Lifeboat Foundation

Scientists at Lund University, Sweden showed that it is possible to prevent type 2 diabetes in mice by inhibiting a protein known as VDAC1. This inhibitor might be employed in treating this disease in humans [1].

Abstract

Type 2 diabetes (T2D) develops after years of prediabetes during which high glucose (glucotoxicity) impairs insulin secretion. We report that the ATP conducting mitochondrial outer membrane voltage dependent anion channel-1 (VDAC1) is upregulated in islets from T2D and non-diabetic organ donors under glucotoxic conditions. This is caused by a glucotoxicity-induced transcriptional program, triggered during years of prediabetes with suboptimal blood glucose control. Metformin counteracts VDAC1 induction. VDAC1 overexpression causes its mistargeting to the plasma membrane of the insulin secreting β cells with loss of the crucial metabolic coupling factor ATP. VDAC1 antibodies and inhibitors prevent ATP loss. Through direct inhibition of VDAC1 conductance, metformin, like specific VDAC1 inhibitors and antibodies, restores the impaired generation of ATP and glucose-stimulated insulin secretion in T2D islets.

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China has included 17 life-saving cancer drugs in its national public insurance after negotiations drastically cut their prices, in response to their cost fuelling the smuggling of cheap drugs from abroad in an echo of the popular Chinese film Dying to Survive.

Costs slashed by over half on average, in wake of hit movie featuring the plight of those unable to afford prohibitively priced medicines and forced to look abroad.

The strictest limits yet on the size of extra dimensions come from the fact that black holes haven’t destroyed the universe.

Don’t look now, but Boston Dynamics’ robot Atlas is back. And now it can do parkour: https://wired.trib.al/B2Aai5y

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Coronal section of the neocortex in a juvenile mouse. Double immunostaining shows microglia (green) and inhibitory interneurons (red), whereas nuclear counterstaining is in blue.

IMAGE: PAOLA SQUARZONI

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Note in the in-capsule video, that Col. Nick Hague’s Falcon stuffed toy is thrown violently upwards as G-forces grip the capsule, followed by both astronauts being shaken violently as well, their hands and arms waving wildly. I won’t share my hypotheses as to what happened as of this point, but I have some ideas.

Aerial footage shows rows of damaged and destroyed homes lining the beach in Mexico Beach, Florida, after Hurricane Michael slammed into the town on October 10, 2018. It was the strongest hurricane on record to hit the Florida Panhandle.

Credit: WJAX

Everyone knows it takes a male and a female to make a baby. But what a new study from the Chinese Academy of Sciences suggests is that maybe it doesn’t. In a new study, the team of scientists reports they did the seemingly impossible: Produce healthy baby mice from two mothers. The researchers describe their achievement in a breakthrough new paper in Cell Stem Cell.

The single-sex parent phenomenon has been observed naturally in reptiles, fish, amphibians, and invertebrates, but it was never thought to be possible in mammals, who reproduce differently. But as the team describe in their paper, all it took was overcoming the genetic limitations that usually make same-sex parenting impossible. The team, which also included researchers from Northeast Agricultural University in Harbin, China, used a combination of stem cells and CRISPR precision gene editing to produce healthy mice from two mothers. Interestingly, they tried the same with embryos from two fathers, but those offspring only lived a few days.

In the paper, they describe the bizarre, ingenious way the mouse embryos were formed using an egg from one mother a stem cell from another mother. The team’s breakthrough was figuring out how to manipulate the DNA of the stem cell so that the babies wouldn’t have birth defects.

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The universe is expanding at an ever-accelerating rate. At least, that’s what the vast majority of scientists would have you believe. But according to a team of Spanish physicists, it may not be the expansion of the universe that’s changing rate, but time itself. Time might be slowing down, and that means that it could eventually stop altogether.