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Archive for the ‘genetics’ category

Mar 17, 2024

Scientists Reveal How our Cells’ Leaky Batteries are making us Sick

Posted by in categories: biotech/medical, genetics, life extension

The new findings could lead to better treatments for rheumatoid arthritis, lupus and other inflammatory diseases – and may even help us slow aging.

Researchers have discovered how “leaky” mitochondria can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis. Scientists may be able to leverage the findings to develop better treatments for those diseases, improve our ability to fight off viruses and even slow aging.

The new discovery reveals how genetic material can escape from our cellular batteries, known as mitochondria, and prompt the body to launch a damaging immune response. By developing therapies to target this process, doctors may one day be able to stop the harmful inflammation and prevent the toll it takes on our bodies.

Mar 17, 2024

19.5y Younger Biological Age: My Best Data Yet (31 Tests Since 2018)

Posted by in categories: biological, genetics, life extension

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7x

Mar 16, 2024

Toppling the Genetic Dominoes in Bone Metastasis

Posted by in categories: biotech/medical, genetics

Researchers at Virginia Commonwealth University unveiled a genetic bullseye—a key gene that plays a pivotal role in initiating a genetic domino cascade, driving bone metastasis in prostate cancer.


A key gene that fuels the molecular cascade driving prostate cancer bone metastasis progression may open avenues for targeted therapies.

Mar 16, 2024

Engineering the Microbiome: CRISPR Leads the Way

Posted by in categories: bioengineering, biotech/medical, genetics

Scientists have categorized different types of CRISPR systems into two classes based on how their Cas nucleases function. In class 1 (types I, III, and IV), different Cas proteins form a complex machinery to identify and cut foreign DNA; in class 2 CRISPR systems (types II, V, and VI), a single Cas protein effector recognizes and cleaves DNA.9

After characterizing CRISPR’s role as a defense mechanism in bacteria, researchers soon realized that they could harness this system for gene manipulation in any cell. All they needed to do was design a CRISPR gRNA sequence that bound to a specific DNA sequence and triggered the Cas nuclease, which would then cut precisely at that location. With CRISPR, researchers routinely knock out gene function by cutting out a DNA fragment, or they insert a desired genetic sequence into the genome by providing a reference DNA template along with the CRISPR components. While editing eukaryotic cells has been the focus for tackling diseases, many researchers now use CRISPR to edit bacterial communities.

“It’s almost like back to the beginning or back to the origins. There’s some irony in bringing CRISPR back to where it came from,” said Rodolphe Barrangou, a functional genomics researcher at North Carolina State University, who helped characterize the immune function of CRISPR and has been working with it for more than 20 years.

Mar 16, 2024

Cavernous Malformations of the Central Nervous System

Posted by in categories: biotech/medical, genetics

Cerebral cavernous malformations occur in 0.5% of the population; 85% are sporadic, and 15% are familial or radiation-induced. Several genetic variants, including variants in CCM, drive their development. Read the full review:


Review Article from The New England Journal of Medicine — Cavernous Malformations of the Central Nervous System.

Mar 15, 2024

Transgenic cows boost human insulin production by 10X

Posted by in categories: biotech/medical, food, genetics

A genetically modified cow has produced milk containing human insulin, according to a new study. The proof-of-concept achievement could be scaled up to, eventually, produce enough insulin to ensure availability and reduced cost for all diabetics requiring the life-maintaining drug.

Unable to rely on their own supply due to damaged pancreatic cells, type 1 diabetics need injectable insulin to live. As do some type 2 diabetics. The World Health Organization estimates that of those who require insulin, between 150 and 200 million people worldwide, only about half are being treated with it. Access to insulin remains inadequate in many low-and middle-income countries – and some high-income countries – and its cost and unavailability have been well-documented.

In a newly published study led by the Department of Animal Sciences in the College of Agricultural, Consumer and Environmental Sciences at the University of Illinois Urbana-Champaign and the Universidade de São Paulo, researchers say they may have developed a way of eliminating insulin scarcity and reducing its cost using cows. Yep, cows.

Mar 15, 2024

Genetically modified cow makes milk with human insulin

Posted by in categories: biotech/medical, food, genetics

Some dairy farms could turn into lifesaving insulin factories.

Mar 13, 2024

‘GPS nanoparticle’ platform precisely delivers therapeutic payload to cancer cells

Posted by in categories: biotech/medical, genetics, nanotechnology

A newly developed “GPS nanoparticle” injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State. They tested their approach in human cell lines and in mice to effectively knock down a cancer-causing gene, reporting that the technique may potentially offer a more precise and effective treatment for notoriously hard-to-treat basal-like breast cancers.

Mar 10, 2024

New study reveals how genes and food availability shape brain development in the womb

Posted by in categories: food, genetics, neuroscience

A groundbreaking study published in Nature Communications reveals how maternal and fetal genes, influenced by food availability, play a crucial role in the growth of a baby’s cerebral cortex, linking higher birth weight to an enlarged brain area. This research highlights the significant impact of genetics and environment on early brain development.

Mar 10, 2024

Revolutionary 3D Snapshot Unveils Secret Machine Behind Photosynthesis

Posted by in categories: biotech/medical, chemistry, evolution, genetics

For the survival of life on Earth, the process where plants perform photosynthesis to generate oxygen and chemical energy using sunlight is crucial. Scientists from Göttingen and Hannover have now achieved a breakthrough by creating a high-resolution 3D visualization of the chloroplasts’ copying mechanism, the RNA polymerase PEP, for the first time. This intricate structure offers fresh perspectives on the operation and evolutionary history of this vital cellular apparatus, instrumental in interpreting the genetic blueprints for proteins involved in photosynthesis.

Without photosynthesis, there would be no air to breathe – it is the basis of all life on Earth. This complex process allows plants to convert carbon dioxide and water into chemical energy and oxygen using light energy from the sun. The conversion takes place in the chloroplasts, the heart of photosynthesis. Chloroplasts developed in the course of evolution when the ancestors of today’s plant cells absorbed a photosynthetic cyanobacterium. Over time, the bacterium became increasingly dependent on its “host cell”, but maintained some significant functions such as photosynthesis and parts of the bacterial genome. The chloroplast therefore still has its own DNA, which contains the blueprints for crucial proteins of the “photosynthesis machinery”

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