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DNA origami vaccine rivals mRNA shots while being easier to store and manufacture

The COVID-19 pandemic brought messenger RNA (mRNA) vaccines to the forefront of global health care. After their clinical trial stages, the first COVID-19 mRNA vaccine was administered on 8 December 2020 and mathematical models suggest that mRNA vaccines prevented at least 14.4 million deaths from COVID-19 in the first year alone.

Their extraordinary effectiveness in having softened the blow of the disease has led to the development of mRNA vaccines to also combat other infectious pathogens.

Clinical trials for influenza virus, Respiratory Syncytial Virus (RSV), HIV, Zika, Epstein-Barr virus, and tuberculosis bacteria are all on the way. Importantly, however, COVID-19 research has revealed shortcomings of mRNA vaccines that highlight the need for different approaches.

Nuclear import of malaria RNA rewires splicing in host immune cells

Abou Karam et al. identify a cell communication mechanism used by the malaria parasite Plasmodium falciparum. The parasite delivers its mRNAs into monocytes and imports them into their protected nuclei, where they perturb the splicing. This extracellular RNA-based strategy disrupts host transcript processing and immune signaling, revealing another layer of host interference.

Mass spectrometry imaging: principles and applications in plant research

A Research review by Sun et al. 👇

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Mass spectrometry imaging (MSI) is an advanced analytical technique that combines mass spectrometry with spatial mapping, enabling the direct, label-free detection and visualization of molecular distributions within biological tissues. This review comprehensively outlines the fundamental principles, major technological platforms, and recent applications of MSI in plant science. We detail key ionization techniques – matrix-assisted laser desorption/ionization (MALDI), desorption electrospray ionization (DESI), and secondary ion mass spectrometry (SIMS) – focusing on their ionization mechanisms and instrumental characteristics.

Light-Directed Evolution of More Complex Proteins

Researchers have discovered how to guide the evolution of proteins with light to develop more complex proteins, paving the way for new possibilities in synthetic biology and biotechnology.

Read the OPN story: biotech technology physics.

New technique creates new possibilities for synthetic biology and biotechnology.

Pretreatment risk model for radiation-induced lymphopenia is associated with adjuvant durvalumab efficacy in patients with unresectable stage III NSCLC

Can we predict immunotherapy success by forecasting severe radiation-induced lymphopenia (RIL)? A pretreatment NSCLC nomogram shows only low RIL-risk patients benefit from adjuvant durvalumab, potentially enabling personalized RIL mitigation and optimized immunotherapy. Read it here in the RedJournal.

Severe radiation-induced lymphopenia (RIL) during concurrent chemoradiotherapy (CCRT) for NSCLC has been associated with poorer outcomes and reduced immunotherapy efficacy. Because RIL often develops late during CCRT, identifying patients at risk before treatment may be clinically relevant. This study aimed to develop and validate a nomogram based on pretreatment predictors for severe RIL, and secondarily to explore associations between predicted RIL risk and adjuvant durvalumab-associated survival.

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