Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer.
Montoya et al. uncover a role for alanine as a conserved metabolic substrate for MYC-driven liver cancer. GPT2 is a therapeutic target for MYC-overexpressing liver tumors.
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Ancient DNA reveals pervasive directional selection across West Eurasia
The researchers found that natural selection has played a much larger role in determining which traits survived or declined since the Ice Age, identifying 479 genetic variations that were greatly impacted — many more than the 20 previous instances of directional selection.
Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being rare over this period as previously assumed.
Scientists stunned as bacteria rewire DNA machinery to shape cells
Cyanobacteria—ancient microbes that oxygenated Earth and made complex life possible—are still revealing surprises billions of years later. Scientists have now discovered that a molecular system once used to separate DNA has been repurposed into something entirely different: a structure that shapes the cell itself.
Nvidea CEO Jensen Huang follows just one rule to maximise daily productivity. ‘I do this every single morning, exactly the same way.’
NVIDIA CEO Jensen Huang says his daily success comes from a simple habit, starting each morning by completing his highest priority task first. Speaking at the California Institute of Technology graduation ceremony, he explained that this approach gives him a sense of achievement early in the day and frees up time to focus on others.
The Future of Medicine Isn’t Treatment- It’s Prevention
What if we stopped managing disease…and started eliminating it entirely?
