Lifeboat Foundation

Mitochondria that power cellular activity fragment and change shape in breast cancer cells that migrate to the brain, an adaptation that appears necessary for the cells to survive, UT Southwestern Medical Center researchers report in a new study. The findings, published in Nature Cancer, could lead to new ways to prevent brain metastases, or the spread of cells from primary tumors to the brain.

“Through mitochondrial plasticity, these cancer cells undergo metabolic reprogramming that aids their survival in the brain niche that otherwise would not be available to them. Exploiting this vulnerability could offer a way to prevent brain metastases,” said study leader Srinivas Malladi, Ph.D., Assistant Professor of Pathology at UT Southwestern and a member of the Harold C. Simmons Comprehensive Cancer Center.

Metastatic cancer, which is treated as stage IV cancer, is responsible for the majority of cancer deaths.

In short, data-driven solutions themselves are only part of the overall approach. It is the effective integration of this fast-evolving technology into existing workflows and processes that leads to successful business outcomes.

The first step to integrating AI is identifying places and processes where it can help increase efficiency or accuracy. Businesses should step back and identify their pain points, creating a list of processes that are slow, tedious, cumbersome or suffering from a lack of staff. They should also analyze where additional data or information could help make better decisions.

In the pharma industry, data-driven AI solutions have been widely adopted in sales and marketing processes. For example, by analyzing patient and physician data, electronic medical records and demographic information, AI algorithms can identify trends, patterns and insights that help sales representatives tailor their messaging and presentations to specific HCPs.

Hurling spear-thrower projectiles at archery targets revealed that these loops may have been finger grips.

The current understanding of the biology of aging is largely based on research aimed at identifying factors that influence lifespan. However, lifespan as a sole proxy measure of aging has limitations because it can be influenced by specific pathologies (not generalized physiological deterioration in old age). Hence, there is a great need to discuss and design experimental approaches that are well-suited for studies targeting the biology of aging, rather than the biology of specific pathologies that restrict the lifespan of a given species. For this purpose, we here review various perspectives on aging, discuss agreement and disagreement among researchers on the definition of aging, and show that while slightly different aspects are emphasized, a widely accepted feature, shared across many definitions, is that aging is accompanied by phenotypic changes that occur in a population over the course of an average lifespan. We then discuss experimental approaches that are in line with these considerations, including multidimensional analytical frameworks as well as designs that facilitate the proper assessment of intervention effects on aging rate. The proposed framework can guide discovery approaches to aging mechanisms in all key model organisms (e.g., mouse, fish models, D. melanogaster, C. elegans) as well as in humans.

Keywords: Aging; experimental design; lifespan; models; phenotypes.

Copyright © 2023 Elsevier B.V. All rights reserved.

Researchers at the University of Houston are working to make T-cell immunotherapy safer, developing a tool called CrossDome, which uses a combination of genetic and biochemical information to predict if T-cell immunotherapies might mistakenly attack healthy cells.

T-cell based immunotherapies hold tremendous potential in the fight against cancer and infectious diseases, thanks to their capacity to specifically target diseased cells, including cancer metastasis. Nevertheless, this potential has been tempered with safety concerns regarding the possible recognition of unknown off targets displayed by healthy cells.

In one case, scientists created special T-cells that were supposed to target a protein found in a type of skin cancer called melanoma. However, these T-cells also ended up attacking a different protein found in the heart cells of some patients. This caused severe damage to the heart.

When prodded with a tiny glass rod, leaves released waves of calcium signals to cells that quickly diminish after the touch.

NEW YORK, June 13 (Reuters) — Meta Platforms (META.O) said on Tuesday that it would provide researchers with access to components of a new “human-like” artificial intelligence model that it said can analyze and complete unfinished images more accurately than existing models.

The model, I-JEPA, uses background knowledge about the world to fill in missing pieces of images, rather than looking only at nearby pixels like other generative AI models, the company said.

That approach incorporates the kind of human-like reasoning advocated by Meta’s top AI scientist Yann LeCun and helps the technology to avoid errors that are common to AI-generated images, like hands with extra fingers, it said.

Starting today, users in the US can see how women’s tops from H&M, Anthropologie, Everlane, and Loft will look on a wide range of real human models. New filters aim to make finding clothes easier.

Google is introducing two new features for its online shopping experience that are designed to help users search for clothes in more detail and better visualize how clothing will look on different body types.

Starting today, Google Shopping users in the US can access a virtual try-on experience that realistically displays how an item of clothing will look on a selection of real human models. These models are available with various skin tones, ethnicities, hair types, and body shapes, ranging in size… More.

Continue reading “Google Shopping introduces new AI modeling feature” »

OpenAI CEO Sam Altman over the weekend called for enhanced collaboration between the U.S. and China on artificial intelligence development. Without mentioning the fact that his company’s products like ChatGPT are not available in China, he argued that China should be a major player in ensuring the safety of global AI development and rollout.

“With the emergence of the increasingly powerful AI systems, the stakes for global cooperation have never been higher,” he said in the keynote address for a conference hosted by the Beijing Academy of Artificial Intelligence, sounding more like someone leading an advocacy group on responsible tech than what he is: the CEO of a company responsible for shepherding that emergence.

Continue reading “OpenAI’s Sam Altman Makes Global Call For AI Regulation—And Includes China” »