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Cuffless Devices for the Measurement of Blood Pressure: A Scientific Statement From the American Heart Association

Cuffless BP devices have the potential to increase access and overcome barriers to BP screening, particularly for underresourced communities. Individuals from these communities—including people from rural areas, with low income, or from underrepresented racial or ethnic groups—often have a higher prevalence of hypertension and uncontrolled BP than their counterparts and face barriers to accessing health care services, including regular BP monitoring and confirmation of office BP with ABPM.32–34

One of the primary barriers to BP screening in underresourced communities is a lack of health care facilities and trained physicians.35 Cuffless devices, which are often portable and convenient and can be incorporated into everyday objects (eg, watches, smartphones), can be deployed in homes, in community centers, among lay community health workers, and by individuals themselves.4,5,36 This accessibility eliminates the need for individuals to travel long distances to receive basic health screenings, making it easier for residents of rural areas, or areas with shortages of health care professionals, to monitor their out-of-office BP regularly.

Cost is a major barrier hindering access to health care and traditional BP monitoring methods for individuals from underresourced populations, many of whom may be uninsured or underinsured. Cuffless BP devices could theoretically reduce costs, particularly when integrated into wearable or mobile devices that consumers purchase for multiple uses.36 However, because of the limitations of cuffless devices, including the need for calibration with additional purchased devices and insufficient accuracy, cost-effectiveness remains speculative.

One-hour saliva test spots biomarker linked to several cancers

QUT researchers have developed a simple one-hour saliva test for a protein biomarker that has been linked with oral, colon and pancreatic cancers. The findings are published in the journal Talanta.

The paper is titled “Label free paper sensor and light driven material for the rapid screening of S100P cancer biomarker in saliva.” Corresponding author, Associate Professor Emad Kiriakous, from QUT’s School of Chemistry and Physics, said this technology could pave the way for simple, low-cost, point-of-care screening tools to help identify and treat cancer early.

Professor Kiriakous said the QUT team developed a rapid testing technique of saliva using paper coated in gold and silver nanoparticles to create a highly sensitive sensor that records the Raman spectrum (or SERS, the process by which a substance scatters laser light which is used to identify molecules) of saliva samples.

Myocarditis and look-alikes: when the diagnosis matters

Myocarditis is an inflammatory disease of the heart muscle that can be triggered by various causes, including viruses, autoimmune response, molecular mimicry and exposure to immune-stimulating drugs or vaccines. Most cases of myocarditis heal, and cardiac dysfunction, if present, recovers; however, selected forms may require targeted therapy to improve outcomes. We herein review five conditions presenting with or mimicking myocarditis that require targeted diagnostic approaches, including endomyocardial biopsy, and/or targeted treatments. Giant cell myocarditis is an intense and unresolving inflammation of the heart, characterised by rapid progression, significant arrhythmias, heart failure and shock, that is unlikely to resolve without immunosuppression therapy.

The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics

This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity.

Chemical recycling of imine-linked covalent organic frameworks

Imine-linked covalent organic frameworks (COFs) have been explored for various applications; however, chemical recycling of end-of-life COFs is an undeveloped area of research. Here, we report closed-loop recycling methods for imine-linked COFs, realizing their chemical depolymerization and reconstruction through d.

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