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Temporal evolution of GRB 240825A afterglow provides insight into origins of optically dark gamma-ray bursts

Researchers from the Yunnan Observatories of the Chinese Academy of Sciences have conducted a new study on the temporal evolution of the afterglow from gamma-ray burst GRB 240825A. The study offers new evidence to better understand the physical environment surrounding gamma-ray bursts and provides insights into the mechanisms that govern their afterglow emission. The findings were recently published in The Astrophysical Journal.

Long-duration gamma-ray bursts (LGRBs) are widely believed to form from the core collapse of massive stars, usually occurring in dense star-forming regions. NASA’s Swift satellite detected GRB 240825A on August 25, 2024, and observed an unusually bright optical counterpart.

Early measurements yielded an X-ray afterglow spectral index of 0.79 and a significantly softer optical afterglow spectral index of 2.48, compared with a typical value near 1. Under standard models, a gamma-ray burst is classified as “optically dark” when its observed optical afterglow flux falls below the level predicted from its X-ray spectral index.

A glaucoma drug may help prevent opioid relapse

An existing drug currently used to treat glaucoma, altitude sickness, and seizures may also have the potential to prevent relapse in opioid use disorder, according to a study by researchers at University of Iowa Health Care. The work is published in the journal Neuropsychopharmacology.

The UI researchers led by John Wemmie, MD, Ph.D., focused on the drug known as acetazolamide (AZD) because it blocks the activity of a brain enzyme called carbonic anhydrase 4 (CA4). Wemmie’s team had previously discovered that inhibiting CA4 in the whole brain, or just in its reward center (the nucleus accumbens), of mice, significantly reduced the brain changes that occurred after cocaine withdrawal. In addition, blocking the CA4 enzyme reduced drug-seeking behavior and relapse in the mice.

“What makes this approach promising is that it works in a completely different way from current treatments,” says Wemmie, a professor of psychiatry in the UI Carver College of Medicine. “Instead of targeting opioid receptors, AZD targets a different pathway involved in drug-induced synaptic changes and drug-seeking behavior. This could open the door to new therapies that help people stay in recovery by addressing the brain’s long-term response to drug use.”

Strategies for blood–brain barrier rejuvenation and repair

The blood–brain barrier (BBB) is a dynamic interface that tightly regulates the transport of substances from the blood into the brain. BBB dysfunction can occur with ageing and is a hallmark of many major diseases but is underappreciated as a therapeutic target. Here, Searson and Banks review studies on BBB repair and rejuvenation, highlighting common mechanisms across disorders and potential strategies for pharmacological intervention.

A Giant Star Vanished, And Scientists Think a Black Hole Is to Blame

One of the brightest stars in the Andromeda galaxy quietly collapsed into a black hole without any of the fanfare of a spectacular supernova.

What makes this startling discovery even more remarkable is that the first signs of the transformation were recorded back in 2014 – data that is crucial for understanding the different ways black holes can form after the death of a giant star.

“This has probably been the most surprising discovery of my life,” says astronomer Kishalay De of Columbia University in the US, who led the research. “The evidence of the disappearance of the star was lying in public archival data, and nobody noticed for years until we picked it out.”

The Singularity: Everyone’s Certain. Everyone’s Guessing

The Technological Singularity is the most overconfident idea in modern futurism: a prediction about the point where prediction breaks. It’s pitched like a destination, argued like a religion, funded like an arms race, and narrated like a movie trailer — yet the closer the conversation gets to specifics, the more it reveals something awkward and human. Almost nobody is actually arguing about “the Singularity.” They’re arguing about which future deserves fear, which future deserves faith, and who gets to steer the curve when it stops looking like a curve and starts looking like a cliff.

The Singularity begins as a definitional hack: a word borrowed from physics to describe a future boundary condition — an “event horizon” where ordinary forecasting fails. I. J. Good — British mathematician and early AI theorist — framed the mechanism as an “intelligence explosion,” where smarter systems build smarter systems and the loop feeds on itself. Vernor Vinge — computer scientist and science-fiction author — popularized the metaphor that, after superhuman intelligence, the world becomes as unreadable to humans as the post-ice age would have been to a trilobite.

In my podcast interviews, the key move is that “Singularity” isn’t one claim — it’s a bundle. Gennady Stolyarov II — transhumanist writer and philosopher — rejects the cartoon version: “It’s not going to be this sharp delineation between humans and AI that leads to this intelligence explosion.” In his framing, it’s less “humans versus machines” than a long, messy braid of tools, augmentation, and institutions catching up to their own inventions.

Genflow reports positive interim data from SIRT6 gene therapy trial in aged dogs

First dogs, then …

Biotechnology group says treated animals showed improved survival and functional measures in early-stage study

Genflow Biosciences Ltd (LSE: GENF, OTCQB: GENFF, FRA: WQ5) said positive preliminary interim results from its SLAB clinical trial showed improved survival and functional outcomes in aged dogs treated with its proprietary SIRT6 centenarian gene therapy.

The biotechnology company, which focuses on developing gene therapies for age-related diseases, said the randomised, blinded study enrolled 24 beagle dogs aged over 10 years and was conducted by an independent contract research organisation.

Cannabis Access Tied to Big Drop in Daily Opioid Use

Greater access to legal cannabis is associated with a significant drop in daily opioid use, suggesting that cannabis availability may reduce reliance on opioids for pain or other use.

How can cannabis legalization influence opioid use? This is what a recent study published in Drug and Alcohol Dependence hopes to address as a team of researchers investigated behavior connections between cannabis use and opioid use. This study has the potential to help scientists, medical professionals, legislators, and the public better understand the benefits of cannabis, including how it can help the opioid epidemic.

For the study, the researchers analyzed survey data collected from 28,069 individuals designated as people who inject drugs (PWID) during 2012, 2015, 2018, and 2022 across 13 states. The goal of the study was to compare medical cannabis and medical plus recreational cannabis use to opioid use. The respondents were asked to report their past 30-day use for both cannabis and opioids. In the end, the researchers found that users who subscribed to both medical plus recreational cannabis use compared to just medical cannabis use experienced a 9–11 percent decline in opioid use.

The study notes in its conclusions, “Cannabis legalization may shape daily opioid consumption among PWID, potentially reducing drug-related harms. Differences in cannabis use following legalization may reflect disparate impact by race, due to structural racism or other factors. Future research examining whether policy attributable changes in substance use manifest health benefits among PWID is critical to developing evidence-based cannabis reform.”

Scientists Discover a Brain Circuit That Enhances Physical Endurance In Mice

The effects of exercise would not be nearly as powerful without the input of the brain, according to new research.

A study on mice has found a critical signal in the central nervous system that helps build physical endurance in the wider body after repeated exercise.

Traditionally, scientists thought that our body’s extensive response to frequent exercise occurred mainly in the periphery, such as the bones and muscles, and the heart.

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