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Light-based sensor detects early molecular signs of cancer in the blood

Researchers have developed a highly sensitive light-based sensor that can detect extremely low concentrations of cancer biomarkers in the blood. The new technology could one day make it possible to spot early signs of cancer and other conditions using a simple blood test.

Biomarkers such as proteins, DNA or other molecules can be used to reveal the presence, progression or risk of cancer and other diseases. However, one of the main challenges in early disease diagnosis is the extremely low concentration of biomarkers present at the onset.

“Our sensor combines nanostructures made of DNA with quantum dots and CRISPR gene editing technology to detect faint biomarker signals using a light-based approach known as second harmonic generation (SHG),” said research team leader Han Zhang from Shenzhen University in China.

The Frontier Labs War: Opus 4.6, GPT 5.3 Codex, and the SuperBowl Ads Debacle

Questions to inspire discussion AI Model Performance & Capabilities.

🤖 Q: How does Anthropic’s Opus 4.6 compare to GPT-5.2 in performance?

A: Opus 4.6 outperforms GPT-5.2 by 144 ELO points while handling 1M tokens, and is now in production with recursive self-improvement capabilities that allow it to rewrite its entire tech stack.

🔧 Q: What real-world task demonstrates Opus 4.6’s agent swarm capabilities?

A: An agent swarm created a C compiler in Rust for multiple architectures in weeks for **$20K, a task that would take humans decades, demonstrating AI’s ability to collapse timelines and costs.

🐛 Q: How effective is Opus 4.6 at finding security vulnerabilities?

Continue reading “The Frontier Labs War: Opus 4.6, GPT 5.3 Codex, and the SuperBowl Ads Debacle” | >

Functional Characterization of a De Novo SCN2A Mixed Variant Linked to Early Infantile Developmental and Epileptic Encephalopathy

Background and ObjectivesPathogenic variants in the SCN2A gene, encoding the α-subunit type 2 of the voltage-gated sodium channel NaV1.2, cause a phenotypic spectrum including 4 major disorders as benign familial infantile seizures, developmental and…

Quantum Calculations Boosted By Doubling Computational Space For Complex Molecules

Researchers have developed a new computational method, DOCI-QSCI-AFQMC, which accurately simulates complex molecular systems by effectively doubling the number of orbitals considered in standard quantum simulations and overcoming limitations of existing single-reference techniques, as demonstrated through successful modelling of chemical bonds and reactions.

Scientists discover new gatekeeper cell in the brain

VIB and Ghent University researchers have identified and characterized a previously unknown cellular barrier in the brain, which sheds new light on how the brain is protected from the rest of the body. In a study published in Nature Neuroscience, the scientists also reveal a new pathway by which the immune system can impact the brain.

Prof. Roosmarijn Vandenbroucke (VIB–UGent Center for Inflammation Research), said, “These findings reveal how vulnerable and protectable the brain is, opening new perspectives for more targeted interventions in brain disorders.”

The brain is protected from the rest of the body by multiple barriers that maintain a stable, tightly regulated environment and defend it against harmful substances and pathogens. The most well-known of these barriers is the blood-brain barrier, but another critical interface is the choroid plexus, a small structure found within the brain’s fluid-filled spaces, which produces cerebrospinal fluid.

Major earthquakes are just as random as smaller ones

For obvious reasons, it would be useful to predict when an earthquake is going to occur. It has long been suspected that large quakes in the Himalayas follow a fairly predictable cycle, but nature, as it turns out, is not so accommodating. A new study published in the journal Science Advances shows that massive earthquakes are just as random as small ones. A team of researchers led by Zakaria Ghazoui-Schaus at the British Antarctic Survey reached this conclusion after analyzing sediments from Lake Rara in Western Nepal.

The team extracted a 4-meter-long tube from the bottom of the lake and identified 50 sediment layers spanning 6,000 years. Whenever a major quake shakes the region, underwater landslides create layers of sediment called turbidites. These deposits are characterized by coarse materials that settle first, followed by sand, then silt and finally clay. Each layer is essentially a snapshot of an individual earthquake, although they can also result from floods and slope failures.

To confirm that these layers were caused by quakes, the team compared them with modern records and computer models. They concluded that only a quake of magnitude 6.5 or higher could trigger underwater landslides. Radiocarbon dating of organic material within each layer revealed roughly when each of the major quakes occurred.

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