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Metabolic inflammation at the adipose-brain axis
Adipose-brain axis in metabolic inflammation.
White adipose tissue (WAT) in addition to storing excess energy also releases cytokines, lipid mediators, adipokines, and extracellular vesicles that influence brain physiology.
The inflammatory mediators disrupt key brain interfaces, including the blood-brain barrier (BBB), perivascular and glymphatic clearance pathways, promoting endothelial dysfunction, altered astrocyte-pericyte support, impaired amyloid-b clearance, and region-specific glial activation.
In the brain, obesity-associated neuroinflammation leads to various neuronal dysfunction including cognition.
The authors discuss the role of adipokines in adipose-brain communication during obesity including how they contribute to neuroinflammation and synaptic dysfunction.
The authors also discuss therapeutic strategies targeting the adipose-brain axis, including exercise and dietary interventions and pharmacological approaches such as orlistat and incretin-based therapies. sciencenewshighlights ScienceMission https://sciencemission.com/adipose-brain-axis
Oxford physicists achieve first-ever “quadsqueezing” breakthrough in quantum physics
Scientists have created a powerful new way to control quantum systems, achieving the first-ever demonstration of quadsqueezing—an elusive fourth-order quantum effect. By combining simple forces in a clever way, they made previously hidden quantum behaviors visible and usable, opening new frontiers for quantum technology.
Mysterious black goo discovered aboard ship reveals species unknown to science
“The biggest surprise was that the ship goo had life in it at all,” researcher Cody Sheik, who discovered the substance, said in a press release. “We thought we’d find nothing. But surprisingly, we found DNA, and it wasn’t too destroyed, nor was the biomass too low.”
After further analysis, the team reconstructed 20 genomes from the sample. Some appear to represent entirely new branches of life, including what could be a previously unknown order of archaea and even a new bacterial phylum.
Inside the goo, scientists found microbes that thrive in semi-warm environments with no oxygen — conditions that closely match those inside the ship’s mechanical systems. Researchers believe the organisms may have hitchhiked on oil used to grease the rudder, remaining dormant until conditions allowed them to grow.
Scientists Develop New Antibody For Virus That Infects 95% of People
The Epstein-Barr virus (EBV) is one of the world’s most common viruses, thought to be lurking in 95 percent of adults. For most, it causes no obvious symptoms.
But EBV is more than a short-term infection.
Once it enters the body, EBV can stay for life, and it has been linked to several cancers, multiple sclerosis, and other severe health complications. Now, new research has given us a promising way to fight it.
WHY A MULTIVERSE IS REAL | Leonard Susskind
Is our universe just one of many? In this profound exploration of modern cosmology, we look at why the \.
Risk, Resilience, And Humanity’s Expanding Technological Frontiers
“As we approach the Convergence Age, the physical, digital, biological, and even cosmic realms are merging into a hyperconnected environment. Our understanding of risk and danger is blurring. Dissolution provides fresh opportunities and problems beyond grasp. It’s not speculation. It’s inevitable due to exponential technology. It’s unlike anything humanity has ever experienced”
As we approach the Convergence Age, the physical, digital, and biological are merging into a hyperconnected environment. Our understanding of risk and danger is blurring.
What If The Universe Is Math?
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In his essay “The Unreasonable Effectiveness of Mathematics”, the physicist Eugine Wigner said that “the enormous usefulness of mathematics in the natural sciences is something bordering on the mysterious”. This statement was inspired by the observation that so many aspects of the physical world seem to be describable and predictable by mathematical equations to incredible precision especially as quantum phenomena. But quantum phenomena have no subjective qualities and have questionable physicality. They seem to be completely describable by only numbers, and their behavior precisely defined by equations. In a sense, the quantum world is made of math. So does that mean the universe is made of math too? If you believe the Mathematical Universe Hypothesis then yes. And so are you.
#space #universe #maths.
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