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Mechanochemistry simplifies synthesis of challenging conductive organic molecules

Mechanochemistry is a growing field for chemical reactions that proceed in the solid state in the absence, or with minuscule amounts, of solvent added. For decades, solvents have been considered conventional for the progression of modern chemistry; nonetheless, researchers are increasingly demonstrating that mechanochemistry can synthesize complex molecules more effectively. With more progress, mechanochemistry could alleviate solvent-related environmental and financial burdens in chemical industries.

Using mechanochemistry, researchers from Nagoya University, including Koya M. Hori, Yoshifumi Toyama, and Hideto Ito successfully developed a two-step synthetic method for dihydrodinaphthopentalenes (DHDPs), conductive organic molecules that are considerably challenging to synthesize. These findings were recently published in the journal RSC Mechanochemistry on February 5, 2026. The results are expected to advance the synthesis of compounds with applications in organic materials.

Conductive organic molecules are used in increasingly essential technologies such as OLEDs in smartphone screens, solar cells for renewable energy, anti-static polymer coatings, and more. Perhaps due to their complex and expensive synthesis, however, DHDPs have not been integrated into any commercialized products.

Abstract: SLC26A4-gene mutations are a frequent cause of hereditary HearingLoss

SLC26A4-gene mutations are a frequent cause of hereditary HearingLoss.

https://doi.org/10.1172/JCI193812 Here, Tsai et al. report that targeted AAV delivery to the endolymphatic sac and cochlear lateral wall restores auditory physiology and ameliorates cochlear pathology in a mouse model of Slc26a4-related deafness. Pendred syndrome DFNB4.

The image shows an AAV-GFP–transduced spiral prominence, a structure within the cochlear lateral wall. GFP (green) marks successfully transduced cells, phalloidin-568 (red) labels the actin cytoskeleton, and DAPI (blue) stains nuclei, highlighting efficient gene transfer to inner ear tissues essential for auditory function.


Address correspondence to: Chen-Chi Wu, Department of Otolaryngology, National Taiwan University Hospital, No. 1, Changde St., Zhongzheng Dist., Taipei City 100,229, Taiwan. Phone: 886.2.2312.3456; Email: chenchiwu@ntuh.gov.tw. Or to: Yen-Fu Cheng, Department of Medical Research, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei City 11,217, Taiwan. Phone: 886.2.2875.7642; Email: yfcheng2@vghtpe.gov.tw.

Find articles by Tsai, Y. in: | Google Scholar

1Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Hackers arrested for hijacking and selling 610,000 Roblox accounts

The Ukrainian police have arrested three individuals who hacked more than 610,000 Roblox gaming accounts and sold them for a profit of $225,000.

The arrests were made by the police in Lviv after conducting ten searches on targeted locations, seizing $35,000 in cash, 37 mobile phones, 11 desktop computers, seven laptops, five tablets, and four USB drives.

Although the police did not specify the game platform targeted by the hackers, aged 19, 21, and 22, the Prosecutor General’s Office stated that it was Roblox.

Abstract: Newborns’ immune systems are uniquely primed to tolerate harmless antigens

https://doi.org/10.1172/JCI200062 Here, Tiffany C. Scharschmidt & team report on the early life window for immune tolerance using human samples, finding naïve CD4+ T cells in cord blood have distinct metabolic traits that enable their regulatory potential.

The schematic shows mass cytometry metabolic markers in their corresponding pathways.


Address correspondence to: Tiffany C. Scharschmidt, 1701 Divisadero Street, 3rd Floor, San Francisco, California 94,115, USA. Phone: 415.476.1696; Email: tiffany.scharschmidt@ucsf.edu.

Canada arrests three for operating “SMS blaster” device in Toronto

Canadian authorities have arrested three men for operating an “SMS blaster” device that pretends to be a cellular tower to send phishing texts to nearby phones.

Such tools trick devices into connecting to them by emitting signals that mimic a legitimate tower. Mobile phones in its range automatically link to them as there is stronger reception.

Once the connection is established, the operators of these rogue cellular base stations can push SMS messages directly to connected devices, which appear to come from trusted entities such as banks or the government.

Introducing MirrorBot, a robot designed to foster human connection

While technology has made the world “smaller,” it has also pulled individuals apart, thanks to mobile phones and other devices that command our attention. Cornell University researchers are using technology, in the form of a mirror-equipped robot, to help bring people together. Members of the Architectural Robotics Lab, led by Keith Evan Green, have built a four-foot-tall robot—dubbed MirrorBot—with dual mirrors that, when placed in front of a pair of strangers, let each participant see themself in one mirror and the other person in the other.

In a study involving participants in a waiting-room setting, MirrorBot spurred conversations, playful exchanges and other interactions between strangers. The findings suggest that robots can act not only as conversational partners, but also as spatial mediators. The research is published in the journal Proceedings of the 21st ACM/IEEE International Conference on Human-Robot Interaction.

“We weren’t just trying to trigger conversations, but to support the very first moment of social connection, which is the eye contact,” said Serena Guo, lead author of the paper.

Abstract: Proposing a no-nonsense strategy for the treatment of dominant neurodevelopmental disorders:

Xiaochang Zhang & team introduce exon annotation for nonsense-mediated mRNA (EANMD) and report on alternatively spliced exons in the brain that trigger mRNA decay, noting modulation of such exons in disease-causal genes can potentially treat neurodevelopmental disorders.


Address correspondence to: Xiaochang Zhang, University of Chicago, Cummings Life Science Center 507A, 920 E. 58th St., Chicago, Illinois 60,637, USA. Phone: 773.834.5369; Email: xczhang@uchicago.edu.

Quasiparticles reveal a magneto-optical transport phenomenon

Excitons are being explored in materials science and information technology as a means of storing light. These luminous quasiparticles move through individual layers of quantum materials and can absorb and emit light with high efficiency. They form when a laser pulse excites an electron, leaving behind a positively charged “hole.” The electron and hole attract each other and behave together like a new, independent particle. When the quasiparticle recombines, it emits light and can be detected in high-tech laboratories.

Excitons in ultrathin quantum materials have been intensively studied for more than a decade, including by Alexey Chernikov and his team. At the Cluster of Excellence ctd.qmat—Complexity, Topology and Dynamics in Quantum Matter—at the Universities of Würzburg and Dresden, Chernikov and an international research team based in Dresden have now made a surprising discovery: excitons can be carried along by the magnetic excitations of a quantum material and, as a result, accelerated to ultrahigh speeds. The findings are published in the journal Nature Nanotechnology.

“The fact that the motion of optical particles can be controlled by magnetism is new. Until now, we only knew that the transport of electrons could be controlled by the magnetic order in a quantum material—this is how some sensors in smartphones work, for example. This newly discovered link between optics and magnetism could open up entirely new technological possibilities,” explains Florian Dirnberger, head of an Emmy Noether Junior Research Group at the Technical University of Munich and formerly a postdoctoral researcher in Alexey Chernikov’s Chair of Ultrafast Microscopy and Photonics, where he was responsible for carrying out the research project.

Supporting the concept that GLP1 agonist drugs lower BloodPressure independent from their weight loss effects

Daniel J. Drucker & team identify the vascular smooth muscle GLP-1 receptor as a key cellular target for the actions of GLP-1 medicines to lower blood pressure.

The figure: Renal GLP1R/Glp1r is expressed in human and murine vascular smooth muscle cells (VSMCs) and Glp1rVSM-/- mice have reduced Glp1r transcripts in renal tissues.


1Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.

2Section of Nephrology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.

Address correspondence to: Daniel J. Drucker, Mt. Sinai Hospital, 600 University Ave. Mailbox 39, Toronto, Ontario, Canada, M5G1X5. Phone: 416.361.2661; Email: drucker@lunenfeld.ca.

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