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Researchers from the University of Michigan Rogel Cancer Center have found that a genetic mutation seen in about half of all brain tumors produces a response that prevents radiation treatment from working. Altering that response using FDA-approved drugs restores tumors’ sensitivity to radiation therapy, extending survival in mice.

The paper, representing more than five years of research, is published in Science Translational Medicine.

“These findings have great potential to impact medical treatment of patients with low-grade glioma, which is critically needed for this terrible disease,” says senior author Maria G. Castro, Ph.D., R. C. Schneider Collegiate Professor of Neurosurgery and a professor of cell and developmental biology at Michigan Medicine.

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By ricocheting neutrons off the atoms of yttrium manganite (YMnO3) heated to 3,000 degrees Fahrenheit, researchers have discovered the atomic mechanisms that give the unusual material its rare electromagnetic properties. The discovery could help scientists develop new materials with similar properties for novel computing devices and micro-actuators.

The experiment was conducted as a collaboration between Duke University and Oak Ridge National Laboratory (ORNL) and appeared online in Nature Communications on January 2, 2018.

Ferromagnetism is the scientific term for the phenomenon responsible for permanent magnets like iron. Such exist because their molecular structure consists of tiny magnetic patches that all point in the same direction. Each patch, or domain, is said to have a , with a north and a south pole, which, added together, produce the magnetic fields so often seen at work on refrigerator doors.

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What they found was surprising. The new map, published on the preprint server arXiv, suggests that the huge structure of dark matter in the universe formed more slowly that previously believed — results that “appear to challenge current understanding of the fundamental laws of physics,” according to the press release.

Road Ahead

But before physicists throw out the rulebook, Hikage cautioned that the new map needs to be corroborated.

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Cancer is a complicated disease. Tumors are made up of many different types of cancer cells, and our current treatment techniques can’t always clear them all out. Now, a team of Oxford researchers has developed a way to track the genetic “life histories” of thousands of individual cancer cells at once, which may lead to more effective and personalized cancer treatments.

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