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Category: biotech/medical – Page 1,304

Q&A: ‘Crystal ribcage’ technology pioneers new approaches to lung health

It’s no secret that our lungs play a vital role in our daily lives—ensuring we can breathe, fend off infections, and adapt to various challenges. Despite their importance, the organs still puzzle many medical experts, especially when they’re affected by diseases. While traditional tools like MRI and CT scans are helpful when a patient is experiencing a lung-related illness, they can still fall short in providing the detailed, real-time information needed to understand the intricacies of lung health.

Enter the groundbreaking innovation known as the crystal ribcage. Developed by researchers in Boston University’s College of Engineering, Pulmonary Center, Center for Multiscale and Translational Mechanobiology, and Neurophtonics Center, the technology is poised to revolutionize not only our understanding of lung function but also holds immense potential for other organs and treatments.

In new research, published this month in Nature Methods, the crystal ribcage acts as a clear, protective shield for a mouse’s lungs, allowing scientists to get a close view of how these organs work in real-time, and at a cellular level. What makes this technology special is that it doesn’t disrupt the lung’s natural processes—breathing and continue as usual while the researchers observe.

Stacking order and strain boosts second-harmonic generation with 2D Janus hetero-bilayers

A group of researchers from Tohoku University, Massachusetts Institute of Technology (MIT), Rice University, Hanoi University of Science and Technology, Zhejiang University, and Oak Ridge National Laboratory have proposed a new mechanism to enhance short-wavelength light (100–300 nm) by second harmonic generation (SHG) in a two-dimensional (2D), thin material composed entirely of commonplace elements.

Since UV with SHG plays an important role in semiconductor lithography equipment and medical applications that do not use fluorescent materials, this discovery has important implications for existing industries and all optical applications.

Details of the research were published in the journal ACS Nano on August 29, 2023. The study was selected to be featured on the cover.

What’s Stopping Us From Building a Warp Drive?

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A faster-than-light (FTL) warp drive would arguably represent the most important invention of all time. In 1994, Miguel Alcubierre gave all of us hope as he found a solution within general relativity that would cause the necessary warping of space. But after nearly 30 years of further study, what does our current understanding of physics say about the feasibility of a warp drive?

Written & presented by Prof. David Kipping. Thanks to Bobrick Martire for clarifications and to John Michael Godier and team for audio from their interview with Alcubierre (https://youtu.be/JafY92PhgKU). Thumbnail image by Zamanday Yolculugunu (www.zamandayolculuk.com)

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REFERENCES

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More research is examining how we carry the ‘genetic legacy’ of extinct human species

And the answers point to a profound reality: We have far more in common with our extinct cousins than we ever thought.

Neanderthals within us

Until recently, the genetic legacy from ancient humans was invisible because scientists were limited to what they could glean from the shape and size of bones. But there has been a steady stream of discoveries from ancient DNA, an area of study pioneered by Nobel Prize winner Svante Paabo who first pieced together a Neanderthal genome.

Scientists Discover That Australian Honeypot Ant Honey Possesses Unique Anti-Microbial Properties

Researchers have found that the honey produced by ants native to Australia possesses unique anti-microbial activity against bacteria and fungi that could make the liquid useful medicinally.

The study, which was recently published in the journal PeerJ, was led by Andrew Dong and Dr. Kenya Fernandes from the Carter Lab at the University of Sydney. The lab is under the guidance of Professor Dee Carter from the School of Life and Environmental Sciences and the Sydney Institute for Infectious Diseases.

The team studied the Australian honeypot ant, Camponotus inflatus, which is found throughout desert areas mainly in Western Australia and the Northern Territory.

Amyloid Beta and Serotonin May Be Keys to Predicting Who Develops Late-Life Depression

Image from a Johns Hopkins Medicine study showing PET scans from brains of people with and without late-life depression. The brains of patients with late-life depression show more yellow to red regions (scans on the left), indicating higher amyloid beta protein levels, and more blue regions (scans on the right), indicating lower serotonin transporter levels. Both imaging measures are markers of late-life depression. Credit: Graphic adapted from Smith et al, Nature, Sept. 13, 2021.

Using AI to find disease-causing genes

A new artificial intelligence program is helping scientists speedily sift through thousands of data sets and millions of papers to home in on genes that underly disease, drastically condensing a search process that once took months.

Using computer software, scientists can scan entire genomes, or an organism’s full set of DNA, of mice that model human diseases. The goal: to identify genetic mutations that cause those diseases and open new doors for scientists to better harness genetics to develop disease treatments, said Gary Peltz, MD, PhD, professor of anesthesiology, perioperative and pain medicine at Stanford Medicine.

But to do that, scientists must search through massive sets of genomic data, which yields more false positives than researchers care to admit. It’s also time intensive. Peltz wanted to make the genetic discovery process easier, faster and more accurate.

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