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Abstract: From synaptogenic to synaptotoxic

This issue’s cover features work by Alberto Siddu & team on the promotion of synapse formation in human neurons by free amyloid-beta peptides, in contrast to aggregated forms that are synaptotoxic:

The image shows a human induced neuron exposed to a nontoxic concentration of amyloid-beta42 peptide, revealing enhanced synaptogenesis, visible as synaptic puncta along the dendritic arbor.


Address correspondence to: Alberto Siddu, Lorry Lokey Stem Cell Building, 265 Campus Dr., Room G1015, Stanford, California 94,305, USA. Phone: 650.721.1418; Email: asiddu@stanford.edu. Or to: Thomas C. Südhof, Lorry Lokey Stem Cell Building, 265 Campus Dr., Room G1021, Stanford, California 94,305, USA. Phone: 650.721.1418; Email: tcs1@stanford.edu.

An Old Jeweler’s Trick Could Unlock the Next Generation of Nuclear Clocks

Last year, a research team led by UCLA achieved a milestone scientists had pursued for half a century. They succeeded in making radioactive thorium nuclei interact with light by absorbing and emitting photons, similar to how electrons behave inside atoms. First envisioned by the group in 2008, the breakthrough is expected to transform precision timekeeping and could significantly improve navigation systems, while also opening the door to discoveries that challenge some of the most basic constants in physics.

The advance comes with a major limitation. The required isotope, thorium-229, exists only as a byproduct of weapons-grade uranium, making it extremely rare. Researchers estimate that just 40 grams of this material are currently available worldwide for use in nuclear clock research.

A new study now shows a way around this obstacle. An international collaboration led by UCLA physicist Eric Hudson has developed an approach that uses only a small fraction of the thorium needed in earlier experiments, while delivering the same results previously achieved with specialized crystals. Described in Nature, the technique is both straightforward and low cost, raising the possibility that nuclear clocks could one day be small and affordable enough to fit into everyday devices like phones or wristwatches. Beyond consumer electronics, the clocks could replace existing systems used in power grids, cell phone towers, and GPS satellites, and may even support navigation where GPS is unavailable, such as in deep space or underwater.

New ‘DNA cassette tape’ can store up to 1.5 million times more data than a smartphone — and the data can last 20,000 years if frozen

Scientists have discovered that over half a mile of DNA could hold over 360,000 terabytes of data.

Abstract: ZMIZ1 and estrogen receptor α form an essential partnership in endometrial biology:

This Commentary by Md Saidur Rahman, Kyeong A. So & Jae-Wook Jeong discusses Sylvia C. Hewitt et al.: https://doi.org/10.1172/JCI193212


1Department of Obstetrics, Gynecology & Women’s Health, University of Missouri School of Medicine, Columbia, Missouri, USA.

2Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Republic of Korea.

Address correspondence to: Jae-Wook Jeong, 1,030 Hitt Street, NextGen Precision Health Building, Columbia, Missouri 65,211, USA. Phone: 573.884.1882; Email: jeongjw@health.missouri.edu.

Tiny optical modulator could enable giant future quantum computers

Researchers have made a major advance in quantum computing with a new device that is nearly 100 times smaller than the diameter of a human hair.

Published in the journal Nature Communications, the breakthrough optical phase modulators could help unlock much larger quantum computers by enabling efficient control of lasers required to operate thousands or even millions of qubits—the basic units of quantum information.

Critically, the team of scientists have developed these devices using scalable manufacturing, avoiding complex, custom builds in favor of those used to make the same technology behind processors already found in computers, phones, vehicles, home appliances—virtually everything powered by electricity (even toasters).

Abstract: The antibody Teplizumab can delay type 1 diabetes, but therapeutic responses are heterogeneous

Here, Conny Gysemans & team find variable patient responses align with specific immune gene signatures, offering a tool to predict treatment success or resistance.


Address correspondence to: Conny Gysemans, Leuven Diabetes Lab, Clinical and Experimental Endocrinology (CEE), CHROMETA, KU Leuven, Leuven, Belgium. Phone: 32.16.377454; Email: conny.gysemans@kuleuven.be.

Abstract: The mechanistic basis of chronic liver disease is still only partially understood

Harmeet Malhi & team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments:

The figure shows reduction within the high-fat,-fructose, and-cholesterol,-lipotoxicity-influenced enhancer (FFC-LIE) mouse groups compared with FFC-scramble controls.


Address correspondence to: Harmeet Malhi, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55,905, USA. Phone: 507.284.0686; Email: Malhi.harmeet@mayo.edu.

Reconfigurable platform slows lights for on-chip photonic engineering

Integrated circuits are the brains behind modern electronic devices like computers or smart phones. Traditionally, these circuits—also known as chips—rely on electricity to process data. In recent years, scientists have turned their attention to photonic chips, which perform similar tasks using light instead of electricity to improve speed and energy efficiency.

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