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Unlocking the genome’s hidden half with new DNA sequencing technology

Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome. Transposons play critical roles in immune response, neurological function and genetic evolution, and implications of the finding include agricultural advancements and understanding disease development and treatment.

In a paper published in iScience, senior author Patrick Murphy, Ph.D. ‘13, associate professor of molecular biology and genetics in the College of Agriculture and Life Sciences, and co-authors demonstrate that a high-resolution genome mapping technique called CUT&Tag can overcome shortcomings in existing sequencing methods to enable study of transposons.

Once derided as “junk DNA,” transposons make up half the human genome and are descended from ancient viruses encountered by our evolutionary ancestors.

Rethinking where language comes from: Framework reveals complex interplay of biology and culture

A new study challenges the idea that language stems from a single evolutionary root. Instead, it proposes that our ability to communicate evolved through the interaction of biology and culture, and involves multiple capacities, each with different evolutionary histories. The framework, published in Science, unites discoveries across disciplines to explain how the ability to learn to speak, develop grammar, and share meaning converged to create complex communication.

For centuries, philosophers and scientists have wrestled with understanding how human language came about. Language defines us as a species, yet its origins have remained a mystery. In a remarkable international collaboration, 10 experts from different disciplines present a unified framework to address this enduring puzzle, harnessing powerful new methods and insights from their respective scientific domains.

“Crucially, our goal was not to come up with our own particular explanation of language evolution,” says first author Inbal Arnon, “Instead, we wanted to show how multifaceted and biocultural perspectives, combined with newly emerging sources of data, can shed new light on old questions.”

Dusty star-forming galaxy at high redshift discovered

An international team of astronomers reports the discovery of a new dusty star-forming galaxy at high redshift. The newfound galaxy, designated AC-2168, was detected using the Atacama Large Millimeter/submillimeter Array (ALMA) and the Northern Extended Millimeter Array (NOEMA). The finding was detailed in a paper published Nov. 11 on the pre-print server arXiv.

The so-called dusty star-forming galaxies (DSFGs) are highly obscured galaxies undergoing a period of intense star formation, with star-formation rates reaching even 1,000 solar masses per year. They represent the most intense starbursts in the universe and are crucial to improving our understanding of galaxy formation and evolution.

However, although many DSFGs are known, their nuclear structure, which can be essential to better understand the evolution of these galaxies, is still not fully explored. Hence, finding new DSFGs and investigating them in detail could shed more light on this matter.

Chang’e-6 samples reveal first evidence of impact-formed hematite and maghemite on the moon

A joint research team from the Institute of Geochemistry of the Chinese Academy of Sciences (IGCAS) and Shandong University has for the first time identified crystalline hematite (α-Fe2O3) and maghemite (γ-Fe2O3) formed by a major impact event in lunar soil samples retrieved by China’s Chang’e-6 mission from the South Pole–Aitken (SPA) Basin. This finding, published in Science Advances on November 14, provides direct sample-based evidence of highly oxidized materials on the lunar surface.

Redox reactions are a fundamental component of planetary formation and evolution. Nevertheless, scientific studies have shown that neither the oxygen fugacity of the lunar interior nor the environment favors oxidation. Consistent with this, multivalent iron on the moon primarily exists in its ferrous (Fe2+) and metallic (Fe0) states, suggesting an overall reduced state. However, with further lunar exploration, recent orbital remote sensing studies using visible-near-infrared spectroscopy have suggested the widespread presence of hematite in the moon’s high-latitude regions.

Furthermore, earlier research on Chang’e-5 samples first revealed impact-generated sub-micron magnetite (Fe3O4) and evidence of Fe3+ in impact glasses. These results indicate that localized oxidizing environments on the moon existed during lunar surface modification processes driven by external impacts.

Homoploutia: Income and Wealth Inequality in the U.S.

The rich in the U.S. just keep getting richer. Over the five decades, incomes have risen materially faster at the very top than anywhere below, and similarly, wealth has accumulated much more quickly at the top than anywhere below. A report from the Stone Center On Socio-Economic Inequality (at CUNY) looks at the mutually-reinforcing relationship between these two dynamics…

Homoploutia describes the situation in which the same people (homo) are wealthy (ploutia) in the space of capital and labor income in some countries. It can be quantified by the share of capital income rich who are also labor income rich. In this paper, we combine several datasets covering different time periods to document the evolution of homoploutia in the United States from 1950 to 2020. We find that homoploutia was low after World War II, has increased by the early 1960s, and then decreased until the mid-1980s. Since 1985 it has been sharply increasing: In 1985, about 17% of adults in the top decile of capital income earners were also in the top decile of labor-income earners. In 2018 this indicator was about 30%. This makes the traditional division between capitalists and laborers less relevant today. It makes periods characterized by high interpersonal inequality, high capital-income ratio, and high capital share of income in the past fundamentally different from the current situation. High homoploutia has far-reaching implications for social mobility and equality of opportunity. We also study how homoploutia is related to total income inequality. We find that rising homoploutia accounts for about 20% of the increase in total income inequality in the United States since 1986…

Note that the report was written in the 2020 (and published in The Review of Income and Wealth in 2023). The dynamic has continued since; the polarizing impact has grown.

Stable molecule trapped with deep ultraviolet light for the first time

Researchers from the Department of Molecular Physics at the Fritz Haber Institute have demonstrated the first magneto-optical trap of a stable “closed-shell” molecule: aluminum monofluoride (AlF). They were able to cool AlF with lasers and selectively trap it in three different rotational quantum levels—breaking new ground in ultracold physics.

Their experiments open the door to advanced precision spectroscopy and quantum simulation with AlF. The work has been accepted for publication in Physical Review Letters and is currently available on the arXiv preprint server.

Cooling matter to temperatures near absolute zero (0 K, −273.15°C) acts like a microscope for quantum mechanical behavior, bringing physics that is normally blurred out into sharp focus. Classic historical examples include the 1911 discovery of superconductivity in mercury metal cooled near 4 K, and anomalous thermal behavior in due to its “ortho” and “para” spin states. These phenomena confounded classical physics theories of the time, driving both the evolution of quantum mechanics, as well as efforts to reach ever lower temperatures.

Scientists discover creature with “all-body brain”

This is the conclusion of an international team of researchers, who found that this nervous system has a genetic organization resembling that of the brain of vertebrates, like humans.

“Our results show that animals without a conventional central nervous system can still develop a brainlike organization,” said paper author and biologist Jack Ullrich-Lüter of the Natural History Museum, Berlin, in a statement.

He added: “This fundamentally changes how we think about the evolution of complex nervous systems.”

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