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Circulating Ketone Bodies and Incident Cardiovascular Outcomes and Mortality: Insights From the UK Biobank
Higher ketone body levels are associated with increased cardiovascular events and mortality in a large population cohort. @paragchevli @DrMichaelShapir @wakeforestmed @WFCardiology
BackgroundKetone bodies (KB) are endogenous energy sources synthesized by the liver in response to metabolic stress. Their associations with atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and mortality and their potential beneficial or harmful effects have yet to be determined. This study aimed to examine the association between KB and incident cardiovascular outcomes and mortality in a large general population cohort free from ASCVD and HF at baseline.
Challenges and opportunities in adapting high-throughput functional assays for in vivo neuroscience
High-throughput functional assays such as CRISPR screens and massively parallel reporter assays have transformed studies of gene regulation in cultured cells, but their translation to neuroscience remains limited.
The brain presents unique barriers to scaling these assays, including delivery bottlenecks, low recovery, and the complexity of cellular diversity and spatial architecture.
Emerging strategies—ranging from optimized viral vectors and streamlined library design to integration with singlecell and spatial transcriptomics—offer paths to overcome these limitations.
Together, these innovations are paving the way toward in vivo functional genomics approaches that can bridge the gap between genetic variation, regulatory logic, and brain function. sciencenewshighlights ScienceMission https://sciencemission.com/high-throughput-functional-assays
Precision tumor imaging with a fluorescence probe and engineered enzymes
Successful cancer surgery depends on a surgeon’s ability to remove tumors, while minimizing harm to healthy tissues. Surgeons currently use glowing dyes which mark cancer cells to help differentiate from healthy cells, but these dyes aren’t perfect and will light up some healthy tissues too. For the first time, researchers including those from the University of Tokyo developed what they call a bioorthogonal fluorescence probe and a matching reporter enzyme that can activate the probe selectively at targeted tumor sites. This enables high-contrast tumor visualization with very low background. This study was performed in mice.
Cancer is a universal issue which affects uncountably many people around the world. Many will turn to surgery in the hope a surgeon will be able to completely remove a tumor leaving healthy tissues unaffected. Various tools and techniques have been developed over the years to improve the way these surgeries are performed, and visual imaging methods such as glowing dyes have proven to be very useful. But one drawback is that some probes can also be activated in healthy tissues by endogenous enzymes, creating background fluorescence and making it harder to judge what should be removed. The opposite is also possible, where cancer cells are left unmarked and are missed during surgery, increasing the chance of recurrence.
“Our group acknowledged this current shortcoming and improved upon this way to make cancer cells light up inside the body. In tests on mice, we delivered a special enzyme to tumors and used a fluorescence probe that only turns on when that enzyme is present,” said Associate Professor Ryosuke Kojima from the Laboratory of Chemical Biology and Molecular Imaging at the University of Tokyo. “Older probes often light up healthy tissue by mistake, creating background noise, but our highly selective, or bioorthogonal, dye probe is designed to stay completely off unless it meets its matching engineered enzyme. We essentially trained the enzyme through repeated mutation and selection, a form of directed evolution, so it could activate the probe strongly enough to work inside living animals.”
Microbes harvest metals from meteorites aboard space station
If humankind is to explore deep space, one small passenger should not be left behind: microbes. In fact, it would be impossible to leave them behind, since they live on and in our bodies, surfaces and food. Learning how they react to space conditions is critical, but they could also be invaluable fellows in our endeavor to explore space.
Microorganisms such as bacteria and fungi can harvest crucial minerals from rocks and could provide a sustainable alternative to transporting much-needed resources from Earth.
Researchers from Cornell and the University of Edinburgh collaborated to study how those microbes extract platinum group elements from a meteorite in microgravity, with an experiment conducted aboard the International Space Station. They found that “biomining” fungi are particularly adept at extracting the valuable metal palladium, while removing the fungus resulted in a negative effect on nonbiological leaching in microgravity.
Pearls & Oy-sters: Reversible Leukoencephalopathy and Parkinsonism Due to CNS Involvement in Cryoglobulinemia
What is metabolic dysfunction–associated steatotic liver disease?
Metabolic dysfunction–associated steatotic liver disease (MASLD) involves accumulation of fat in the liver and may progress to liver inflammation and scarring.
The main risk factors for MASLD are obesity and type 2 diabetes.
Usually people with MASLD show no symptoms but some may feel tired or have pain or discomfort in the upper right side of their abdomen.
Eating a low-carbohydrate, low-fat, and low-calorie diet; avoiding alcohol; and exercise are the first-line of treatment for MASLD. sciencenewshighlights ScienceMission https://sciencemission.com/What-Is–MASLD
This JAMA Patient Page describes metabolic dysfunction–associated steatotic liver disease (MASLD) and its risk factors, symptoms and complications, diagnosis, and treatment.
How an overlooked electrostatic force could drive the motor of the future
When we hear about moving objects with electricity, most of us imagine a “pulling force.” Positive and negative charges attract each other, drawing objects together. It is natural to think that this attractive force—known as electrostatic force—is what makes things move.
However, this force is not very strong, and it has not been suitable for driving large machines in our daily lives. For that reason, most practical motors rely on a different mechanism. For example, the motors in electric fans and electric vehicles do not use electricity directly to create motion. Instead, they use electricity to generate a magnetic field, and then use that magnetic force to rotate.
Neutrons Illuminate the Magnetic Dance of Chiral Phonons
Neutron scattering has provided a new and broader view of the twirling collective atomic vibrations in a magnetic crystal.
Phonons—quantized conveyors of sound and heat in solids—are usually visualized as collective vibrations in which atoms simply bounce back and forth, almost as if they were weights on springs. However, atoms can sometimes form “chiral phonons” that twirl and swivel clockwise or counterclockwise, in a way that resembles a coordinated dance [1]. When these circular, chiral motions entrain ionic charge, they generate a magnetic moment, which suggests that there might be a way to control sound and heat using magnetic fields. Until recently, this magnetic dance was primarily observed using optical techniques, granting access to only one corner of the “stage”—the point in the phonon’s momentum space where the momentum is nearly zero. Song Bao of Nanjing University in China and his collaborators have now broadened the view of momentum space by using inelastic neutron spectroscopy.
NASA’s MAVEN detects first evidence of lightning-like activity on Mars
While sifting through the extensive data collected by NASA’s Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft over the last decade, scientists discovered a familiar type of electromagnetic signal commonly caused by lightning. This rare find represents the first direct indication of lightning activity on Mars. The team recently published their findings in Science Advances, where they describe the event and why it’s so difficult to detect lightning-like activity on Mars.
Whistler waves are low-frequency radio wave signals generated by lightning, which create an impulse that propagates through a planet’s magnetosphere, following along the magnetic field lines. The whistler waves disperse due to the slower velocity of the lower frequencies through the plasma of the ionosphere and magnetosphere. These waves are typical on Earth, but have also been observed on Jupiter, Saturn and Neptune. All of these planets all possess strong magnetic fields and corresponding magnetospheres, facilitating the movement of whistler waves.
Mars, on the other hand, does not have a global, Earth-like magnetic field. This is because the internal activity that causes these magnetic fields ceased on Mars billions of years ago. This may contribute to the fact that lightning-like discharges in the Martian atmosphere have not yet been observed. But lightning-like activity on Mars is not impossible.
Superfluids emerge in 2D moiré crystal formed from time, study predicts
Conventional crystals are materials in which atoms arrange themselves in repeating spatial patterns. Time crystals, on the other hand, are phases of matter characterized by repeating motions over time without constantly heating up, breaking a physical rule known as time-translation symmetry.
Researchers at East China Normal University and Shanghai Jiao Tong University recently predicted the formation of a new type of time crystal, dubbed a two-dimensional (2D) moiré time crystal. This crystal was theorized to emerge when periodic perturbations (i.e., regular, repeated disturbances) are applied to ultracold atoms held in a smooth, continuous trap, as opposed to an optical lattice trap. The paper is published in the journal Physical Review Letters.
“We were inspired by two exciting concepts in physics,” Keye Zhang, professor at East China Normal University and co-senior author of the paper, told Phys.org. “The first is the concept of ‘twistronics,’ where twisting atom-thin layers creates moiré patterns with exotic material properties. While the second is that of ‘time crystals’ (a new phase of matter with persistent rhythmic motion). We wondered: could we combine these ideas by treating time itself as a dimension that can be ‘twisted’?”