Lifeboat Foundation

For decades, various physicists have theorized that even the slightest changes in the fundamental laws of nature would make it impossible for life to exist. This idea, also known as the “fine-tuned universe” argument, suggests that the occurrence of life in the universe is very sensitive to the values of certain fundamental physics. Alter any of these values (as the logic goes), and life would not exist, meaning we must be very fortunate to be here.

But can this really be the case, or is it possible that life can emerge under different physical constants, and we just don’t know it? This question was recently tackled by Luke A. Barnes, a postdoctoral researcher at the Sidney Institute for Astronomy (SIA) in Australia. In his book, “A Fortunate Universe: Life in a Finely Tuned Cosmos,” he and Sydney astrophysics professor Geraint F. Lewis argued that a fine-tuned universe makes sense from a physics standpoint.

The authors also summarized these arguments in an invited contribution paper, which appeared in the Routledge Companion to Philosophy of Physics (1st ed.) In this paper, titled “The Fine-Tuning of the Universe for Life,” Barnes explains how “fine-tuning” consists of explaining observations by employing a “suspiciously precise assumption.” This, he argues, has been symptomatic of incomplete theories throughout history and is a common feature of modern cosmology and particle physics.

For decades physicists have been perplexed about why our cosmos appears to have been precisely tuned to foster intelligent life. It is widely thought that if the values of certain physical parameters, such as the masses of elementary particles, were tweaked, even slightly, it would have prevented the formation of the components necessary for life in the universe—including planets, stars, and galaxies. But recent studies, detailed in a new report by the Foundational Questions Institute, FQXi, propose that intelligent life could have evolved under drastically different physical conditions. The claim undermines a major argument in support of the existence of a multiverse of parallel universes.

“The tuning required for some of these physical parameters to give rise to life turns out to be less precise than the tuning needed to capture a station on your radio, according to new calculations,” says Miriam Frankel, who authored the FQXi report, which was produced with support from the John Templeton Foundation. “If true, the apparent fine tuning may be an illusion,” Frankel adds.

Over the last few decades, the subject of fine tuning has attracted some of the sharpest minds in physics. By probing the universe’s physical laws and precisely pinning down the values of physical constants—such as the masses of elementary particles and the strengths of forces—physicists have discovered that surprisingly small variations in these values would have rendered the universe lifeless. This led to a puzzle: why are physical conditions seemingly tailored towards human existence?

A new University of Illinois project is using advanced object recognition technology to keep toxin-contaminated wheat kernels out of the food supply and to help researchers make wheat more resistant to fusarium head blight, or scab disease, the crop’s top nemesis.

“Fusarium head blight causes a lot of economic losses in wheat, and the associated toxin, deoxynivalenol (DON), can cause issues for human and animal health. The disease has been a big deterrent for people growing wheat in the Eastern U.S. because they could grow a perfectly nice crop, and then take it to the elevator only to have it get docked or rejected. That’s been painful for people. So it’s a big priority to try to increase resistance and reduce DON risk as much as possible,” says Jessica Rutkoski, assistant professor in the Department of Crop Sciences, part of the College of Agricultural, Consumer and Environmental Sciences (ACES) at Illinois. Rutkoski is a co-author on the new paper in the Plant Phenome Journal.

Increasing resistance to any crop disease traditionally means growing a lot of genotypes of the crop, infecting them with the disease, and looking for symptoms. The process, known in plant breeding as phenotyping, is successful when it identifies resistant genotypes that don’t develop symptoms, or less severe symptoms. When that happens, researchers try to identify the genes related to disease resistance and then put those genes in high-performing hybrids of the crop.

Researchers at Kanazawa University report in ACS Nano how high-speed atomic force microscopy can be used to study the biomolecular mechanisms underlying gene editing.

The DNA of prokaryotes—single-cell organisms, for example bacteria—is known to contain sequences that are derived from DNA fragments of viruses that infected the prokaryote earlier. These sequences, collectively referred to as CRISPR, for “clustered regularly interspaced short palindromic repeats,” play a major role in the antiviral defense system of bacteria, as they enable the recognition and subsequent neutralization of infecting viruses. The latter is done through the enzyme Cas9 (“CRISPR-associated protein 9”), a biomolecule that can locally unwind DNA, check for the existence of the CRISPR sequence and, when found, cut the DNA.

Continue reading “Detect, bind and cut: Biomolecular action at the nanoscale” »

An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study. Details of the clinical study and its findings have been published in the New England Journal of Medicine.

Trial participants using the artificial pancreas spent approximately three more hours per day in their target blood sugar range compared with participants in a control group who continued relying on the methods they were already using to manage their blood sugar.

The Control-IQ system, manufactured by Tandem Diabetes Care, is a diabetes management device that automatically monitors and regulates blood glucose. The artificial pancreas has an insulin pump that uses advanced control algorithms based on the person’s glucose monitoring information to adjust the insulin dose as needed.

In a universe with more than a hundred billion billion planets, why have we only found life on one? DEAD SPACE offers a terrifying reason why: gigantic “Brethren Moons” made of meat with an unrelenting hunger for biomass.

💪 JOIN [THE FACILITY] for members-only live streams, behind-the-scenes posts, and the official Discord: https://www.patreon.com/kylehill.

Continue reading “How DEAD SPACE Solves the Fermi Paradox” »

Generative artificial intelligence (AI) systems will inspire an explosion of creativity in the music industry and beyond, according to the University of Surrey researchers who are inviting the public to test out their new text-to-audio model.

AudioLDM is a new AI-based system from Surrey that allows users to submit a text prompt, which is then used to generate a corresponding audio clip. The system can process prompts and deliver clips using less computational power than current AI systems without compromising sound quality or the users’ ability to manipulate clips.

The general public is able to try out AudioLDM by visiting its Hugging Face space. Their code is also open-sourced on GitHub with 1000+ stars.

A multi-state study from the U.S. Center for Disease Control and Prevention’s (CDC) VISION Network has found that first-generation COVID-19 mRNA vaccines were associated with protection against COVID-19 during periods of omicron BA.4/BA.5 predominance.

The new analysis found that mRNA vaccines were protective against COVID-19-associated hospitalization and ICU admission or in-hospital death and noted less severe disease during BA.4/BA.5 predominance compared to earlier omicron variants.

During BA.4/BA.5 predominance, estimated 3-dose vaccine effectiveness against hospitalization was 68 percent between 7-and 119-days post-vaccination. Vaccine effectiveness against hospitalization decreased to 36 percent by 120 days or more post-vaccination.

A new study published in Nature reports that a technology known as spatial omics can be used to map simultaneously how genes are switched on and off and how they are expressed in different areas of tissues and organs. This improved technology, developed by researchers at Yale University and Karolinska Institutet, could shed light on the development of tissues, as well as on certain diseases and how to treat them.

Almost all cells in the body have the same set of genes and can in principle become any kind of cell. What distinguishes the cells is how the genes in our DNA are used. In recent years, spatial omics have given us a deeper understanding of how cells read the genome in precise locations in tissues. Now, researchers have further evolved this technology to increase knowledge of how tissues develop and how different diseases arise.

A key part of the study is the researchers’ ability to spatially map simultaneously two crucial components of our genetic makeup, the epigenome and the transcriptome. The epigenome controls the switching mechanisms that turn genes on and off in individual cells, whereas the transcriptome is the result of those gene expressions and what makes each cell unique.