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An international study led by the Institut de Neurociències at the UAB (INc-UAB) has shown that increasing levels of the Klotho protein in mice extends lifespan and improves both physical and cognitive health when aging.

As we grow older, it is natural to lose and , leading to greater frailty and a higher risk of falls and serious injuries. Cognitively, neurons progressively degenerate and lose connections, while diseases such as Alzheimer’s and Parkinson’s become more prevalent. In a society where the population is steadily aging, reducing these effects is one of the main challenges for research.

Now, in an article published in Molecular Therapy, an international research team led by Professor Miguel Chillón, ICREA researcher at the INc-UAB, has shown that increasing levels of the secreted form of the Klotho protein (s-KL) improves aging in mice.

In the 2024 SWC Lecture, Blaise Agüera y Arcas, VP and Fellow at Google Research and Google’s CTO of Technology & Society, challenged the notion that the brain is not a computer. He explained how both life and intelligence are inherently computational and may even be selected for in the same way.

Live illustration by Alex Cagan.

University of Wollongong researchers have experimentally confirmed that changes in hammer strike angle significantly affect the fracture path and form of stone flakes produced by Neanderthals during the Middle Paleolithic.

Published in Archaeological and Anthropological Sciences, the findings contradict a widely cited fracture model that credited rock core geometry and stiffness with flaking patterns and predicted that hammer strike angle would have minimal effect on flake formation. Results suggest a greater degree of cognitive control by early human tool makers than previously recognized.

Middle Paleolithic stone tool technology is defined by deliberate core preparation to produce flakes of predetermined size and shape. First appearing in the between 200,000 and 400,000 years ago, the Levallois method is a hallmark of Neanderthal tool making in this period.

The global climate is in an imbalance. Potential “tipping elements” include the Greenland ice sheet, coral reefs, and the Amazon rainforest. Together they form a network that can collapse if just one individual component tips.

Researchers from Bonn University Hospital (UKB) and the University of Bonn have now shed light on seemingly sudden and rare, often irreversible changes within a system, such as those that can be observed in the climate, the economy, social networks or even the human brain. They took a closer look at extreme events such as epileptic seizures.

Their aim was to better understand the mechanisms underlying such changes in order to ultimately make predictions. The results of their work have now been published in the journal Physical Review Research.

Our research found that the phenomenon arises when the part of the brain which detects familiarity de-synchronises with reality. Déjà vu is the signal which alerts you to this weirdness: it is a type of “fact checking” for the memory system.

But repetition can do something even more uncanny and unusual. The opposite of déjà vu is “jamais vu”, when something you know to be familiar feels unreal or novel in some way. In our recent research, which has just won an Ig Nobel award for literature, we investigated the mechanism behind the phenomenon.

Jamais vu may involve looking at a familiar face and finding it suddenly unusual or unknown. Musicians have it momentarily – losing their way in a very familiar passage of music. You may have had it going to a familiar place and becoming disorientated or seeing it with “new eyes”

Bollmann et al. track reactivated CA1 assemblies representing spatial memories during 16–20 h of sleep/rest. Assemblies initially reflect recently learned spatial memories but are gradually transformed into those seen during the memory recall session following rest. Whereas slow-wave sleep accelerates the assembly drift, REM epochs counteract it.

As they age, some people find it harder to understand speech in noisy environments. Now, University at Buffalo researchers have identified the area in the brain, called the insula, that shows significant changes in people who struggle with speech in noise.

The findings, published in the journal Brain and Language, contribute to the growing link between hearing loss and leading to . Previous research has separately established connections between hearing difficulties and dementia, as well as insula abnormalities and cognitive decline.

The insulae are two complicated structures that interact with the brain’s frontal lobe, which is responsible for higher-level cognitive function. The insulae integrate sensory, emotional and cognitive information.

Since the dawn of philosophy, thinkers from Plato to Kant have considered how beauty affects human experience, and whether it has the power to transform our state of mind.

Now, a new study from the University of Cambridge suggests that stopping to contemplate the beauty of artistic objects in a gallery or museum boosts our ability to think in abstract ways and consider the “bigger picture” when it comes to our lives.

Researchers say the findings offer that engaging with artistic beauty helps us escape the “mental trappings of daily life,” such as current anxieties and to-do lists, and induce “psychological distancing”: the process of zooming out on your thoughts to gain clarity.