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A team of materials scientists, physicists, mechanical engineers, and molecular physiologists at Stanford University have developed a nanoparticle technique that can be used to measure force dynamics inside a living creature, such as Caenorhabditis elegans worms biting their food.

In their paper published in the journal Nature, the group describes how they used to excite luminescent nanocrystals in a way that allowed the energy levels of cells inside a C. elegans worm to be measured.

Andries Meijerink, with Utrecht University, has published a News & Views piece in the same journal issue, outlining the work done by the team in California.

Mechanical force is an essential feature for many physical and biological processes. Remote measurement of mechanical signals with high sensitivity and spatial resolution is needed for a wide range of applications, from robotics to cellular biophysics and medicine and even to space travel. Nanoscale luminescent force sensors excel at measuring piconewton forces, while larger sensors have proven powerful in probing micronewton forces.

However, large gaps remain in the force magnitudes that can be probed remotely from subsurface or interfacial sites, and no individual, non-invasive sensor has yet been able to make measurements over the large dynamic range needed to understand many systems.

A groundbreaking technique using time-resolved electron microscopy and multi-polarization lasers has allowed scientists to analyze plasmonic waves with great precision.

This method helped uncover the stable and dynamic nature of meron pairs’ spin textures, opening new avenues in nanoscale technology.

Advancing Plasmonics with Multi-Polarization Laser Techniques.

Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.

In a new paper in Nano Letters, the researchers demonstrate how peptides — short strings of amino acids — can serve as precise targeting molecules, enabling LNPs to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons.

This represents an important advance in delivering mRNA to the cell types that would be key in treating neurodegenerative diseases; any such treatments will need to ensure that mRNA arrives at the correct location. Previous work by the same researchers proved that LNPs can cross the BBB and deliver mRNA to the brain, but did not attempt to control which cells the LNPs targeted.

In a breakthrough set to revolutionize the semiconductor industry, the School of Engineering of the Hong Kong University of Science and Technology (HKUST) has developed the world’s first-of-its-kind deep-ultraviolet (UVC) microLED display array for lithography machines. This enhanced efficiency UVC microLED has showcased the viability of a lowered cost maskless photolithography through the provision of adequate light output power density, enabling exposure of photoresist films in a shorter time.

Conducted under the supervision of Prof. Kwok Hoi-Sing, Founding Director of the State Key Laboratory of Advanced Displays and Optoelectronics Technologies at HKUST, the study was a collaborative effort with the Southern University of Science and Technology, and the Suzhou Institute of Nanotechnology of the Chinese Academy of Sciences.

A lithography machine is crucial equipment for semiconductor manufacturing, applying short-wavelength ultraviolet light to make integrated circuit chips with various layouts. However, traditional mercury lamps and deep ultraviolet LED light sources have shortcomings such as large device size, low resolution, high energy consumption, low light efficiency, and insufficient optical power density.

Living organisms monitor time—and react to it—in many different ways, from detecting light and sound in microseconds to responding physiologically in pre-programmed ways, via their daily sleep cycle, monthly menstrual cycle, or to changes in the seasons.

Such an ability to react at different timescales is made possible via molecular switches or nanomachines that act or communicate as precise molecular timers, programmed to turn on and off in response to the environment and time.

Now, scientists at Université de Montréal have successfully recreated and validated two distinct mechanisms that can program both the activation and deactivation rates of nanomachines in living organisms across multiple timescales.

The 21st century faces an unprecedented energy challenge that demands innovative solutions. This video explores Zero Point Energy (ZPE), a groundbreaking concept rooted in quantum mechanics that promises limitless, clean, and sustainable power. Learn how the quantum vacuum—long considered empty—is teeming with virtual particles and untapped energy potential. From understanding the Casimir effect to leveraging advanced technologies like fractal energy collectors and quantum batteries, this video details how ZPE could revolutionize industries, mitigate climate change, and empower underserved communities. Dive into the science, challenges, and global implications of a ZPE-powered future.

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With so much fascinating research going on in quantum science and technology, it’s hard to pick just a handful of highlights. Fun, but hard. Research on entanglement-based imaging and quantum error correction both appear in Physics World’s list of 2024’s top 10 breakthroughs, but beyond that, here are a few other achievements worth remembering as we head into 2025 – the International Year of Quantum Science and Technology.

Quantum sensing

In July, physicists at Germany’s Forschungszentrum Jülich and Korea’s IBS Center for Quantum Nanoscience (QNS) reported that they had fabricated a quantum sensor that can detect the electric and magnetic fields of individual atoms. The sensor consists of a molecule containing an unpaired electron (a molecular spin) that the physicists attached to the tip of a scanning-tunnelling microscope. They then used it to measure the magnetic and electric dipole fields emanating from a single iron atom and a silver dimer on a gold substrate.

Researchers have successfully stabilized ferrocene molecules on a flat substrate for the first time, enabling the creation of an electronically controllable sliding molecular machine.

Artificial molecular machines, composed of only a few molecules, hold transformative potential across diverse fields, including catalysis, molecular electronics, medicine, and quantum materials. These nanoscale devices function by converting external stimuli, such as electrical signals, into controlled mechanical motion at the molecular level.

Ferrocene—a unique drum-shaped molecule featuring an iron (Fe) atom sandwiched between two five-membered carbon rings—is a standout candidate for molecular machinery. Its discovery, which earned the Nobel Prize in Chemistry in 1973, has positioned it as a foundational molecule in this area of study.