential drug molecules inside living cells, making it much quicker and easier to discover new treatments for difficult-to-treat cancers.
Scientists based at the University’s Department of Life Sciences are investigating peptides—short chains of amino acids, the building blocks of proteins—as potential drugs for a family of notoriously “undruggable” cancer drivers known as transcription factors. These proteins act as master switches that control gene activity and are frequently overactive in cancer.
Poking a nanostring: Scientists uncover energy cascades in tiny resonators
Scientists at TU Delft have designed a nanostring that, when poked, doesn’t lose its energy to the environment immediately. Instead, the energy leaks out within the string, triggering a cascade of distinct vibrational modes. For the first time, researchers have observed this cascade reaching all the way up to the fifth mode, while only actuating the first mode.
This discovery offers new insights that could benefit the development of extremely sensitive sensors. The results have been published in Physical Review Letters.
“Imagine plucking a guitar string,” associate professor Farbod Alijani begins to explain. “Eventually its energy dissipates into its surroundings and the vibrations slowly die out.” The team engineered a nanoscale string that behaves in a very distinct manner.