The interdict hypothesis is interesting too.
An exploration of the firstborn and reset hypothetical solutions to the Fermi Paradox.
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How Epigenetic Reprogramming Makes Cells Act Young Again
Aging doesn’t rewrite your DNA, it scrambles how your cells read it.
This clip explains epigenetic drift and how Life Biosciences’ therapy, ER100, uses Yamanaka factors to restore youthful epigenetic patterns in aged cells. By resetting the chemical marks that control gene expression, cells can behave as if they’re young again without changing the underlying DNA.
It’s the same biological process that happens early in embryonic development, applied in a controlled way to adult cells.
Abstract: In a cohort of over 1,000 patients with BreastCancer
Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor (GEF) for RAB11A, and its inhibition lowers lung metastasis and cell spreading in triple negative breast cancer models (TNBC):
The figure shows immunohistochemical assessment of SH3BP5L expression in tissue from patients with breast cancer.
@unito.it @fondazioneumbertoveronesi
1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “G. Tarone,” University of Torino, Torino, Italy.
2IEO, European Institute of Oncology IRCCS, Milan, Italy.
3Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy.
When water meets rock: Exploring water quality impacts from legacy lithium mining in North Carolina
Starting just outside Charlotte, North Carolina, a vast underground deposit of lithium stretches south for 25 miles. A key component of rechargeable batteries and energy grid storage systems, the soft, silvery metal is a global commodity, making this subterranean cache a geopolitically important and potentially lucrative resource.
Here, lithium primarily occurs within granite-like rocks called pegmatite, bound to a green-tinged mineral called spodumene. Two large lithium mines once operated in this region—called the Carolina Tin-Spodumene Belt—but closed decades ago. As demand for renewable energy climbs, mining companies have growing interest in the area.
The presence of historic, or legacy, lithium mines and the prospect of new lithium mining activity have led nearby residents to wonder about the possibility of drinking water contamination. Over the past several years, a team led by Avner Vengosh, Distinguished Professor and Nicholas Chair of Environmental Quality at Duke University’s Nicholas School of the Environment, has been working to address those concerns.
This job has become the ultimate case study for why AI won’t replace human workers
Want to understand how artificial intelligence could change your job? Look to radiology as a clue.
Radiology has come up multiple times as an example of a field that’s been impacted by AI without replacing the need for human workers.
Antibodies block bacteria that cause tuberculosis, study shows
A study led by UT Southwestern Medical Center researchers has found that certain antibodies inhibit Mycobacterium tuberculosis, the cause of tuberculosis (TB), the infectious disease that claims the most lives worldwide. Published in Cell Reports, the study identified characteristics of these antibodies and revealed insights that may lead to clinical tools that help prevent TB and other diseases.
“This data changes how we think about using the immune system against tuberculosis by showing how some antibodies activate immune cells in patients to block Mycobacterium tuberculosis (Mtb),” said the study’s senior author, Lenette Lu, M.D., Ph.D., Assistant Professor of Internal Medicine and Immunology and a member of the Division of Infectious Diseases and Geographic Medicine at UT Southwestern.
Despite widespread use of Bacillus Calmette-Guérin (BCG), the only licensed TB vaccine, the Centers for Disease Control and Prevention (CDC) estimates that 10.8 million people became ill with TB in 2023 and 1.25 million died.
Humans will merge with AI in 10 years | Ray Kurzweil and Lex Fridman
Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=ykY69lSpDdo.
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Ray Kurzweil is an author, inventor, and futurist.
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“The Bioelectric Interface to the Collective Intelligence of Morphogenesis” by Michael Levin
This is a ~57 minute talk titled “The Bioelectric Interface to the Collective Intelligence of Morphogenesis: development, regeneration, cancer, and beyond” which I gave at a UCSF seminar for an audience of graduate students and post-docs in Biophysics, Bioinformatics, and Chemical Biology. I covered the role of bioelectricity as cognitive glue underlying high-level adaptive plasticity in living tissue, recent progress in exploiting that interface, and new developments in research platforms for this field.
Brave New Biology: Intelligence Trumps DNA — with Dr. Michael Levin and Dr. John Vervaeke
Dr. Michael Levin is a professor in the Department of Biology at Tufts University and an associate faculty member at the Wyss Institute at Harvard. He directs the Allen Discovery Center at Tufts, where his team integrates biophysics, computational modeling, and behavioral science to study how cellular collectives make decisions during embryogenesis, regeneration, and cancer.
Levin’s research centers on diverse forms of intelligence and unconventional embodied minds, bridging conceptual theory, experimental biology, and translational work aimed at regenerative medicine. His lab also pioneers efforts in artificial intelligence and the bioengineering of novel living machines.
Read more about Dr. Michael Levin’s work: https://drmichaellevin.org/
X: https://twitter.com/drmichaellevin.
YouTube: @drmichaellevin
John Vervaeke’s YouTube channel: @johnvervaeke
📖 Let’s take our stories back. Check out our latest book in the Tales for Now and Ever series, Rapunzel and the Evil Witch: https://rapunzelbook.com/
Join Fr. Stephen De Young in his Jubilees and the Nephilim course, now streaming live on The Symbolic World: https://www.thesymbolicworld.com/cour… 00:00 — Coming up 01:14 — Intro music 01:40 — Introduction 02:23 — What Michael does 06:19 — Example experiments 07:51 — Memories outside the brain 12:46 — Terminology: memory 13:59 — Communicate to biological cells 15:54 — Limitations? 17:39 — Platonic patterns 34:06 — Incarnation and constraints 39:26 — Causes 49:28 — New beings in new spaces 52:25 — What the Enlightenment dismissed 55:32 — Molecular medicine 57:36 — Subtle bodies 01:00:45 — Ethics 01:03:37 — Medical and meaning applications 01:11:42 — Frightening 01:14:31 — Against the status quo 01:19:03 — Should we dabble in this technology? 💻 Website and blog: http://www.thesymbolicworld.com 🔗 Linktree: https://linktr.ee/jonathanpageau 🔒 BECOME A PATRON: https://thesymbolicworld.com/subscribe Our website designers: https://www.resonancehq.io/ My intro was arranged and recorded by Matthew Wilkinson: https://matthewwilkinson.net/