Acetate helps the female rodents form memories but is less effective in males.
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Reference Handbook of Gynecologic Pelvic MRI
Accurate interpretation of gynecologic pelvic MRI depends on tailored protocols, thorough anatomic knowledge, and a systematic lesion-based approach. This review outlines classification by lesion origin and tissue composition.
MRI is used routinely in patients with gynecologic conditions due to its superior soft-tissue contrast and multiplanar capability. It can provide a detailed assessment of pelvic anatomy, lesion origin, tissue characteristics, and disease extent. Its indications include (a) characterizing US-indeterminate adnexal masses, (b) evaluating the cause of pelvic pain and abnormal uterine bleeding, © mapping symptomatic uterine leiomyomas and differentiating them from uterine sarcomas, (d) staging gynecologic cancers, and (e) addressing complex congenital müllerian duct anomalies. Additional indications include evaluating for pelvic floor dysfunction, fistulas, or placental abnormalities.
This article aims to enhance the interpretation of female pelvic MRI for gynecologic conditions. After outlining patient preparation, tailored MRI protocols, and the normal female pelvic anatomy, a step-by-step approach to interpretation is presented, focusing on evaluating lesion origin, lesion tissue composition, and solid tissue morphology (Fig 1). The review also emphasizes the importance of incorporating the patient’s clinical history to narrow the differential diagnosis and the role of disease-specific structured reporting in improving communication (Fig 1).
Does suppression of HIV replication protect against severe M
tuberculosis infection?
Philana Ling Lin & team report on SIV/ART/TB models, finding antiretroviral treatment reduces pulmonary TB pathology, yet does not prevent extrapulmonary spread of TB.
1Department of Pediatrics, Children’s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
2Center for Vaccine Research.
3Department of Microbiology and Molecular Genetics, and.
4Division of Laboratory Animal Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
PDE5A+ cancer-associated fibroblasts enhance immune suppression in gastric cancer
GUTImage from the paper by Wang et al entitled.
via.
GastricCancer.
Background Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) in GC.
Objective Identifying a critical subpopulation of CAFs in promoting an immunosuppressive TME and enabling immune evasion, which may influence therapeutic effectiveness of immune checkpoint inhibitors (ICIs) for GC.
Standardization Versus Adaptability: Where Is the Sweet Spot?
New in practicalRO.
Standardization in clinical workflows is widely recognized as a driver of safety, efficiency, and consistency. The challenge for modern practice is determining the appropriate degree and rigidity of standardization, especially as automation and adaptive technologies reshape workflows.
🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
Editor’s note: raised a $100m Series A in September and is rumored to have reached a unicorn valuation. They have all-star advisors from Geoff Hinton to Yann Lecun and team of deep domain experts to tackle this next frontier in AI applications.
Major battery breakthrough paving way for EV upgrade
Chinese scientists have developed a lithium metal battery that boasts an energy density of more than 700 watt-hours per kilogram and stable performance at extremely low temperatures, marking a significant advancement in the production of high-energy batteries for electric vehicles. The research paper was published on Thursday in the science journal Nature.
Chen Jun, an academician of the Chinese Academy of Sciences and vice-president of Nankai University in Tianjin, was among the researchers who led the breakthrough. Chen said the team has replaced oxygen atoms with fluorine ones. It designed and synthesized novel fluorinated hydrocarbon solvent molecules, creating a new electrolyte system based on lithium-fluorine coordination.