Majoros, Zhang, and Rahmati et al. identify a link between maternal autoimmunity and disrupted neuronal network development in the hippocampus of mice. In utero exposure to NMDA receptor autoantibodies impairs GABAergic signaling and early network synchrony in neonates, hindering the emergence of continuous hippocampal activity around eye opening.
Simulated lunar dirt can be turned into extremely durable structures, potentially paving the way to more sustainable and cost-effective space missions, a new study suggests. Using a special laser 3D printing method, researchers melted fake lunar soil—a synthetic version of the fine dusty material on the moon surface, called regolith simulant—into layers and fused it with a base surface to manufacture small, heat-resistant objects.
If utilized on the lunar surface, the material may help build sturdy, nontoxic habitats and tools for future astronauts, capabilities that would be vital to the NASA Artemis missions that aim to establish a long-term human presence on the moon by the end of the decade.
But to assess how well this new construction material may work in space, the team tested their fabrication process under a range of different environmental conditions, revealing that the overall quality of the material depends greatly on the surface onto which the soil is printed.
It’s now time to dig into quantum field theories with considerably more rigor than earlier in the series. First up is quantum electrodynamics, or QED. This was the first successful QFT, combining quantum mechanics and special relativity. Let’s learn what this model is all about, and how to do math with Feynman diagrams.
Script by andrew mattson, physics phd student at johns hopkins university.
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Traumatic head injuries from collision and combat sports disrupt the blood-brain barrier and trigger inflammation for years after retirement, shows a new MRI and transcriptomic analysis of retired athletes.
Find out more in Science TranslationalMedicine.
Sci. Transl. Med. 18, eadu6037 (2026). DOI:10.1126/scitranslmed.adu6037
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The European Space Agency announced Thursday it has re-established communication with a spacecraft that is part of its Proba-3 mission, after losing contact with the satellite a month ago.
Proba-3, which launched on a two-year mission in 2024, uses two spacecraft flying in precise formation to simulate a solar eclipse more than 60,000 kilometers (37,000 miles) above Earth.
Scientists have used this delicate dance to get a rare glimpse of the sun’s little-known outer atmosphere, which is called the corona.
Nutrient stress in DNA damage.
The dynamic interplay between nutrient stress and DNA damage governs cellular survival through coordinated regulation of genomic integrity and metabolic adaptation. Nutrient deprivation, such as glucose or amino acid limitation, engages nutrient sensors, including AMPK and mTORC1, to rewire energy homeostasis while directly influencing DNA repair via regulating PARP1, BRCA1, and other core repair machinery.
DNA damage-activated kinases (ATM/ ATR) orchestrate metabolic reprogramming to fuel repair processes, enforcing context-dependent cell fate decisions via cell cycle arrest or apoptosis regulation.
Nutrient stress exacerbates genomic instability through depleting antioxidants, such as NADPH or glutathione (GSH), promoting oxidative DNA lesions that overwhelm repair capacity, while defective DNA repair conversely drives metabolic dysregulation in tumors.
In the future, more efficacious tumor therapeutic strategies propose combining targeted nutrient stress with DNA damage repair inhibitors to exploit synthetic lethality. However, clinical translation requires resolving key challenges including tumor heterogeneity in nutrient stress-response pathways and adaptive metabolic plasticity during therapy sciencenewshighlights ScienceMission https://sciencemission.com/nutrient-stress–and-DNA-damage
Cells are constantly exposed to various stresses, including nutrient deprivation and genotoxic stress, which dynamically interact with cellular sensing pathways to influence metabolism, gene expression, and homeostasis. The integration of nutrient-sensing mechanisms and DNA damage response pathways is critical in cancer progression. While individual processes are well-characterized, their cross-regulatory mechanisms are just beginning to emerge. Deciphering the interplay between nutrient stress and DNA damage is crucial for elucidating the mechanisms underlying cellular responses to stress and developing therapeutic strategies for various diseases, including cancer. This review highlights the relationship between nutrient stress and DNA damage, especially its underlying sensing pathway and cell fate determination.
Yuan et al. report a high-quality chromosome-scale genome of the hexaploid halophyte Sesuvium portulacastrum. Comparative genomics and transcriptomics provide insights into its salt-adaptation evolution and identify the key salt-tolerant gene SpHAK3, offering genetic resources for improving crop tolerance.
