Researchers have demonstrated that a nanoparticle of 7,000 sodium atoms can act as a wave, creating a record-setting superposition.
Category: nanotechnology – Page 2
Live-cell tracking reveals dynamic interaction between protein folding helpers and newly produced proteins
Proteins are the molecular machines of cells. They are produced in protein factories called ribosomes based on their blueprint—the genetic information. Here, the basic building blocks of proteins, amino acids, are assembled into long protein chains. Like the building blocks of a machine, individual proteins must have a specific three-dimensional structure to properly fulfill their functions.
To achieve this, the newly produced protein chains in human cells are folded into their stable and functional form with the help of various protein folding helper proteins, known as chaperones, such as TRiC/PFD, or HSP70/40. The protein folding helpers isolate the amino acid chains, which have different chemical properties depending on the amino acid, from the cellular environment. This prevents the newly produced protein chains from clumping together and causing disease.
F.-Ulrich Hartl, a director at the Max Planck Institute of Biochemistry, has spent decades studying the mechanisms of protein folding. Niko Dalheimer, a scientist in Hartl’s department and one of the two lead authors of a new study published in Nature, explains: Much of what we know about protein folding has been learned from studies conducted in test tubes. However, it is virtually impossible to faithfully replicate the cellular environment in vitro.
The Scientist Behind Moderna on How Engineering Revolutionizes Medicine
What does it take to turn bold ideas into life-saving medicine?
In this episode of The Big Question, we sit down with @MIT’s Dr. Robert Langer, one of the founding figures of bioengineering and among the most cited scientists in the world, to explore how engineering has reshaped modern healthcare. From early failures and rejected grants to breakthroughs that changed medicine, Langer reflects on a career built around persistence and problem-solving. His work helped lay the foundation for technologies that deliver large biological molecules, like proteins and RNA, into the body, a challenge once thought impossible. Those advances now underpin everything from targeted cancer therapies to the mRNA vaccines that transformed the COVID-19 response.
The conversation looks forward as well as back, diving into the future of medicine through engineered solutions such as artificial skin for burn victims, FDA-approved synthetic blood vessels, and organs-on-chips that mimic human biology to speed up drug testing while reducing reliance on animal models. Langer explains how nanoparticles safely carry genetic instructions into cells, how mRNA vaccines train the immune system without altering DNA, and why engineering delivery, getting the right treatment to the right place in the body, remains one of medicine’s biggest challenges. From personalized cancer vaccines to tissue engineering and rapid drug development, this episode reveals how science, persistence, and engineering come together to push the boundaries of what medicine can do next.
#Science #Medicine #Biotech #Health #LifeSciences.
Chapters:
00:00 Engineering the Future of Medicine.
01:55 Failure, Persistence, and Scientific Breakthroughs.
05:30 From Chemical Engineering to Patient Care.
08:40 Solving the Drug Delivery Problem.
11:20 Delivering Proteins, RNA, and DNA
14:10 The Origins of mRNA Technology.
17:30 How mRNA Vaccines Work.
20:40 Speed and Scale in Vaccine Development.
23:30 What mRNA Makes Possible Next.
26:10 Trust, Misinformation, and Vaccine Science.
28:50 Engineering Tissues and Organs.
31:20 Artificial Skin and Synthetic Blood Vessels.
33:40 Organs on Chips and Drug Testing.
36:10 Why Science Always Moves Forward.
The Big Question with the Museum of Science:
Peppermint oil plasma coating could cut catheter infections without releasing drugs
Australian researchers have developed a high‑performance coating made from peppermint essential oil that can be applied to the surfaces of many commonly used medical devices, offering a safer way to protect patients from infection and inflammation.
Matthew Flinders Professor and senior author of the new study, Professor Krasimir Vasilev, says the idea emerged after noticing that eating peppermint leaves from his drink significantly relieved his sore throat, inspiring him to explore whether its bioactivity could be converted into a durable coating using plasma technology—something he has been researching for more than two decades.
The team from Flinders’s Biomedical Nanoengineering Laboratory—including Professor Vasilev (Director), Associate Professor Vi‑Khanh Truong, Dr. Andrew Hayes, and Ph.D. candidates Trong Quan Luu and Tuyet Pham—created a nanoscale peppermint‑oil coating that protects against infection, inflammation and oxidative stress, while remaining compatible with human tissue and suitable for medical materials.
Electron-phonon ‘surfing’ could help stabilize quantum hardware, nanowire tests suggest
That low-frequency fuzz that can bedevil cellphone calls has to do with how electrons move through and interact in materials at the smallest scale. The electronic flicker noise is often caused by interruptions in the flow of electrons by various scattering processes in the metals that conduct them.
The same sort of noise hampers the detecting powers of advanced sensors. It also creates hurdles for the development of quantum computers—devices expected to yield unbreakable cybersecurity, process large-scale calculations and simulate nature in ways that are currently impossible.
A much quieter, brighter future may be on the way for these technologies, thanks to a new study led by UCLA. The research team demonstrated prototype devices that, above a certain voltage, conducted electricity with lower noise than the normal flow of electrons.
Platinum nanostructure sensor can differentiate mirror-image volatile scent compounds
Terpenes are volatile organic compounds that are responsible for, among other things, the typical scents of plants, resins or citrus fruits. These compounds occur naturally in the environment and influence chemical processes in the atmosphere. At high concentrations, they can irritate the respiratory tract and contribute to the formation of harmful derivatives. Many terpenes exist in two mirror-image forms, known as enantiomers, which can differ significantly in terms of their effects and how they are perceived—but which are difficult to distinguish between using technical means.
Now, researchers from the Department of Chemistry at the University of Basel have presented a new approach that allows these mirror-image forms of the molecules to be detected specifically.
“Our work focused on a specially developed platinum-based molecule that works as a sensor,” explains Dr. Annika Huber, first author of the study and a former doctoral student at the Swiss Nanoscience Institute’s Ph.D. School. “This sensor molecule has a fixed, three-dimensional shape and aggregates with a large number of identical molecules to form tiny stack-like nanostructures that react differently to the two mirror-image forms of the terpenes.”
Niobium’s superconducting switch cuts near-field radiative heat transfer 20-fold
When cooled to its superconducting state, niobium blocks the radiative flow of heat 20 times better than when in its metallic state, according to a study led by a University of Michigan Engineering team. The experiment marks the first use of superconductivity—a quantum property characterized by zero electrical resistance—to control thermal radiation at the nanoscale.
Leveraging this effect, the researchers also experimentally demonstrated a cryogenic thermal diode that rectifies the flow of heat (i.e., the heat flow exhibits a directional preference) by as much as 70%.
“This work is exciting because it experimentally shows, for the very first time, how nanoscale heat transfer can be tuned by superconductors with potential applications for quantum computing,” said Pramod Sangi Reddy, a professor of mechanical engineering and materials science and engineering at U-M and co-corresponding author of the study published in Nature Nanotechnology.