Lifeboat Foundation

Rapamycin has been proven to extend the lifespan of mice, warms and yeast. Lifespan.io is starting a large clinical trial named Participatory Evaluation (of) Aging (with) Rapamycin (for) Longevity Study, or PEARL, to see if the antiaging effects of Rapamycin apply to humans. This will be the first study to see if Rapamycin works as well in humans as it does in mice.

The PEARL trial will follow up to 200 participants over 12 months testing four different Rapamycin dosing regimens. It will be double-blind, randomized, placebo-controlled and registered with clinicaltrials.gov. The principal investigator is Dr. James P Watson at UCLA, who was also a PI for the famous TRIIM trial.

Continue reading “Lifespan.io Starting Rapamycin Antiaging Human Trials” »

A literature search revealed that one of the Siglec molecules had been previously linked to the autoimmune disease lupus. Finding connections between these different kinds of molecules starts to fill in a new and emerging picture of biology, Bertozzi says. That picture may look something like this: RNA hangs out on the cell surface, decorated with sugars. These sugars stick to Siglec proteins that help the immune system distinguish friend from foe.

In a surprise find, scientists have discovered sugar-coated RNA molecules decorating the surface of cells.

These so-called ‘glycoRNAs’ poke out from mammalian cells’ outer membrane, where they can interact with other molecules. This discovery, reported May 17, 2021, in the journal Cell, upends the current understanding of how the cell handles RNAs and glycans.

Continue reading “Some RNA molecules have unexpected sugar coating” »

Interesting as I recall Aubrey lamenting that he had met Bezos several times over the years but never got a dime from him. Also I wonder where he would put the cash. Just donor all h by is SENS? Pick a company like Age-x?

Jeff Bezos is said to get into the Longevity Industry next month according to Aubrey De Grey. Having a billionaire invest into finding a cure for aging is both amazing and worrisome.
The field of longevity research was long underfunded but recently, with more and more results coming in, investors like Jeff Bezos are getting more and more interested in the field.

Continue reading “Jeff Bezos wants to LIVE FOREVER — Aubrey De Grey: Secret Longevity Investor” »

They are linked to cancer, birth defects, liver disease, thyroid disease, plummeting sperm counts and a range of other serious health problems.

The peer-reviewed study, published on Thursday in the Environmental Science and Technology journal, found PFAS at levels in milk ranging from 50 parts per trillion (ppt) to more than 1850ppt.

Toxic chemicals known as PFAS found in all 50 samples tested at levels nearly 2000 times what is considered safe in drinking water.

Continue reading “Study finds alarming levels of ‘forever chemicals’ in US mothers’ breast milk” »

The Duke team tested the nanoparticle vaccine by injecting it into macaque monkeys, finding that it provides total protection against SARS-CoV-2, the coronavirus that causes COVID-19. Additionally, the vaccine created antibodies against SARS, bat coronaviruses and the more contagious variants of the virus that causes COVID-19.

May 17—Duke University researchers are developing a vaccine that could provide protection against multiple kinds of coronaviruses, according to a study published last week in Nature, a leading scientific journal. The vaccine, which was developed at Duke’s Human Vaccine Institute, uses nanoparticles to show the immune system 24 copies of a specific part of the virus’ spike protein that attaches to human cells. An additional substance promotes the creation of antibodies that attack that part of the virus.

Hey guys — you might like this interview I did with Alex Steele about counter-ageing and the quest for biological immortality (focused around his new book ‘Ageless: The New Science of Getting Old Without Getting Older’. If you do very grateful for any subs to help support the channel!

I speak with Andrew Steele; author, scientist and anti-ageing campaigner about his book Ageless: The New Science of Getting Old Without Getting Older”. Interview covers why humans age, the growing anti-ageing movement, scientific progress over the past decade and potential anti-ageing treatments.

Continue reading “Is Ageing a disease and can it be CURED? Andrew Steele interview” »

CAR natural killer T cells that co-express GD2 and interleukin-15 were found to be safe and to demonstrate evidence of in vivo expansion and localization to metastatic sites in patients with stage IV relapsed/refractory neuroblastoma.

Scientists modify CAR T-Cell therapy, making it more effective and less toxic, for possible use in solid tumors such as neuroblastoma.

Chimeric Antigen Receptor T-cell therapy — CAR T — has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical studies using certain CAR T against neuroblastoma revealed toxic effects. Now, a group of scientists at Children’s Hospital Los Angeles have developed a modified version of CAR T that shows promise in targeting neuroblastoma, spares healthy brain tissue and more effectively kills cancer cells. Their study was published today in Nature Communications. While this work is in the preclinical phase, it reveals potential for lifesaving treatment in children and adults with solid tumors.

Shahab Asgharzadeh, MD, a physician scientist at the Cancer and Blood Disease Institute of CHLA, is working to improve the lifesaving CAR T-cell therapy, in which scientists take a patient’s own immune system T-cells and engineer them to recognize and destroy cancer cells.

“The CAR T therapy works in leukemia,” he says, “by targeting a unique protein (or antigen) on the surface of leukemia cells. When the treatment is given, leukemia cells are killed. CAR T turns the patient’s immune system into a powerful and targeted cancer-killer in patients with leukemia. This antigen is also on normal B cells in the blood, but this side effect can be treated medically.”

The Latest Research

Two active forms of vitamin B12 offer support to the aging brain. Preclinical data shows one of the forms protects dopamine levels.

By Michael Downey.