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Eyes may be a window into early Alzheimer’s detection

The eyes—specifically, the outer area of the retina—may provide a window into early detection of Alzheimer’s disease (AD) long before irreversible brain damage has occurred, according to new research from Houston Methodist. This discovery could dramatically change how the disease is diagnosed, monitored and treated.

“Retinal Müller glia alterations and their impact on ocular glymphatic clearance in an Alzheimer’s disease mouse model,” is online and will appear in an upcoming edition of the Journal of Alzheimer’s Disease. Led by Stephen Wong, Ph.D., the John S. Dunn Presidential Distinguished Chair in Biomedical Engineering at Houston Methodist and director of T. T. & W. F. Chao Center for BRAIN, the study reveals how the peripheral retina (versus the central retina) could be a window into early diagnosis of AD.

“The eyes are indeed a window into the brain, but our study reveals that we have been looking at the wrong part of the window,” Wong said. “While most clinical eye exams focus on the central retina, the most critical early indicators of AD appear to be hidden at the periphery of the eye. By identifying these retinal changes that occur before the brain’s ‘plumbing’ system fails, doctors may eventually be able to use routine eye exams to catch and treat the disease years before memory loss begins.”

Alzheimer’s ‘Clock’ Uses Blood Test to Forecast Symptom Onset

Researchers developed a “clock” model that based on a single blood test can estimate Alzheimer’s symptom onset in cognitively unimpaired adults.

The model predicted onset age with a roughly 3-year median margin of error.

— Findings could streamline enrollment for Alzheimer’s clinical trials.

Radiologic Biomarkers in Multiple Sclerosis: Improving Detection and Diagnosis

MRI is central to modern MultipleSclerosis diagnosis.

A review article by Drs. Elfasi and Fagundo highlights radiologic lbiomarkers in the 2024 McDonald criteria—including the central vein sign, paramagnetic rim lesions, cortical lesions, and optic nerve imaging.

https://ow.ly/cZrC50Yj69O National Multiple Sclerosis Society ACTRIMS American Academy of Neurology (AAN) Radiological Society of North America (RSNA) University of South Florida.

Imaging biomarkers, including cortical lesions, the central vein sign, and paramagnetic rim lesions, allow for more timely and accurate diagnosis of multiple sclerosis.

Scientists Believe Quantum Computers AreAbout to Cross a Major Line

We began this inquiry by looking at the mismatch between our computers and our brains. We realized that we were trying to run biological software on the wrong hardware. That era is ending. As we refine these quantum processors, we are finally building a mirror that is accurate enough to reflect the true nature of the mind. We are not just building faster computers. We are building a vessel that can hold the physics of thought.

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Timestamps:
0:00 Quantum Computers.
1:18 The Scale Problem.
4:40 The Thermodynamic Wall.
8:11 Quantum Mechanics in Wetware.
13:58 The \

Microsoft’s glass data storage system saves terabytes for 10,000 years

Imagine being an explorer, cracking open a 10,000-year-old tomb, uncovering a priceless ancient artifact – and getting rickrolled. Our deep descendants might just get the pleasure, thanks to a Global Music Vault due to be built in Norway, featuring Microsoft’s Project Silica, a tough new data storage medium that’s never gonna give you up.

There’s a common saying that once something is on the internet, it’s there forever, and even if you delete it, it will persist in some server somewhere. But that’s demonstrably untrue – just try to find your cringey old MySpace page. Even the most secure data center is vulnerable to the increasingly common and severe environmental disasters brought on by climate change. Many will lose their data if there’s a long-term power outage, or a large-scale electromagnetic pulse from an attack or, worse still, the Sun. Even in the best-case scenario, physical storage media like Blu-Rays, archival tape, hard drives and even solid state drives will degrade in decades.

To ensure that our history lives on for longer, Microsoft has been experimenting with storing data on glass with what it calls Project Silica. In 2019, the company demonstrated the tech in a partnership with Warner Bros by writing the 1978 movie Superman onto a slide of quartz silica glass and reading it back. The slide, measuring just 75 × 75 mm (3 × 3 in) and 2 mm (0.08 in) thick, could hold as much as 75.6 GB, and remained readable even after being scratched, baked, boiled, microwaved, flooded and demagnetized.

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