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ADJUVANT Randomized Controlled Trial: Rationale and Design

ADJUVANT: Testing if IV tirofiban is non-inferior to thrombolysis before endovascular thrombectomy for acute ischemic stroke. Read about the upcoming trial.

BackgroundIntravenous thrombolysis followed by endovascular thrombectomy (EVT) is a first‐line recommended strategy for thrombolysis‐eligible patients with stroke due to acute large‐vessel occlusion. Tirofiban, one of the most used glycoprotein IIb/IIIa receptor inhibitors, has been increasingly advocated to counteract different stages of thrombosis mediated by activated platelets. It is unclear whether tirofiban could be used as an alternative to thrombolysis as adjuvant medicine for EVT. This trial aims to assess whether intravenous tirofiban plus EVT is noninferior to intravenous thrombolysis bridging with EVT in patients with acute ischemic stroke due to large‐vessel occlusion who are eligible for thrombolysis.

New photonic device efficiently beams light into free space

If a lot of light could be rapidly and precisely beamed off the chip, free from the confines of the wiring, it could open the door to higher-resolution displays, smaller Lidar systems, more precise 3D printers, or larger-scale quantum computers.

Now, researchers from MIT and elsewhere have developed a new class of photonic devices that enable the precise broadcasting of light from the chip into free space in a scalable way.

Revisiting the proto-transhumanists: Diderot and Condorcet

Think transhumanism is a relatively new social and intellectual phenomenon? Guess again.

Many of the ideas characteristic of the movement have already been bantered about for literally hundreds of years—whether it be such things as radical life extension or the construction of machine minds. The Enlightenment period in particular was a fruitful time for these ideas to take flight, mostly on account of the new sciences, the rise of rationalism and secular humanism, and the waning influence of religion. Two thinkers that best exemplified Enlightenment-era proto-transhumanism were Denis Diderot and Marquis de Condorcet, and their early contributions are worth revisiting.

Scientists Solve a 70-Year Mystery Behind the Universe’s Strange Magnetic Fields

Researchers have identified a potential mechanism that explains how turbulent plasma can produce the vast, ordered magnetic fields observed across the universe Cosmic magnetic fields are everywhere, but their origin has remained one of plasma astrophysics’ most persistent mysteries. Planets, star

Asteroid Spaceships: Turning Rocks into Interstellar Vehicles

Asteroids could be the ultimate spacecraft. Explore how space rocks become starships, habitats, and interstellar vessels.

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Credits:
Using Asteroids As Spaceships.
Science & Futurism with Isaac Arthur.
Episode 379, January 26, 2023
Written, Produced & Narrated by Isaac Arthur.

Editors:
Briana Brownell.
David McFarlane.
Donagh B.

Graphics by:
Fishy Tree.
Jeremy Jozwik.
Ken York.
Sergio Botero.
Udo Schroeter.

Music Courtesy of Epidemic Sound http://epidemicsound.com/creator.

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