Lifeboat Foundation

Famed longevity pioneer Aubrey de Grey, Chief Science Officer of SENS Research Foundation, joins Geoffrey Woo, Founder and Chairman of Health Via Modern Nutrition Inc., for an enlightening conversation about advances in longevity, the investments and technologies that extend life, and the challenges and opportunities of a world in which people live longer. He walks us through his damage repair therapies with a focus on rejuvenation, prevention, and wearable technologies. Filmed on May 17, 2021. To continue the discussion with fellow Real Vision members on this interview, click here to visit the Exchange: https://rvtv.io/2T7nqZL

Key Learnings: Longevity escape velocity, which is a term de Grey coined, is the idea in which life expectancy is extended longer than the time that is passing, and he estimates a 50% chance that aging could be brought under medical control in as little as 15 years’ time. To learn more about SENS’ research and advancements, please visit their site here: https://www.sens.org/.

Scientists working at Canada’s highest-security infectious-disease laboratory have been collaborating with Chinese military researchers to study and conduct experiments on deadly pathogens.

Seven scientists in the special pathogens unit at the National Microbiology Laboratory (NML) in Winnipeg and Chinese military researchers have conducted experiments and co-authored six studies on infectious diseases such as Ebola, Lassa fever and Rift Valley fever. The publication dates of the studies range from early 2016 to early 2020.

The Globe and Mail has also learned that one of the Chinese researchers, Feihu Yan, from the People’s Liberation Army’s (PLA) Academy of Military Medical Sciences, worked for a period of time at the Winnipeg lab, a Level 4 facility equipped to handle some of the world’s deadliest diseases. This researcher is credited as a co-author on all six of the papers. However, on two of them, he is listed as being affiliated with both the Winnipeg lab and the military medical academy.

A previously unknown novel coronavirus capable of infecting people has been discovered in Borneo, says a team of researchers from Duke University.

It occurred naturally, and scientists know this for certain.

Pediatrician, Medical Innovator, Educator — Dr. Jamie Wells, MD, FAAP — Director, Research Science Institute (RSI), Center for Excellence in Education, Massachusetts Institute of Technology (MIT) — Professor, Drexel University School of Biomedical Engineering, Science and Health Systems.

Dr. Jamie L. Wells, MD, FAAP, is an Adjunct Professor at Drexel University’s School of Biomedical Engineering, Science and Health Systems, where she has been involved in helping to spearhead the nation’s first-degree program focused on pediatric engineering, innovation, and medical advancement.

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In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta—the neurotoxin believed to be at the root of Alzheimer’s disease (AD)—forms in axons and related structures that connect neurons in the brain, where it causes the most damage. Their findings, published in Cell Reports, could serve as a guidepost for developing new therapies to prevent the onset of this devastating neurological disease.

Among his many contributions to research on AD, Rudolph Tanzi, Ph.D., vice chair of Neurology and co-director of the McCance Center for Brain Health at MGH, led a team in 1986 that discovered the first Alzheimer’s disease gene, known as APP, which provides instructions for making amyloid protein precursor (APP). When this protein is cut (or cleaved) by enzymes—first, beta secretase, followed by gamma secretase—the byproduct is amyloid beta (sometimes shortened to Abeta). Large deposits of amyloid beta are believed to cause neurological destruction that results in AD. Amyloid beta formed in the brain’s axons and nerve endings causes the worst damage in AD by impairing communication between nerve cells (or neurons) in the brain. Researchers around the world have worked intensely to find ways to block the formation of amyloid beta by preventing cleavage by beta secretase and gamma secretase. However, these approaches have been hampered by safety issues.

Despite years of research, a major mystery has remained. “We knew that Abeta is made in the axons of the brain’s nerve cells, but we didn’t know how,” says Tanzi. He and his colleagues probed the question by studying the brains of mice, as well as with a research tool known as Alzheimer’s in a dish, a three-dimensional cell culture model of the disease created in 2014 by Tanzi and a colleague, Doo Yeon Kim, Ph.D. Earlier, in 2013, several other MGH researchers, including neurobiologist Dora Kovacs, Ph.D. (who is married to Tanzi), and Raja Bhattacharyya, Ph.D., a member of Tanzi’s lab, showed that a form of APP that has undergone a process called palmitoylation (palAPP) gives rise to amyloid beta. That study indicated that, within the neuron, palAPP is transported in a fatty vesicle (or sac) known as a lipid raft. But there are many forms of lipid rafts.

The National Center of Excellence in Mass Spectrometry Imaging at NPL, in collaboration with the University of Surrey and Ionoptika Ltd reveal latest findings showing how a single fingerprint left at a crime scene could be used to determine whether someone has touched or ingested class A drugs.

In a paper published in Royal Society of Chemistry’s Analyst journal, the consortium reveal how they have been able to identify the differences between the fingerprints of people who touched cocaine compared with those who have ingested the drug—even if the hands are not washed. The science behind the advance is the mass spectrometry imaging tools applied to the detection of cocaine and its metabolites in fingerprints.

In 2020 researchers were able to determine the difference between touch and ingestion if someone had washed their hands prior to giving a sample. Given that a suspect at a crime scene is unlikely to wash their hands before leaving fingerprints, these new findings are a significant advantage to crime forensics.

The tech giant says its “dermatology assist” tool can recognise 288 different skin ailments.

“This was a short-term experiment, just eight weeks,” Liu said. “In people, obesity doesn’t occur overnight or even in eight weeks. People have a suboptimal lifestyle for 20, 30 years before they become obese. It’s possible that if you have Western diet for so long, you cross a point of no return and your Paneth cells don’t recover even if you change your diet. We’d need to do more research before we can say whether this process is reversible in people.”

Eating a Western diet impairs the immune system in the gut in ways that could increase risk of infection and inflammatory bowel disease, according to a study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic.

The study, in mice and people, showed that a diet high in sugar and fat causes damage to Paneth cells, immune cells in the gut that help keep inflammation in check. When Paneth cells aren’t functioning properly, the gut immune system is excessively prone to inflammation, putting people at risk of inflammatory bowel disease and undermining effective control of disease-causing microbes. The findings, published today (May 18, 2021) in Cell Host & Microbe, open up new approaches to regulating gut immunity by restoring normal Paneth cell function.

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