Lifeboat Foundation

Genetics of human brain development.

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Brain organoids are self-organizing tissue cultures grown from patient cell-derived induced pluripotent stem cells. They form tissue structures that resemble the brain in vivo in many ways. This makes brain organoids interesting for studying both normal brain development and for the development of neurological diseases. However, organoids have been poorly studied in terms of neuronal activity, as measured by electrical signals from the cells.

A team of scientists led by Dr. Thomas Rauen from the Max Planck Institute for Molecular Biomedicine in Münster, Germany, in collaboration with Dr. Peter Jones’ group at the NMI (Natural and Medical Sciences Institute at the University of Tübingen, Germany), has now developed a novel microelectrode array system (Mesh-MEA) that not only provides optimal growth conditions for human brain organoids, but also allows non-invasive electrophysiological measurements throughout the entire growth period. This opens up new perspectives for the study of various brain diseases and the development of new therapeutic approaches.

The study is published in the journal Biosensors and Bioelectronics.

Researchers at Rutgers and Emory University are gaining insights into how schizophrenia develops by studying the strongest-known genetic risk factor.

When a small portion of chromosome 3 is missing—known as 3q29 deletion syndrome—it increases the risk for schizophrenia by about 40-fold.

Researchers have now analyzed overlapping patterns of altered gene activity in two models of 3q29 deletion syndrome, including mice where the deletion has been engineered in using CRIPSR, and human brain organoids, or three-dimensional tissue cultures used to study disease. These two systems both exhibit impaired mitochondrial function. This dysfunction can cause energy shortfalls in the brain and result in psychiatric symptoms and disorders.

Research conducted by Brown University’s Carney Institute for Brain Science illustrates how parts of the brain need to work together to focus on important information while filtering out distractions.

Imagine a busy restaurant: dishes clattering, music playing, people talking loudly over one another. It’s a wonder that anyone in that kind of environment can focus enough to have a conversation. A new study by researchers at Brown University’s Carney Institute for Brain Science provides some of the most detailed insights yet into the brain mechanisms that help people pay attention amid such distraction, as well as what’s happening when they can’t focus.

In an earlier psychology study, the researchers established that people can separately control how much they focus (by enhancing relevant information) and how much they filter (by tuning out distractions). The team’s new research, published in Nature Human Behaviour, unveils the process by which the brain coordinates these two critical functions.

Researchers from Tohoku University have created a theoretical framework for an advanced spin wave reservoir computing (RC) system that leverages spintronics. This innovation advances the field toward realizing energy-efficient, nanoscale computing with unparalleled computational power.

Details of their findings were published in npj Spintronics on March 1, 2024.

When people lack visual imagination, this is known as aphantasia. Researchers from the University Hospital Bonn (UKB), the University of Bonn, and the German Center for Neurodegenerative Diseases (DZNE) investigated how the lack of mental imagery affects long-term memory.

They were able to show that changes in two important brain regions, the hippocampus, and the occipital lobe, as well as their interaction, have an influence on the impaired recall of personal memories in aphantasia. The study results, which advance the understanding of autobiographical memory, have now been published online by the specialist journal eLife.

Most of us find it easy to remember personal moments from our own lives. These memories are usually linked to vivid inner images. People who are unable to create mental images, or only very weak ones, are referred to as aphantasics. Previous neuroscientific studies have shown that the hippocampus, in particular, which acts as the brain’s buffer during memory formation, supports both autobiographical memory and visual imagination.

Year 2011 This brain wave replication can eventually lead to thought transfer or even downloading things like the matrix.

In an exclusive excerpt from his new book, a pioneering neuroscientist argues that brain-wave control of machines will allow the paralyzed to walk, and portends a future of mind melds and thought downloads.

By Miguel A. L. Nicolelis

When neurons strengthen their synapses, they “infect” surrounding cells with a virus-like protein to weaken those cells’ excitatory connections, according to a new preprint.

Summary: Researchers propose a new approach to determine when consciousness emerges in infancy. Their suggestion, based on identifying markers of consciousness in adults and tracking when these markers appear in babies’ development, offers a potential pathway to understand this long-standing question.

The approach includes looking for specific behaviors or brain activation patterns known to correlate with consciousness in adults and then finding when these begin in infants. By identifying and grouping a broad range of markers present in early and late development, the researchers aim to pinpoint the emergence of consciousness more accurately. This method could provide insights into the complex process of becoming conscious, despite challenges like the inability of infants to communicate their experiences.