Lifeboat Foundation

Identifying how to help a loved one struggling with mental health challenges can feel overwhelming. Our helpful guide is filled with tips, strategies, and resources that can accelerate the journey to recovery.

In a study from Yale-NUS College, researchers found evidence that metabolic dysfunction is a primary cause of Alzheimer’s disease is the most common neurodegenerative disease affecting the elderly worldwide, as well as one of the most common causes of dementia. In Singapore, one in 10 people aged 60 or above is believed to suffer from dementia.

Memories are stored in all different areas across the brain as networks of neurons called engrams. In addition to collecting information about incoming stimuli, these engrams capture emotional information. In a new study, Steve Ramirez, a neuroscientist at Boston University, discovered where the brain stores positive and negative memories and uncovered hundreds of markers that differentiate positive-memory neurons from negative-memory neurons.

In 2019, Ramirez found evidence that good and bad memories are stored in different regions of the hippocampus, a cashew-shaped structure that holds sensory and emotional information necessary for forming and retrieving memories. The top part of the hippocampus activated when mice underwent enjoyable experiences, but the bottom region activated when they had negative experiences.

His team also found that they could manipulate memories by activating these regions. When he and his team activated the top area of the hippocampus, bad memories were less traumatic. Conversely, when they activated the bottom part, mice exhibited signs of long-last lasting anxiety-related behavioral changes. Ramirez suspected this difference in effect was because the neurons that store good and bad memories have different functions beyond simply keeping positive and negative emotions. However, before he could unravel this difference, he needed to identify which cells were storing good and bad memories. The results were published in the journal Communications Biology.

Researchers at the University of Colorado Anschutz find that the overexpression of a gene improves learning and memory in Alzheimer’s.

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

Nothing in biology makes sense except in the light of evolution. The gradualism of evolution has explained and dissolved life’s mysteries—life’s seemingly irreducible complexity and the illusion that living things possess some sort of mysterious vitalizing essence. So, too, evolution is likely to be key to demystifying the seemingly inexplicable, ethereal nature of consciousness.

First, what does it even mean to say that “Nothing in biology makes sense except in the light of evolution”? If the chosen topic is human consciousness, Martin Luther King and Mother Teresa come quickly to mind. But then what does the term “evolution” contribute to the discussion of the origin of human consciousness? Is it something useful or something theorists are stuck with, come what may?

Science theories should make predictions. Who predicted either King or Mother Teresa?

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Hello and welcome! My name is Anton and in this video, we will talk about incredible discoveries about the human brain.
Links:
https://www.pnas.org/doi/full/10.1073/pnas.2204900119
https://www.nature.com/articles/s41586-022-05277-w.
https://en.wikipedia.org/wiki/ARHGAP11B
https://www.scienceinpublic.com.au/corticallabs.
https://www.nature.com/articles/s41586-019-1654-9
Synthetic cells: https://youtu.be/OxVZPKmm58M
#brain #biology #neuroscience.

Continue reading “Groundbreaking Discoveries About The Human Brain and Our Neurons” »

Summary: Study reveals a signaling pathway that controls the formation of synapses between pyramidal neurons and inhibitory neurons expressing the parvalbumin protein.

Source: King’s College London.

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has demonstrated that brain wiring requires the control of local protein synthesis at the level of specific synapse types.

Magnetic fields are all around us. They exist whenever there is electric current and have been used in various aspects of medicine for decades. Today, magnetic fields are used in applications including magnetic resonance imaging (MRI), bone fracture repair, wound healing and pain reduction.

Taking things a step further, US startup EMulate Therapeutics has developed a unique magnetic field technology that has been shown to replicate the effect of drugs in humans and animal models – all without the presence of chemicals. Having spun-out companies in cancer, pain management and beyond, the company is seeking partners for longevity applications of its technology.

Longevity. Technology: The concept behind EMulate’s approach is mind-boggling. The company “records” the electromagnetic signature of specific molecules and is then able to use those recordings to effect changes in cellular behaviour, without using chemicals. In its most advanced programme, EMulate’s technology has completed feasibility clinical trials for adults and children with terminal brain cancer, using a recording derived from chemotherapy drug paclitaxel. We caught up with EMulate’s CEO Chris Rivera to find out more.

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Mathematics and sex are deeply intertwined. From using mathematics to reveal patterns in our sex lives, to using sex to prime our brain for certain types of problems, to understanding them both in terms of the evolutionary roots of our brain, Dr Clio Cresswell shares her insight into it all.

Continue reading “Mathematics and sex | Clio Cresswell | TEDxSydney” »