The effects of exercise would not be nearly as powerful without the input of the brain, according to new research.
A study on mice has found a critical signal in the central nervous system that helps build physical endurance in the wider body after repeated exercise.
Traditionally, scientists thought that our body’s extensive response to frequent exercise occurred mainly in the periphery, such as the bones and muscles, and the heart.
Humanoid robots with full-body autonomy are rapidly advancing and are expected to create a $50 trillion market, transforming industries, economy, and daily life ## ## Questions to inspire discussion.
Neural Network Architecture & Control.
🤖 Q: How does Figure 3’s neural network control differ from traditional robotics? A: Figure 3 uses end-to-end neural networks for full-body control, manipulation, and room-scale planning, replacing the previous C++-based control stack entirely, with System Zero being a fully learned reinforcement learning controller running with no code on the robot.
🎯 Q: What enables Figure 3’s high-frequency motor control for complex tasks? A: Palm cameras and onboard inference enable high-frequency torque control of 40+ motors for complex bimanual tasks, replanning, and error recovery in dynamic environments, representing a significant improvement over previous models.
🔄 Q: How does Figure’s data-driven approach create competitive advantage? A: Data accumulation and neural net retraining provides competitive advantage over traditional C++ code, allowing rapid iteration and improvement, with positive transfer observed as diverse knowledge enables emergent generalization with larger pre-training datasets.
🧠 Q: Where is the robot’s compute located and why? A: The brain-like compute unit is in the head for sensors and heat dissipation, while the torso contains the majority of onboard computation, with potential for latex or silicone face for human-like interaction.
Narges Alipanah-Lechner & team perform multi-omics analysis of patients with ARDS, revealing 4 molecular signatures associated with death, all characterized by mitochondrial dysfunction.
1Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, UCSF, San Francisco, California, USA.
2Division of Clinical and Translational Research, Department of Anesthesia, Washington University School of Medicine, St. Louis, Missouri, USA.
3Cardiovascular Research Institute, UCSF, San Francisco, California, USA.
James J. Collins, the Termeer Professor of Medical Engineering and Science at MIT and faculty co-lead of the Abdul Latif Jameel Clinic for Machine Learning in Health, is embarking on a multidisciplinary research project that applies synthetic biology and generative artificial intelligence to the growing global threat of antimicrobial resistance (AMR).
The research project is sponsored by Jameel Research, part of the Abdul Latif Jameel International network. The initial three-year, $3 million research project in MIT’s Department of Biological Engineering and Institute of Medical Engineering and Science focuses on developing and validating programmable antibacterials against key pathogens.
AMR — driven by the overuse and misuse of antibiotics — has accelerated the rise of drug-resistant infections, while the development of new antibacterial tools has slowed. The impact is felt worldwide, especially in low-and middle-income countries, where limited diagnostic infrastructure causes delays or ineffective treatment.
MILAN — The French-German aerospace company The Exploration Company completed mock splashdown tests for its Nyx space capsule, a modular, reusable spacecraft designed to transport cargo and eventually crew to low Earth orbit and beyond. The company conducted water-impact tests on a mock capsule from Jan. 13 through 28.
The testing campaign was not a full splashdown test, but a model-validation exercise carried out at the “Umberto Pugliese” towing tank facility in Italy. The company used a 135-kilogram, 1:4-scale mock-up in a 13.5-meter by 6.5-meter tank to characterize Nyx’s water-impact behavior and validate its numerical models. The testing is intended as a step toward future certification activities and subsequent splashdown activities.
“The primary objective was validation of the numerical splashdown model,” a company spokesperson told SpaceNews. “To do that, we varied release heights and velocities in a controlled way to reproduce multiple impact conditions with high repeatability.”
Found in everything from protein bars to energy drinks, erythritol has long been considered a safe alternative to sugar.
But research suggests this widely used sweetener may be quietly undermining one of the body’s most crucial protective barriers – with potentially serious consequences for heart health and stroke risk.
A study from the University of Colorado suggests erythritol may damage cells in the blood-brain barrier, the brain’s security system that keeps out harmful substances while letting in nutrients.
Researchers at Johns Hopkins Medicine report that they have uncovered a promising drug target that could allow scientists to increase or decrease the activity of specific brain proteins. The discovery may lead to new treatments for psychiatric conditions such as anxiety and schizophrenia, as well as a neurological disorder that affects movement and balance. The work was supported by funding from the National Institutes of Health.
The proteins at the center of the research are known as delta-type ionotropic glutamate receptors, or GluDs. These proteins are known to play an important role in how neurons communicate with each other. According to the researchers, mutations in GluDs have been linked to psychiatric disorders, including anxiety and schizophrenia. Despite this connection, scientists have struggled for years to understand exactly how these proteins work, making it difficult to design treatments that could regulate their activity.
“This class of protein has long been thought to be sitting dormant in the brain,” says Edward Twomey, Ph.D., assistant professor of biophysics and biophysical chemistry at the Johns Hopkins University School of Medicine. “Our findings indicate they are very much active and offer a potential channel to develop new therapies.”
Microsoft is investigating an outage that blocks some administrators with business or enterprise subscriptions from accessing the Microsoft 365 admin center.
While the company has yet to disclose which regions are affected by this ongoing service degradation, it is tracking it on its official service health status page to provide impacted organizations with up-to-date information.
“Some users in the North America region may be unable to access the Microsoft 365 admin center. We’re reviewing service monitoring telemetry to isolate the root cause and develop a remediation plan,” Microsoft said when it acknowledged the issue.