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Jan 25, 2018
Bioquark Inc. — Best Damn Podcast — Ira Pastor
Posted by Ira S. Pastor in categories: aging, bioengineering, business, cosmology, cryonics, DNA, futurism, genetics, health, life extension
Jan 25, 2018
Graphene based glucose-monitoring contact lens comfortable enough to wear
Posted by Saúl Morales Rodriguéz in categories: biotech/medical, materials
A team of researchers with the Ulsan National Institute of Science and Technology in the Republic of Korea has developed a glucose monitoring contact lens that its makers claim is comfortable enough to wear. In their paper published on the open access site Science Advances, the group describes their contact lens and suggests it could be ready for commercial use within five years.
Diabetes results in unmanageable glucose levels, requiring those who have the disease to monitor and adjust them with insulin or medicine. Monitoring, unfortunately, requires pricking a finger to retrieve a blood sample for testing, which most people do not like. For that reason, scientists seek another way. A new method employs a contact lens. Prior research has shown glucose levels in tears follows that of glucose levels in the blood in many respects. To date, there are no commercially available contact lens products because, as the researchers note, they are made of hard materials that are uncomfortable in the eye. They claim to have overcome that problem by breaking apart the pieces of their sensing device and encapsulating each in a soft polymer and then connecting them together in a flexible mesh.
The polymer is the same type used in conventional contact lenses. The components of the device consist of a graphene-based sensor, a rectifier, LED display and a stretchable antenna. Power for the sensor is still external—it is held in the air a minimum of nine millimeters from the lens. The LED glows during normal conditions and turns off when high levels of glucose are detected. The flexibility of the lens and sensor components also allows for removal of the device in the same way as normal contact lenses—by grabbing and bending.
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Jan 25, 2018
Bioquark Inc. — Caring For Aging Parents Podcast — Ira Pastor
Posted by Ira S. Pastor in categories: aging, bioengineering, biotech/medical, business, cryonics, DNA, genetics, health, life extension
Jan 25, 2018
Top Journal Reveals Keys to Telomere Length and Human Disease
Posted by Brady Hartman in categories: biotech/medical, life extension
Jan 25, 2018
Scientists Reveal Keys to Our Telomere Length
Posted by Brady Hartman in category: life extension
Jan 25, 2018
Chinese Scientists Just Cloned a Monkey—Here Are the Details
Posted by Gerard Bain in category: biotech/medical
https://youtube.com/watch?v=VHizi6njTag
In 1996, Dolly the sheep became the first mammal to be cloned from a somatic cell. Twenty years later, scientists have succeeded in using the same technique on primates—as detailed in a study published today in the journal Cell, two long-tailed macaque monkeys were born at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai.
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Jan 25, 2018
We are happy to announce Dr. Michael West as a speaker for the 2018 Undoing Aging Conference
Posted by Michael Greve in category: life extension
Jan 25, 2018
How To Launch A Space Startup
Posted by Klaus Baldauf in categories: policy, space travel
Jan 25, 2018
TIGIT as a Biomarker for T Cell Senescence and Exhaustion
Posted by Steve Hill in categories: biotech/medical, life extension
In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.
In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.
Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), a novel co-inhibitory receptor, was upregulated in CD8 + T cells of elderly adults. Aged TIGIT + CD8 + T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by TIGIT knockdown.
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