Lifeboat Foundation

Exposure to environmental pollutants can cause alterations in brain development that affect sexual development and fertility for several generations, according to findings to be presented in Lyon, at the European Society of Endocrinology annual meeting, ECE 2019. The offspring of pregnant rats exposed to a mixture of common endocrine-disrupting chemicals (EDCs), at doses equivalent to those commonly experienced by people, showed impairments in sexual development and maternal behaviour that were passed on through several generations. These findings suggest that current levels of endocrine-disrupting chemicals in our environment may already be causing long-lasting harm and that people and agencies should take measures to minimise exposure.

Endocrine-disrupting chemicals can interfere with the normal function of our hormones and have previously been associated with infertility and altered sexual development in animals and people. We are exposed to hundreds of these pollutants in our daily lives, as they are used in the manufacture of plastics, pesticides and medicines. However, the extent of damage being done to our health and the consequences to future generations remains unclear. Rodent studies have suggested that exposure to EDCs can affect brain development through several generations but the generational effects on sexual development and reproduction have not previously been investigated.

In this study, David Lopez Rodriguez a graduate student in Anne-Simone Parent’s lab at the University of Liege in Belgium monitored the sexual development of three generations of rats, whose parent generation only were exposed to a mixture of common EDCs during pregnancy and lactation. The female rats born in the first and second generation showed impairments in their care for their own pups. However, the female rats in the second and third generation exhibited a delayed onset of puberty and altered reproductive cycle and ovarian follicle development, indicating that their fertility was affected, even though they were never themselves exposed to the EDCs. These changes were associated with altered gene expression in their brains that are known to affect how reproductive hormones are regulated.

Continue reading “Environmental toxins can impair sexual development and fertility of future generations” »

In 2018, researchers at the Biogerontology Research Foundation and the International Longevity Alliance submitted a joint proposal to the World Health Organization to re-classify aging as a disease. Months later, 11th Revision of the International Classification of Diseases (ICD-11) officially introduced some aging-related conditions such as age-associated cognitive decline.

This matters because, for the first time in human history, the once natural process of aging is becoming recontextualized as a condition to be treated and prevented. This will gradually lead to pharmaceutical companies and governments redirecting funding to new drugs and therapies that not only extend human life expectancy but reverse the effects of aging entirely.

Thus far, people in developed nations have seen their average life expectancy rise from ~35 in 1820 to 80 in 2003. And with the advances you’re about to learn about, you’ll see how that progression will continue until 80 becomes the new 40. In fact, the first humans expected to live to 150 may have already been born.

Continue reading “Future of human population” »

Can we, as adults, grow new neurons? Neuroscientist Sandrine Thuret says that we can, and she offers research and practical advice on how we can help our brains better perform neurogenesis—improving mood, increasing memory formation and preventing the decline associated with aging along the way.

TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design — plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/translate

Continue reading “You can grow new brain cells. Here’s how | Sandrine Thuret” »

Nearly a year in space changed Scott Kelly’s genes, brain function and more, NASA’s Twin Study shows.

The wars of the future will be fought in megacities around the world by soldiers connected — and possibly even augmented — by neural implants and AIn this episode, we examine how military leaders are preparing for a radical shift in combat.

Looking for more episodes? Find them wherever you listen to podcasts.

Subscribe.

Continue reading “The Next Battlefield: Connected, Augmented and Urban” »

Clusters of human brain cells can integrate into rat brains, and that’s raising concerns about giving animals some form of human consciousness.

Researchers can grow stem cells into tiny clumps of cells, called organoids, that display similar activity and structure to human brains. To find out more about how exactly that works, read our primer from when we made the technique one of our Ten Breakthrough Technologies of 2015.

Now, though, reports Stat, several labs have inserted those organoids into rat brains and connected them to blood vessels; some of the organoids have even grown physical links with the rat brains. From Stat’s report:

Continue reading “Tiny Human Brains Inside Rats Are Sparking Ethical Concern” »

It’s the first brain-computer interface to synthesize an entire sentence.

Silicon transistors and the brain don’t mix.

At least not optimally. As scientists and companies are increasingly exploring ways to interface your brain with computers, fashioning new hardware that conforms to and compliments our biological wetware becomes increasingly important.

To be fair, silicon transistors, when made into electrode arrays, can perform the basics: record neural signals, process and analyze them with increasingly sophisticated programs that detect patterns, which in turn can be used to stimulate the brain or control smart prosthetics.

Continue reading “A New Ion-Drive Transistor Is Here to Interface With Your Brain” »

University at Buffalo researchers have identified the first human-specific fusion gene—a hybrid of two genes—implicated in Alzheimer’s disease. The finding suggests that a neurotransmitter receptor, previously successful in animal studies but that failed in human trials for Alzheimer’s, might still turn out to be a valuable therapy.

In a paper published in February in Translational Psychiatry, the UB researchers reported that this human fusion gene acts on a receptor for the neurotransmitter acetylcholine, which is involved in memory and learning, and which is reduced in people with Alzheimer’s.

The fusion gene is CHRFAM7A, which is very common in people and has been implicated in many neuropsychiatric disorders, such as schizophrenia and bipolar disease.

Continue reading “Researchers have identified the first human-specific fusion gene” »