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News stories, articles and whitepapers referencing Queensland Brain Institute on Drug Target Review.

CRISPR has transformed gene editing, but still presents challenges in hard-to-transfect cells, such as pluripotent stem cells and primary cells.¹ The key to obtaining successful transfection in these cells lies in innovative workflows. Here Georges Müller, CEO and cofounder of SEED Biosciences, shares his perspective on why focusing on editing a single cell, rather than bulk cells, is a pivotal strategy to optimise CRISPR delivery.

Delivery of ribonucleoprotein (RNP) into cells is an essential factor for successful CRISPR gene editing. However, this is difficult to guarantee using traditional CRISPR gene editing methods, especially in hard-to-transfect cells. The standard CRISPR technique involves gathering a group of cells and then electroporating them, using short high-voltage pulses to overcome the barrier of their cell membranes. This allows bulk transfection of ribonucleoprotein (RNP) into the cells and then hopefully, nuclear translocation.

In this special episode, we’re joined by Cytosurge CSO Tobias Beyer, Ph.D., and SEED Biosciences CEO and Co-Founder Georges Muller, Ph.D., for an overview of gene editing with Cytosurge’s FluidFM® in combination with DispenCell™ dispensing technologies.

Tobias and Georges explain the FluidFM® technique and how it differs from traditional CRISPR methods along with the advantages the technology has over other methods of gene editing.

Continue reading “The Ins and Outs of Single Cell Gene Editing (Sponsored by Molecular Devices)” »

We are one of the leading providers of high-performance bioanalytical measurement solutions for life science research, pharmaceutical and biotherapeutic development. Our products enable scientists to improve productivity and efficiency in scientific disco.

SpaceX is preparing for upcoming Starship launches and is working on upgrading launch support infrastructure, but still needs FAA approval for the new launch schedule.

Questions to inspire discussion.

Continue reading “SpaceX’s Upcoming Starship Launch Schedule and FAA Approval Update” »

To save on fuel and reduce aircraft emissions, engineers are looking to build lighter, stronger airplanes out of advanced composites. These engineered materials are made from high-performance fibers that are embedded in polymer sheets. The sheets can be stacked and pressed into one multilayered material and made into extremely lightweight and durable structures.

Human mini-lungs grown by University of Manchester scientists can mimic the response of animals when exposed to certain nanomaterials. The study is published in Nano Today.

Quantum dots are already moving in the premium display category, particularly through QD-OLED TVs and monitors. The next step could be QDEL, short for “quantum dot electroluminescent,” also known as NanoLED, screens. Not to be confused with the QLED (quantum light emitting diode) tech already available in TVs, QDEL displays don’t have a backlight. Instead, the quantum dots are the light source. The expected result is displays with wider color spaces than today’s QD-OLEDs (quantum dot OLEDs) that are also brighter, more affordable, and resistant to burn-in.

It seems like QDEL is being eyed as one of the most potentially influential developments for consumer displays over the next two years.

If you’re into high-end display tech, QDEL should be on your radar.

NVIDIA is all set to aid Japan in building the nation’s hybrid quantum supercomputer, fueled by the immense power of its HPC & AI GPUs.

Japan To Rapidly Progressing In Quantum and AI Computing Segments Through Large-Scale Developments With The Help of NVIDIA’s AI & HPC Infrastructure

Nikkei Asia reports that the National Institute of Advanced Industrial and Technology (AIST), Japan, is building a quantum supercomputer to excel in this particular segment for prospects. The new project is called ABCI-Q & will be entirely powered by NVIDIA’s accelerated & quantum computing platforms, hinting towards high-performance and efficiency results out of the system. The Japanese supercomputer will be built in collaboration with Fujitsu as well.