Bryan Johnson took ketamine and monitored his brain activity for 15 days, recording the experience and sharing about it on X.
Johnson is a 47-year-old longevity-obsessed entrepreneur, known for sharing biohacking content across his social media channels. His most recent health experiment involved treatment with the popularized horse tranquilizer.
As he shared in a tweet, he wanted to test what happens to the brain before, during, and after ketamine treatment.
Ketamine has gained popularity as a fast-acting treatment for depression, PTSD, and chronic pain. Unlike traditional antidepressants, it works quickly by targeting the brain’s glutamate system to restore neural connections.
To monitor his brain activity, Johnson used his self-invented Kernel Flow—a form of non-invasive brain interface technology worn on the head.
S brain activity followed fixed, predictable patterns. After, he found his once-rigid thinking to be more flexible, varied, and open to new beliefs or ways of thinking. + Johnson likened his brain on ketamine to a global air traffic network, where each airport—or brain region—has consistent flight routes and traffic volumes.
“After ketamine, my brain’s activity patterns were completely scrambled. Instead of predictable routes between major hubs, traffic was rerouted to smaller, less-used airports across the U.S., Europe, and Asia,” he said in a tweet.
