An environmental chemistry laboratory at Duke University has solved a longstanding mystery of the origin of high levels of PFAS—so-called “forever chemicals”—contaminating water sources in the Piedmont region of North Carolina.
By sampling and analyzing sewage in and around Burlington, NC, the researchers traced the chemicals to a local textile manufacturing plant. The source remained hidden for years because the facility was not releasing chemical forms of PFAS that are regulated and monitored. The culprit was instead solid nanoparticle PFAS “precursors” that degrade into the chemicals that current tests are designed to detect.
Incredibly, these precursors were being released into the sewer system at concentrations up to 12 million parts-per-trillion—approximately 3 million times greater than the Environmental Protection Agency’s recently-enacted drinking water regulatory limit for certain types of PFAS.
Ultrasound-responsive nanoparticles (URNs) enable spatiotemporal activation of immunomodulators that can remodel the tumor microenvironment and strengthen immune responses. This review summarizes how URNs enhance immune checkpoint blockade, vaccines, T cell therapies, cytokine delivery, and innate immune modulators, while synergizing with strategies such as oxygenation, extracellular matrix depletion, metabolic reprogramming, and phototherapy. By offering precise control and reduced systemic toxicity, URNs represent a promising platform for the rational design of next-generation cancer immunotherapies.
Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain–machine interfaces have changed over time, along with the available technology. Mechanical levers and cable winches were used to move parts of the brain during the mechanical age. Sophisticated electronic wiring and remote control have arisen during the electronic age, ultimately leading to plug-and-play computer interfaces. Nonetheless, our brains are so complex that these visions, until recently, largely remained unreachable dreams. The general problem, thus far, is that most of our technology is mechanically and/or electrically engineered, whereas the brain is a living, dynamic entity. As a result, these worlds are difficult to interface with one another.
High-energy cosmic radiation damages cells and DNA, causing cancer, and secondary neutrons—generated especially from the planetary surfaces—can be up to 20 times more harmful than other radiations. Aluminum, the most widely used shielding material, has the drawback of generating additional secondary neutrons when below a certain thickness.
Consequently, boron nitride nanotubes (BNNTs), which are lightweight, strong, and possess excellent neutron shielding capabilities, are emerging as a promising alternative.
BNNTs are ultrafine tubular only about 5 nanometers in diameter—roughly 1/20,000 the thickness of a human hair—making them extremely light and strong, with excellent thermal neutron absorption capability. However, due to limitations in fabrication technology, they have so far only been produced into thin and brittle sheet, restricting their practical applications.
Not exactly a brain chip per se by a bit of nanotech.
While companies like Elon Musk’s Neuralink are hard at work on brain-computer interfaces that require surgery to cut open the skull and insert a complex array of wires into a person’s head, a team of researchers at MIT have been researching a wireless electronic brain implant that they say could provide a non-invasive alternative that makes the technology far easier to access.
They describe the system, called Circulatronics, as more of a treatment platform than a one-off brain chip. Working with researchers from Wellesley College and Harvard University, the MIT team recently released a paper on the new technology, which they describe as an autonomous bioelectronic implant.
As New Atlas points out, the Circulatronics platform starts with an injectable swarm of sub-cellular sized wireless electronic devices, or “SWEDs,” which can travel into inflamed regions of the patient’s brain after being injected into the bloodstream. They do so by fusing with living immune cells, called monocytes, forming a sort of cellular cyborg.
The ability to precisely study and manipulate electrons in electron microscopes could open new possibilities for the development of both ultrafast imaging techniques and quantum technologies.
Over the past few years, physicists have developed new experimental tools for studying the behavior of electrons not bounded to any material by utilizing the so-called nanoscale field emitters, tiny metallic tips that release electrons when exposed to strong electric fields.
Researchers at the Max Planck Institute for Multidisciplinary Sciences recently carried out a study aimed at shedding new light on how pairs of emitted electrons relate to each other and how their behavior unfolds over time.
*This video was recorded at ‘Paths to Progress’ at LabWeek hosted by Protocol Labs & Foresight Institute.*
Protocol Labs and Foresight Institute are excited to invite you to apply to a 5-day mini workshop series to celebrate LabWeek, PL’s decentralized conference to further public goods. The theme of the series, Paths to Progress, is aimed at (re)-igniting long overdue progress in longevity bio, molecular nanotechnology, neurotechnology, crypto & AI, and space through emerging decentralized, open, and technology-enabled funding mechanisms.
*This mini-workshop is focused on Paths to Progress in Molecular Nanotechnology* Molecular manufacturing, in its most ambitious incarnation, would use programmable tools to bring together molecules to make precisely bonded components in order to build larger structures from the ground up. This would enable general-purpose manufacturing of new materials and machines, at a fraction of current waste and price. We are currently nowhere near this ambitious goal. However, recent progress in sub-fields such as DNA nanotechnology, protein-engineering, STM, and AFM provide possible building blocks for the construction of a v1 of molecular manufacturing; the molecular 3D printer. Let’s explore the state of the art and what type of innovation mechanisms could bridge the valley of death: how might we update the original Nanotech roadmap; is a tech tree enough? how might we fund the highly interdisciplinary progress needed to succeed: FRO vs. DAO?
*About The Foresight Institute*
The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1986 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support. From molecular nanotechnology, to brain-computer interfaces, space exploration, cryptocommerce, and AI, Foresight gathers leading minds to advance research and accelerate progress toward flourishing futures.
*We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page:* https://foresight.org/donate/
Eric Drexler is a Senior Visiting Fellow at the Oxford Martin School, and a pioneering nanotechnology researcher and author. His 1981 paper in the Proceedings of the National Academy of Sciences established fundamental principles of molecular engineering and identified development paths leading to advanced nanotechnologies.
In his 1986 book, Engines of Creation, he introduced a broad audience to the promise of high-throughput atomically precise manufacturing, a prospective technology using nanoscale machinery to guide molecular motion and bonding, thereby structuring matter from the bottom up.
Link to full video: • Nanotechnology: the big picture with Dr Er…
