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Senescent cells after pregnancy may fuel postpartum breast cancer spread

Postpartum breast cancer is diagnosed five to ten years after giving birth. It is associated with a higher risk of metastasis and a lower survival rate compared with women who have not been pregnant or those diagnosed during pregnancy. A team from the Institut Pasteur set out to understand the mammary gland mechanisms involved in tumor formation during involution, a major tissue remodeling process that occurs after pregnancy.

In a preclinical study, the scientists revealed how senescence, a cellular response inducing stable cell cycle arrest, plays an ambivalent role during mammary gland involution. While it is crucial for the normal tissue remodeling process in the mammary gland, senescence can also be hijacked by tumor cells to help them spread. This discovery, published in Nature Aging on February 18, 2026, suggests that targeting senescent cells during mammary gland involution could reduce the risk of postpartum breast cancer.

How Artificial Intelligence Is Creating New Job Opportunities

Artificial Intelligence (AI) has become a buzzword in recent years. We’ve heard countless stories about how AI could potentially eliminate jobs, particularly in the engineering and contracting realm. However, we tend to forget that AI is also capable of creating new opportunities for employment and growth. I’d like to explore exactly how AI can help create jobs for engineers and other professionals in the contracting industry.

AI Enhances Demand for Skilled Workers

One of the most significant ways that AI can create jobs is by enhancing efficiency and productivity. By reducing manual labor and streamlining processes, organizations are able to focus their energy on more complex tasks that require human expertise. This shift means a greater need for skilled labor, which means more job openings for engineers and other professionals. For example, AI can be used to automate mundane tasks such as data entry or administrative work, allowing humans to focus their attention on more technical projects – and this means engineers have more time to create solutions that change the world.

How ADHD Stimulants

In a large US-based brain imaging study, researchers found that these drugs do not primarily affect attention networks, but instead act on systems linked to arousal, sleep, and motivation.

The puzzle of ADHD stimulants

Prescription stimulants such as methylphenidate and amphetamines are among the most used psychoactive drugs in children and adolescents with ADHD, where they remain a first-line treatment. Estimates for receiving a prescription for ADHD medication among diagnosed children vary from 38–81%. Despite their widespread use, there is still disagreement about how these drugs work in the brain.

Sjögren Syndrome Candidate Autoantigen AQP5 Triggers AQP4 CNS Autoimmunity Through Self-Antigen Mimicry

Tumor-immune-neural circuit in cancer cachexia.

The mechanisms involved in cancer-mediated cachexia and anorexia are not well understood.

The researchers in this study delineate an interplay among tumor cells, immune cells, and the nervous system that drives cancer cachexia and anorexia.

The authors show thay loss of GDF15 protects against appetite loss, muscle wasting, and fat loss in pancreatic, lung, and skin cancers.

Disrupting this feedforward loop with GDF15-neutralizing antibody, anti-CSF1R antibody, or Rearranged during Transfection (RET) inhibitor alleviates cachexia and anorexia across cancer models. sciencenewshighlights ScienceMission https://sciencemission.com/Tumor-immune-neural-circuit

Shi et al. delineate an interplay among tumor cells, immune cells, and the nervous system that drives cancer cachexia and anorexia. Specifically, tumor-derived CSF1 induces macrophage GDF15, which signals through the GFRAL-RET neural axis to enhance β-adrenergic activity and systemic wasting. Disrupting this feedforward loop alleviates cachexia across cancer models.

Continue reading “Sjögren Syndrome Candidate Autoantigen AQP5 Triggers AQP4 CNS Autoimmunity Through Self-Antigen Mimicry” | >

A Clearer Look at the Rise of Myopia

Reading this on your phone in the dark?

A new study suggests that focusing up close in low-light settings may contribute to rising myopia rates.

Here’s what the researchers found.

Half of the world’s population will be nearsighted by 2050. Scientists propose that the amount of light reaching the retina in dark environments could be why.

Did Life Begin in the Cold? New Experiments Point to an Icy Origin

Experiments reveal that unsaturated lipid membranes promote vesicle fusion and DNA retention during freeze–thaw cycles, highlighting icy environments as potential drivers of protocell evolution. Today’s cells are extraordinarily intricate. They contain internal scaffolding known as cytoskeletons.

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