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Study finds that UV-emitting nail polish dryers damage DNA and cause mutations in cells

The ultraviolet nail polish drying devices used to cure gel manicures may pose more of a public health concern than previously thought. Researchers at the University of California San Diego have studied these ultraviolet (UV) light emitting devices, and found that their use leads to cell death and cancer-causing mutations in human cells.

The devices are a common fixture in nail salons, and generally use a particular spectrum of UV light (340-395nm) to cure the chemicals used in gel manicures. While use a different spectrum of UV light (280-400nm) that studies have conclusively proven to be carcinogenic, the spectrum used in the nail dryers has not been well studied.

“If you look at the way these devices are presented, they are marketed as safe, with nothing to be concerned about,” said Ludmil Alexandrov, a professor of bioengineering as well as cellular and at UC San Diego, and corresponding author of the study published in Nature Communications. “But to the best of our knowledge, no one has actually studied these devices and how they affect at the molecular and cellular levels until now.”

Humans plunder the periodic table while turning blind eye to the risks of doing so, say researchers

For millions of years, nature has basically been getting by with just a few elements from the periodic table. Carbon, calcium, oxygen, hydrogen, nitrogen, phosphorus, silicon, sulfur, magnesium and potassium are the building blocks of almost all life on our planet (tree trunks, leaves, hairs, teeth, etc). However, to build the world of humans—including cities, health care products, railways, airplanes and their engines, computers, smartphones, and more—many more chemical elements are needed.

A recent article, published in Trends in Ecology and Evolution and written by researchers from CREAF, the Universitat Autònoma de Barcelona (UAB) and the Spanish National Research Council (CSIC), warns that the range of chemical elements humans need (something scientifically known as the human elementome) is increasingly diverging from that which nature requires (the biological elementome).

In 1900, approximately 80% of the elements humans used came from biomass (wood, plants, food, etc.). That figure had fallen to 32% by 2005, and is expected to stand at approximately 22% in 2050. We are heading for a situation in which 80% of the elements we use are from non-biological sources.

Dr Haileyesus Getahun, MD, MPH, PhD — WHO — Leading The Fight Against Antimicrobial Resistance (AMR)

Leading The Global Fight Against Antimicrobial Resistance (AMR) — Dr. Haileyesus Getahun, MD, MPH, Ph.D., Director of AMR Global Coordination, World Health Organization (WHO)


Dr. Haileyesus Getahun, MD, MPH, Ph.D. is Director of AMR (Antimicrobial Resistance) Global Coordination at the World Health Organization (WHO) and the Quadripartite (FAO/UNEP/WHO/WOAH) Joint Secretariat on Antimicrobial Resistance. (https://www.who.int/about/people/biography/dr-haileyesus-getahun)

Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. AMR occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death. As a result, the medicines become ineffective and infections persist in the body, increasing the risk of spread to others. Over 1.27 million deaths worldwide were attributed to AMR infections in 2019. Antimicrobials — including antibiotics, antivirals, antifungals and antiparasitics — are medicines used to prevent and treat infections in humans, animals and plants. Microorganisms that develop antimicrobial resistance are sometimes referred to as “superbugs”.

Dr. Getahun coordinates the global One Health multi-sectoral response to AMR across the human, animal, plant, food, feed and environment sectors; directs the Secretariat of the Global Leaders Group on AMR (https://www.amrleaders.org) currently co-chaired by Their Excellencies Prime Minister of Barbados and Bangladesh; facilitates the research and development agenda through priority setting and gap analysis, and provides policy and programmatic guidance to nurture and scale up evidence-based interventions to enhance antimicrobial stewardship activities, awareness and behavioral change across all sectors.

Dr. Getahun was formerly the Director of the Secretariat of the United Nations Interagency Coordination Group on Antimicrobial Resistance (IACG) which was established by the UN Secretary General and released the 2019 ground-breaking report on how to respond to the global AMR crisis. Before that he worked in the Global TB Program of WHO leading its work on TB/HIV and community care.

What The Internet Looked Like In The 1990s | Flashback | NBC News

A “Nightly News” segment from 1993 captures the early stages of how people were using the Internet.
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What The Internet Looked Like In The 1990s | Flashback | NBC News.

Artificial Pancreas Developed That Can Help Maintain Healthy Glucose Levels in Type 2 Diabetes Patients

Scientists at the University of Cambridge have successfully trialed an artificial pancreas for use by patients living with type 2 diabetes. The device – powered by an algorithm developed at the University of Cambridge – doubled the amount of time patients were in the target range for glucose compared to standard treatment and halved the time spent experiencing high glucose levels.

Around 415 million people worldwide are estimated to be living with type 2 diabetes, which costs around $760 billion in annual global health expenditure. According to Diabetes UK, more than 4.9 million people have diabetes in the UK alone, of whom 90% have type 2 diabetes, and this is estimated to cost the NHS £10 billion per year.

“Many people with type 2 diabetes struggle to manage their blood sugar levels using the currently available treatments, such as insulin injections. The artificial pancreas can provide a safe and effective approach to help them, and the technology is simple to use and can be implemented safely at home.” —

Recent study offers new insight into deadly fungal invasion of the lungs

Fungi such as Aspergillus are so common in our surroundings that we breathe in hundreds to thousands of spores every day. In healthy people, fungi typically pose no threat, but they can cause deadly infections in those with compromised immune systems. However, it is increasingly recognized that viral infections such as influenza or SARS-CoV-2 can increase the risk of invasive Aspergillus infections even in healthy people.

The World Health Organization (WHO) has stated that invasive fungal infections are an increasing threat to human health and has reiterated that more research is needed. Until now little was known about how the Aspergillus fungus was able to take root, and what could be done to get rid of it. Researchers at the University of Calgary working with researchers at McGill University have provided new insight on why the immune system fails.

“We discovered that influenza and COVID-19 destroy a previously unknown natural immunity that we need to resist invasive fungal infections,” says Nicole Sarden, a Ph.D. candidate at the University of Calgary and first author on the study.

Open-Sourcing And Accelerating Precision Health Of The Future: Progress, Potential and Possibilities Podcast episode

https://youtu.be/I5Xarr7pBuk

Simon Waslander is the Director of Collaboration, at the CureDAO Alliance for the Acceleration of Clinical Research (https://www.curedao.org/), a community-owned platform for the precision health of the future.

CureDAO is creating an open-source platform to discover how millions of factors, like foods, drugs, and supplements affect human health, within a decentralized autonomous organization (DAO), making suffering optional through the creation of a “WordPress of health data”.

Simon is a native of the Dutch Caribbean island of Aruba, having been born on the island and initially chose to study medicine at the University of Groningen, but then transitioned over to healthcare innovation studies at the University of Maastricht where he wrote his master thesis on the topic of Predictive Healthcare Algorithms.

(For information on the discussion segment on AGI, please contact — www.Norn.AI)

Super-resistant mosquitoes in Asia pose growing threat: Study

Mosquitoes that transmit dengue and other viruses have evolved growing resistance to insecticides in parts of Asia, and novel ways to control them are desperately needed, new research warns.

Health authorities commonly fog mosquito-infested areas with clouds of insecticide, and resistance has long been a concern, but the scale of the problem was not well understood.

Japanese scientist Shinji Kasai and his team examined mosquitos from several countries in Asia as well as Ghana and found a series of mutations had made some virtually impervious to popular pyrethroid-based chemicals like permethrin.

Visualizing the Inside of Cells at Previously Impossible Resolutions Provides Vivid Insights Into How They Work

New tools are steadily bridging this gap. And ongoing development of one particular technique, cryo-electron tomography, or cryo-ET, has the potential to deepen how researchers study and understand how cells function in health and disease.

As the former editor-in-chief of Science magazine and as a researcher who has studied hard-to-visualize large protein structures for decades, I have witnessed astounding progress in the development of tools that can determine biological structures in detail. Just as it becomes easier to understand how complicated systems work when you know what they look like, understanding how biological structures fit together in a cell is key to understanding how organisms function.

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