Now online! A multi-omic single-cell atlas of the aging mouse brain reveals cell-type-specific transposon methylation changes, strengthening of 3D genome boundaries, and regionally heterogeneous aging signatures. These findings offer a resource to understand the molecular mechanisms of brain aging and guide future research on neurodegeneration.
https://doi.org/10.1172/jci.insight.
Here, Gavin E. Arteel & team perform alpha diversity analysis of hepatic transcriptome, revealing distinct pathways in alcohol-associated hepatitis and offering new perspectives on disease progression and identifying potentially informative biomarkers.
4Pittsburgh Liver Research Center, and.
5Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
6Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
From O’Neill cylinders to spiral habitats, discover how humanity might build colossal, interconnected cities high above Earth.
Watch my exclusive video The Economics of Immortality: https://nebula.tv/videos/isaacarthur–… Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa… Use the link https://gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $36. Visit our Website: http://www.isaacarthur.net Join Nebula: https://go.nebula.tv/isaacarthur Support us on Patreon: / isaacarthur Support us on Subscribestar: https://www.subscribestar.com/isaac-a… Facebook Group:
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/ discord Credits: Orbital Arcologies — Mega Cities in Space Written, Produced & Narrated by: Isaac Arthur Graphics: Bryan Versteeg, Jeremy Jozwik, Katie Byrne, Udo Schroeter Select imagery/video supplied by Getty Images Music Courtesy of Epidemic Sound http://epidemicsound.com/creator Chapters 0:00 Intro — The Conductor’s Tale 4:43 Why Megacities in Space? 6:02 The Four Foundational Assumptions of Space Habitat Design 10:11 Flawed Assumptions & Specialized Habitats 11:28 The Urban Web – Tethered Transit and Megacity Growth 17:14 Nebula 18:24 Spiral Habitats – A Rolled-Up City in Space 20:19 Density and Design – Population Scaling 23:17 Green Limits – CO₂, Heat, and Living Space 26:08 The Future of Orbital Urbanization – Terran Swarms and Beyond.
Get Nebula using my link for 40% off an annual subscription: https://go.nebula.tv/isaacarthur.
Get a Lifetime Membership to Nebula for only $300: https://go.nebula.tv/lifetime?ref=isa…
Use the link https://gift.nebula.tv/isaacarthur to give a year of Nebula to a friend for just $36.
Visit our Website: http://www.isaacarthur.net.
Join Nebula: https://go.nebula.tv/isaacarthur.
Support us on Patreon: / isaacarthur.
Support us on Subscribestar: https://www.subscribestar.com/isaac-a…
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SFIA Discord Server: / discord.
Credits:
Orbital Arcologies — Mega Cities in Space.
Written, Produced & Narrated by: Isaac Arthur.
Graphics: Bryan Versteeg, Jeremy Jozwik, Katie Byrne, Udo Schroeter.
Select imagery/video supplied by Getty Images.
Music Courtesy of Epidemic Sound http://epidemicsound.com/creator.
Chapters.
0:00 Intro — The Conductor’s Tale.
4:43 Why Megacities in Space?
6:02 The Four Foundational Assumptions of Space Habitat Design.
10:11 Flawed Assumptions & Specialized Habitats.
11:28 The Urban Web – Tethered Transit and Megacity Growth.
17:14 Nebula.
18:24 Spiral Habitats – A Rolled-Up City in Space.
20:19 Density and Design – Population Scaling.
23:17 Green Limits – CO₂, Heat, and Living Space.
26:08 The Future of Orbital Urbanization – Terran Swarms and Beyond.
The instruments we use to observe the universe might be playing a significant role in creating what we see. Are we discovering reality, or shaping it? #QuantumPhysics #ScientificMethod #PhilosophyOfScience #Observation Full podcast with Julian Barbour: • The Physicist Who Says Time Doesn’t Exist.
Who cares about running DOOM on a pregnancy test?
Microsoft may soon allow PC players to enjoy original Xbox and Xbox 360 games thanks to an official emulator for Windows. While the talk of the town is the upcoming Project Helix, a new report suggests that we might get the classic Xbox experience before the next-gen Xbox platform.
It seems like the company is exploring emulation as a way to improve backwards compatibility across platforms, especially as the company continues to blur the lines between Xbox consoles and Windows PCs.
Over the last decade or so, Microsoft has been slowly pushing toward a unified gaming ecosystem that spans Windows PCs, handhelds, and Xbox consoles. And it seems that emulation could be a new part of this strategy, particularly for games that aren’t easily accessible on modern platforms.
The sight of a delectable plate of lasagna or the aroma of a holiday ham are sure to get hungry bellies rumbling in anticipation of a feast to come. But although we’ve all experienced the sensation of “eating” with our eyes and noses before food meets mouth, much less is known about the information superhighway, known as the vagus nerve, that sends signals in the opposite direction — from your gut straight to your brain.
These signals relay more than just what you’ve eaten and when you are full. A new study in mice from researchers at Stanford Medicine and the Palo Alto, California-based Arc Institute has identified a critical link between the bacteria that live in your gut and the cognitive decline that often occurs with aging.
“Although memory loss is common with age, it affects people differently and at different ages,” said Christoph Thaiss, PhD, assistant professor of pathology. “We wanted to understand why some very old people remain cognitively sharp while other people see significant declines beginning in their 50s or 60s. What we learned is that the timeline of memory decline is not hardwired; it’s actively modulated in the body, and the gastrointestinal tract is a critical regulator of this process.”
Aging causes changes in gut bacteria in mice, which hampers communication between the intestines and the brain. Restoring this connection helped old mice form memories as well as young animals.
Whole-brain cell mapping using AI
The researchers developed a highly multiplexed whole-mount staining technique, utilizing the repeated application of fluorescence in situ hybridization.
The technique called mFISH3D for multiplexed mRNA staining in whole mouse organs and human tissue.
The technique helps to visualize 10 types of mRNAs in an intact mouse brain.
This workflow provides a robust approach to studying selective cell vulnerability in disease. sciencenewshighlights ScienceMission https://sciencemission.com/Artificial-intelligence-driven-wh…ll-mapping
Murakami et al. developed mFISH3D for multiplexed mRNA staining in whole-mouse organs and human tissue. Analysis of the stained mouse brains using the AI-driven ZenCell platform reveals unique cell populations activated by pharmacological perturbation. This workflow provides a robust approach to studying selective cell vulnerability in disease.
A man-made food source provided honey bees a nutritious diet at a commercial scale over the course of two winter seasons, according to a new study led by Washington State University researchers. The study, published in the journal Insects, looked at the new feed as used by five commercial beekeepers in California and Idaho from fall 2022 to spring 2024. This study is a follow-up to an initial paper describing the bee feed.
The nutritionally complete feed, which resembles an oversized, very thin granola bar, was developed by APIX Biosciences, a biotech company based in Belgium with a U.S. subsidiary. The company worked with WSU’s Honey Bee Program to test the nutritional supplement.
“The first paper was a trial during the spring and summer pollination season to make sure the feed worked in real-world field conditions,” said Brandon Hopkins, WSU’s P.F. Thurber Endowed Distinguished Professor of Pollinator Ecology and a corresponding author on the paper. “This study happened during the other half of the year when beekeepers tend to see the biggest losses and depend the most on supplemental feeding. It was also done on a significantly larger scale than our previous study.”