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Increasing autophagy in macrophages is a promising avenue of research aiming at heart disease and other age-related diseaeses.

Today we thought it was a good time to take a look at a new study that demonstrates that increasing autophagy is a good approach to slowing aging and could be the foundation for a variety of therapies to treat age-related diseases.

What is Autophagy?

Autophagy is an intracellular degradation system that delivers unwanted cell components to a type of cellular garbage disposal system, known as the lysosome. The lysosome uses powerful enzymes that break down the unwanted material for recycling. However, as we age the lysosomes become clogged up with materials that are so fused together not even the potent enzymes can destroy them and this causes the lysosomes to become dysfunctional and eventually the cell dies. This is a particular problem for long lived cells with a very low rate of replacement such as the heart, the back of the eye, nerve cells and other cells that rarely divide if at all. Ultimately as more and more cells become dysfunctional over time due to lysosome dysfunction, tissue function become impaired and age-related disease sets in.

Continue reading “Boosting Autophagy to treat heart disease” | >

NEW YORK (AP) — How long has our species been around? New fossils from Morocco push the evidence back by about 100,000 years.

The bones, about 300,000 years old, were unearthed thousands of miles from the previous record-holder, found in fossil-rich eastern Africa. The new discovery reveals people from an early stage of our species’ evolution, with a mix of modern and more primitive traits.

“They are not just like us,” said Jean-Jacques Hublin, one of the scientists reporting the find. But they had “basically the face you could meet on the train in New York.”

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The Poás Volcano in Costa Rica is home to two crater lakes, and they could not be more different. The first fills an inactive crater, its water is clear blue and its rim lush with vegetation. The other could be accurately described as a hell hole.

Laguna Caliente—literally hot lagoon in Spanish—derives its hellish qualities from the churning of magma underneath the active crater. Sulfur-rich vapor rises out of the lake, gagging anyone unlucky enough to get a whiff and poisoning anyone unlucky enough to get too many whiffs. The water itself is three times as acidic as battery acid. And every once in awhile, a rumbling below shoots a jet of hot, acidic water into the sky. It’s not the kind of place where you want to paddle a boat.

So Guy van Rentergem decided to build a drone boat. Van Rentergem visited Laguna Caliente in 2015 with friends and volcanologists, but he is not a volcanologist himself. However he is a chemist, a constant tinkerer, and a long-time caver who’s worked with geologists in the past. Next year, he told his colleagues, he’s coming back with an autonomous boat so they can map the bottom of the lake.

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It might seem like an idea taken straight out of science fiction, but a ‘space nation’ could soon become a reality.

The ambitious plans, first announced last year, were hatched by an international group of scientists and are backed by a Russian billionaire.

The floating nation, dubbed ‘Asgardia’, is set to take its first step into space later this year with the launch of its maiden data satellite.

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One of Apple’s new announcements has tech experts excited for augmented reality. One chief executive calls it a “game-changer.”

Apple unveiled its new operating system for its iPhone and iPad products, the iOS 11, at the Apple Worldwide Developers Conference on Monday.

The system also introduces ARKit, a new framework for developers to more easily build apps that use augmented reality: the tech that allows devices to display computer-generated images over the real world.

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The largest floating solar power plant in the world is now online in China. Floating where coal used to be mined, the installation is helping China transition toward renewables and making the most of its surroundings.

The world’s largest floating solar power plant is now online in China. Built by Sungrow, a supplier of PV inverter systems, the 40MW plant is now afloat in water four to 10 meters deep, and successfully linked to Huainan, China’s grid. The placement was chosen in large part because the area was previously the location of coal mining operations; and, as a result, the water there is now mineralized and mostly useless. The lake itself was only formed after years of mining operations, the surrounding land collapsed and created a cavity that was filled with rainwater.

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