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Potential Risks of Blocking GDF15âBased Brain Energy Sensing
GDF15 signals energetic stress to the brain, leading to unpleasant symptoms as the body conserves and reallocates energy. In conditions such as frailty and cancer, suppression of GDF15 signaling is expected to lead to an improvement in symptoms, but potentially at the cost of long-term health and survival.
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants
Jamaluddin et al. investigated how the MRAP2 accessory protein enhances signaling by three appetite-regulating GPCRs. MRAP2 disrupts GPCR oligomerization to form interactions, and its cytoplasmic region is essential for signaling. MRAP2 variants modulate receptor constitutive activity, enhance internalization, and reduce signaling, contributing to weight gain and hyperglycemia observed in humans.
Dune Messiah Meaning: The Warning We Keep Ignoring
Too many people misread Dune.
They walked out of Part One and Part Two inspired. Ready to cheer for Paul Atreides. Ready to root for the underdog against the empire.
They saw exactly what Frank Herbert was afraid they would see.
Dune is not about resilience. It is not a heroâs journey. It is not an invitation to find your inner messiah.
According to Herbert himself, Dune is a warning against charismatic leadership â not an example of it.
The liberation movement becomes the next oppressor. The just cause fuses with a messiah myth and stops being just. And the sequels go to places most audiences never expected â and most film fans have never encountered.
Heisenberg Made a Discovery in 1925. We Still Canât Explain It
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2025 is ⊠was the international year of quantum science and technology. Yes because quantum tech is increasingly important, but especially because quantum mechanics was invented 100 years ago this year. In 1925, our strangest true theory went from being a peculiar set of ideas to describe some funny results from experiments, to a full-blown theoretical framework that overturned how we think reality really works. So today, as the centenary year approaches its end I want to take you on a little journey through what may be the most paradigm-destroying several months in scientific history.
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Wind-powered robot could enable long-term exploration of hostile environments
Researchers at Cranfield University have created WANDER-bot, a low-cost, 3D-printed robot that is powered by wind energy. Designed to spend long durations in hostile, windy environments such as certain deserts, polar regions or even other planets, WANDER-bot doesnât need a battery to power movement, enabling longer operations without having to pause and recharge.
Movement accounts for around 20% of battery use in most robots, so running on natural energy makes WANDER-bot an efficient solution for long-term exploration or mapping of unknown terrains. As a result, any electronic elements added to future versions for data collection or transmission purposes could have their own smaller, lighter power source. Using natural energy also counters the issue of performance degradation over time in traditional power sources, such as solar cells and radioisotope thermoelectric generators.
Designed by Dr. Saurabh Upadhyay and Sam Kurian, Research Associate in Space Engineering, the robot uses parts that are entirely 3D printed, with the design deliberately simple to allow for quick repair and replacement. This means that, in theory, you could print and construct WANDER-bot anywhere and make replacement parts in situ as needed, removing the need for time-consuming and costly resupply missions.
