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Category: sex

Known risk factors alone do not explain disease accumulation, finds study

As the population ages, multimorbidity, or when a patient has multiple diseases at once, is becoming increasingly common. The onset of one disease increases the risk of developing other diseases, making it necessary to investigate how a range of risk factors together affect such accumulation. Prior studies have focused on individual risk factors and related individual diseases.

A study explored how the risk factors measured from birth to middle age and unmeasured, or latent, factors covering the entire lifespan predict and explain the incidence of chronic diseases in eight organ systems from middle to old age: the cardiovascular, metabolic, gastrointestinal, musculoskeletal, respiratory, neurological and psychiatric systems, and the sensory organs.

The study, published in The Lancet Healthy Longevity journal, analyzed 22 risk factors, including age, sex, (e.g., size at birth, early childhood growth, childhood wartime evacuee status), socioeconomic factors (e.g., socioeconomic status in childhood, income in adulthood), lifestyle factors (e.g., smoking, , , diet), clinical measurements and biomarkers (e.g., body mass index, , blood glucose).

Adolescent health is at a tipping point, global analysis suggests

By 2030, there will still be over 1 billion of the world’s adolescents (aged 10–24 years) living in countries where preventable and treatable health problems like HIV/AIDS, early pregnancy, unsafe sex, depression, poor nutrition and injury collectively threaten the health and well-being of adolescents, suggests a new analysis from the second Lancet Commission on adolescent health and well-being.

Commission co-chair, Professor Sarah Baird, George Washington University (U.S.) says, The health and well-being of adolescents worldwide is at a tipping point, with mixed progress observed over the past three decades.

While tobacco and alcohol use has declined and participation in secondary and tertiary education has increased, overweight and obesity have risen by up to eight-fold in some countries in Africa and Asia over the past three decades, and there is a growing burden of poor adolescent mental health globally.

Hormone cycles shape the structure and function of key memory regions in the brain

“To date, there was little understanding of how the estrous cycle affects neurons in living mice,” said Nora Wolcott, the paper’s lead author. Now, thanks to advanced microscopy techniques, Goard’s team was able to measure the structure and activity of neurons across multiple estrous cycles, thereby gaining insight into sex hormones’ role in brain plasticity and memory. Other authors on the paper include William Redman, Marie Karpinska, and Emily Jacobs.

Researchers observe how fluctuations in ovarian hormones shape the structure and function in the mouse hippocampus, with implications for neural plasticity in humans.

Brain structure changes in people who work long hours

If you need an excuse to turn off the laptop over the weekend or rein in overtime, scientists have found that working extended hours actually changes parts of the brain linked to emotional regulation, working memory and solving problems. While we know the toll that “overwork” takes physically and mentally, the precise neurological impact has not been well understood.

An international team of researchers including scientists from Korea’s Chung-Ang University assessed 110 healthcare workers – 32 who worked excessive hours (52 or more per week) and 78 who clocked less than 52 hours per week, or what would be considered closer to standard hours in the field. Voxel based morphometry (VBM) to assess gray matter and atlas-based analysis was then applied to MRI scans of each individual’s brain, identifying volume and connectivity differences.

When the scientists adjusted the results to account for age and sex, they found that, in the overworked cohort, the imaging showed a significant difference in brain volume in 17 different regions of the organ – including the middle frontal gyrus (MFG), insula and superior temporal gyrus (STG). Atlas-based analysis identified that, in the overworked individuals, there was 19% more volume in the left caudal MFG. The MFG – part of the brain’s frontal lobe – is the heavy lifter when it comes to executive functioning like emotional regulation, working memory, attention and planning, while the STG’s main task is auditory and language processing. The insula, meanwhile, is key in pain processing and other sensory signaling.

Sex-based brain differences: Structure of a single neuron in C. elegans provides new insights

Is there a difference in brain structure between men and women? If we were to find such a difference in a single neuron, would it matter?

One of the most useful models for studying these questions is the nematode Caenorhabditis elegans (C. elegans). This tiny worm has several characteristics that make it an excellent research model, one of which is that every cell in its body has a predetermined identity and lineage.

Like humans, C. elegans has two sexes. However, instead of male and female, the two sexes of this worm are male and hermaphrodite—a self-fertilizing individual capable of producing both male and female gametes (sperm and eggs), allowing it to reproduce without a partner.

Cannabis consumption is associated with lower COVID-19 severity among hospitalized patients: a retrospective cohort analysis

While cannabis is known to have immunomodulatory properties, the clinical consequences of its use on outcomes in COVID-19 have not been extensively evaluated. We aimed to assess whether cannabis users hospitalized for COVID-19 had improved outcomes compared to non-users.

We conducted a retrospective analysis of 1831 patients admitted to two medical centers in Southern California with a diagnosis of COVID-19. We evaluated outcomes including NIH COVID-19 Severity Score, need for supplemental oxygen, ICU (intensive care unit) admission, mechanical ventilation, length of hospitalization, and in-hospital death for cannabis users and non-users. Cannabis use was reported in the patient’s social history. Propensity matching was used to account for differences in age, body-mass index, sex, race, tobacco smoking history, and comorbidities known to be risk factors for COVID-19 mortality between cannabis users and non-users.

Of 1831 patients admitted with COVID-19, 69 patients reported active cannabis use (4% of the cohort). Active users were younger (44 years vs. 62 years, p < 0.001), less often diabetic (23.2% vs 37.2%, p < 0.021), and more frequently active tobacco smokers (20.3% vs. 4.1%, p < 0.001) compared to non-users. Notably, active users had lower levels of inflammatory markers upon admission than non-users—CRP (C-reactive protein) (3.7 mg/L vs 7.6 mg/L, p < 0.001), ferritin (282 μg/L vs 622 μg/L, p < 0.001), D-dimer (468 ng/mL vs 1,140 ng/mL, p = 0.017), and procalcitonin (0.10 ng/mL vs 0.15 ng/mL, p = 0.001). Based on univariate analysis, cannabis users had significantly better outcomes compared to non-users as reflected in lower NIH scores (5.1 vs 6.0, p < 0.001), shorter hospitalization (4 days vs 6 days, p < 0.001), lower ICU admission rates (12% vs 31%, p < 0.001), and less need for mechanical ventilation (6% vs 17%, p = 0.027).

Lab-Grown Gametes: The Future of Fertility Treatment on the Horizon

Recent advancements in in-vitro gametogenesis (IVG) suggest that lab-grown eggs and sperm could become viable within the next decade. This technology holds the promise of revolutionizing fertility treatments, particularly for individuals facing infertility and same-sex couples desiring biological children. However, it also raises significant ethical and medical considerations that must be carefully addressed.

The Human Fertilisation and Embryology Authority (HFEA), the UK’s fertility regulator, has reported that the development of lab-grown gametes, known as in-vitro gametogenesis (IVG), may become a practical option within the next decade. This technology involves creating eggs and sperm from reprogrammed skin or stem cells, potentially transforming fertility treatments by removing age-related barriers and enabling same-sex couples to have biological children.

IVG represents a significant advancement in reproductive science. By generating gametes in the laboratory, scientists can overcome challenges associated with traditional fertility treatments. This approach could provide new avenues for individuals with infertility issues and offer same-sex couples the opportunity to have children genetically related to both partners.

Variation exists in the expression of romantic love: A cluster analytic study of young adults experiencing romantic love

Variation exists in the expression of romantic love, but to date, no studies have specifically investigated this phenomenon. This study employed a TwoStep cluster analysis to group 809 partnered young adults experiencing romantic love from the Romantic Love Survey 2022 according to intensity of romantic love, obsessive thinking, commitment, and frequency of sex per week. The results revealed four clusters: (i) mild romantic lovers (20.02%) characterized by the lowest intensity, lowest obsessive thinking, lowest commitment, and lowest frequency of sex; (ii) moderate romantic lovers (40.91%), characterized by relatively low intensity, relatively low obsessive thinking, relatively high commitment, and relatively moderate frequency of sex; (iii) libidinous romantic lovers (9.64%), characterized by relatively high intensity, relatively high obsessive thinking, relatively high commitment, and exceptionally high frequency of sex; and (iv) intense romantic lovers (29.42%), characterized by the highest intensity, highest obsessive thinking, highest commitment, and relatively high frequency of sex. Each cluster differs on a range of personal and relationship characteristics. The findings can generate theory and hypotheses about romantic love and provide impetus for future research.

They’d rather die: The lesson that male roundworms refuse to learn

In human society, men tend to be seen as risk-takers, while women are seen as being more cautious. According to evolutionary psychologists, this difference developed in the wake of threats to each sex and their respective needs. While such generalizations are, of course, too binary and simplistic to faithfully describe complex and multifaceted human behavior, clearcut differences between females and males are often evident in other animals, even in simple organisms such as worms.

In a new study published in Nature Communications, Weizmann Institute of Science researchers showed that male worms are worse at learning from experience and find it hard to avoid taking risks—even at the cost of their own lives—and that allowing them to mate with members of the opposite sex improves these capabilities.

The scientists also discovered a protein, evolutionarily conserved in creatures from worms all the way to humans, that appears to be responsible for the different learning abilities of the two sexes.