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Researchers led by the University of California, Irvine are the first to reveal how two neural circuits located in the brain’s retrosplenial cortex are directly linked to spatial navigation and memory storage. This discovery could lead to more precise medical treatments for Alzheimer’s disease and other cognitive disorders by allowing them to target pathway-specific neural circuits.

The study, published in Molecular Psychiatry, identified two types of RSC pathways, connected to different parts of the brain, each with its own pattern of inputs and functions.

“By demonstrating how specific circuits in the RSC contribute to different aspects of cognition, our findings provide an anatomical foundation for future studies and offer new insights into how we learn and remember the space around us,” said lead and co-corresponding author Xiangmin Xu, UC Irvine Chancellor’s Professor of anatomy and neurobiology and director of the campus’s Center for Neural Circuit Mapping.

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Think back to that basic biology class you took in high school. You probably learned about organelles, those little ‘organs’ inside cells that form compartments with individual functions.

For example, mitochondria produce energy, lysosomes recycle waste and the nucleus stores DNA. Although each organelle has a different function, they are similar in that every one is wrapped up in a membrane.

Membrane-bound organelles were the textbook standard of how scientists thought cells were organized until they realized in the mid-2000s that some organelles don’t need to be wrapped in a membrane.

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A new model based on the famous alien-hunting Drake equation suggests that some parallel universes within the hypothetical “multiverse” could have higher chances of containing extraterrestrial life than our universe.

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In our increasingly interconnected digital world, the foundations of secure communication and data privacy are built upon cryptographic algorithms that have stood the test of time.

Discover how quantum computing threatens current API security and learn strategies to prepare your APIs for Q-Day by adopting post-quantum cryptography solutions.

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Akash Systems has signed a non-binding preliminary memorandum of terms with the U.S. Department of Commerce for $18.2 million in direct funding and $50 million in federal and state tax credits through the CHIPS Act. Although this isn’t yet a binding contract that will give the company the promised funds, it’s an important first step in the negotiation process for the Oakland-based startup, which shows that both the company and the U.S. government are gradually moving towards a formal agreement. According to Akash Systems (h/t Axios), it will use the funds to ramp up its operations for producing diamond-cooled semiconductors for AI, data centers, space applications, and defense markets.

Diamond-cooling technology goes deeper than just thermal paste with nano-diamond technology. For example, some use synthetic diamonds as the chip substrate, utilizing the material’s thermal conductivity to more efficiently move heat away from the processor. So, let’s look closer at Akash’s solution.

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I believe that nanotechnology could be imbedded into paper so a paper computer could give one the same information as a smartphone but at pennies per smartphone. Right now we can print out 3D copies of paper phones and other things next would be nanotechnology made of paper with quantum mechanical engineering.

Irish company Mcor’s unique paper-based 3D printers make some very compelling arguments. For starters, instead of expensive plastics, they build objects out of cut-and-glued sheets of standard 80 GSM office paper. That means printed objects come out at between 10–20 percent of the price of other 3D prints, and with none of the toxic fumes or solvent dips that some other processes require.

Secondly, because it’s standard paper, you can print onto it in full color before it’s cut and assembled, giving you a high quality, high resolution color “skin” all over your final object. Additionally, if the standard hard-glued object texture isn’t good enough, you can dip the final print in solid glue, to make it extra durable and strong enough to be drilled and tapped, or in a flexible outer coating that enables moving parts — if you don’t mind losing a little of your object’s precision shape.

The process is fairly simple. Using a piece of software called SliceIt, a 3D model is cut into paper-thin layers exactly the thickness of an 80 GSM sheet. If your 3D model doesn’t include color information, you can add color and detail to the model through a second piece of software called ColorIt.

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Year 2021 face_with_colon_three

Scientific Reports — 3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as an optimized fiber channel design for precise alignment of optical fibers, an optically clear window to visualize the trapping region, and a sample channel which facilitates hydrodynamic focusing of samples. A square zig–zag structure incorporated in the sample channel increases the number of particles at the trapping site and focuses the cells and particles during experiments when operating the chip at low Reynolds number. To evaluate the performance of the device for optical manipulation, we implemented on-chip, fiber-based optical trapping of different-sized microscopic particles and performed trap stiffness measurements. In addition, optical stretching of MCF-7 cells was successfully accomplished for the purpose of studying the effects of a cytochalasin metabolite, pyrichalasin H, on cell elasticity. We observed distinct changes in the deformability of single cells treated with pyrichalasin H compared to untreated cells. These results demonstrate that 3D printed microfluidic lab-on-a-chip devices offer a cost-effective and customizable platform for applications in optical manipulation.

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Science Corporation, a biotech startup launched by a Neuralink cofounder, claims that it’s achieved a breakthrough in brain-computer interface technology that can help patients with severe vision loss.

In preliminary clinical trials, legally blind patients who had lost their central vision received the company’s retina implants, which restored their eyesight and even allowed them to read books and recognize faces, the startup announced last week.

“To my knowledge, this is the first time that restoration of the ability to fluently read has ever been definitively shown in blind patients,” CEO Max Hodak, who was president of Neuralink before founding Science Corp, said in a statement.

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