Zhao et al. delineate the dynamic evolution of the gastric mucosal microenvironment and characterize diverse immune cell populations during gastric cancer progression under H. pylori infection. They identify and validate that H. pylori-associated activated mast cells promote gastric cancer through PGE2-and adenosine-mediated suppression of CD8+ T cell cytotoxicity.
It is increasingly clear, though, that the loss of synapses—the flexible and adaptive relay stations central to our brains’ ability to think, learn, and remember—is central to the rise of cognitive decline and dementia in old age.
Now, researchers have discovered clues that may tie synapse loss to another hallmark of brain aging: the declining ability of brain cells to break down and recycle damaged proteins.
Published in Nature, the study shows that synaptic proteins are particularly susceptible to this age-related garbage-disposal problem: In old age, synaptic proteins break down much more slowly, they become more likely to pile up into the tangled clumps of protein characteristic of neurodegenerative disease, and they are more likely to make their way into microglia, immune cells that prune away damaged synapses.
Those findings are the latest in a series of discoveries that suggest new links between the brain’s waste management systems, microglia, and neurodegeneration—and they could yield new insights into human brain aging and neurodegeneration, said the study’s lead author. ScienceMission sciencenewshighlights.
Researchers from the Yunnan Observatories of the Chinese Academy of Sciences have conducted a new study on the temporal evolution of the afterglow from gamma-ray burst GRB 240825A. The study offers new evidence to better understand the physical environment surrounding gamma-ray bursts and provides insights into the mechanisms that govern their afterglow emission. The findings were recently published in The Astrophysical Journal.
Long-duration gamma-ray bursts (LGRBs) are widely believed to form from the core collapse of massive stars, usually occurring in dense star-forming regions. NASA’s Swift satellite detected GRB 240825A on August 25, 2024, and observed an unusually bright optical counterpart.
Early measurements yielded an X-ray afterglow spectral index of 0.79 and a significantly softer optical afterglow spectral index of 2.48, compared with a typical value near 1. Under standard models, a gamma-ray burst is classified as “optically dark” when its observed optical afterglow flux falls below the level predicted from its X-ray spectral index.
An existing drug currently used to treat glaucoma, altitude sickness, and seizures may also have the potential to prevent relapse in opioid use disorder, according to a study by researchers at University of Iowa Health Care. The work is published in the journal Neuropsychopharmacology.
The UI researchers led by John Wemmie, MD, Ph.D., focused on the drug known as acetazolamide (AZD) because it blocks the activity of a brain enzyme called carbonic anhydrase 4 (CA4). Wemmie’s team had previously discovered that inhibiting CA4 in the whole brain, or just in its reward center (the nucleus accumbens), of mice, significantly reduced the brain changes that occurred after cocaine withdrawal. In addition, blocking the CA4 enzyme reduced drug-seeking behavior and relapse in the mice.
“What makes this approach promising is that it works in a completely different way from current treatments,” says Wemmie, a professor of psychiatry in the UI Carver College of Medicine. “Instead of targeting opioid receptors, AZD targets a different pathway involved in drug-induced synaptic changes and drug-seeking behavior. This could open the door to new therapies that help people stay in recovery by addressing the brain’s long-term response to drug use.”
How can gravity and the quantum world be unified? What are the different string theories? And what is \.
The blood–brain barrier (BBB) is a dynamic interface that tightly regulates the transport of substances from the blood into the brain. BBB dysfunction can occur with ageing and is a hallmark of many major diseases but is underappreciated as a therapeutic target. Here, Searson and Banks review studies on BBB repair and rejuvenation, highlighting common mechanisms across disorders and potential strategies for pharmacological intervention.
One of the brightest stars in the Andromeda galaxy quietly collapsed into a black hole without any of the fanfare of a spectacular supernova.
What makes this startling discovery even more remarkable is that the first signs of the transformation were recorded back in 2014 – data that is crucial for understanding the different ways black holes can form after the death of a giant star.
“This has probably been the most surprising discovery of my life,” says astronomer Kishalay De of Columbia University in the US, who led the research. “The evidence of the disappearance of the star was lying in public archival data, and nobody noticed for years until we picked it out.”
The Technological Singularity is the most overconfident idea in modern futurism: a prediction about the point where prediction breaks. It’s pitched like a destination, argued like a religion, funded like an arms race, and narrated like a movie trailer — yet the closer the conversation gets to specifics, the more it reveals something awkward and human. Almost nobody is actually arguing about “the Singularity.” They’re arguing about which future deserves fear, which future deserves faith, and who gets to steer the curve when it stops looking like a curve and starts looking like a cliff.
The Singularity begins as a definitional hack: a word borrowed from physics to describe a future boundary condition — an “event horizon” where ordinary forecasting fails. I. J. Good — British mathematician and early AI theorist — framed the mechanism as an “intelligence explosion,” where smarter systems build smarter systems and the loop feeds on itself. Vernor Vinge — computer scientist and science-fiction author — popularized the metaphor that, after superhuman intelligence, the world becomes as unreadable to humans as the post-ice age would have been to a trilobite.
In my podcast interviews, the key move is that “Singularity” isn’t one claim — it’s a bundle. Gennady Stolyarov II — transhumanist writer and philosopher — rejects the cartoon version: “It’s not going to be this sharp delineation between humans and AI that leads to this intelligence explosion.” In his framing, it’s less “humans versus machines” than a long, messy braid of tools, augmentation, and institutions catching up to their own inventions.
First dogs, then …
Biotechnology group says treated animals showed improved survival and functional measures in early-stage study
Genflow Biosciences Ltd (LSE: GENF, OTCQB: GENFF, FRA: WQ5) said positive preliminary interim results from its SLAB clinical trial showed improved survival and functional outcomes in aged dogs treated with its proprietary SIRT6 centenarian gene therapy.
The biotechnology company, which focuses on developing gene therapies for age-related diseases, said the randomised, blinded study enrolled 24 beagle dogs aged over 10 years and was conducted by an independent contract research organisation.
