Natural ingredients have long been utilized to enhance human health.
Category: health – Page 3
CISA flags VMware Aria Operations RCE flaw as exploited in attacks
The U.S. Cybersecurity and Infrastructure Security Agency (CISA) has added a VMware Aria Operations vulnerability tracked as CVE-2026–22719 to its Known Exploited Vulnerabilities catalog, flagging the flaw as exploited in attacks.
Broadcom also warned that it is aware of reports indicating the vulnerability is exploited but says it cannot independently confirm the claims.
VMware Aria Operations is an enterprise monitoring platform that helps organizations track the performance and health of servers, networks, and cloud infrastructure.
Abstract: This study challenges the long-standing notion of fibroblasts as passive bystanders in atopic dermatitis
Richard L. Gallo & team discover dermal fibroblasts respond to IL4 and IL13, producing Ccr3-binding chemokines, and driving T cell recruitment in atopic dermatitis:
The figure shows reduction of T cells (red) in an CCR3 antagonist-treated mouse model of atopic dermatitis.
Address correspondence to: Richard L. Gallo, Department of Dermatology, MC0869, UCSD, 9,500 Gilman Dr., La Jolla, California, 92,093, USA. Phone: 858.822.4608; Email: rgallo@health.ucsd.edu.
Find articles by Numata, T. in: | Google Scholar | 
Department of dermatology, UCSD, la jolla, california, USA.
Does This ED Drug Harm the Retina?
Men with erectile dysfunction (ED) who used sildenafil had a higher risk for serous retinal detachment than those who did not use the drug, a new study finds.
“Our results extend prior claims-based signals of an association between” phosphodiesterase type 5 (PDE5) inhibitors and serous retinal detachment, the researchers reported.
The absence of associations with retinal vascular occlusion and ischemic optic neuropathy suggest sildenafil’s ocular risks may be specific to serous retinal pathology rather than ischemic events affecting the vessels or optic nerve, they wrote.
The study was led by Jaffer Shah of Weill Cornell Medicine in New York City. It was published online on February 21 in Eye.
The use of electronic health records may have introduced residual confounding and misclassification of the use of sildenafil.
SRIC4 Newsletter #04 — What is Quality of Life?
What truly defines “Quality of Life” (QoL), and why we have titled the SRI IV World Congress on it?QoL is a broad concept, including all of the aspects of the life of us, human inhabitants of the third planet of this Solar System. Traditionally, we define QoL through the essentials—food, shelter, health, and education. These are the pillars of economic and cultural development, and they are non-negotiable. Yet, at Space Renaissance, we believe QoL aims higher. It is the freedom to pursue our highest ideals, to have a beautiful life, to explore spirituality, and to seek a global reduction in suffering. Interestingly, the perception of QoL varies wildly across our globe today. The Western post-industrial societies are often clouded by a lack of confidence and a fading hope for what lies ahead. The Eastern emerging societies, fueled by rapid industrial growth, look toward the horizon with immense anticipation. If we could measure QoL through the lens of hope, these emerging societies might actually outrank the West. Why? Because the belief that one is part of a “great project”—one that glorifies human intelligence and potential—is the ultimate antidote to social suffering.
Whether we progress or regress, fall into crisis or rise in a renaissance, it all depends on the mass-psychological mood of the people. When survival is secured, and economic growth creates opportunities for all, social fear dissolves. And as John Lennon famously sang, when fear fades, we finally “give peace a chance.”
We align ourselves with this progressive spirit, like a modern Promethean manifesto. However, we must be realistic: this hope has an expiration date. Without the launch of civil space development by 2030, the “closed world” will inevitably reach its limits. Eastern hopes will be dashed, and Western lifestyles will suffer a sharp decline.
Social Risk Prevalence in AYAs With and Without a History of Cancer
About one-third of adolescents and young adults, with or without Cancer, reported at least one social risk such as financial hardship or food insecurity, highlighting the need for routine screening.
This cross-sectional study used data from KPNW, an integrated health care system serving more than 620 000 members in northwest Oregon and southwest Washington, representing approximately 16% of the region’s population. The KPNW Institutional Review Board deemed the study exempt from review and informed consent under category 4 of the Common Rule, meaning that this research was determined to be low risk as it involves the use of secondary data. The study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline for cross-sectional studies.
Members of KPNW are demographically similar to the surrounding community, with a broad age distribution (approximately 23% aged 18–35 years and 40% aged 36–64 years), a nearly equal sex distribution (52% female), and a racial and ethnic composition comparable to that of the regional population. Approximately 18% of members live below 200% of the federal poverty level, and approximately 80% receive coverage through employer-sponsored plans, contributing to high annual retention rates (approximately 88%). In early 2020, KPNW implemented a social risk screening tool via the EPIC-based (Epic Systems Corp) HealthConnect system. Full details of the screening process have been previously described.22,23
We included KPNW members aged 15 to 40 years who received care at KPNW; completed the social determinants of health screener between January 1, 2022, and December 31, 2024 (the first screening was defined as the index date); and had at least 6 months of follow-up data (eFigure 1 in Supplement 1).
Pearls & Oy-sters: Reversible Leukoencephalopathy and Parkinsonism Due to CNS Involvement in Cryoglobulinemia
What is metabolic dysfunction–associated steatotic liver disease?
Metabolic dysfunction–associated steatotic liver disease (MASLD) involves accumulation of fat in the liver and may progress to liver inflammation and scarring.
The main risk factors for MASLD are obesity and type 2 diabetes.
Usually people with MASLD show no symptoms but some may feel tired or have pain or discomfort in the upper right side of their abdomen.
Eating a low-carbohydrate, low-fat, and low-calorie diet; avoiding alcohol; and exercise are the first-line of treatment for MASLD. sciencenewshighlights ScienceMission https://sciencemission.com/What-Is–MASLD
This JAMA Patient Page describes metabolic dysfunction–associated steatotic liver disease (MASLD) and its risk factors, symptoms and complications, diagnosis, and treatment.
Chemotherapeutic drugs: Cell death- and resistance-related signaling pathways. Are they really as smart as the tumor cells?
Cancer is characterized by the uncontrolled cell proliferation, invasion, and check-point evasion of abnormal cells that are mostly nonfunctional. Cancer can arise due to diet insufficiencies, inherited mutations, and tobacco consumption, to say the least [1, 2]. Cancer’s incident is increasing due to the sedentary lifestyle, overpopulated, polluted megacities, and individuals’ growing desire for consuming processed foods containing preservatives additives [3], [4], [5]. Since cancers might not manifest symptoms in their early onset, it would be difficult or even improbable to treat them when they are diagnosed in their late stage. By and large, tumors are composed of two main parts, including the proliferating cells and stroma, which contains connective tissue and blood supply [6]. Chemotherapy has been among our best options against malignancies.
Chemotherapy is defined by the administration of numerous drugs and chemicals either alone or in combination to kill the cancer cells. Chemotherapeutic drugs kill cancer cells or control their progression all over the patient’s body, while radiation-and surgery-based treatments are directed to a particular site. Cure, control, and palliation are the three objectives of chemotherapies. Killing cancer cells by implementing chemotherapy drugs means “Cure”, whereas “Control” defines the situation that full remission seems far-fetched; therefore, the objective of the therapy would be to decrease the tumor size or to diminish the growth rate and angiogenesis. Palliation aims to alleviate the pain, symptoms, and medical conditions arisen due to cancer. It is mostly accomplished when cancer is in the advanced stages and cannot be eradicated; therefore, our aim would be to improve the quality of life.
The chemotherapy prescription approaches rely on various elements, including the cancer’s type, the cancer’s stage, the patient’s age, the patient’s general health status, the other concurrent health issues, and the history of receiving chemotherapies. Since chemotherapeutic drugs cannot distinguish normal cells against cancerous cells, the prescribed dosage is the other crucial aspect toward achieving the best possible response. The administration dosage depends on the patient’s weight, body surface area, age, nutrition status, history of radiation therapy, and blood cell count. Besides, a suitable drug administration schedule might help obtain the most efficient anti-cancer activity and minimum side effects [7, 8].
Genetic sequencing has aided in the discovery of novel mutations in inborn errors of immunity, but their clinical relevance often remains unclear
In this Research Article, Marcus Altfeld & team identify a TLR8 gene mutation causing immune overactivation and inflammation in two siblings, linking genetic change to immune system dysfunction and disease: Immunology.
14 Hamburg Center for Translational Immunology;
15 German Center for Child and Adolescent Health (DZKJ), partner site Hamburg; and.
16 Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Insufficient Sleep in Adolescents and the Need for System Changes
💬 Editor’s Note by JAMA Editorial Fellow Randi Bates and JAMA Deputy Editor Tracy Lieu: Adolescents face increasing rates of insufficient sleep, driven by early school start times and digital media use, undermining cognitive and mental health.
Insufficient sleep is one of the most common health risks in adolescents and is associated with worse cognitive performance and academic achievement, as well as depression, other mental health conditions, and physical concerns. The American Academy of Sleep Medicine and American Academy of Pediatrics (AAP) recommend adolescents aged 13 to 18 years sleep for 8 to 10 hours each night.1 Yet, studies have found that adequate sleep eludes most adolescents.2
In this issue of JAMA, Bommersbach and colleagues report worsening trends in insufficient sleep duration among US high school students based on an analysis of the national Youth Risk Behavior Survey.3 Insufficient sleep increased from 68.9% in 2007 to 76.8% in 2023, largely from increases in very short sleep durations of less than or equal to 5 hours per night. This trend was observed in all demographic groups and was generally consistent across subgroups characterized by behavioral risk factors.
These sweeping patterns suggest that structural and environmental factors may be driving increases in insufficient sleep at the population level. Although some studies have focused on changing individual behavior to increase sleep, such interventions may have limitations in adolescents whose self-regulatory and decision-making abilities are still maturing. Additionally, adolescents may lack sufficient agency to overcome school or social system barriers that limit sleep.