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Category: nanotechnology – Page 200

Lipid nanoparticles carry gene-editing cancer drugs past tumor defenses

As they grow, solid tumors surround themselves with a thick, hard-to-penetrate wall of molecular defenses. Getting drugs past that barricade is notoriously difficult. Now, scientists at UT Southwestern have developed nanoparticles that can break down the physical barriers around tumors to reach cancer cells. Once inside, the nanoparticles release their payload: a gene editing system that alters DNA inside the tumor, blocking its growth and activating the immune system.

The new , described in Nature Nanotechnology, effectively stopped the growth and spread of ovarian and liver tumors in mice. The system offers a new path forward for the use of the gene editing tool known as CRISPR-Cas9 in , said study leader Daniel Siegwart, Ph.D., Associate Professor of Biochemistry at UT Southwestern.

“Although CRISPR offers a new approach for treating , the technology has been severely hindered by the low efficiency of delivering payloads into tumors,” said Dr. Siegwart, a member of the Harold C. Simmons Comprehensive Cancer Center.

J. Randall & S. Kalinin | Ready for Atomically Precise Manufacturing & Electron Microscopy

Foresight Molecular Machines Group.
Program & apply to join: https://foresight.org/molecular-machines/

John Randall.
Why the world is finally ready for Atomically Precise Manufacturing.

Sergei Kalinin.
Electron Microscopy: The Fab on a Beam.

John Randall is currently President/CEO at Zyvex Labs. Prior to Zyvex, John spent 15 years with Texas Instruments (TI) where he worked in high resolution processing for integrated circuits, MEMS, and quantum effect devices and also worked at MIT’s Lincoln Laboratory on ion beam and x-ray lithography. John is Executive VP at NanoRetina and currently lends his 30+ years of experience in micro-and nano-fabrication to his roles as.
Adjunct Professor at UT Dallas and Fellow of the AVS and IEEE.

Sergei Kalinin is a corporate fellow at the Center for Nanophase Materials.
Sciences (CNMS) at Oak Ridge National Laboratory. He is also a Joint Associate Professor at the Department of Materials Science and Engineering at the University of Tennessee-Knoxville. He is a recipient of the Blavatnik Award (2018) and the RMS medal for Scanning Probe Microscopy (2015).

Find a written summary of this talk here (including slides, notes and more):

Continue reading “J. Randall & S. Kalinin | Ready for Atomically Precise Manufacturing & Electron Microscopy” | >

Using microbrewery waste to synthesize carbon quantum dots

For a few years now, spent grain, the cereal residue from breweries, has been reused in animal feed. This material could also be used in nanotechnology. Professor Federico Rosei’s team at the Institut national de la recherche scientifique (INRS) has shown that microbrewery waste can be used as a carbon source to synthesize quantum dots. The work, done in collaboration with Claudiane Ouellet-Plamondon of the École de technologie supérieure (ÉTS), was published in the Royal Society of Chemistry’s journal RSC Advances.

Often considered “artificial atoms,” are used in the transmission of light. With a range of interesting physicochemical properties, this type of nanotechnology has been successfully used as a sensor in biomedicine or as LEDs in next generation displays. But there is a drawback. Current quantum dots are produced with heavy and toxic metals like cadmium. Carbon is an interesting alternative, both for its biocompatibility and its accessibility.

Scientists observe longitudinal plasmonic field in nanocavity at subnano-scale

A group of scientists working on surface-enhanced Raman spectroscopy (SERS) has made a nanoruler to provide insight into the longitudinal plasmonic fields in nanocavities, according to research published in the Journal of the American Chemical Society.

SERS is a highly sensitive and powerful spectral analysis technique applicable in various fields. In to weak Raman scattering, SERS achieves a dramatically enhanced Raman signal of up to 1010–15, allowing the analysis of single molecules.

“How we develop the technology depends, to a large extent, on what we know about fields. In the experiments, we observed an uneven distribution in the plasmonic field at the nano-scale. But it lacks theoretic and experimental support. So we decided to figure it out,” said Yang Liangbao, who leads the team at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences.

Nanostructured surfaces for future quantum computer chips

Quantum computers are one of the key future technologies of the 21st century. Researchers at Paderborn University, working under Professor Thomas Zentgraf and in cooperation with colleagues from the Australian National University and Singapore University of Technology and Design, have developed a new technology for manipulating light that can be used as a basis for future optical quantum computers. The results have now been published in Nature Photonics.

New optical elements for manipulating light will allow for more advanced applications in modern information technology, particularly in quantum computers. However, a major challenge that remains is non-reciprocal light propagation through nanostructured surfaces, where these surfaces have been manipulated at a tiny scale.

Professor Thomas Zentgraf, head of the working group for ultrafast nanophotonics at Paderborn University, explains that “in reciprocal propagation, light can take the same path forward and backward through a structure; however, non-reciprocal propagation is comparable to a one-way street where it can only spread out in one direction.”

Technique allows researchers to align gold nanorods using magnetic fields

An international team of researchers has demonstrated a technique that allows them to align gold nanorods using magnetic fields, while preserving the underlying optical properties of the gold nanorods.

“Gold nanorods are of interest because they can absorb and scatter specific , making them attractive for use in applications such as biomedical imaging, sensors, and other technologies,” says Joe Tracy, corresponding author of a paper on the work and a professor of materials science and engineering at North Carolina State University.

It is possible to tune the wavelengths of light absorbed and scattered by engineering the dimensions of the gold nanorods. Magnetically controlling their orientation makes it possible to further control and modulate which wavelengths the nanorods respond to.

Functional DNA-based cytoskeletons for synthetic cells

Cytoskeletons are essential components of cells that perform a variety of tasks, and artificial cytoskeletons that perform these functions are required for the bottom-up assembly of synthetic cells. Now, a multi-functional cytoskeleton mimic has been engineered from DNA, consisting of confined DNA filaments that are capable of reversible self-assembly and transport of gold nanoparticles and vesicular cargo.

Atom Scale Manufacturing: The Path to Ultimate Green Technologies | Robert Wolkow | TEDxYYC

Manufacturing with atoms has been the siren’s call for many researchers who believed it was the key that could unlock enormous new potential in how we build things. We could develop products that are perfectly precise, contain zero waste and that are 1000x more energy efficient. The problem has always been the same: How? Until now. Wolkow has taken a leading role in laying a new, stable foundation for the world to begin building on the tiniest of scales. Robert Wolkow is a Professor in the Department of Physics, iCORE Chair of Nanoscale Information and Communications Technology at the University of Alberta and Fellow of the Royal Society of Canada. He is also the Principal Research Officer and Nanoelectronics Program Coordinator at the NRC Nanotechnology Research Centre (NRC-NANO), AITF Industrial Chair in Atom Scale Fabrication and CTO of Quantum Silicon Inc.

An award-winning innovator, Wolkow has had a leading role in discovering, altering and deploying atom scale properties of silicon. His years of fundamental advances have laid a broad foundation for practical applications. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

Nanoparticles that control flow of light like road signs direct traffic

Developed in collaboration with colleagues from China, Germany and Singapore, the new technology uses nanoparticles, so small that about 12,000 of them can fit within a cross-section of a human hair. These tiny particles are arranged into unique patterns on the slides.

Physicists at The Australian National University (ANU) have developed tiny translucent slides capable of producing two very different images by manipulating the direction in which light travels through them.

As light passes through the slide, an image of Australia can be seen, but when you flip the slide and look again, an image of the Sydney Opera House is visible. The pair of images created is just one example of an untapped number of possibilities.

The ability to produce two distinctly different images is possible thanks to the ANU scientists’ ability to control the direction in which light can and can’t travel at the nanoscale. The development could pave the way for new light-based devices that could lead to faster, cheaper and more reliable Internet. It could also serve as the foundation for many of the technologies of tomorrow.

Microsoft Lasers Music into Glass for 1000 Years of Storage

Philip Glass to release a short silence on the matter.

The music vault is a parallel project to the Global Seed Vault (opens in new tab), which keeps the seeds of today’s trees and plants safe for the future, just in case we need to rebuild agriculture for any reason. The vault is located on the island of Spitsbergen, Norwegian territory, within the Arctic circle. It lacks tectonic activity, is permanently frozen, is high enough above sea level to stay dry even if the polar caps melt, and even if the worst happens, it won’t thaw out fully for 200 years. Just to be on the safe side, the main vault is built 120m into a sandstone mountain, and its security systems are said to be robust. As of June 2021, the seed vault had conserved 1,081,026 different crop samples.

The music is to be stored in a dedicated vault in the same mountain used by the seed vault. The glass used is an inert material, shaped into platters 75mm (3 inches) across and 2mm (less than 1/8th of an inch) thick. A laser encodes data in the glass by creating layers of three-dimensional nanoscale gratings and deformations. Machine learning algorithms read the data back by decoding images and patterns created as polarized light shines through the glass. The silica glass platters are fully resistant to electromagnetic pulses and the most challenging of environmental conditions. It can be baked, boiled, scoured and flooded without degradation of the data written into the glass. Tests to see if it really does last many thousands of years, however, can be assumed to be ongoing.

Jurgen Willis, Vice President of Program Management at Microsoft, said, “In this proof of concept, Microsoft and Elire Group worked together to demonstrate how Project Silica can help achieve the goal of preserving and safeguarding the world’s most valuable music for posterity, on a medium that will stand the test of time, using innovative archival storage in glass.”

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