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Archive for the ‘genetics’ category

Apr 14, 2024

Attempting To Slow The Epigenetic Pace Of Aging (13-Test Analysis)

Posted by in categories: genetics, life extension

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Apr 13, 2024

Newly Found Genetic Variant Defends Against Alzheimer’s Disease

Posted by in categories: biotech/medical, genetics, neuroscience

Columbia neuroscientists have identified a genetic mutation that fends off Alzheimer’s in people at high risk and could lead to a new way to protect people from the disease.

Apr 12, 2024

Large NIH Grant Supports CRISPR-based Gene Therapy Development for Brain Diseases

Posted by in categories: biotech/medical, genetics, neuroscience

If we can prove the concept of this technology in the two diseases we’re studying, we can then apply it to hundreds or thousands of diseases of the brain.

Yong-Hui Jiang, MD, PhD

Yes, please. Huntington disease hopefully.

Continue reading “Large NIH Grant Supports CRISPR-based Gene Therapy Development for Brain Diseases” »

Apr 12, 2024

Longer-Lived People Have Less Epigenetic Noise

Posted by in categories: biotech/medical, genetics

A team of researchers has reported in Aging Cell that longer-lived Chinese women have less epigenetic noise in crucial areas of the genome. Order and disorder We have previously reported that the accumulation of epigenetic noise appears […].

Apr 12, 2024

Researchers find the “recipe” for growing new limbs

Posted by in categories: biotech/medical, genetics

For as long as superheroes have been imagined, there’s been a superhero who can regrow limbs. Other animals (like salamanders and sharks) do it, why couldn’t we? Scientists have also tackled this question because, obviously, humans don’t naturally regrow limbs. But before we move on to regrowing limbs ourselves, we need to understand how other species do it.

In a new study, researchers mapped the proteins that kick off limb creation in mice and chicks, finding that a cocktail of just three proteins performs the initial magic.

“People in the field have known a lot of the proteins critical for limb formation, but we found that there are proteins we missed,” said study co-first author ChangHee Lee, research fellow in genetics in the lab of Cliff Tabin at Harvard Medical School.

Apr 11, 2024

New study finds potential targets at chromosome ends for degenerative disease prevention

Posted by in categories: biotech/medical, genetics, life extension

We depend on our cells being able to divide and multiply, whether it’s to replace sunburnt skin or replenish our blood supply and recover from injury. Chromosomes, which carry all of our genetic instructions, must be copied in a complete way during cell division. Telomeres, which cap the ends of chromosomes, play a critical role in this cell-renewal process—with a direct bearing on health and disease.

Apr 11, 2024

New treatment approach shows promise in hard-to-treat pediatric cancers

Posted by in categories: biotech/medical, genetics

Researchers have developed a functional precision medicine approach that targets cancer by combining genetic testing with a new way to test individual drugs on tumor samples. The results of the clinical study were published in Nature Medicine.

Apr 10, 2024

Brain Acidity Linked With Multiple Neurological Disorders

Posted by in categories: biotech/medical, genetics, neuroscience

In a global research effort, scientists have uncovered a relationship between metabolism problems in the brain and a range of neuropsychiatric and neurodegenerative disorders, from autism to Alzheimer’s disease and more.

Despite their diverse symptoms, these conditions – as well as depression, epilepsy, schizophrenia, intellectual disability, and bipolar disorder – all involve a degree of cognitive impairment and often share genetic or metabolic features, hinting at a common biological basis.

The extensive collaboration by the International Brain pH Project Consortium, involving 131 scientists from 105 labs in seven countries, identified changes in brain acidity and lactate levels in animals as key signs of this metabolic dysfunction.

Apr 10, 2024

A Bold Gene-Editing Solution Began Testing—Then Hit the Strangest Twist

Posted by in categories: biotech/medical, genetics

The medical breakthrough will have to wait a bit longer.

Apr 10, 2024

First-of-its-kind integrated dataset enables genes-to-ecosystems research

Posted by in categories: bioengineering, biotech/medical, chemistry, genetics

A first-ever dataset bridging molecular information about the poplar tree microbiome to ecosystem-level processes has been released by a team of Department of Energy scientists led by Oak Ridge National Laboratory. The project aims to inform research regarding how natural systems function, their vulnerability to a changing climate, and ultimately how plants might be engineered for better performance as sources of bioenergy and natural carbon storage.

The data, described in Nature Publishing Group’s Scientific Data, provides in-depth information on 27 genetically distinct variants, or genotypes, of Populus trichocarpa, a poplar tree of interest as a bioenergy crop. The genotypes are among those that the ORNL-led Center for Bioenergy Innovation previously included in a genome-wide association study linking genetic variations to the trees’ physical traits. ORNL researchers collected leaf, soil and root samples from poplar fields in two regions of Oregon — one in a wetter area subject to flooding and the other drier and susceptible to drought.

Details in the newly integrated dataset range from the trees’ genetic makeup and gene expression to the chemistry of the soil environment, analysis of the microbes that live on and around the trees and compounds the plants and microbes produce.

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